| Abundance of ACVR1B transcript is elevated during septic conditions: Perspectives obtained from a hands-on reductionist investigation. | Abundance of ACVR1B transcript is elevated during septic conditions: Perspectives obtained from a hands-on reductionist investigation.
Preechanukul A, Yimthin T, Tandhavanant S, Brummaier T, Chomkatekaew C, Das S, Syed Ahamed Kabeer B, Toufiq M, Rinchai D, West TE, Chaussabel D, Chantratita N, Garand M., Free PMC Article | 04/10/2023 |
| Activin receptor ALK4 promotes adipose tissue hyperplasia by suppressing differentiation of adipocyte precursors. | Activin receptor ALK4 promotes adipose tissue hyperplasia by suppressing differentiation of adipocyte precursors.
Lee ES, Guo T, Srivastava RK, Shabbir A, Ibáñez CF., Free PMC Article | 02/4/2023 |
| Lack of Tgfbr1 and Acvr1b synergistically stimulates myofibre hypertrophy and accelerates muscle regeneration. | Lack of Tgfbr1 and Acvr1b synergistically stimulates myofibre hypertrophy and accelerates muscle regeneration.
Hillege MMG, Shi A, Galli RA, Wu G, Bertolino P, Hoogaars WMH, Jaspers RT., Free PMC Article | 04/23/2022 |
| Implication of rare genetic variants of NODAL and ACVR1B in congenital heart disease patients from Indian population. | Implication of rare genetic variants of NODAL and ACVR1B in congenital heart disease patients from Indian population.
Yadav ML, Ranjan P, Das P, Jain D, Kumar A, Mohapatra B. | 12/11/2021 |
| Activin A increases human trophoblast invasion by upregulating integrin beta1 through ALK4. | Activin A increases human trophoblast invasion by upregulating integrin β1 through ALK4.
Zhu S, Li Z, Cui L, Ban Y, Leung PCK, Li Y, Ma J. | 06/26/2021 |
| ALK4-SMAD3/4 mediates the effects of activin A on the upregulation of PAI-1 in human granulosa lutein cells. | ALK4-SMAD3/4 mediates the effects of activin A on the upregulation of PAI-1 in human granulosa lutein cells.
Chen B, Chang HM, Zhang Z, Cao Y, Leung PCK. | 02/6/2021 |
| [Involvement of Notch1 and ALK4/5 Signaling Pathways in Renal Tubular Cell Death: Their Application to Clarification of Cadmium Toxicity]. | [Involvement of Notch1 and ALK4/5 Signaling Pathways in Renal Tubular Cell Death: Their Application to Clarification of Cadmium Toxicity].
Fujiki K. | 02/6/2021 |
| Alterations in activin A-myostatin-follistatin system associate with disease activity in inflammatory myopathies. | Alterations in activin A-myostatin-follistatin system associate with disease activity in inflammatory myopathies.
Vernerová L, Horváthová V, Kropáčková T, Vokurková M, Klein M, Tomčík M, Oreská S, Špiritović M, Štorkánová H, Heřmánková B, Kubínová K, Kryštůfková O, Mann H, Ukropec J, Ukropcová B, Vencovský J. | 02/2/2021 |
| Blockade of ALK4/5 signaling suppresses cadmium- and erastin-induced cell death in renal proximal tubular epithelial cells via distinct signaling mechanisms. | Blockade of ALK4/5 signaling suppresses cadmium- and erastin-induced cell death in renal proximal tubular epithelial cells via distinct signaling mechanisms.
Fujiki K, Inamura H, Sugaya T, Matsuoka M., Free PMC Article | 09/12/2020 |
| Multiple emphysema apicobasal distribution loci colocalize to regulatory elements that are active across multiple tissues and cell types, and functional analyses confirm the presence of an emphysema apicobasal distribution-associated functional variant that regulates ACVR1B expression, indicating that transforming growth factor-b signaling plays a role in the emphysema apicobasal distribution phenotype. | Integrative Genomics Analysis Identifies ACVR1B as a Candidate Causal Gene of Emphysema Distribution.
