| HRS Regulates Small Extracellular Vesicle PD-L1 Secretion and Is Associated with Anti-PD-1 Treatment Efficacy. | HRS Regulates Small Extracellular Vesicle PD-L1 Secretion and Is Associated with Anti-PD-1 Treatment Efficacy.
Xiao BL, Wang XL, Xia HF, Zhang LZ, Wang KM, Chen ZK, Zhong YH, Jiang HG, Zhou FX, Wang W, Chen GL, Chen G. | 02/10/2023 |
| Hepatocyte growth factor-regulated tyrosine kinase substrate is essential for endothelial cell polarity and cerebrovascular stability. | Hepatocyte growth factor-regulated tyrosine kinase substrate is essential for endothelial cell polarity and cerebrovascular stability.
Yu Z, Zeng J, Wang J, Cui Y, Song X, Zhang Y, Cheng X, Hou N, Teng Y, Lan Y, Chen Y, Yang X., Free PMC Article | 12/4/2021 |
| Epstein-Barr Virus LMP1 Promotes Syntenin-1- and Hrs-Induced Extracellular Vesicle Formation for Its Own Secretion To Increase Cell Proliferation and Migration. | Epstein-Barr Virus LMP1 Promotes Syntenin-1- and Hrs-Induced Extracellular Vesicle Formation for Its Own Secretion To Increase Cell Proliferation and Migration.
Nkosi D, Sun L, Duke LC, Patel N, Surapaneni SK, Singh M, Meckes DG Jr., Free PMC Article | 04/13/2021 |
| Study provides in vivo evidence that Beclin 1 suppresses tumor proliferation by regulating the endocytic trafficking and degradation of the EGFR and transferrin (TFR1) receptors. Beclin 1 promoted endosomal recruitment of hepatocyte growth factor tyrosine kinase substrate (HRS), which was necessary for sorting surface receptors to intraluminal vesicles for signal silencing and lysosomal degradation. | Beclin 1 Promotes Endosome Recruitment of Hepatocyte Growth Factor Tyrosine Kinase Substrate to Suppress Tumor Proliferation.
Matthew-Onabanjo AN, Janusis J, Mercado-Matos J, Carlisle AE, Kim D, Levine F, Cruz-Gordillo P, Richards R, Lee MJ, Shaw LM., Free PMC Article | 06/20/2020 |
| The ESCRT-0 protein HRS interacts with the HTLV-II antisense protein APH-2 and suppresses viral replication. [APH-2] | The ESCRT-0 Protein HRS Interacts with the Human T Cell Leukemia Virus Type 2 Antisense Protein APH-2 and Suppresses Viral Replication.
Martini F, Arone C, Hasset A, Hall WW, Sheehy N., Free PMC Article | 06/13/2020 |
| Post-traumatic stress disorder (PTSD) is associated with differential methylation, measured in blood, within HGS and NRG1 across three civilian cohorts. | Epigenetic meta-analysis across three civilian cohorts identifies NRG1 and HGS as blood-based biomarkers for post-traumatic stress disorder.
Uddin M, Ratanatharathorn A, Armstrong D, Kuan PF, Aiello AE, Bromet EJ, Galea S, Koenen KC, Luft B, Ressler KJ, Wildman DE, Nievergelt CM, Smith A., Free PMC Article | 08/3/2019 |
| Degradation of CLR-RAMP2 was sensitive to overexpression of hepatocyte growth factor-regulated tyrosine kinase substrate (HRS), but not to HRS knockdown, whereas CLRDelta9KR-RAMP2 degradation was unaffected. Overexpression, but not knockdown of HRS, promoted hyperubiquitination of CLR under basal conditions. These results propose a role for ubiquitin and HRS in the regulation of AM-induced degradation of CLR-RAMP2. | The Role of Ubiquitination and Hepatocyte Growth Factor-Regulated Tyrosine Kinase Substrate in the Degradation of the Adrenomedullin Type I Receptor.
Roux BT, Bauer CC, McNeish AJ, Ward SG, Cottrell GS., Free PMC Article | 07/6/2019 |
| Results demonstrate the existence of crosstalk between beta-catenin signaling and HGS in two different types of cancer (hepatoblastoma and colorectal). | A kinome siRNA screen identifies HGS as a potential target for liver cancers with oncogenic mutations in CTNNB1.
Canal F, Anthony E, Lescure A, Del Nery E, Camonis J, Perez F, Ragazzon B, Perret C., Free PMC Article | 09/24/2016 |
| detailed analysis of the subcellular localization and functional significance of Hrs in macropinocytosis-mediated entry of Kaposi's Sarcoma-Associated Herpesvirus | ESCRT-0 Component Hrs Promotes Macropinocytosis of Kaposi's Sarcoma-Associated Herpesvirus in Human Dermal Microvascular Endothelial Cells.
Veettil MV, Kumar B, Ansari MA, Dutta D, Iqbal J, Gjyshi O, Bottero V, Chandran B., Free PMC Article | 08/6/2016 |
| ESCRT-0 protein hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) is targeted to endosomes independently of signal-transducing adaptor molecule (STAM) and the complex formation with STAM promotes its endosomal dissociation. | ESCRT-0 protein hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) is targeted to endosomes independently of signal-transducing adaptor molecule (STAM) and the complex formation with STAM promotes its endosomal dissociation.
Kojima K, Amano Y, Yoshino K, Tanaka N, Sugamura K, Takeshita T., Free PMC Article | 02/14/2015 |
| we identified an interaction between EsxH, which is secreted by the Esx-3 TSSS, and human hepatocyte growth factor-regulated tyrosine kinase substrate (Hgs/Hrs), a component of the endosomal sorting complex required for transport (ESCRT). | Mycobacterium tuberculosis type VII secreted effector EsxH targets host ESCRT to impair trafficking.
