| Study on the expression and function of chordin-like 1 in oral squamous cell carcinoma. | Study on the expression and function of chordin-like 1 in oral squamous cell carcinoma.
Han Y, Xia L, Wang X, Xiong H, Zeng L, Wang Z, Zhang T, Xia K, Hu X, Su T. | 06/15/2023 |
| Bioinformatics identify the role of chordin-like 1 in thyroid cancer. | Bioinformatics identify the role of chordin-like 1 in thyroid cancer.
Yu JW, Pang R, Liu B, Zhang L, Zhang JW., Free PMC Article | 02/14/2023 |
| Finally, in vivo experiments confirmed that CHRDL1 acted as a tumor suppressor gene in suppressing tumor growth and metastasis | Hypermethylation of the CHRDL1 promoter induces proliferation and metastasis by activating Akt and Erk in gastric cancer.
Pei YF, Zhang YJ, Lei Y, Wu WD, Ma TH, Liu XQ., Free PMC Article | 12/2/2017 |
| Results show that Chrdl1 expression is upregulated in numerous breast cancer cells following TGF-beta stimulation and demonstrated that Chrdl1 acts as an inhibitor of BMP4-induced migration and invasion. | Chordin-Like 1 Suppresses Bone Morphogenetic Protein 4-Induced Breast Cancer Cell Migration and Invasion.
Cyr-Depauw C, Northey JJ, Tabariès S, Annis MG, Dong Z, Cory S, Hallett M, Rennhack JP, Andrechek ER, Siegel PM., Free PMC Article | 05/30/2017 |
| These studies have identified and validated new factors enriched in juvenile chondrocytes as compared to adult chondrocytes including secreted extracellular matrix factors chordin-like 1 (CHRDL1) and microfibrillar-associated protein 4 (MFAP4). | Identification of Human Juvenile Chondrocyte-Specific Factors that Stimulate Stem Cell Growth.
Taylor SE, Lee J, Smeriglio P, Razzaque A, Smith RL, Dragoo JL, Maloney WJ, Bhutani N. | 01/14/2017 |
| We provide the initial confirmation that X-linked megalocornea is associated with mutations in the CHRDL1 gene. | X-linked Megalocornea Associated with the Novel CHRDL1 Gene Mutation p.(Pro56Leu*8).
Han J, Young JW, Frausto RF, Isenberg SJ, Aldave AJ., Free PMC Article | 02/27/2016 |
| CHRDL1 plays a key role in cornea homeostasis as evidenced by disease causing mutations in X-linked megalocornea. | Molecular mechanism of CHRDL1-mediated X-linked megalocornea in humans and in Xenopus model.
Pfirrmann T, Emmerich D, Ruokonen P, Quandt D, Buchen R, Fischer-Zirnsak B, Hecht J, Krawitz P, Meyer P, Klopocki E, Stricker S, Lausch E, Seliger B, Hollemann T, Reinhard T, Auw-Haedrich C, Zabel B, Hoffmann K, Villavicencio-Lorini P. | 02/20/2016 |
| The detection of mutations in the CHRDL1 gene is useful for differential diagnosis with different forms of megalocornea. | Novel Mutation in the CHRDL1 Gene Detected in Patients With Megalocornea.
Mangialavori D, Colao E, Carnevali A, Bruzzichessi D, Grillone T, Perrotti N, Iuliano R, Scorcia V. | 02/6/2016 |
| Novel CHRDL1 mutations in ten families with X-linked megalocornea, are reported. | Association of CHRDL1 mutations and variants with X-linked megalocornea, Neuhäuser syndrome and central corneal thickness.
Davidson AE, Cheong SS, Hysi PG, Venturini C, Plagnol V, Ruddle JB, Ali H, Carnt N, Gardner JC, Hassan H, Gade E, Kearns L, Jelsig AM, Restori M, Webb TR, Laws D, Cosgrove M, Hertz JM, Russell-Eggitt I, Pilz DT, Hammond CJ, Tuft SJ, Hardcastle AJ., Free PMC Article | 11/14/2015 |
| Observational study of gene-disease association. (HuGE Navigator) | A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.
Grupe A, Li Y, Rowland C, Nowotny P, Hinrichs AL, Smemo S, Kauwe JS, Maxwell TJ, Cherny S, Doil L, Tacey K, van Luchene R, Myers A, Wavrant-De Vrièze F, Kaleem M, Hollingworth P, Jehu L, Foy C, Archer N, Hamilton G, Holmans P, Morris CM, Catanese J, Sninsky J, White TJ, Powell J, Hardy J, O'Donovan M, Lovestone S, Jones L, Morris JC, Thal L, Owen M, Williams J, Goate A., Free PMC Article | 02/4/2014 |
| CHRDL1 is expressed in the developing human cornea and anterior segment in addition to the retina. | X-linked megalocornea caused by mutations in CHRDL1 identifies an essential role for ventroptin in anterior segment development.
Webb TR, Matarin M, Gardner JC, Kelberman D, Hassan H, Ang W, Michaelides M, Ruddle JB, Pennell CE, Yazar S, Khor CC, Aung T, Yogarajah M, Robson AG, Holder GE, Cheetham ME, Traboulsi EI, Moore AT, Sowden JC, Sisodiya SM, Mackey DA, Tuft SJ, Hardcastle AJ., Free PMC Article | 06/23/2012 |
| reports the cloning of chick ventroptin and its importance in topographic retinotectal projection | Ventroptin: a BMP-4 antagonist expressed in a double-gradient pattern in the retina.
Sakuta H, Suzuki R, Takahashi H, Kato A, Shintani T, Iemura Si, Yamamoto TS, Ueno N, Noda M. | 01/14/2009 |
| Hypoxia-induced upregulation of CHL-1 alters the homeostatic balance between BMP-4 and VEGF to synergize with VEGF in driving retinal angiogenesis. | Chordin-like 1, a bone morphogenetic protein-4 antagonist, is upregulated by hypoxia in human retinal pericytes and plays a role in regulating angiogenesis.
Kane R, Godson C, O'Brien C., Free PMC Article | 01/21/2010 |