| Cancer-testis non-coding RNA LEF1-AS1 regulates the nuclear translocation of PDCD5 and suppresses its interaction with p53 signaling: a novel target for immunotherapy in esophageal squamous cell carcinoma. | Cancer-testis non-coding RNA LEF1-AS1 regulates the nuclear translocation of PDCD5 and suppresses its interaction with p53 signaling: a novel target for immunotherapy in esophageal squamous cell carcinoma.
Xiao Z, Si M, Cao J, Chen X, Wang Z, Zhang T, Zhou Y, Li H, Dai J, Wang C, Chen L, Xu J. | 06/1/2023 |
| PDCD5 inhibits progression of renal cell carcinoma by promoting T cell immunity: with the involvement of the HDAC3/microRNA-195-5p/SGK1. | PDCD5 inhibits progression of renal cell carcinoma by promoting T cell immunity: with the involvement of the HDAC3/microRNA-195-5p/SGK1.
Liu SC, Chen LB, Chen PF, Huang ML, Liu TP, Peng J, Lu XS., Free PMC Article | 10/29/2022 |
| Prognostic potentials of miRNA-19a-3p and PDCD5 in nasopharynx carcinoma. | Prognostic potentials of miRNA-19a-3p and PDCD5 in nasopharynx carcinoma.
Zhong JH, Zhong JJ, Shi YN, Hu XM, Xu MJ, Guo Z, Zhong TY, Li WS, Wang Y. | 07/3/2021 |
| Club cell-specific role of programmed cell death 5 in pulmonary fibrosis. | Club cell-specific role of programmed cell death 5 in pulmonary fibrosis.
Park SY, Hong JY, Lee SY, Lee SH, Kim MJ, Kim SY, Kim KW, Shim HS, Park MS, Lee CG, Elias JA, Sohn MH, Yoon HG., Free PMC Article | 06/5/2021 |
| The N-terminal extracellular domain of Lgr5 could directly bind to PDCD5. Lgr5 induced p53 degradation by blocking the nuclear translocation of PDCD5 and leading to the loss of p53 stabilization. | Lgr5-mediated p53 Repression through PDCD5 leads to doxorubicin resistance in Hepatocellular Carcinoma.
Ma Z, Guo D, Wang Q, Liu P, Xiao Y, Wu P, Wang Y, Chen B, Liu Z, Liu Q., Free PMC Article | 06/20/2020 |
| Collectively, these data demonstrate that PPEF-1 plays a pivotal role in tumorigenesis of lung cancer cells by reducing PDCD5-mediated genotoxic stress responses. | Protein serine/threonine phosphatase PPEF-1 suppresses genotoxic stress response via dephosphorylation of PDCD5.
Park SY, Seo J, Choi HK, Oh HJ, Guk G, Lee YH, Lee J, Jun WJ, Choi KC, Yoon HG., Free PMC Article | 09/29/2018 |
| In the high malignant group the PDCD4 mRNA and PDCD5 mRNA expressions were significantly decreased compared with the low malignant group and the control group. PDCD4 mRNA and PDCD5 mRNA expressions are promising targets for the diagnosis and treatment of glioma. | The importance of expressing PDCD4 and PDCD5 anti-oncogenes in glioma.
Wang C, Li JK, Li HZ, Gong HD. | 08/18/2018 |
| serum PDCD5 levels reflect endothelial NO production and are correlated with diabetes mellitus, high-density lipoprotein cholesterol, and coronary calcium | Programmed cell death 5 suppresses AKT-mediated cytoprotection of endothelium.
Lee SH, Seo J, Park SY, Jeong MH, Choi HK, Lee CJ, Kim MJ, Guk G, Lee S, Park H, Jeong JW, Ha CH, Park S, Yoon HG., Free PMC Article | 08/18/2018 |
| As a transcriptional activator, PITX1 regulates apoptosis-related genes, including PDCD5, during gastric carcinogenesis. | Downregulated PITX1 Modulated by MiR-19a-3p Promotes Cell Malignancy and Predicts a Poor Prognosis of Gastric Cancer by Affecting Transcriptionally Activated PDCD5.
Qiao F, Gong P, Song Y, Shen X, Su X, Li Y, Wu H, Zhao Z, Fan H. | 08/18/2018 |
| DKK-1 and PDCD5 can be independent predictors of overall survival in patients suffering from chondrosarcoma. | Diagnostic investigations of DKK-1 and PDCD5 expression levels as independent prognostic markers of human chondrosarcoma.
Zarea M, Mohammadian Bajgiran A, Sedaghati F, Hatami N, Taheriazam A, Yahaghi E, Shakeri M. | 09/2/2017 |
| Data show that lower serum levels of programmed cell death protein 5 (PDCD5) protein were identified in the gastric cancer patients that with CD133(+) fraction more than 1.6 %. | The roles of serum PDCD5 in circulating CD133 positive cells of the patients with gastric cancer.
Wang D, Wang W, Song CL, Xia P. | 02/18/2017 |
| Endogenous PDCD5 overexpression accelerated multiple myeloma cell apoptosis under dexamethasone treatment. | Establishment of stable multiple myeloma cell line with overexpressed PDCD5 and its proapoptosis mechanism.
