| Circ_0007611 modulates the miR-34c-5p/LPAR2 cascade to suppress proliferation and enhance apoptosis of HTR-8/SVneo cells. | Circ_0007611 modulates the miR-34c-5p/LPAR2 cascade to suppress proliferation and enhance apoptosis of HTR-8/SVneo cells.
Song M, Yan Q, Liu R. | 10/10/2024 |
| LPAR2-mediated action promotes human renal cell carcinoma via MAPK/NF-kappaB signaling to regulate cytokine network. | LPAR2-mediated action promotes human renal cell carcinoma via MAPK/NF-κB signaling to regulate cytokine network.
Wang Y, Qi Z, Li Z, Bai S, Damirin A. | 04/14/2023 |
| Estrogen-increased SGK1 Promotes Endometrial Stromal Cell Invasion in Adenomyosis by Regulating with LPAR2. | Estrogen-increased SGK1 Promotes Endometrial Stromal Cell Invasion in Adenomyosis by Regulating with LPAR2.
Wu Y, Wang H, Li Y, Li Y, Liang Y, Zhong G, Zhang Q. | 10/15/2022 |
| LPAR2 correlated with different prognosis and immune cell infiltration in head and neck squamous cell carcinoma and kidney renal clear cell carcinoma. | LPAR2 correlated with different prognosis and immune cell infiltration in head and neck squamous cell carcinoma and kidney renal clear cell carcinoma.
Sun K, Chen RX, Li JZ, Luo ZX., Free PMC Article | 03/12/2022 |
| Effects of lysophosphatidic acid (LPA) receptor-2 (LPA2) and LPA3 on the regulation of chemoresistance to anticancer drug in lung cancer cells. | Effects of lysophosphatidic acid (LPA) receptor-2 (LPA(2)) and LPA(3) on the regulation of chemoresistance to anticancer drug in lung cancer cells.
Ueda N, Minami K, Ishimoto K, Tsujiuchi T. | 07/31/2021 |
| BRET analysis reveals interaction between the lysophosphatidic acid receptor LPA2 and the lysophosphatidylinositol receptor GPR55 in live cells. | BRET analysis reveals interaction between the lysophosphatidic acid receptor LPA2 and the lysophosphatidylinositol receptor GPR55 in live cells.
Bang G, Ghil S. | 07/17/2021 |
| Transcriptional regulation of lysophosphatidic acid receptors 2 and 3 regulates myeloid commitment of hematopoietic stem cells. | Transcriptional regulation of lysophosphatidic acid receptors 2 and 3 regulates myeloid commitment of hematopoietic stem cells.
Lin KH, Chiang JC, Chen WM, Ho YH, Yao CL, Lee H. | 05/15/2021 |
| Roles of endothelial cells in the regulation of cell motility via lysophosphatidic acid receptor-2 (LPA2) and LPA3 in osteosarcoma cells. | Roles of endothelial cells in the regulation of cell motility via lysophosphatidic acid receptor-2 (LPA(2)) and LPA(3) in osteosarcoma cells.
Minami K, Ueda N, Ishimoto K, Kurisu R, Takamoto M, Ikeda H, Tsujiuchi T. | 05/1/2021 |
| The positive expression rate of LPA2 and KLF5 were statistical different in gastric adenocarcinoma, GIN, and normal gastric tissue (P<0.05). LPA2 positive expression was associated with tumor invasion depth, Lauren type, vascular invasion, local lymph node metastasis, and clinical stage (P<0.05). | Clinical Significance of Lysophosphatidic Acid Receptor-2 (LPA2) and Krüppel-Like Factor 5 (KLF5) Protein Expression Detected by Tissue Microarray in Gastric Adenocarcinoma.
Zhang Z, Zhu X., Free PMC Article | 12/7/2019 |
| It was revealed that LPA may stimulate the expression of Notch1 and Hes family bHLH transcription factor 1, and the phosphorylation of protein kinase B which belongs to the Notch pathway. | Lysophosphatidic acid induces the migration and invasion of SGC-7901 gastric cancer cells through the LPA2 and Notch signaling pathways.
Ren Z, Zhang C, Ma L, Zhang X, Shi S, Tang D, Xu J, Hu Y, Wang B, Zhang F, Zhang X, Zheng H., Free PMC Article | 11/30/2019 |
| Investigated the roles of LPA receptors in the regulation of cellular functions during tumor progression in osteosarcoma cell lines. MG63-R7-C cell activities were inhibited by LPA2 knockdown, suggesting that LPA signaling via LPA2 plays an important role in the acquisition of malignant properties during tumor progression in MG-63 cells. | Involvement of LPA signaling via LPA receptor-2 in the promotion of malignant properties in osteosarcoma cells.
Takahashi K, Fukushima K, Tanaka K, Minami K, Ishimoto K, Otagaki S, Fukushima N, Honoki K, Tsujiuchi T. | 09/28/2019 |
| Study shows that due to the high LPAR2 and LPAR4 transcript and protein expression in endometriotic ovarian cysts and positive correlations of both these receptors with the PR-B and ERbeta, respectively, those receptors seem to be the most promising predictors of the endometriotic cysts. | LPAR2 and LPAR4 are the Main Receptors Responsible for LPA Actions in Ovarian Endometriotic Cysts.
Kowalczyk-Zieba I, Woclawek-Potocka I, Wasniewski T, Boruszewska D, Grycmacher K, Sinderewicz E, Staszkiewicz J, Wolczynski S. | 04/20/2019 |
| LPAR2 and LPAR5 regulate cellular functions during tumor progression in fibrosarcoma HT1080 cells. | Lysophosphatidic acid receptor-2 (LPA(2)) and LPA(5) regulate cellular functions during tumor progression in fibrosarcoma HT1080 cells.
