| SUN1 facilitates CHMP7 nuclear influx and injury cascades in sporadic amyotrophic lateral sclerosis. | SUN1 facilitates CHMP7 nuclear influx and injury cascades in sporadic amyotrophic lateral sclerosis.
Baskerville V, Rapuri S, Mehlhop E, Coyne AN., Free PMC Article | 01/11/2024 |
| Oligomeric CHMP7 mediates three-way ER junctions and ER-mitochondria interactions. | Oligomeric CHMP7 mediates three-way ER junctions and ER-mitochondria interactions.
Chu Q, Wang J, Du Y, Zhou T, Shi A, Xiong J, Ji WK, Deng L., Free PMC Article | 02/4/2023 |
| CDK1 controls CHMP7-dependent nuclear envelope reformation. | CDK1 controls CHMP7-dependent nuclear envelope reformation.
Gatta AT, Olmos Y, Stoten CL, Chen Q, Rosenthal PB, Carlton JG., Free PMC Article | 10/23/2021 |
| Nuclear accumulation of CHMP7 initiates nuclear pore complex injury and subsequent TDP-43 dysfunction in sporadic and familial ALS. | Nuclear accumulation of CHMP7 initiates nuclear pore complex injury and subsequent TDP-43 dysfunction in sporadic and familial ALS.
Coyne AN, Baskerville V, Zaepfel BL, Dickson DW, Rigo F, Bennett F, Lusk CP, Rothstein JD., Free PMC Article | 09/18/2021 |
| Functional validation of CHMP7 as an ADHD risk gene. | Functional validation of CHMP7 as an ADHD risk gene.
Dark C, Williams C, Bellgrove MA, Hawi Z, Bryson-Richardson RJ., Free PMC Article | 05/22/2021 |
| Regulated lipid synthesis and LEM2/CHMP7 jointly control nuclear envelope closure. | Regulated lipid synthesis and LEM2/CHMP7 jointly control nuclear envelope closure.
Penfield L, Shankar R, Szentgyörgyi E, Laffitte A, Mauro MS, Audhya A, Müller-Reichert T, Bahmanyar S., Free PMC Article | 02/20/2021 |
| Gene expression analysis reveals early dysregulation of disease pathways and links Chmp7 to pathogenesis of spinal and bulbar muscular atrophy. | Gene expression analysis reveals early dysregulation of disease pathways and links Chmp7 to pathogenesis of spinal and bulbar muscular atrophy.
Malik B, Devine H, Patani R, La Spada AR, Hanna MG, Greensmith L., Free PMC Article | 10/3/2020 |
| We conclude that Lem2p/LEM2 is a conserved nuclear site-specific adaptor that recruits Cmp7p/CHMP7 and downstream ESCRT factors to the nuclear envelope. | LEM2 recruits CHMP7 for ESCRT-mediated nuclear envelope closure in fission yeast and human cells.
Gu M, LaJoie D, Chen OS, von Appen A, Ladinsky MS, Redd MJ, Nikolova L, Bjorkman PJ, Sundquist WI, Ullman KS, Frost A., Free PMC Article | 04/28/2018 |
| The N terminus of CHMP7 acts as a novel membrane-binding module. This membrane-binding ability allows CHMP7 to bind to the endoplasmic reticulum, an organelle continuous with the nuclear envelope (NE), and it provides a platform to direct NE recruitment of ESCRT-III during mitotic exit. | Membrane Binding by CHMP7 Coordinates ESCRT-III-Dependent Nuclear Envelope Reformation.
Olmos Y, Perdrix-Rosell A, Carlton JG., Free PMC Article | 12/30/2017 |
| Observational study of gene-disease association. (HuGE Navigator) | Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity.
Hosgood HD 3rd, Zhang L, Shen M, Berndt SI, Vermeulen R, Li G, Yin S, Yeager M, Yuenger J, Rothman N, Chanock S, Smith M, Lan Q., Free PMC Article | 12/2/2009 |
| UBPY MIT domain and another ubiquitin isopeptidase, AMSH, reveals common interactions with CHMP1A and CHMP1B but a distinct selectivity of AMSH for CHMP3/VPS24, a core subunit of the ESCRT-III complex, and UBPY for CHMP7. | The MIT domain of UBPY constitutes a CHMP binding and endosomal localization signal required for efficient epidermal growth factor receptor degradation.
Row PE, Liu H, Hayes S, Welchman R, Charalabous P, Hofmann K, Clague MJ, Sanderson CM, Urbé S. | 01/21/2010 |
| Results suggest that CHMP7, a novel CHMP4-associated ESCRT-III-related protein, functions in the endosomal sorting pathway. | CHMP7, a novel ESCRT-III-related protein, associates with CHMP4b and functions in the endosomal sorting pathway.
Horii M, Shibata H, Kobayashi R, Katoh K, Yorikawa C, Yasuda J, Maki M., Free PMC Article | 01/21/2010 |