| HOXA9, RASSF1A and SCGB3A1 promoter methylation significantly associated with testicular germ cell tumor stage. | DNA methylation profiling as a tool for testicular germ cell tumors subtyping.
Costa AL, Moreira-Barbosa C, Lobo J, Vilela-Salgueiro B, Cantante M, Guimarães R, Lopes P, Braga I, Oliveira J, Antunes L, Henrique R, Jerónimo C. | 08/3/2019 |
| Some single nucleotide polymorphisms and their combinations in the Ugrp2 gene are associated with an increased risk of developing adenoid hypertrophy. | Association of Ugrp2 gene polymorphisms with adenoid hypertrophy in the pediatric population.
Atilla MH, Özdaş S, Özdaş T, Baştimur S, Muz SE, Öz I, Kurt K, İzbirak A, Babademez MA, Vatandaş N., Free PMC Article | 02/9/2019 |
| The role of high in normal-1 (HIN-1) as a potential biomarker in combating glioblastoma is being described for the first time in this study. | HIN-1: a New Epigenetic Biomarker Crucial for Therapy Selection in Glioblastoma Multiforme.
Herranz M, Padín-Iruegas ME, Martínez-Lago N, Losada SA, Raña-Díez P, Vázquez EB, Carrera JJ, Antúnez JR, Ruibal A, López-López R. | 12/17/2016 |
| Tumor-adjacent tissues showed higher methylation status of RASSF1A, HIN-1 and MGMT promoters. | Applicability of HIN-1, MGMT and RASSF1A promoter methylation as biomarkers for detecting field cancerization in breast cancer.
Spitzwieser M, Holzweber E, Pfeiler G, Hacker S, Cichna-Markl M., Free PMC Article | 04/23/2016 |
| SCGB3A1-183 T and SCGB3A1 IVS1-189 A alleles might have a protective effect against nasal polyposis. | Investigation of SCGB3A1 (UGRP2) gene arrays in patients with nasal polyposis.
Palalı M, Murat Özcan K, Ozdaş S, Köseoğlu S, Ozdaş T, Erbek SS, Yıldırım E, Ensari S, Dere H. | 09/26/2015 |
| aberrant HIN-1 promoter methylation could be an independent and important biomarker used in predicting the prognosis and progression of breast cancer | Aberrant promoter methylation of HIN-1 gene may contribute to the pathogenesis of breast cancer: a meta-analysis.
Dai D, Dong XH, Cheng ST, Zhu G, Guo XL. | 01/17/2015 |
| Methylation of HIN-1 promoter is a novel epigenetic biomarker associated with poor outcomes in OCCA patients. | Promoter methylation status of HIN-1 associated with outcomes of ovarian clear cell adenocarcinoma.
Ho CM, Huang CJ, Huang CY, Wu YY, Chang SF, Cheng WF., Free PMC Article | 03/23/2013 |
| Methylation of HIN-1, RASSF1A, RIL and CDH13 in breast cancers was associated with clinical characteristics, but only RASSF1A methylation was associated with time to first recurrence and overall survival. | Methylation of HIN-1, RASSF1A, RIL and CDH13 in breast cancer is associated with clinical characteristics, but only RASSF1A methylation is associated with outcome.
Xu J, Shetty PB, Feng W, Chenault C, Bast RC Jr, Issa JP, Hilsenbeck SG, Yu Y., Free PMC Article | 01/26/2013 |
| HIN1, was the most "dietary sensitive" genes, as methylation of their promoters was associated with intakes of at least two out of the eight dietary methyl factors examined. | The influence of one-carbon metabolism on gene promoter methylation in a population-based breast cancer study.
Xu X, Gammon MD, Jefferson E, Zhang Y, Cho YH, Wetmur JG, Teitelbaum SL, Bradshaw PT, Terry MB, Garbowski G, Hibshoosh H, Neugut AI, Santella RM, Chen J., Free PMC Article | 10/6/2012 |
| analysis of AKT signaling pathway activated by HIN-1 methylation in non-small cell lung cancer | AKT signaling pathway activated by HIN-1 methylation in non-small cell lung cancer.
Yu Y, Yin D, Hoque MO, Cao B, Jia Y, Yang Y, Guo M. | 05/5/2012 |
| Data show that SCGB3A1 was down-regulated in invasive compared with DCIS, whereas talin 2 (TLN2) and PTGS1 were up-regulated in invasive compared with DCIS. | Serum estradiol levels associated with specific gene expression patterns in normal breast tissue and in breast carcinomas.
Haakensen VD, Bjøro T, Lüders T, Riis M, Bukholm IK, Kristensen VN, Troester MA, Homen MM, Ursin G, Børresen-Dale AL, Helland Å., Free PMC Article | 02/11/2012 |
| Data suggest that high methylation of the HIN-1 promoter results in silenced HIN-1 expression in gastric cancer, and that 5-aza-2'-deoxycytidine reverses HIN-1 methylation and reduces viability of gastric cancer cells. | Silence of HIN-1 expression through methylation of its gene promoter in gastric cancer.
Gong Y, Guo MZ, Ye ZJ, Zhang XL, Zhao YL, Yang YS., Free PMC Article | 07/23/2011 |
| The methylation levels and frequencies of HIN1, RASSF1A and TWIST, and average MR were significantly lower in basal-like subtype compared to luminal or human epithelial growth factor receptor-2 subtype. | Basal-like breast cancer displays distinct patterns of promoter methylation.