Takahashi K, Minami K, Otagaki S, Ishimoto K, Fukushima K, Fukushima N, Honoki K, Tsujiuchi T. | 01/5/2019 |
| The results indicate that LPA2 and LPA3 receptors play opposing roles during red blood cells differentiation. | Pharmacological activation of lysophosphatidic acid receptors regulates erythropoiesis.
Lin KH, Ho YH, Chiang JC, Li MW, Lin SH, Chen WM, Chiang CL, Lin YN, Yang YJ, Chen CN, Lu J, Huang CJ, Tigyi G, Yao CL, Lee H., Free PMC Article | 04/7/2018 |
| These results suggest that LPA signaling via LPA2 may play an important role in the regulation of cellular functions in HT1080 cells treated with cisplatin. | Enhanced cellular functions through induction of LPA(2) by cisplatin in fibrosarcoma HT1080 cells.
Takahashi K, Fukushima K, Fukushima N, Honoki K, Tsujiuchi T. | 12/9/2017 |
| LPA2 mRNA levels were associated with poorer differentiation, and higher LPA6 levels were associated with microvascular invasion in HCC; both became a risk factor for recurrence after surgical treatment when combined with increased serum ATX levels | Higher LPA2 and LPA6 mRNA Levels in Hepatocellular Carcinoma Are Associated with Poorer Differentiation, Microvascular Invasion and Earlier Recurrence with Higher Serum Autotaxin Levels.
Enooku K, Uranbileg B, Ikeda H, Kurano M, Sato M, Kudo H, Maki H, Koike K, Hasegawa K, Kokudo N, Yatomi Y., Free PMC Article | 08/5/2017 |
| epithelial dysplasia was observed in founder mouse intestine, correlating LPA2 overexpression with epithelial dysplasia. The current study demonstrates that overexpression of LPA2 alone can lead to intestinal dysplasia. | Transgenic Expression of Human Lysophosphatidic Acid Receptor LPA2 in Mouse Intestinal Epithelial Cells Induces Intestinal Dysplasia.
Yoshida M, He P, Yun CC., Free PMC Article | 04/8/2017 |
| LPA2 expression was associated with HIF-1alpha expression and that a high level of LPA2 was associated with shorter overall survival and was an independent prognostic predictor for breast cancer in Chinese women. | Expression of LPA2 is associated with poor prognosis in human breast cancer and regulates HIF-1α expression and breast cancer cell growth.
Li M, Xiao D, Zhang J, Qu H, Yang Y, Yan Y, Liu X, Wang J, Liu L, Wang J, Duan X. | 03/18/2017 |
| LPAR2 mRNA is up-regulation in colorectal cancer. | Sphingosine kinase 1 is upregulated with lysophosphatidic acid receptor 2 in human colorectal cancer.
Shida D, Inoue S, Yoshida Y, Kodaka A, Tsuji T, Tsuiji M., Free PMC Article | 01/28/2017 |
| Data show high expression levels of LPAR2 and LPAR1 in endometrial cancer tissue with positive correlations with FIGO stage suggesting them as potential biomarkers for endometrial cancer progression. | The significance of the altered expression of lysophosphatidic acid receptors, autotaxin and phospholipase A2 as the potential biomarkers in type 1 endometrial cancer biology.
Wasniewski T, Woclawek-Potocka I, Boruszewska D, Kowalczyk-Zieba I, Sinderewicz E, Grycmacher K. | 08/13/2016 |
| Suggest that LPA2 and LPA3 may function as a molecular switch and play opposing roles during megakaryopoiesis of K562 cells. | Opposing regulation of megakaryopoiesis by LPA receptors 2 and 3 in K562 human erythroleukemia cells.
Ho YH, Yao CL, Lin KH, Hou FH, Chen WM, Chiang CL, Lin YN, Li MW, Lin SH, Yang YJ, Lin CC, Lu J, Tigyi G, Lee H. | 08/29/2015 |
| the RhoA-regulated formin Dia1 is involved in entosis downstream of LPAR2 | G-protein-coupled receptor signaling and polarized actin dynamics drive cell-in-cell invasion.
Purvanov V, Holst M, Khan J, Baarlink C, Grosse R., Free PMC Article | 08/1/2015 |
| Crystal structure of NHERF2 PDZ1 domain complex with C-terminal LPA2 sequence. The PDZ1-LPA2 binding specificity is achieved by hydrogen bonds and hydrophobic contacts with the last four LPA2 residues contributing to specific interactions. | Structural insights into PDZ-mediated interaction of NHERF2 and LPA(2), a cellular event implicated in CFTR channel regulation.
Holcomb J, Jiang Y, Lu G, Trescott L, Brunzelle J, Sirinupong N, Li C, Naren AP, Yang Z., Free PMC Article | 06/14/2014 |
| LPA1 and LPA2 are major LPA receptor subtypes compared with low-expressed LPA3 in PANC-1 tumor cells. | Lysophosphatidic acid stimulates activation of focal adhesion kinase and paxillin and promotes cell motility, via LPA1-3, in human pancreatic cancer.
Liao Y, Mu G, Zhang L, Zhou W, Zhang J, Yu H. | 01/25/2014 |
| Lysophosphatidic acid (LPA) increased hepatocellular carcinoma cells cell invasion, which was LPA-receptor dependent. | Enhancement of invasion of hepatocellular carcinoma cells through lysophosphatidic acid receptor.
Lou L, Chen YX, Jin L, Li X, Tao X, Zhu J, Chen X, Wu S, Ye W, He J, Ding G. | 10/19/2013 |