Boueiz A, Pham B, Chase R, Lamb A, Lee S, Naing ZZC, Cho MH, Parker MM, Sakornsakolpat P, Hersh CP, Crapo JD, Stergachis AB, Tal-Singer R, DeMeo DL, Silverman EK, Zhou X, Castaldi PJ, COPDGene investigators, by Core Units:, ECLIPSE Investigators:, GenKOLS Investigators:., Free PMC Article | 12/21/2019 |
| Toxoplasma activates HIF-1 by stabilizing the HIF-1alpha subunit, and this is dependent on the signaling from the the Activin-Like Kinase (ALK) receptor superfamily protein, ALK4. | The Activin Receptor, Activin-Like Kinase 4, Mediates Toxoplasma Gondii Activation of Hypoxia Inducible Factor-1.
Lis A, Wiley M, Vaughan J, Gray PC, Blader IJ., Free PMC Article | 11/30/2019 |
| Expression of ALK4 is upregulated in atrial fibrillation human atrium, with higher ALK4 expression in AF human atrium underlying hypertension. | Activin Receptor-Like Kinase 4 Haplodeficiency Mitigates Arrhythmogenic Atrial Remodeling and Vulnerability to Atrial Fibrillation in Cardiac Pathological Hypertrophy.
Wang Q, Chen Y, Zhang D, Li C, Chen X, Hou J, Fei Y, Wang Y, Li Y., Free PMC Article | 11/23/2019 |
| Overexpression of ALK4 suppressed glioma cell proliferation, migration and invasion through the inactivation of JAK/STAT3 signaling pathway. | Overexpression of ALK4 inhibits cell proliferation and migration through the inactivation of JAK/STAT3 signaling pathway in glioma.
Song C, Fan B, Xiao Z. | 08/18/2018 |
| Results showed that ACVR1B expression is upregulated during latent infection with a miR-UL148D deletion virus. Data indicates miR-UL148D inhibits ACVR1B expression in latently infected cells to limit proinflammatory cytokine secretion. | The Expression of Human Cytomegalovirus MicroRNA MiR-UL148D during Latent Infection in Primary Myeloid Cells Inhibits Activin A-triggered Secretion of IL-6.
Lau B, Poole E, Krishna B, Sellart I, Wills MR, Murphy E, Sinclair J., Free PMC Article | 05/5/2018 |
| Our study provided experimental and clinical evidence for the involvement of activin A and ALK4 in the pathophysiology of atrial fibrosis and atrial fibrillation | The crucial role of activin A/ALK4 pathway in the pathogenesis of Ang-II-induced atrial fibrosis and vulnerability to atrial fibrillation.
Wang Q, Yu Y, Zhang P, Chen Y, Li C, Chen J, Wang Y, Li Y. | 04/7/2018 |
| It was concluded that ALK4 inhibition increases myogenesis but also regulates the tight balance of protein synthesis and degradation. | New function of the myostatin/activin type I receptor (ALK4) as a mediator of muscle atrophy and muscle regeneration.
Pasteuning-Vuhman S, Boertje-van der Meulen JW, van Putten M, Overzier M, Ten Dijke P, Kiełbasa SM, Arindrarto W, Wolterbeek R, Lezhnina KV, Ozerov IV, Aliper AM, Hoogaars WM, Aartsma-Rus A, Loomans CJ., Free PMC Article | 09/2/2017 |
| in a relatively large cohort of athletes from Europe and South America we have shown that the ACVR1B rs2854464 A allele is associated with sprint/power performance in Caucasians but not in Brazilian athletes. | ACVR1B rs2854464 Is Associated with Sprint/Power Athletic Status in a Large Cohort of Europeans but Not Brazilians.
