| Intrinsically Disordered Membrane Anchors of Rheb, RhoA, and DiRas3 Small GTPases: Molecular Dynamics, Membrane Organization, and Interactions. | Intrinsically Disordered Membrane Anchors of Rheb, RhoA, and DiRas3 Small GTPases: Molecular Dynamics, Membrane Organization, and Interactions.
Hutchins CM, Gorfe AA., Free PMC Article | 08/1/2024 |
| DIRAS3 induces autophagy and enhances sensitivity to anti-autophagic therapy in KRAS-driven pancreatic and ovarian carcinomas. | DIRAS3 induces autophagy and enhances sensitivity to anti-autophagic therapy in KRAS-driven pancreatic and ovarian carcinomas.
Bildik G, Gray JP, Mao W, Yang H, Ozyurt R, Orellana VR, De Wever O, Carey MS, Bast RC, Lu Z., | 03/11/2024 |
| Expression of RASSF1A, DIRAS3, and AKAP9 Genes in Thyroid Lesions: Implications for Differential Diagnosis and Prognosis of Thyroid Carcinomas. | Expression of RASSF1A, DIRAS3, and AKAP9 Genes in Thyroid Lesions: Implications for Differential Diagnosis and Prognosis of Thyroid Carcinomas.
Soboska K, Kusiński M, Pawelczyk K, Migdalska-Sęk M, Brzeziańska-Lasota E, Czarnecka-Chrebelska KH., Free PMC Article | 01/16/2024 |
| DIRAS3 regulates autophagy in an endometriosis epithelial cell line. | DIRAS3 regulates autophagy in an endometriosis epithelial cell line.
Yotova I, Proestling K, Haslinger I, Witzmann-Stern M, Widmar B, Kuessel L, Husslein H, Wenzl R, Hudson QJ. | 09/20/2023 |
| Elimination of dormant, autophagic ovarian cancer cells and xenografts through enhanced sensitivity to anaplastic lymphoma kinase inhibition. | Elimination of dormant, autophagic ovarian cancer cells and xenografts through enhanced sensitivity to anaplastic lymphoma kinase inhibition.
Blessing AM, Santiago-O'Farrill JM, Mao W, Pang L, Ning J, Pak D, Bollu LR, Rask P, Iles L, Yang H, Tran S, Elmir E, Bartholomeusz G, Langley R, Lu Z, Bast RC Jr., Free PMC Article | 05/22/2021 |
| A risk signature with four autophagy-related genes for predicting survival of glioblastoma multiforme. | A risk signature with four autophagy-related genes for predicting survival of glioblastoma multiforme.
Wang Y, Zhao W, Xiao Z, Guan G, Liu X, Zhuang M., Free PMC Article | 05/8/2021 |
| The Role of Methylation in the CpG Island of the ARHI Promoter Region in Cancers. | The Role of Methylation in the CpG Island of the ARHI Promoter Region in Cancers.
Liu X, Zhang T, Li Y, Zhang Y, Zhang H, Wang X, Li L. | 10/3/2020 |
| DIRAS3 (ARHI) Blocks RAS/MAPK Signaling by Binding Directly to RAS and Disrupting RAS Clusters. | DIRAS3 (ARHI) Blocks RAS/MAPK Signaling by Binding Directly to RAS and Disrupting RAS Clusters.
Sutton MN, Lu Z, Li YC, Zhou Y, Huang T, Reger AS, Hurwitz AM, Palzkill T, Logsdon C, Liang X, Gray JW, Nan X, Hancock J, Wahl GM, Bast RC Jr., Free PMC Article | 09/26/2020 |
| Epigenetic inhibition of the tumor suppressor ARHI by light at night-induced circadian melatonin disruption mediates STAT3-driven paclitaxel resistance in breast cancer. | Epigenetic inhibition of the tumor suppressor ARHI by light at night-induced circadian melatonin disruption mediates STAT3-driven paclitaxel resistance in breast cancer.
Xiang S, Dauchy RT, Hoffman AE, Pointer D, Frasch T, Blask DE, Hill SM., Free PMC Article | 01/11/2020 |
| Study found that both autophagy and apoptosis were induced after over-expressing ARHI in glioma cells suggesting that ARHI may be a functional tumor suppressor in glioma. | Oncogenic Ras is downregulated by ARHI and induces autophagy by Ras/AKT/mTOR pathway in glioblastoma.
Zhong C, Shu M, Ye J, Wang X, Chen X, Liu Z, Zhao W, Zhao B, Zheng Z, Yin Z, Gao M, Zhao H, Wang K, Zhao S., Free PMC Article | 09/14/2019 |
| study reports somatic mutation of ARHI gene in hepatocellular carcinoma (HCC), however, only one ARHI mutation was detected; data indicate that somatic mutation in ARHI may be rare in HCCs and suggest that somatic mutational events in ARHI may not contribute to development of HCCs | Somatic Mutation of ARHI Gene in Hepatocellular Carcinomas.
Kim CJ, Shin JW, Jung SW, Park BR, Park NH. | 09/7/2019 |
| a novel oncogenic role of DIRAS3 in the development and progression of glioma | Oncogenic DIRAS3 promotes malignant phenotypes of glioma by activating EGFR-AKT signaling.
Peng Y, Jia J, Jiang Z, Huang D, Jiang Y, Li Y. | 05/25/2019 |
| Low DIRAS3 expression is associated with metastasis in gastric cancer. | Distinct subgroup of the Ras family member 3 (DIRAS3) expression impairs metastasis and induces autophagy of gastric cancer cells in mice.
