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    LATS1 large tumor suppressor kinase 1 [ Homo sapiens (human) ]

    Gene ID: 9113, updated on 14-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    HPV18 E7 inhibits LATS1 kinase and activates YAP1 by degrading PTPN14.

    HPV18 E7 inhibits LATS1 kinase and activates YAP1 by degrading PTPN14.
    Blakely WJ, Hatterschide J, White EA., Free PMC Article

    10/29/2024
    LncRNA HOTAIR promotes the migration and invasion of cervical cancer through DNMT3B/LATS1/ YAP1 pS127 axis.

    LncRNA HOTAIR promotes the migration and invasion of cervical cancer through DNMT3B/LATS1/ YAP1 pS127 axis.
    Zhang Z, Zhou X, Li J, Meng Q, Zheng P.

    10/22/2024
    SUMOylation activates large tumour suppressor 1 to maintain the tissue homeostasis during Hippo signalling.

    SUMOylation activates large tumour suppressor 1 to maintain the tissue homeostasis during Hippo signalling.
    Mei L, Qv M, Bao H, He Q, Xu Y, Zhang Q, Shi W, Ren Q, Yan Z, Xu C, Tang C, Hussain M, Zeng LH, Wu X.

    08/26/2024
    m[6]A-induced TRIB3 regulates Hippo pathway through interacting with LATS1 to promote the progression of lung adenocarcinoma.

    m(6)A-induced TRIB3 regulates Hippo pathway through interacting with LATS1 to promote the progression of lung adenocarcinoma.
    Wu J, Yi T, Zhuo C, Wang D, Zhang M, Hu R, Wu D, Hou G, Xing Y.

    05/31/2024
    LATS1 Promotes B-ALL Tumorigenesis by Regulating YAP1 Phosphorylation and Subcellular Localization.

    LATS1 Promotes B-ALL Tumorigenesis by Regulating YAP1 Phosphorylation and Subcellular Localization.
    Zhang F, Issah MA, Fu HY, Zhou HR, Liu TB, Shen JZ.

    02/27/2024
    S100 Calcium Binding Protein A16 Promotes Cell Proliferation by triggering LATS1 ubiquitin degradation mediated by CUL4A ligase to inhibit Hippo pathway in Glioma development.

    S100 Calcium Binding Protein A16 Promotes Cell Proliferation by triggering LATS1 ubiquitin degradation mediated by CUL4A ligase to inhibit Hippo pathway in Glioma development.
    Hu Y, Zhang R, Lu S, Zhang W, Wang D, Ge Y, Jiang F, Qin X, Liu Y., Free PMC Article

    05/15/2023
    WWP2 drives the progression of gastric cancer by facilitating the ubiquitination and degradation of LATS1 protein.

    WWP2 drives the progression of gastric cancer by facilitating the ubiquitination and degradation of LATS1 protein.
    Zou J, Zhou L, Le Y, Fang Z, Zhong M, Nie F, Wei X, Zhang X, Chen Z, Cai L, Wang H, Xiong J, Fang Z, Xiang X., Free PMC Article

    02/23/2023
    DNMT3B and TET1 mediated DNA methylation of LATS1 regulates BC progression via hippo signaling pathway.

    DNMT3B and TET1 mediated DNA methylation of LATS1 regulates BC progression via hippo signaling pathway.
    Wu H, Jiao Y, Guo X, Wu Z, Lv Q.

    12/17/2022
    Inactivation of LATS1/2 drives luminal-basal plasticity to initiate basal-like mammary carcinomas.

    Inactivation of LATS1/2 drives luminal-basal plasticity to initiate basal-like mammary carcinomas.
    Kern JG, Tilston-Lunel AM, Federico A, Ning B, Mueller A, Peppler GB, Stampouloglou E, Cheng N, Johnson RL, Lenburg ME, Beane JE, Monti S, Varelas X., Free PMC Article

    12/10/2022
    Identification of a novel LATS1 variant associated with familial cerebral cavernous malformations in a Chinese family.

    Identification of a novel LATS1 variant associated with familial cerebral cavernous malformations in a Chinese family.
    Geng L, Jiang T, Zhu Y, Wang Q, Yuan W, Hu X, Zou Y, Xiao H, Liu H.

    11/5/2022
    The clinicopathological and prognostic significances of LATS1 expression in breast cancer.

    The clinicopathological and prognostic significances of LATS1 expression in breast cancer.
    Zheng HC, Xiang LW, Cui ZG, Xue H, E Y, Zhao MZ.

    10/15/2022
    TRIM65 Promotes Malignant Cell Behaviors in Triple-Negative Breast Cancer by Impairing the Stability of LATS1 Protein.

    TRIM65 Promotes Malignant Cell Behaviors in Triple-Negative Breast Cancer by Impairing the Stability of LATS1 Protein.
    Lu Y, Xiao Y, Yang J, Su H, Zhang X, Su F, Tian B, Zhao D, Ling X, Zhang T., Free PMC Article

    09/3/2022
    Expression of LATS1 in head and neck squamous cell carcinoma and its effect on tumor cell proliferation and invasion.

    Expression of LATS1 in head and neck squamous cell carcinoma and its effect on tumor cell proliferation and invasion.
    Wan W, Sun B, Yang S, Zhou C, Li Y.