Mehra A, Zahra A, Thompson V, Sirisaengtaksin N, Wells A, Porto M, Köster S, Penberthy K, Kubota Y, Dricot A, Rogan D, Vidal M, Hill DE, Bean AJ, Philips JA., Free PMC Article | 09/6/2014 |
| the role for tumoral c-Met expression or sMet/HGF levels as upfront selection criterion or predictive biomarkers deserve further study in this emerging area of therapeutic focus in RCC | Targeting the hepatocyte growth factor/c-Met signaling pathway in renal cell carcinoma.
Harshman LC, Choueiri TK. | 02/22/2014 |
| Hrs is a regulator of endosomal cholesterol trafficking. | An essential role of Hrs/Vps27 in endosomal cholesterol trafficking.
Du X, Kazim AS, Brown AJ, Yang H. | 07/13/2013 |
| Hrs tyrosine phosphorylation detected upon EGF-stimulation. | Recycling of EGFR and ErbB2 is associated with impaired Hrs tyrosine phosphorylation and decreased deubiquitination by AMSH.
Meijer IM, van Rotterdam W, van Zoelen EJ, van Leeuwen JE. | 01/12/2013 |
| These results suggested that HCV secretion from host cells requires Hrs-dependent exosomal pathway in which the viral assembly is also involved. | Regulation of hepatitis C virus secretion by the Hrs-dependent exosomal pathway.
Tamai K, Shiina M, Tanaka N, Nakano T, Yamamoto A, Kondo Y, Kakazu E, Inoue J, Fukushima K, Sano K, Ueno Y, Shimosegawa T, Sugamura K. | 03/3/2012 |
| Hrs inhibits HIV-1 production by inhibiting citron kinase-mediated exocytosis. | Hrs inhibits citron kinase-mediated HIV-1 budding via its FYVE domain.
Ding J, Su L, Gao G., Free PMC Article | 11/12/2011 |
| ESCRT-0 component HRS is required for HIV-1 Vpu-mediated BST-2/tetherin down-regulation. | The ESCRT-0 component HRS is required for HIV-1 Vpu-mediated BST-2/tetherin down-regulation.
Janvier K, Pelchen-Matthews A, Renaud JB, Caillet M, Marsh M, Berlioz-Torrent C., Free PMC Article | 06/18/2011 |
| Plasma hepatocyte growth factor is associated with periampullary cancer. | Clinical value of plasma hepatocyte growth factor measurement for the diagnosis of periampullary cancer and prognosis after pancreaticoduodenectomy.
Barakat O, Rodriguez GC, Raijman I, Allison PM, Nieto J, Ozaki CF, Wood RP, Engler DA. | 01/8/2011 |
| hSpry2 binds to the endocytic regulatory protein, hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) and blocks intracellular signal propagation. | Spatial regulation of EGFR signaling by Sprouty2.
Kim HJ, Taylor LJ, Bar-Sagi D. | 12/15/2010 |
| Data show that Hrs is essential for lysosomal targeting but not multivesicular body biogenesis and transport to late endosomes, while SNX3 is required for multivesicular body formation, but not for EGF receptor degradation. | Hrs and SNX3 functions in sorting and membrane invagination within multivesicular bodies.
Pons V, Luyet PP, Morel E, Abrami L, van der Goot FG, Parton RG, Gruenberg J., Free PMC Article | 01/21/2010 |
| Data show that Trak1 interacts with hepatocyte-growth-factor-regulated tyrosine kinase substrate (Hrs), an essential component of the endosomal sorting and trafficking machinery. | Hypertonia-associated protein Trak1 is a novel regulator of endosome-to-lysosome trafficking.
Webber E, Li L, Chin LS., Free PMC Article | 01/21/2010 |
| HGS and GUK1 were significantly over expressed in GH-secreting adenomas, compared with ACTH-secreting adenomas and nonfunctioning tumors, and with PRL-secreting adenomas, respectively. | Hepatocyte growth factor-regulated tyrosine kinase substrate (HGS) and guanylate kinase 1 (GUK1) are differentially expressed in GH-secreting adenomas.
da Rocha AA, Giorgi RR, de Sa SV, Correa-Giannella ML, Fortes MA, Cavaleiro AM, Machado MC, Cescato VA, Bronstein MD, Giannella-Neto D. | 01/21/2010 |
| these results indicate that precise sorting of IL-2Rbeta from early to late endosomes is mediated by Hrs, a known sorting component of the ubiquitin-dependent machinery, in a manner that is independent of UIM-ubiquitin binding | Ubiquitin-independent binding of Hrs mediates endosomal sorting of the interleukin-2 receptor beta-chain.
Yamashita Y, Kojima K, Tsukahara T, Agawa H, Yamada K, Amano Y, Kurotori N, Tanaka N, Sugamura K, Takeshita T. | 01/21/2010 |
| These results indicate that Eps15b is an endosomally localized isoform of Eps15 that is present in the Hrs complex via direct Hrs interaction and important for the sorting function of this complex. | An endosomally localized isoform of Eps15 interacts with Hrs to mediate degradation of epidermal growth factor receptor.
Roxrud I, Raiborg C, Pedersen NM, Stang E, Stenmark H., Free PMC Article | 01/21/2010 |
| HRS mediates post-endocytic trafficking of protease-activated receptor 2 and calcitonin receptor-like receptor | Hepatocyte growth factor-regulated tyrosine kinase substrate (HRS) mediates post-endocytic trafficking of protease-activated receptor 2 and calcitonin receptor-like receptor.
Hasdemir B, Bunnett NW, Cottrell GS. | 01/21/2010 |