Voisin S, Guilherme JP, Yan X, Pushkarev VP, Cieszczyk P, Massidda M, Calò CM, Dyatlov DA, Kolupaev VA, Pushkareva YE, Maciejewska A, Sawczuk M, Lancha AH Jr, Artioli GG, Eynon N., Free PMC Article | 07/15/2017 |
| ALK4 is an important profibrotic signaling molecule in the post-MI CF. Haplodeficiency of ALK4 significantly improved LV function and survival rate by attenuating CF in vivo, ameliorated | Haplodeficiency of activin receptor-like kinase 4 alleviates myocardial infarction-induced cardiac fibrosis and preserves cardiac function.
Chen YH, Wang Q, Li CY, Hou JW, Chen XM, Zhou Q, Chen J, Wang YP, Li YG. | 06/3/2017 |
| ALK4 is expressed in male germ cells and Sertoli cells. | NODAL secreted by male germ cells regulates the proliferation and function of human Sertoli cells from obstructive azoospermia and nonobstructive azoospermia patients.
Tian RH, Yang S, Zhu ZJ, Wang JL, Liu Y, Yao C, Ma M, Guo Y, Yuan Q, Hai Y, Huang YR, He Z, Li Z., Free PMC Article | 08/13/2016 |
| This study demonstrated positive regulation of monocyte/macrophage differentiation by lnc-MC and uncovered an elaborate regulation mechanism composed of PU.1, lnc-MC, miR-199a-5p, and ACVR1B. | PU.1-Regulated Long Noncoding RNA lnc-MC Controls Human Monocyte/Macrophage Differentiation through Interaction with MicroRNA 199a-5p.
Chen MT, Lin HS, Shen C, Ma YN, Wang F, Zhao HL, Yu J, Zhang JW., Free PMC Article | 05/7/2016 |
| Data suggest that activin A up-regulates SNAIL expression via ALK4/ACVR1B-induced SMAD signaling in trophoblast cells; elevated SNAIL contributes to up-regulation of MMP2 expression which plays key role in promoting trophoblast cell invasion. | Activin A Increases Human Trophoblast Invasion by Inducing SNAIL-Mediated MMP2 Up-Regulation Through ALK4.
Li Y, Klausen C, Zhu H, Leung PC. | 02/27/2016 |
| ACVR1B functions as a positive regulator of monocyte/macrophage differentiation. ACVR1B knockdown promoted THP-1 proliferation by increasing Rb phosphorylation. Down-regulation reduced p-Smad2/3 and C/EBPalpha, inhibiting monocyte/macrophage differentiation. | miR-199a-5p inhibits monocyte/macrophage differentiation by targeting the activin A type 1B receptor gene and finally reducing C/EBPα expression.
Lin HS, Gong JN, Su R, Chen MT, Song L, Shen C, Wang F, Ma YN, Zhao HL, Yu J, Li WW, Huang LX, Xu XH, Zhang JW. | 01/31/2015 |
| The deletion of the ACVR1B gene may mediate an aggressive cancer phenotype in pancreatic cancer. | Homozygous deletion of the activin A receptor, type IB gene is associated with an aggressive cancer phenotype in pancreatic cancer.
Togashi Y, Sakamoto H, Hayashi H, Terashima M, de Velasco MA, Fujita Y, Kodera Y, Sakai K, Tomida S, Kitano M, Ito A, Kudo M, Nishio K., Free PMC Article | 01/17/2015 |
| Findings define a regulatory role of miR-98 in tumor angiogenesis and invasion through repressed ALK4 and MMP11 expression. | MicroRNA miR-98 inhibits tumor angiogenesis and invasion by targeting activin receptor-like kinase-4 and matrix metalloproteinase-11.
Siragam V, Rutnam ZJ, Yang W, Fang L, Luo L, Yang X, Li M, Deng Z, Qian J, Peng C, Yang BB., Free PMC Article | 08/31/2013 |
| ActRIBCA signaling can promote cell migration in prostate cancer cells via a network of signaling molecules that work together to trigger the process of EMT, and thereby aid in the aggressiveness and progression of prostate cancers. | Activin type IB receptor signaling in prostate cancer cells promotes lymph node metastasis in a xenograft model.
Nomura M, Tanaka K, Wang L, Goto Y, Mukasa C, Ashida K, Takayanagi R. | 05/18/2013 |