Feng W, Fu Y, Zhang Y, Lv B, Li X, Zhang F, Gui R, Liu J., Free PMC Article | 10/1/2016 |
| Studies indicate that programmed cell death 5 (PDCD5) interacts with the tumor protein p53 (p53) pathway to promote cell apoptosis. | PDCD5 functions as a regulator of p53 dynamics in the DNA damage response.
Zhuge C, Sun X, Chen Y, Lei J. | 09/17/2016 |
| This review describes what is known about PDCD5 and its cellular functions. [review] | Cellular functions of programmed cell death 5.
Li G, Ma D, Chen Y. | 06/11/2016 |
| The results suggest a role of PDCD5 in the regulation of p53 function but unrelated to cell cycle arrest or apoptosis, at least in the cell types investigated. | The p53 binding protein PDCD5 is not rate-limiting in DNA damage induced cell death.
Bock FJ, Tanzer MC, Haschka MD, Krumschnabel G, Sohm B, Goetsch K, Kofler R, Villunger A., Free PMC Article | 06/4/2016 |
| PDCD5 selectively mediates HDAC3 dissociation from p53, which induces HDAC3 cleavage and ubiquitin-dependent proteasomal degradation. This is a a mechanism for p53 activation via PDCD5-dependent HDAC3 decay under genotoxic stress conditions. | Programmed cell death 5 mediates HDAC3 decay to promote genotoxic stress response.
Choi HK, Choi Y, Park ES, Park SY, Lee SH, Seo J, Jeong MH, Jeong JW, Jeong JH, Lee PC, Choi KC, Yoon HG., Free PMC Article | 04/9/2016 |
| PDCD5 expression is negatively correlated with disease progression and stage in ovarian cancer. | Low programmed cell death 5 expression is a prognostic factor in ovarian cancer.
Gao L, Ye X, Ma RQ, Cheng HY, Han HJ, Cui H, Wei LH, Chang XH., Free PMC Article | 10/3/2015 |
| These findings uncovered an apoptotic signaling cascade linking YAF2, PDCD5, and TP53 during genotoxic stress responses. | YAF2 promotes TP53-mediated genotoxic stress response via stabilization of PDCD5.
Park SY, Choi HK, Jo SH, Seo J, Han EJ, Choi KC, Jeong JW, Choi Y, Yoon HG. | 09/5/2015 |
| Transgenic mice with systemic overexpression of human PDCD5 were protected from cardiac remodeling. | PDCD5 protects against cardiac remodeling by regulating autophagy and apoptosis.
Zhang S, Li G, Fu X, Qi Y, Li M, Lu G, Hu J, Wang N, Chen Y, Bai Y, Cui M. | 08/1/2015 |
| Findings have uncovered an apoptotic signaling cascade linking PDCD5, OTUD5, and p53 during genotoxic stress responses. | Deubiquitinase OTUD5 mediates the sequential activation of PDCD5 and p53 in response to genotoxic stress.
Park SY, Choi HK, Choi Y, Kwak S, Choi KC, Yoon HG. | 04/25/2015 |
| Authors identified DNAJB1 as a negative regulator of PDCD5-mediated apoptosis and found that the apoptosis network of PDCD5 regulates cancer cell death. | DNAJB1 destabilizes PDCD5 to suppress p53-mediated apoptosis.
Cui X, Choi HK, Choi YS, Park SY, Sung GJ, Lee YH, Lee J, Jun WJ, Kim K, Choi KC, Yoon HG. | 04/25/2015 |
| our study describes a new mechanism for p53 stabilization through PDCD5 upon hypoxia or pVHL loss, and reveals new clinical potential for the treatment of pathobiological disorders linked to hypoxic stress | The von Hippel-Lindau tumor suppressor regulates programmed cell death 5-mediated degradation of Mdm2.
Essers PB, Klasson TD, Pereboom TC, Mans DA, Nicastro M, Boldt K, Giles RH, MacInnes AW. | 04/11/2015 |
| We confirmed that PDCD5 overexpression stimulated the promoter activities of KLF9 by luciferase reporter assays. | The fate of Krüppel-like factor 9-positive hepatic carcinoma cells may be determined by the programmed cell death protein 5.
Fu DZ, Cheng Y, He H, Liu HY, Liu YF. | 08/23/2014 |
| PDCD5 is necessary and sufficient for NF-kappaB p65 mediated apoptosis | NF-κB p65 recruited SHP regulates PDCD5-mediated apoptosis in cancer cells.
Murshed F, Farhana L, Dawson MI, Fontana JA. | 08/23/2014 |
| The expression of PDCD5 and its protein were shown to be reduced in laryngeal squamous cell carcinoma. The functional importance of PDCD5 as a regulating agent in cell apoptosis suggests that it may play a key role in tumour pathogenesis and development. | Expression and clinical significance of the programmed cell death 5 gene and protein in laryngeal squamous cell carcinoma.
Xu F, Wu K, Zhao M, Qin Y, Xia M. | 07/19/2014 |