| Transmembrane protein 88 inhibits transforming growth factor-beta1-induced-extracellular matrix accumulation and epithelial-mesenchymal transition program in human pleural mesothelial cells through modulating TGF-beta1/Smad pathway. | Transmembrane protein 88 inhibits transforming growth factor-β1-induced-extracellular matrix accumulation and epithelial-mesenchymal transition program in human pleural mesothelial cells through modulating TGF-β1/Smad pathway.
Sun Z, Ning Q, Li H, Hu T, Tang L, Wen Q, Shen L. | 02/19/2022 |
| TMEM88 exhibits an antiproliferative and anti-invasive effect in bladder cancer by downregulating Wnt/beta-catenin signaling. | TMEM88 exhibits an antiproliferative and anti-invasive effect in bladder cancer by downregulating Wnt/β-catenin signaling.
Zhao X, Li G, Chong T, Xue L, Luo Q, Tang X, Zhai X, Chen J, Zhang X. | 09/4/2021 |
| MicroRNA-708 modulates Hepatic Stellate Cells activation and enhances extracellular matrix accumulation via direct targeting TMEM88. | MicroRNA-708 modulates Hepatic Stellate Cells activation and enhances extracellular matrix accumulation via direct targeting TMEM88.
Xu T, Pan L, Li L, Hu S, Zhou H, Yang C, Yang J, Li H, Liu Y, Meng X, Li J., Free PMC Article | 05/1/2021 |
| Transmembrane protein 88 exerts a tumor-inhibitory role in thyroid cancer through restriction of Wnt/beta-catenin signaling. | Transmembrane protein 88 exerts a tumor-inhibitory role in thyroid cancer through restriction of Wnt/β-catenin signaling.
Geng Q, Chen X, Chen N. | 03/6/2021 |
| TMEM88 plays a significant role in TNF-alpha-enhanced cytokine (IL-6 and IL-1beta) secretion of LX-2 cells via regulating JNK/P38 and canonical Wnt/beta-catenin signaling pathway. | TMEM88 mediates inflammatory cytokines secretion by regulating JNK/P38 and canonical Wnt/β-catenin signaling pathway in LX-2 cells.
Xu T, Pan LX, Ge YX, Li P, Meng XM, Huang C, Li J. | 02/23/2019 |
| TMEM88 inhibits the TGF-beta1-stimulated cell proliferation, migration and extracellular matrix expression in keloid fibroblasts. | TMEM88 inhibits extracellular matrix expression in keloid fibroblasts.
Zhao H, Lu F, Cui S, Zhang X, Wang W, Si E, Yuan Z. | 06/23/2018 |
| TMEM88, CCL14, and CLEC3B genes were stable and available in predicting the survival and palindromia time of hepatocellular carcinoma. These genes could function as potential prognostic genes contributing to improve patients' outcomes and survival | TMEM88, CCL14 and CLEC3B as prognostic biomarkers for prognosis and palindromia of human hepatocellular carcinoma.
Zhang X, Wan JX, Ke ZP, Wang F, Chai HX, Liu JQ. | 07/29/2017 |
| Results support that OC platinum resistance was correlated with TMEM88 overexpression regulated through decreased promoter methylation. Data suggest that TMEM88 functions as an inhibitor of Wnt signaling, contributing to the development of platinum resistance. | Transmembrane protein 88 (TMEM88) promoter hypomethylation is associated with platinum resistance in ovarian cancer.
de Leon M, Cardenas H, Vieth E, Emerson R, Segar M, Liu Y, Nephew K, Matei D., Free PMC Article | 05/20/2017 |
| TMEM88 stimulated triple negative breast cancer cell invasion by interacting with DVL1. | Cytosolic TMEM88 promotes triple-negative breast cancer by interacting with Dvl.
Yu X, Zhang X, Zhang Y, Jiang G, Mao X, Jin F., Free PMC Article | 07/30/2016 |
| mislocalization of TMEM88 to the cytosol in non-small cell lung cancer cells ablates its Wnt pathway regulatory properties, thereby promoting invasion and metastasis by activating the p38-GSK3beta-Snail signaling pathway. | Cytosolic TMEM88 promotes invasion and metastasis in lung cancer cells by binding DVLS.
Zhang X, Yu X, Jiang G, Miao Y, Wang L, Zhang Y, Liu Y, Fan C, Lin X, Dong Q, Han Q, Zhao H, Han Y, Han X, Rong X, Ding S, Wang E, Wang E. | 02/27/2016 |
| TMEM88 is crucial for heart development and acts downstream of GATA factors in the pre-cardiac mesoderm to specify lineage commitment of cardiomyocyte. | Transmembrane protein 88: a Wnt regulatory protein that specifies cardiomyocyte development.
Palpant NJ, Pabon L, Rabinowitz JS, Hadland BK, Stoick-Cooper CL, Paige SL, Bernstein ID, Moon RT, Murry CE., Free PMC Article | 11/16/2013 |
| miRNA-708 acts as an oncogene contributing to tumor growth and disease progression by directly downregulating TMEM88 | Increased miR-708 expression in NSCLC and its association with poor survival in lung adenocarcinoma from never smokers.
Jang JS, Jeon HS, Sun Z, Aubry MC, Tang H, Park CH, Rakhshan F, Schultz DA, Kolbert CP, Lupu R, Park JY, Harris CC, Yang P, Jen J., Free PMC Article | 10/27/2012 |
| TMEM88 associates with Dvl proteins and regulates Wnt signaling in a context-dependent manner | Identification of transmembrane protein 88 (TMEM88) as a dishevelled-binding protein.
Lee HJ, Finkelstein D, Li X, Wu D, Shi DL, Zheng JJ., Free PMC Article | 02/26/2011 |