Qiu J, Li X, He Y, Sun D, Li W, Xin Y., Free PMC Article | 10/6/2018 |
| lncRNA GAS5 functions as a competing endogenous RNA for miR-221 to suppress cell growth and EMT in osteosarcoma by regulating the miR-221/ARHI pathway. | Long Noncoding RNA GAS5 Suppresses Cell Growth and Epithelial-Mesenchymal Transition in Osteosarcoma by Regulating the miR-221/ARHI Pathway.
Ye K, Wang S, Zhang H, Han H, Ma B, Nan W. | 01/6/2018 |
| DiRas3 binds to KSR1 independently of its interaction with activated Ras and RAF. | Stabilization of C-RAF:KSR1 complex by DiRas3 reduces availability of C-RAF for dimerization with B-RAF.
Baljuls A, Dobrzyński M, Rauch J, Rauch N, Kolch W. | 12/2/2017 |
| We demonstrate that DIRAS3 knock-down (KD) in adipose stromal/progenitor cells (ASCs) induces activation of Akt-mTOR signaling and proliferation arrest. DIRAS3 KD ASCs lose the potential to form colonies and are negative for Ki-67. Moreover, silencing of DIRAS3 results in a premature senescence phenotype. | Silencing of the small GTPase DIRAS3 induces cellular senescence in human white adipose stromal/progenitor cells.
Ejaz A, Mattesich M, Zwerschke W., Free PMC Article | 11/18/2017 |
| ARHI-mediated up-regulation of glycolysis and glutaminolysis was found to be autophagy-dependent and inhibition of these metabolic pathways resulted in decreased cell viability. | Induction of autophagy by ARHI (DIRAS3) alters fundamental metabolic pathways in ovarian cancer models.
Ornelas A, McCullough CR, Lu Z, Zacharias NM, Kelderhouse LE, Gray J, Yang H, Engel BJ, Wang Y, Mao W, Sutton MN, Bhattacharya PK, Bast RC Jr, Millward SW., Free PMC Article | 09/30/2017 |
| The overexpression of ARHI promotes colon cancer SW480 cell apoptosis by inhibiting the level of Akt. | [Overexpression of aplysia Ras homolog I (ARHI) increases apoptosis in colon cancer SW480 cells].
Chen X, Jiang Z. | 06/24/2017 |
| Transcriptional, but not post-transcriptional, silencing of GNG12-AS1 causes concomitant upregulation of DIRAS3, indicating a function in transcriptional interference. | Transcriptional silencing of long noncoding RNA GNG12-AS1 uncouples its transcriptional and product-related functions.
Stojic L, Niemczyk M, Orjalo A, Ito Y, Ruijter AE, Uribe-Lewis S, Joseph N, Weston S, Menon S, Odom DT, Rinn J, Gergely F, Murrell A., Free PMC Article | 06/28/2016 |
| ARHI mRNA and protein expression is markedly decreased in osteosarcoma MG-63 cells lines. Overexpression of ARHI inhibits cell viability and proliferation. | Aplasia Ras homologue member Ⅰ overexpression inhibits tumor growth and induces apoptosis through inhibition of PI3K/Akt survival pathways in human osteosarcoma MG-63 cells in culture.
Ye K, Wang S, Yang Y, Kang X, Wang J, Han H. | 05/14/2016 |
| ARHI-mediated autophagy-associated cell death enhances chemosensitivity to cisplatin in ovarian cancer cell lines and xenografts. | ARHI (DIRAS3)-mediated autophagy-associated cell death enhances chemosensitivity to cisplatin in ovarian cancer cell lines and xenografts.
Washington MN, Suh G, Orozco AF, Sutton MN, Yang H, Wang Y, Mao W, Millward S, Ornelas A, Atkinson N, Liao W, Bast RC Jr, Lu Z., Free PMC Article | 04/16/2016 |
| EZH2-''induced H3K27me3 is associated with epigenetic repression of the ARHI tumor-suppressor gene in epithelial ovarian cancer | EZH2-induced H3K27me3 is associated with epigenetic repression of the ARHI tumor-suppressor gene in ovarian cancer.
Fu Y, Chen J, Pang B, Li C, Zhao J, Shen K. | 02/27/2016 |
| ARHI competes with RanGTPase and interacts with importin beta via basic-acidic patch interaction, which leads to inhibition of STAT3 translocation. | Structural perspective of ARHI mediated inhibition of STAT3 signaling: an insight into the inactive to active transition of ARHI and its interaction with STAT3 and importinβ.
Muthu K, Panneerselvam M, Topno NS, Jayaraman M, Ramadas K. | 12/26/2015 |
| Letter: ARHI suppresses pancreatic cancer by regulating ERK 1/2 signaling. | ARHI suppresses pancreatic cancer by regulating MAPK/ERK 1/2 pathway.
Hu Y, Yang H, Lu XQ, Xu F, Li J, Qian J. | 11/28/2015 |
| JMJD2A-dependent silencing of Sp1 in advanced breast cancer promotes metastasis by downregulation of DIRAS3. | JMJD2A-dependent silencing of Sp1 in advanced breast cancer promotes metastasis by downregulation of DIRAS3.
Li L, Gao P, Li Y, Shen Y, Xie J, Sun D, Xue A, Zhao Z, Xu Z, Zhang M, Li B, Jiang J. | 07/25/2015 |