| TBX18 knockdown sensitizes esophageal squamous cell carcinoma to radiotherapy by blocking the CHN1/RhoA axis. | TBX18 knockdown sensitizes esophageal squamous cell carcinoma to radiotherapy by blocking the CHN1/RhoA axis.
Zhou J, Wu J, Wu G, Huang J, Zhang Y, Che J, Zhu K, Geng J, Fan Q. | 08/25/2023 |
| The role of TBX18 in congenital heart defects in humans not confirmed. | The role of TBX18 in congenital heart defects in humans not confirmed.
Engwerda A, Abbott KM, Hitzert MM, van Ravenswaaij-Arts CMA, Kerstjens-Frederikse WS., Free PMC Article | 02/13/2023 |
| MicroRNA-dependent suppression of biological pacemaker activity induced by TBX18. | MicroRNA-dependent suppression of biological pacemaker activity induced by TBX18.
Sanchez L, Mesquita T, Zhang R, Liao K, Rogers R, Lin YN, Miguel-Dos-Santos R, Akhmerov A, Li L, Nawaz A, Holm K, Marbán E, Cingolani E., Free PMC Article | 01/14/2023 |
| Tbx18 promoted the conversion of human-induced pluripotent stem cell-derived cardiomyocytes into sinoatrial node-like pacemaker cells. | Tbx18 promoted the conversion of human-induced pluripotent stem cell-derived cardiomyocytes into sinoatrial node-like pacemaker cells.
Zhang W, Zhao H, Quan D, Tang Y, Wang X, Huang C. | 04/16/2022 |
| TBX18 gene over expression induces human-induced pluripotent stem cells to differentiate into pacemaker-like cells. | TBX18 transcription factor overexpression in human-induced pluripotent stem cells increases their differentiation into pacemaker-like cells.
Gorabi AM, Hajighasemi S, Tafti HA, Atashi A, Soleimani M, Aghdami N, Saeid AK, Khori V, Panahi Y, Sahebkar A. | 12/14/2019 |
| Although TBX3 and TBX18 do not play a significant role in promoting the enrichment and differentiation of HiPS into sinoatrial node-like cells, TBX3 shows a certain promoting trend, which can be further explored in the future. | [Role of over-expression of TBX3 and TBX18 in the enrichment and differentiation of human induced pluripotent stem cells into sinoatrial node-like cells].
Liu F, Fang Y, Xiong Q, Luo L, Zhou R, Liao B., Free PMC Article | 08/10/2019 |
| Study identified and characterized new TBX18 binding partners that may influence the transcriptional activity of TBX18 in vivo. Proteomic screen strongly supports an exclusive nuclear function of TBX18 as a repressor of chromatin accessibility. | Proteomic analysis identifies transcriptional cofactors and homeobox transcription factors as TBX18 binding proteins.
Rivera-Reyes R, Kleppa MJ, Kispert A., Free PMC Article | 01/19/2019 |
| Tbx18-positive cells represent a part of PE cells in the initial phase of differentiation and subsequently include SMCs as well as fibroblasts. These results indicate that Tbx18-positive cells serve as a PE progenitor to supply a variety of cells that contribute to the formation of coronary arteries. | Tbx18-positive cells differentiated from murine ES cells serve as proepicardial progenitors to give rise to vascular smooth muscle cells and fibroblasts.
Ikeda N, Nakazawa N, Kurata Y, Yaura H, Taufiq F, Minato H, Yoshida A, Ninomiya H, Nakayama Y, Kuwabara M, Shirayoshi Y, Hisatome I. | 04/28/2018 |
| Gene product expressions of SHH, TBX18 and TSHZ3 are statistically higher in patients with UPJ obstruction, when compared with control group. The explanation may be the reactivation of the processes, which had shown their effects in the embryological period, due to the chronic inflammation and long-term micro-trauma created by the disease | Sonic hedgehog, TBX18, and TSHZ3 proteins involved in pyeloureteral motility development are overexpressed in ureteropelvic junction obstruction. An immunohistochemical, histopathological, and clinical comparative study.
Yilmaz O, Nese N, Dalgic M, Kesici GP, Genc A, Taneli C, Gunsar C, Sencan A, Cayirli H, Isisag A., Free PMC Article | 08/12/2017 |
| Data indicate that human T-box 18 (TBX18) gene induces rat adipose-derived stem cells (ADSCs) to differentiate into pacemaker-like cells in the cardiac microenvironment. | TBX18 gene induces adipose-derived stem cells to differentiate into pacemaker-like cells in the myocardial microenvironment.
Yang M, Zhang GG, Wang T, Wang X, Tang YH, Huang H, Barajas-Martinez H, Hu D, Huang CX., Free PMC Article | 03/25/2017 |
| Mutations in TBX18 cause dominant urinary tract malformations via transcriptional dysregulation of ureter development. | Mutations in TBX18 Cause Dominant Urinary Tract Malformations via Transcriptional Dysregulation of Ureter Development.
Vivante A, Kleppa MJ, Schulz J, Kohl S, Sharma A, Chen J, Shril S, Hwang DY, Weiss AC, Kaminski MM, Shukrun R, Kemper MJ, Lehnhardt A, Beetz R, Sanna-Cherchi S, Verbitsky M, Gharavi AG, Stuart HM, Feather SA, Goodship JA, Goodship TH, Woolf AS, Westra SJ, Doody DP, Bauer SB, Lee RS, Adam RM, Lu W, Reutter HM, Kehinde EO, Mancini EJ, Lifton RP, Tasic V, Lienkamp SS, Jüppner H, Kispert A, Hildebrandt F., Free PMC Article | 10/31/2015 |
| The DNA sequence variants within the TBX18 gene promoter identified in ventricular septal defects (VSD) patients may be involved in the VSD etiology. | Novel and functional variants within the TBX18 gene promoter in ventricular septal defects.
Ma L, Li J, Liu Y, Pang S, Huang W, Yan B. | 09/27/2014 |
| connexin43 transcriptional suppression by TBX18 undermines cardiomyocyte cell-cell electrical coupling | Transcriptional suppression of connexin43 by TBX18 undermines cell-cell electrical coupling in postnatal cardiomyocytes.
Kapoor N, Galang G, Marbán E, Cho HC., Free PMC Article | 07/2/2011 |
| Tbx18 interacts with Gata4 and Nkx2-5 and competes Tbx5-mediated activation of the cardiac Natriuretic peptide precursor type a-promoter. Tbx18 down-regulates Tbx6-activated Delta-like 1 expression in the somitic mesoderm in vivo | Transcriptional repression by the T-box proteins Tbx18 and Tbx15 depends on Groucho corepressors.
Farin HF, Bussen M, Schmidt MK, Singh MK, Schuster-Gossler K, Kispert A. | 01/21/2010 |