| Dysregulation of the LPC-ATX-LPA axis in autoimmune hepatitis is associated with monocyte activation. | Dysregulation of the LPC-ATX-LPA axis in autoimmune hepatitis is associated with monocyte activation.
Yang F, Fan X, Yang L. | 01/8/2024 |
| Network Medicine Approach in Prevention and Personalized Treatment of Dyslipidemias. | Network Medicine Approach in Prevention and Personalized Treatment of Dyslipidemias.
Benincasa G, de Candia P, Costa D, Faenza M, Mansueto G, Ambrosio G, Napoli C. | 01/8/2022 |
| Variations in TM6SF2, PCSK9 and PCSK7 genes and risk of hepatic steatosis after liver transplantation: a cross-sectional study. | Variations in TM6SF2, PCSK9 and PCSK7 genes and risk of hepatic steatosis after liver transplantation: a cross-sectional study.
Eshraghian A, Moasser E, Azarpira N, Fattahi MR, Nikeghbalian S, Malek-Hosseini SA, Geramizadeh B., Free PMC Article | 12/18/2021 |
| The rs508487, rs236911, and rs236918 Genetic Variants of the Proprotein Convertase Subtilisin-Kexin Type 7 (PCSK7) Gene Are Associated with Acute Coronary Syndrome and with Plasma Concentrations of HDL-Cholesterol and Triglycerides. | The rs508487, rs236911, and rs236918 Genetic Variants of the Proprotein Convertase Subtilisin-Kexin Type 7 (PCSK7) Gene Are Associated with Acute Coronary Syndrome and with Plasma Concentrations of HDL-Cholesterol and Triglycerides.
Vargas-Alarcón G, Pérez-Méndez O, González-Pacheco H, Ramírez-Bello J, Posadas-Sánchez R, Escobedo G, Fragoso JM., Free PMC Article | 11/6/2021 |
| Proprotein convertase 7 (PCSK7) reduces apoA-V levels. | Proprotein convertase 7 (PCSK7) reduces apoA-V levels.
Ashraf Y, Duval S, Sachan V, Essalmani R, Susan-Resiga D, Roubtsova A, Hamelin J, Gerhardy S, Kirchhofer D, Tagliabracci VS, Prat A, Kiss RS, Seidah NG. | 05/22/2021 |
| Variants in PCSK7, PNPLA3 and TM6SF2 are risk factors for the development of cirrhosis in hereditary haemochromatosis. | Variants in PCSK7, PNPLA3 and TM6SF2 are risk factors for the development of cirrhosis in hereditary haemochromatosis.
Buch S, Sharma A, Ryan E, Datz C, Griffiths WJH, Way M, Buckley TWM, Ryan JD, Stewart S, Wright C, Dongiovanni P, Fracanzani A, Zwerina J, Merle U, Weiss KH, Aigner E, Krones E, Dejaco C, Fischer J, Berg T, Valenti L, Zoller H, McQuillin A, Hampe J, Stickel F, Morgan MY. | 04/3/2021 |
| The motif EXEXXXL in the cytosolic tail of the secretory human proprotein convertase PC7 regulates its trafficking and cleavage activity. | The motif EXEXXXL in the cytosolic tail of the secretory human proprotein convertase PC7 regulates its trafficking and cleavage activity.
Durand L, Duval S, Evagelidis A, Guillemot J, Dianati V, Sikorska E, Schu P, Day R, Seidah NG., Free PMC Article | 10/24/2020 |
| PCSK7 gene variation is associated with dyslipidemia and more severe liver disease in high risk individuals, likely by modulating PCSK7 expression/activity. | PCSK7 gene variation bridges atherogenic dyslipidemia with hepatic inflammation in NAFLD patients.
Dongiovanni P, Meroni M, Baselli G, Mancina RM, Ruscica M, Longo M, Rametta R, Cespiati A, Pelusi S, Ferri N, Ranzani V, Nobili V, Pihlajamaki J, Fracanzani AL, Badiali S, Petta S, Fargion S, Romeo S, Kozlitina J, Valenti L., Free PMC Article | 07/18/2020 |
| Our present data suggest that PCSK7 as well as PCSK9 may be associated with lipids, especially triglyceride, and may serve as a candidate for a new drug target to treat lipid abnormality syndromes. | Genome-wide association study of serum lipids confirms previously reported associations as well as new associations of common SNPs within PCSK7 gene with triglyceride.
Kurano M, Tsukamoto K, Kamitsuji S, Kamatani N, Hara M, Ishikawa T, Kim BJ, Moon S, Jin Kim Y, Teramoto T. | 04/8/2017 |
| PCSK7 rs236918 C allele is a risk factor for cirrhosis development in Italian patients with HFE-Hemochromatosis. | Proprotein convertase 7 rs236918 associated with liver fibrosis in Italian patients with HFE-related hemochromatosis.
Pelucchi S, Galimberti S, Greni F, Rametta R, Mariani R, Pelloni I, Girelli D, Busti F, Ravasi G, Valsecchi MG, Valenti L, Piperno A. | 03/25/2017 |
| Furin and PC7 siRNAs induced HIF-1alpha protein by increasing its translation, resulting in upregulation of VEGF-A. | Regulation of HIF-1 alpha by the proprotein convertases furin and PC7 in human squamous carcinoma cells.
