| Molecular Architecture of a Network of Potential Intracellular EGFR Modulators: ARNO, CaM, Phospholipids, and the Juxtamembrane Segment. | Molecular Architecture of a Network of Potential Intracellular EGFR Modulators: ARNO, CaM, Phospholipids, and the Juxtamembrane Segment.
Viegas A, Yin DM, Borggräfe J, Viennet T, Falke M, Schmitz A, Famulok M, Etzkorn M. | 10/3/2020 |
| INAVA-CUPID exhibits dual functions, coordinated directly by ARNO, that bridge epithelial barrier function with extracellular signals and inflammation. | INAVA-ARNO complexes bridge mucosal barrier function with inflammatory signaling.
Luong P, Hedl M, Yan J, Zuo T, Fu TM, Jiang X, Thiagarajah JR, Hansen SH, Lesser CF, Wu H, Abraham C, Lencer WI., Free PMC Article | 03/2/2019 |
| ARNO-ARF1 regulates formation of podosomes by inhibition of RhoA/myosin-II and promotion of actin core assembly. | Podosome assembly is controlled by the GTPase ARF1 and its nucleotide exchange factor ARNO.
Rafiq NB, Lieu ZZ, Jiang T, Yu CH, Matsudaira P, Jones GE, Bershadsky AD., Free PMC Article | 06/3/2017 |
| Authors' experiments argue against ARNO being a robust modifier of EGFR catalytic activity. | Lack of Evidence that CYTH2/ARNO Functions as a Direct Intracellular EGFR Activator.
Anastasi S, Zhu SJ, Ballarò C, Manca S, Lamberti D, Wang LJ, Alemà S, Yun CH, Segatto O. | 11/12/2016 |
| Data establish a role for cytohesin-2/ARNO as a regulator of R-Ras and integrin recycling and suggest that ARF-regulated trafficking of R-Ras is required for R-Ras-dependent effects on spreading and adhesion formation. | ARF-GEF cytohesin-2/ARNO regulates R-Ras and α5-integrin recycling through an EHD1-positive compartment.
Salem JC, Reviriego-Mendoza MM, Santy LC., Free PMC Article | 07/30/2016 |
| The authors show that Shigella flexneri IpgD phosphatase activity is required for recruitment of the ARF6 guanine nucleotide exchange factor (GEF) ARF nucleotide binding site opener (ARNO) to bacterial entry sites. | Shigella flexneri regulation of ARF6 activation during bacterial entry via an IpgD-mediated positive feedback loop.
Garza-Mayers AC, Miller KA, Russo BC, Nagda DV, Goldberg MB., Free PMC Article | 02/27/2016 |
| inhibiting cytohesins or ARNO as cytoplasmic activators of EGFR and IGF-I in colorectal cancer resulted in anti-proliferation, reduced invasion, decreased migration, and suppressed growth in vivo and in vitro. | Cytohesins/ARNO: the function in colorectal cancer cells.
Pan T, Sun J, Hu J, Hu Y, Zhou J, Chen Z, Xu D, Xu W, Zheng S, Zhang S., Free PMC Article | 05/30/2015 |
| Cytohesin-2 constitutively suppresses platelet dense granule secretion and aggregation by keeping ARF6 in a GTP-bound state | Cytohesin-2 phosphorylation by protein kinase C relieves the constitutive suppression of platelet dense granule secretion by ADP-ribosylation factor 6.
van den Bosch MT, Poole AW, Hers I., Free PMC Article | 01/31/2015 |
| Expression of CYTH2 mutant deficient of the EFh2 domain in cells also inhibits Arf6 activation and neurite extension. | Arf6 guanine-nucleotide exchange factor, cytohesin-2, interacts with actinin-1 to regulate neurite extension.
Torii T, Miyamoto Y, Nakamura K, Maeda M, Yamauchi J, Tanoue A. | 03/1/2014 |
| Phosphorylation of Ser392 of ARNO stabilized the C-terminal alpha-helix via formation of salt bridges between phospho-Ser392 and Arg390, Lys395, and Lys396. | Effect of Ser392 phosphorylation on the structure and dynamics of the polybasic domain of ADP ribosylation factor nucleotide site opener protein: a molecular simulation study.
Srinivasaraghavan K, Nacro K, Grüber G, Verma CS. | 12/28/2013 |
| There is an association between cytohesin-2 expression and overall survival and disease-free survival in patients with hepatocellular carcinoma. | Cytohesin-2 as a novel prognostic marker for hepatocellular carcinoma.
Xu K, Gao J, Yang X, Yao Y, Liu Q. | 11/2/2013 |
| Arf6/ ARNO signaling mediates phospholipase-D, ERK1/2 and cofilin activation in pancreatic beta-cells. | Phagocytic NADPH oxidase links ARNO-Arf6 signaling pathway in glucose-stimulated insulin secretion from the pancreatic β-cell.
Jayaram B, Kowluru A. | 06/1/2013 |
| Kinetics of interaction between ADP-ribosylation factor-1 (Arf1) and the Sec7 domain of Arno guanine nucleotide exchange factor, modulation by allosteric factors, and the uncompetitive inhibitor brefeldin A | Kinetics of interaction between ADP-ribosylation factor-1 (Arf1) and the Sec7 domain of Arno guanine nucleotide exchange factor, modulation by allosteric factors, and the uncompetitive inhibitor brefeldin A.
