| A long-term prognosis study of human USP8-mutated ACTH-secreting pituitary neuroendocrine tumours. | A long-term prognosis study of human USP8-mutated ACTH-secreting pituitary neuroendocrine tumours.
Miao H, Wang L, Gong F, Duan L, Wang L, Yao Y, Feng M, Deng K, Wang R, Xiao Y, Ling Q, Zhu H, Lu L. | 06/14/2024 |
| Polymorphic USP8 allele promotes Parkinson's disease by inducing the accumulation of alpha-synuclein through deubiquitination. | Polymorphic USP8 allele promotes Parkinson's disease by inducing the accumulation of α-synuclein through deubiquitination.
Wu S, Lin T, Xu Y., Free PMC Article | 03/14/2024 |
| USP8 prevents aberrant NF-kappaB and Nrf2 activation by counteracting ubiquitin signals from endosomes. | USP8 prevents aberrant NF-κB and Nrf2 activation by counteracting ubiquitin signals from endosomes.
Endo A, Fukushima T, Takahashi C, Tsuchiya H, Ohtake F, Ono S, Ly T, Yoshida Y, Tanaka K, Saeki Y, Komada M., Free PMC Article | 01/9/2024 |
| Clinical Spectrum of USP8 Pathogenic Variants in Cushing's Disease. | Clinical Spectrum of USP8 Pathogenic Variants in Cushing's Disease.
Rebollar-Vega RG, Zuarth-Vázquez JM, Hernández-Ramírez LC. | 12/27/2023 |
| Central role of ubiquitin-specific protease 8 in leptin signaling pathway in pulmonary arterial hypertension. | Central role of ubiquitin-specific protease 8 in leptin signaling pathway in pulmonary arterial hypertension.
Jutant EM, Chelgham MK, Ottaviani M, Thuillet R, Le Vely B, Humbert M, Guignabert C, Tu L, Huertas A. | 12/27/2023 |
| USP8 targeted by Mir-874-3p promotes trophoblastic cell invasion by stabilizing the expression of ENaC on trophoblast membrane. | USP8 targeted by Mir-874-3p promotes trophoblastic cell invasion by stabilizing the expression of ENaC on trophoblast membrane.
Zhang S, Shi Y, Dong P. | 10/25/2023 |
| USP8 promotes gemcitabine resistance of pancreatic cancer via deubiquitinating and stabilizing Nrf2. | USP8 promotes gemcitabine resistance of pancreatic cancer via deubiquitinating and stabilizing Nrf2.
Cui J, Guo Y, Yin T, Gou S, Xiong J, Liang X, Lu C, Peng T. | 09/19/2023 |
| piRNA-1742 promotes renal cell carcinoma malignancy by regulating USP8 stability through binding to hnRNPU and thereby inhibiting MUC12 ubiquitination. | piRNA-1742 promotes renal cell carcinoma malignancy by regulating USP8 stability through binding to hnRNPU and thereby inhibiting MUC12 ubiquitination.
Zhang W, Zheng Z, Wang K, Mao W, Li X, Wang G, Zhang Y, Huang J, Zhang N, Wu P, Liu J, Zhang H, Che J, Peng B, Zheng J, Li W, Yao X., Free PMC Article | 07/6/2023 |
| USP8 Down-Regulation Promotes Parkin-Independent Mitophagy in the Drosophila Brain and in Human Neurons. | USP8 Down-Regulation Promotes Parkin-Independent Mitophagy in the Drosophila Brain and in Human Neurons.
Mauri S, Bernardo G, Martinez A, Favaro M, Trevisan M, Cobraiville G, Fillet M, Caicci F, Whitworth AJ, Ziviani E., Free PMC Article | 05/23/2023 |
| Ubiquitin-specific Protease 8 Gene Expression in Sporadic Pituitary Adenomas. | Ubiquitin-specific Protease 8 Gene Expression in Sporadic Pituitary Adenomas.
Hatipoglu E, Gunaldi O, Erkan B, Avcikurt A, Mert M, Niyazoglu M. | 10/22/2022 |
| USP8 promotes cancer progression and extracellular vesicle-mediated CD8+ T cell exhaustion by deubiquitinating the TGF-beta receptor TbetaRII. | USP8 promotes cancer progression and extracellular vesicle-mediated CD8+ T cell exhaustion by deubiquitinating the TGF-β receptor TβRII.
Xie F, Zhou X, Li H, Su P, Liu S, Li R, Zou J, Wei X, Pan C, Zhang Z, Zheng M, Liu Z, Meng X, Ovaa H, Ten Dijke P, Zhou F, Zhang L., Free PMC Article | 08/27/2022 |
| Improved pasireotide response in USP8 mutant corticotroph tumours in vitro. | Improved pasireotide response in USP8 mutant corticotroph tumours in vitro.
Albani A, Perez-Rivas LG, Tang S, Simon J, Lucia KE, Colón-Bolea P, Schopohl J, Roeber S, Buchfelder M, Rotermund R, Flitsch J, Thorsteinsdottir J, Herms J, Stalla G, Reincke M, Theodoropoulou M. | 08/6/2022 |
| Deubiquitinase USP8 increases ID1 stability and promotes esophageal squamous cell carcinoma tumorigenesis. | Deubiquitinase USP8 increases ID1 stability and promotes esophageal squamous cell carcinoma tumorigenesis.
