| Association of UBE2L6 and ABCB6 Expression With Platinum Resistance in Serous Ovarian Carcinoma. | Association of UBE2L6 and ABCB6 Expression With Platinum Resistance in Serous Ovarian Carcinoma.
Shibahara M, Kurita T, Murakami M, Harada H, Koi C, Izumi H, Yoshino K. | 08/4/2023 |
| Increased UBE2L6 regulated by type 1 interferon as potential marker in TB. | Increased UBE2L6 regulated by type 1 interferon as potential marker in TB.
Gao J, Li C, Li W, Chen H, Fu Y, Yi Z., Free PMC Article | 03/26/2022 |
| Inhibition of UBE2L6 attenuates ISGylation and impedes ATRA-induced differentiation of leukemic cells. | Inhibition of UBE2L6 attenuates ISGylation and impedes ATRA-induced differentiation of leukemic cells.
Orfali N, Shan-Krauer D, O'Donovan TR, Mongan NP, Gudas LJ, Cahill MR, Tschan MP, McKenna SL., Free PMC Article | 07/3/2021 |
| UBE2L6 is Involved in Cisplatin Resistance by Regulating the Transcription of ABCB6. | UBE2L6 is Involved in Cisplatin Resistance by Regulating the Transcription of ABCB6.
Murakami M, Izumi H, Kurita T, Koi C, Morimoto Y, Yoshino K. | 06/5/2021 |
| An integrative analysis identifying transcriptional features and key genes involved in COVID-19. | An integrative analysis identifying transcriptional features and key genes involved in COVID-19.
Li G, Wang J, He X, Zhang L, Ran Q, Xiong A, Wu D, Hu L, Song Q, Zhu D., Free PMC Article | 01/9/2021 |
| TNF-alpha, similar to the response by IFN-beta, could directly induce expression of ISG15 and its conjugation machinery, UbE1L and UbcH8, in human lung carcinoma. | Up-regulation of interferon-stimulated gene 15 and its conjugation machinery, UbE1L and UbcH8 expression by tumor necrosis factor-α through p38 MAPK and JNK signaling pathways in human lung carcinoma.
Lertsooksawat W, Wongnoppavich A, Chairatvit K. | 01/18/2020 |
| hese findings establish UBE2L6 as a novel target of UHRF1 that regulates the apoptosis function of UHRF1. | UHRF1 epigenetically down-regulates UbcH8 to inhibit apoptosis in cervical cancer cells.
Zhang Q, Qiao L, Wang X, Ding C, Chen JJ., Free PMC Article | 09/7/2019 |
| Depletion of either ISG15 or UBE2L6/UBCH8 resulted in enhanced endogenous autophagic flux. | UBE2L6/UBCH8 and ISG15 attenuate autophagy in esophageal cancer cells.
Falvey CM, O'Donovan TR, El-Mashed S, Nyhan MJ, O'Reilly S, McKenna SL., Free PMC Article | 09/23/2017 |
| Data indicate that reduced expression of the ubiquitin-conjugating enzyme UbcH8 protein correlated with poor outcome in nasopharyngeal carcinoma (NPC) patients. | Epigenetic downregulation of the ISG15-conjugating enzyme UbcH8 impairs lipolysis and correlates with poor prognosis in nasopharyngeal carcinoma.
Zhou X, Wei J, Chen F, Xiao X, Huang T, He Q, Wang S, Du C, Mo Y, Lin L, Xie Y, Wei L, Lan Y, Murata M, Huang G, Ernberg I, Matskova L, Zhang Z., Free PMC Article | 10/1/2016 |
| study reports that UBCH8 and UBE2G1 and UBE2G2 cooperate with CRL4Cdt2 in promoting the polyubiquitylation and subsequent degradation of p21 and Cdt1, respectively | Selective ubiquitylation of p21 and Cdt1 by UBCH8 and UBE2G ubiquitin-conjugating enzymes via the CRL4Cdt2 ubiquitin ligase complex.
Shibata E, Abbas T, Huang X, Wohlschlegel JA, Dutta A., Free PMC Article | 09/17/2011 |
| gain and loss-of-function approaches show that UBCH8 and the ubiquitin-ligase SIAH1 physically interact with and target FLT3-ITD for proteasomal degradation | Ubiquitin conjugase UBCH8 targets active FMS-like tyrosine kinase 3 for proteasomal degradation.
Buchwald M, Pietschmann K, Müller JP, Böhmer FD, Heinzel T, Krämer OH. | 09/20/2010 |
| The structure of UbcH8 does not undergo a significant conformational change upon forming a complex with ubiquitin. | The structure of the UbcH8-ubiquitin complex shows a unique ubiquitin interaction site.
Serniwka SA, Shaw GS. | 01/21/2010 |
| Ube1L was required for transfer of ISG15 to UbcH8 and for binding of Ube1L to UbcH8 | The basis for selective E1-E2 interactions in the ISG15 conjugation system.
Durfee LA, Kelley ML, Huibregtse JM., Free PMC Article | 01/21/2010 |
| Quantitative-PCR and Northern analysis confirmed down-regulation of UCRP and UBE2L6 with BRCA2 knockdown, respectively. | Down-regulation of UCRP and UBE2L6 in BRCA2 knocked-down human breast cells.
Tripathi MK, Chaudhuri G., Free PMC Article | 01/21/2010 |