    09/3/2022
    LATS kinases and SLUG regulate the transition to advanced stage in aggressive oral cancer cells.

    LATS kinases and SLUG regulate the transition to advanced stage in aggressive oral cancer cells.
    Fujibayashi E, Mukai S, Torigata K, Ando Y, Uchihashi T, Nozaki M, Tanaka S, Okada M, Kogo M, Nojima H, Yabuta N., Free PMC Article

    07/30/2022
    Long non-coding RNA FAM66C regulates glioma growth via the miRNA/LATS1 signaling pathway.

    Long non-coding RNA FAM66C regulates glioma growth via the miRNA/LATS1 signaling pathway.
    Xiao K, Peng G.

    06/18/2022
    HucMSCs-exosomes containing miR-21 promoted estrogen production in ovarian granulosa cells via LATS1-mediated phosphorylation of LOXL2 and YAP.

    HucMSCs-exosomes containing miR-21 promoted estrogen production in ovarian granulosa cells via LATS1-mediated phosphorylation of LOXL2 and YAP.
    Cai JH, Sun YT, Bao S.

    05/7/2022
    The Hippo pathway kinases LATS1 and LATS2 attenuate cellular responses to heavy metals through phosphorylating MTF1.

    The Hippo pathway kinases LATS1 and LATS2 attenuate cellular responses to heavy metals through phosphorylating MTF1.
    Han H, Nakaoka HJ, Hofmann L, Zhou JJ, Yu C, Zeng L, Nan J, Seo G, Vargas RE, Yang B, Qi R, Bardwell L, Fishman DA, Cho KWY, Huang L, Luo R, Warrior R, Wang W., Free PMC Article

    02/26/2022
    Long non-coding RNA LOC107985656 represses the proliferation of hepatocellular carcinoma cells through activation of the tumor-suppressive Hippo pathway.

    Long non-coding RNA LOC107985656 represses the proliferation of hepatocellular carcinoma cells through activation of the tumor-suppressive Hippo pathway.
    Zeng Y, Xu Q, Xu N., Free PMC Article

    02/19/2022
    A phosphatidic acid-binding lncRNA SNHG9 facilitates LATS1 liquid-liquid phase separation to promote oncogenic YAP signaling.

    A phosphatidic acid-binding lncRNA SNHG9 facilitates LATS1 liquid-liquid phase separation to promote oncogenic YAP signaling.
    Li RH, Tian T, Ge QW, He XY, Shi CY, Li JH, Zhang Z, Liu FZ, Sang LJ, Yang ZZ, Liu YZ, Xiong Y, Yan Q, Li X, Ju HQ, Liu J, Wang LJ, Shao JZ, Wang W, Zhou T, Lin A., Free PMC Article

    01/29/2022
    Identification of the tumorsuppressive role of circular RNAFOXO3 in colorectal cancer via regulation of miR543/LATS1 axis.

    Identification of the tumor‑suppressive role of circular RNA‑FOXO3 in colorectal cancer via regulation of miR‑543/LATS1 axis.
    Deng YY, Min YJ, Zhou K, Yang QS, Peng M, Cui ZR, Zhu XL, Liu H, Wang M, Zhang X, Liu LX., Free PMC Article

    01/8/2022
    lncRNA TINCR attenuates the proliferation and invasion, and enhances the apoptosis of cutaneous malignant melanoma cells by regulating the miR4245p/LATS1 axis.

    lncRNA TINCR attenuates the proliferation and invasion, and enhances the apoptosis of cutaneous malignant melanoma cells by regulating the miR‑424‑5p/LATS1 axis.
    Han X, Jia Y, Chen X, Sun C, Sun J., Free PMC Article

    01/8/2022
    LncRNA HCG11 mediated by METTL14 inhibits the growth of lung adenocarcinoma via IGF2BP2/LATS1.

    LncRNA HCG11 mediated by METTL14 inhibits the growth of lung adenocarcinoma via IGF2BP2/LATS1.
    Mao J, Qiu H, Guo L.

    01/1/2022
    RASSF1A-Mediated Suppression of Estrogen Receptor Alpha (ERalpha)-Driven Breast Cancer Cell Growth Depends on the Hippo-Kinases LATS1 and 2.

    RASSF1A-Mediated Suppression of Estrogen Receptor Alpha (ERα)-Driven Breast Cancer Cell Growth Depends on the Hippo-Kinases LATS1 and 2.
    Roßwag S, Sleeman JP, Thaler S., Free PMC Article

    12/25/2021
    Promoter Hypermethylation of LATS1 Gene in Oral Squamous Cell Carcinoma (OSCC) among North Indian Population.

    Promoter Hypermethylation of LATS1 Gene in Oral Squamous Cell Carcinoma (OSCC) among North Indian Population.
    Goel H, Mathur R, Syeda S, Shrivastava A, Jha AK., Free PMC Article

    11/22/2021
    WBP2 negatively regulates the Hippo pathway by competitively binding to WWC3 with LATS1 to promote non-small cell lung cancer progression.

    WBP2 negatively regulates the Hippo pathway by competitively binding to WWC3 with LATS1 to promote non-small cell lung cancer progression.
    Han Q, Rong X, Lin X, Zhang X, Fan C, Zhao H, Wang E., Free PMC Article

    10/16/2021
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