Li L, Liu Y, Zhao Y, Feng R, Li Y, Yu X, Liu Z, Wang L. | 06/25/2022 |
| Responsiveness to DDAVP in Cushing's disease is associated with USP8 mutations through enhancing AVPR1B promoter activity. | Responsiveness to DDAVP in Cushing's disease is associated with USP8 mutations through enhancing AVPR1B promoter activity.
Shichi H, Fukuoka H, Kanzawa M, Yamamoto M, Yamamoto N, Suzuki M, Urai S, Matsumoto R, Kanie K, Fujita Y, Bando H, Iguchi G, Inoshita N, Yamada S, Takahashi Y, Ogawa W. | 06/18/2022 |
| Usp8 promotes tumor cell migration through activating the JNK pathway. | Usp8 promotes tumor cell migration through activating the JNK pathway.
Zhao Y, Peng D, Liu Y, Zhang Q, Liu B, Deng Y, Ding W, Zhou Z, Liu Q., Free PMC Article | 04/16/2022 |
| USP8, USP48, and BRAF mutations differ in their genotype-phenotype correlation in Asian Indian patients with Cushing's disease. | USP8, USP48, and BRAF mutations differ in their genotype-phenotype correlation in Asian Indian patients with Cushing's disease.
Abraham AP, Pai R, Beno DL, Chacko G, Asha HS, Rajaratnam S, Kapoor N, Thomas N, Chacko AG. | 03/26/2022 |
| Specific Deubiquitinating Enzymes Promote Host Restriction Factors Against HIV/SIV Viruses. | Specific Deubiquitinating Enzymes Promote Host Restriction Factors Against HIV/SIV Viruses.
Gao W, Rui Y, Li G, Zhai C, Su J, Liu H, Zheng W, Zheng B, Zhang W, Yang Y, Hua S, Yu X., Free PMC Article | 01/8/2022 |
| Molecular basis of ubiquitin-specific protease 8 autoinhibition by the WW-like domain. | Molecular basis of ubiquitin-specific protease 8 autoinhibition by the WW-like domain.
Kakihara K, Asamizu K, Moritsugu K, Kubo M, Kitaguchi T, Endo A, Kidera A, Ikeguchi M, Kato A, Komada M, Fukushima T., Free PMC Article | 12/18/2021 |
| USP8 and TP53 Drivers are Associated with CNV in a Corticotroph Adenoma Cohort Enriched for Aggressive Tumors. | USP8 and TP53 Drivers are Associated with CNV in a Corticotroph Adenoma Cohort Enriched for Aggressive Tumors.
Uzilov AV, Taik P, Cheesman KC, Javanmard P, Ying K, Roehnelt A, Wang H, Fink MY, Lau CY, Moe AS, Villar J, Bederson JB, Stewart AF, Donovan MJ, Mahajan M, Sebra R, Post KD, Chen R, Geer EB. | 09/25/2021 |
| TrkB deubiquitylation by USP8 regulates receptor levels and BDNF-dependent neuronal differentiation. | TrkB deubiquitylation by USP8 regulates receptor levels and BDNF-dependent neuronal differentiation.
Martín-Rodríguez C, Song M, Anta B, González-Calvo FJ, Deogracias R, Jing D, Lee FS, Arevalo JC., Free PMC Article | 08/7/2021 |
| Inhibiting USP8 overcomes hepatocellular carcinoma resistance via suppressing receptor tyrosine kinases. | Inhibiting USP8 overcomes hepatocellular carcinoma resistance via suppressing receptor tyrosine kinases.
Zhu Y, Xu J, Hu W, Wang F, Zhou Y, Gong W, Xu W., Free PMC Article | 07/24/2021 |
| Deubiquitylation and stabilization of Notch1 intracellular domain by ubiquitin-specific protease 8 enhance tumorigenesis in breast cancer. | Deubiquitylation and stabilization of Notch1 intracellular domain by ubiquitin-specific protease 8 enhance tumorigenesis in breast cancer.
Shin S, Kim K, Kim HR, Ylaya K, Do SI, Hewitt SM, Park HS, Roe JS, Chung JY, Song J., Free PMC Article | 07/3/2021 |
| The ubiquitin-specific protease USP8 directly deubiquitinates SQSTM1/p62 to suppress its autophagic activity. | The ubiquitin-specific protease USP8 directly deubiquitinates SQSTM1/p62 to suppress its autophagic activity.
Peng H, Yang F, Hu Q, Sun J, Peng C, Zhao Y, Huang C., Free PMC Article | 06/12/2021 |
| The oncogenic role of ubiquitin specific peptidase (USP8) and its signaling pathways targeting for cancer therapeutics. | The oncogenic role of ubiquitin specific peptidase (USP8) and its signaling pathways targeting for cancer therapeutics.
Islam MT, Chen F, Chen H. | 04/24/2021 |
| Ubiquitin-Specific Protease 8 Mutant Corticotrope Adenomas Present Unique Secretory and Molecular Features and Shed Light on the Role of Ubiquitylation on ACTH Processing. | Ubiquitin-Specific Protease 8 Mutant Corticotrope Adenomas Present Unique Secretory and Molecular Features and Shed Light on the Role of Ubiquitylation on ACTH Processing.
Sesta A, Cassarino MF, Terreni M, Ambrogio AG, Libera L, Bardelli D, Lasio G, Losa M, Pecori Giraldi F., Free PMC Article | 02/20/2021 |