Fu J, Zhang J, Gong Y, Testa CL, Klein-Szanto AJ., Free PMC Article | 11/7/2015 |
| The data suggest that PCSK7 genotypes may interact with dietary CHO intake on changes in insulin sensitivity in the white Americans. | PCSK7 genotype modifies effect of a weight-loss diet on 2-year changes of insulin resistance: the POUNDS LOST trial.
Huang T, Huang J, Qi Q, Li Y, Bray GA, Rood J, Sacks FM, Qi L., Free PMC Article | 09/12/2015 |
| Results demonstrate that PCSK7 variation is a strong host risk factor of liver cirrhosis in hereditary hemochromatosis patients homozygous for HFE C282Y. | Evaluation of genome-wide loci of iron metabolism in hereditary hemochromatosis identifies PCSK7 as a host risk factor of liver cirrhosis.
Stickel F, Buch S, Zoller H, Hultcrantz R, Gallati S, Österreicher C, Finkenstedt A, Stadlmayr A, Aigner E, Sahinbegovic E, Sarrazin C, Schafmayer C, Braun F, Erhart W, Nothnagel M, Lerch MM, Mayerle J, Völzke H, Schaller A, Kratzer W, Boehm BO, Sipos B, D'Amato M, Torkvist L, Stal P, Arlt A, Franke A, Becker T, Krawczak M, Zwerina J, Berg T, Hinrichsen H, Krones E, Dejaco C, Strasser M, Datz C, Hampe J. | 02/14/2015 |
| overexpression of PCs, furin and PC5, but not PC7, which are all expressed in SMC, increase PKGI cleavage in a dose-dependent manner | Proprotein convertases play an important role in regulating PKGI endoproteolytic cleavage and nuclear transport.
Kato S, Zhang R, Roberts JD Jr., Free PMC Article | 09/28/2013 |
| Among the PC family members, only furin activates hepcidin in hepatocytes, and uniquely the full-length membrane-bound PC7 can directly shed hTfR1 by cleavage at Arg100 | Implication of the proprotein convertases in iron homeostasis: proprotein convertase 7 sheds human transferrin receptor 1 and furin activates hepcidin.
Guillemot J, Canuel M, Essalmani R, Prat A, Seidah NG. | 08/31/2013 |
| Region encoded by amino acids ala713-asp730 is essential and sufficient for endocytosis. | Internalization of proprotein convertase PC7 from plasma membrane is mediated by a novel motif.
Declercq J, Meulemans S, Plets E, Creemers JW., Free PMC Article | 06/16/2012 |
| PCSK7 is involved in sTfR generation and iron homeostasis. | Novel association to the proprotein convertase PCSK7 gene locus revealed by analysing soluble transferrin receptor (sTfR) levels.
Oexle K, Ried JS, Hicks AA, Tanaka T, Hayward C, Bruegel M, Gögele M, Lichtner P, Müller-Myhsok B, Döring A, Illig T, Schwienbacher C, Minelli C, Pichler I, Fiedler GM, Thiery J, Rudan I, Wright AF, Campbell H, Ferrucci L, Bandinelli S, Pramstaller PP, Wichmann HE, Gieger C, Winkelmann J, Meitinger T., Free PMC Article | 05/28/2011 |
| Proprotein convertase PC7 enhances the activation of the EGF receptor pathway through processing of the EGF precursor. | Proprotein convertase PC7 enhances the activation of the EGF receptor pathway through processing of the EGF precursor.
Rousselet E, Benjannet S, Marcinkiewicz E, Asselin MC, Lazure C, Seidah NG., Free PMC Article | 05/21/2011 |
| PC7 is distinct from other proprotein convertases in its zymogen activation, subcellular localization, and trafficking. | The proprotein convertase PC7: unique zymogen activation and trafficking pathways.
Rousselet E, Benjannet S, Hamelin J, Canuel M, Seidah NG., Free PMC Article | 03/5/2011 |
| Mass spectrometry analysis provides evidence that the HLA-B51-presented peptide profile is altered in the absence of peptide-loading complex quality control or lack of PC7 function in major histocompatibility (MHC) class I-mediated antigen presentation. | Post-endoplasmic reticulum rescue of unstable MHC class I requires proprotein convertase PC7.
Leonhardt RM, Fiegl D, Rufer E, Karger A, Bettin B, Knittler MR. | 05/10/2010 |
| we investigated the specificity and potency of complete prodomains and short C-terminal prodomain peptides of each SPC on highly purified, soluble enzyme preparations of human SPC1, SPC6, and SPC7. | Inhibitory potency and specificity of subtilase-like pro-protein convertase (SPC) prodomains.
Fugère M, Limperis PC, Beaulieu-Audy V, Gagnon F, Lavigne P, Klarskov K, Leduc R, Day R. | 01/21/2010 |
| in binding VEGFR-2, furin and PC5 promote cleavage of N-and C-terminal VEGF-D propeptides, whereas PC7 promotes cleavage of the C-terminal propeptide only | Proprotein convertases promote processing of VEGF-D, a critical step for binding the angiogenic receptor VEGFR-2.
McColl BK, Paavonen K, Karnezis T, Harris NC, Davydova N, Rothacker J, Nice EC, Harder KW, Roufail S, Hibbs ML, Rogers PA, Alitalo K, Stacker SA, Achen MG. | 01/21/2010 |