Lee JS, Fackler MJ, Lee JH, Choi C, Park MH, Yoon JH, Zhang Z, Sukumar S., Free PMC Article | 02/26/2011 |
| Hypermethylation of HIN-1 is associated with lymphatic metastasis of breast cancers. | Tumor suppressor genes are frequently methylated in lymph node metastases of breast cancers.
Feng W, Orlandi R, Zhao N, Carcangiu ML, Tagliabue E, Xu J, Bast RC Jr, Yu Y., Free PMC Article | 02/5/2011 |
| HIN-1, RAR-beta, RASSF1A, and Twist had the ability to distinguish high-grade squamous intraepithelial lesions/squamous cell carcinomas from low-grade squamous intraepithelial lesions/negative cervical scrapings | Quantitative assessment of DNA methylation for the detection of cervical neoplasia in liquid-based cytology specimens.
Kim JH, Choi YD, Lee JS, Lee JH, Nam JH, Choi C, Kweon SS, Fackler MJ, Sukumar S. | 08/23/2010 |
| The epigenetic silencing of tumor suppressor genes involved in the Ras/PI3K/AKT pathway plays an important role in oral squamous cell carcinoma radioresistance | Methylation of RASSF1A, RASSF2A, and HIN-1 is associated with poor outcome after radiotherapy, but not surgery, in oral squamous cell carcinoma.
Huang KH, Huang SF, Chen IH, Liao CT, Wang HM, Hsieh LL. | 01/21/2010 |
| Results show that cumulative RASSF1A, TWIST1, and HIN1 gene methylation accurately distinguished ducts with cancerous versus benign lesions. | Hypermethylated genes as biomarkers of cancer in women with pathologic nipple discharge.
Fackler MJ, Rivers A, Teo WW, Mangat A, Taylor E, Zhang Z, Goodman S, Argani P, Nayar R, Susnik B, Sukumar S, Khan SA. | 01/21/2010 |
| The combination of RARB M4, INK4a/ARF, PRB, and HIN-1 CpG island promoter methylation may predict non-BRCA1/2-associated mammary carcinogenesis and tumor progression. | CpG island tumor suppressor promoter methylation in non-BRCA-associated early mammary carcinogenesis.
Vasilatos SN, Broadwater G, Barry WT, Baker JC Jr, Lem S, Dietze EC, Bean GR, Bryson AD, Pilie PG, Goldenberg V, Skaar D, Paisie C, Torres-Hernandez A, Grant TL, Wilke LG, Ibarra-Drendall C, Ostrander JH, D'Amato NC, Zalles C, Jirtle R, Weaver VM, Seewaldt VL., Free PMC Article | 01/21/2010 |
| HIN-1 silencing is associated with dense promoter region hypermethylation in esophageal cancer and suggest that methylation of HIN-1 is an early event in dysplastic transformation. | Promoter methylation of HIN-1 in the progression to esophageal squamous cancer.
Guo M, Ren J, Brock MV, Herman JG, Carraway HE. | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | Evaluating new candidate SNPs as low penetrance risk factors in sporadic breast cancer: a two-stage Spanish case-control study.
Vega A, Salas A, Milne RL, Carracedo B, Ribas G, Ruibal A, de León AC, González-Hernández A, Benítez J, Carracedo A. | 11/5/2008 |
| HIN-1 was strongly associated with breast cytologic atypia. HIN-1 methylation increased rapidly between ages 32 and 40. | DNA methylation in benign breast epithelium in relation to age and breast cancer risk.
Euhus DM, Bu D, Milchgrub S, Xie XJ, Bian A, Leitch AM, Lewis CM. | 01/21/2010 |
| DNA hypermethylation of tumour suppressor genes seems to play an important role in ovarian carcinogenesis and HOXA9, HOXB5, SCGB3A1, and CRABP1 are identified as novel hypermethylated target genes in this tumour type | DNA methylation profiling of ovarian carcinomas and their in vitro models identifies HOXA9, HOXB5, SCGB3A1, and CRABP1 as novel targets.
Wu Q, Lothe RA, Ahlquist T, Silins I, Tropé CG, Micci F, Nesland JM, Suo Z, Lind GE., Free PMC Article | 01/21/2010 |
| CASP8, DCR2, and HIN-1 methylation leads to progression of neuroblastoma | Methylation of CASP8, DCR2, and HIN-1 in neuroblastoma is associated with poor outcome.
Yang Q, Kiernan CM, Tian Y, Salwen HR, Chlenski A, Brumback BA, London WB, Cohn SL. | 01/21/2010 |
| Studies provide further evidence that HIN-1 possesses tumor suppressor functions, and that these activities may be mediated through the AKT signaling pathway. | HIN-1, an inhibitor of cell growth, invasion, and AKT activation.
Krop I, Parker MT, Bloushtain-Qimron N, Porter D, Gelman R, Sasaki H, Maurer M, Terry MB, Parsons R, Polyak K. | 01/21/2010 |
| Lack of HIN-1 methylation defines specific breast tumor subtypes including medullary carcinoma of the breast and BRCA1-linked tumors | Lack of HIN-1 methylation defines specific breast tumor subtypes including medullary carcinoma of the breast and BRCA1-linked tumors.
Tisserand P, Fouquet C, Barrois M, Gallou C, Dendale R, Stoppa-Lyonnet D, Sastre-Garau X, Fourquet A, Soussi T. | 01/21/2010 |