Rouhana J, Padilla A, Estaran S, Bakari S, Delbecq S, Boublik Y, Chopineau J, Pugnière M, Chavanieu A., Free PMC Article | 05/4/2013 |
| The N termini of a-subunit isoforms are involved in signaling between vacuolar H+-ATPase (V-ATPase) and cytohesin-2 | The N termini of a-subunit isoforms are involved in signaling between vacuolar H+-ATPase (V-ATPase) and cytohesin-2.
Hosokawa H, Dip PV, Merkulova M, Bakulina A, Zhuang Z, Khatri A, Jian X, Keating SM, Bueler SA, Rubinstein JL, Randazzo PA, Ausiello DA, Grüber G, Marshansky V., Free PMC Article | 04/27/2013 |
| The PH domains of cytohesin 2/ARNO and cytohesin 3/GRP1 are responsible for the differential effects of these proteins on cell adhesion to fibronectin. | Phosphoinositide specificity determines which cytohesins regulate β1 integrin recycling.
Oh SJ, Santy LC. | 01/26/2013 |
| ARNO in turn triggered WAVE regulatory complex recruitment and activation, which was dramatically enhanced when ARNO cooperated with Salmonella SopE. | Salmonella virulence effector SopE and Host GEF ARNO cooperate to recruit and activate WAVE to trigger bacterial invasion.
Humphreys D, Davidson A, Hume PJ, Koronakis V., Free PMC Article | 06/9/2012 |
| role for endothelial ARNO in VEGF-dependent initiation of angiogenesis by regulation of VEGFR-2 internalization in endothelial cells, resulting in the activation of the Akt pathway, vessel permeability, and ultimately endothelial proliferation | ARNO regulates VEGF-dependent tissue responses by stabilizing endothelial VEGFR-2 surface expression.
Mannell HK, Pircher J, Chaudhry DI, Alig SK, Koch EG, Mettler R, Pohl U, Krötz F. | 05/12/2012 |
| Data that aldolase forms a complex with ARNO/Arf6 and the V-ATPase and that it may contribute to remodeling of the actin cytoskeleton. | Aldolase directly interacts with ARNO and modulates cell morphology and acidic vesicle distribution.
Merkulova M, Hurtado-Lorenzo A, Hosokawa H, Zhuang Z, Brown D, Ausiello DA, Marshansky V., Free PMC Article | 08/27/2011 |
| Arno behaves as a bistable switch, having an absolute requirement for activation by an Arf protein but, once triggered, becoming highly active through the positive feedback effect of Arf1-GTP. | Kinetic studies of the Arf activator Arno on model membranes in the presence of Arf effectors suggest control by a positive feedback loop.
Stalder D, Barelli H, Gautier R, Macia E, Jackson CL, Antonny B., Free PMC Article | 03/26/2011 |
| cytohesin-2, through a previously unexplored complex formation with paxillin, regulates preadipocyte migration; paxillin plays a previously unknown role as a scaffold protein of Arf guanine-nucleotide exchange factor | Cytohesin-2/ARNO, through its interaction with focal adhesion adaptor protein paxillin, regulates preadipocyte migration via the downstream activation of Arf6.
Torii T, Miyamoto Y, Sanbe A, Nishimura K, Yamauchi J, Tanoue A., Free PMC Article | 09/20/2010 |
| Specific motifs of the V-ATPase a2-subunit isoform interact with catalytic and regulatory domains of ARNO. | Specific motifs of the V-ATPase a2-subunit isoform interact with catalytic and regulatory domains of ARNO.
Merkulova M, Bakulina A, Thaker YR, Grüber G, Marshansky V. | 08/23/2010 |
| protein-protein interaction mediated by ARNO coiled-coil domain required for ARNO induced motility; coiled-coil domain promotes assembly of multiprotein complex containing ARNO and Dock180; assembly of complex requires coiled-coil domain, GRASP and IPCEF | GRASP and IPCEF promote ARF-to-Rac signaling and cell migration by coordinating the association of ARNO/cytohesin 2 with Dock180.
White DT, McShea KM, Attar MA, Santy LC., Free PMC Article | 07/26/2010 |
| data suggest cells ruffle upon CaSR (calcium sensing receptor)stimulation via a mechanism that involves translocation of beta-arrestin 1 pre-assembled with the CaSR or ARNO (Arf nucleotide binding site opener) | The calcium-sensing receptor changes cell shape via a beta-arrestin-1 ARNO ARF6 ELMO protein network.
Bouschet T, Martin S, Kanamarlapudi V, Mundell S, Henley JM., Free PMC Article | 01/21/2010 |
| Study shows that three related Arf-like GTPases Arl4a, Arl4c, and Arl4d, are able to recruit ARNO and other cytohesins to the plasma membrane by binding to their PH domains irrespective of whether they are in the diglycine or triglycine form. | The Arl4 family of small G proteins can recruit the cytohesin Arf6 exchange factors to the plasma membrane.
Hofmann I, Thompson A, Sanderson CM, Munro S. | 01/21/2010 |
| cytohesin 2 binds to IPCEF1, which modifies its activity | Interaction protein for cytohesin exchange factors 1 (IPCEF1) binds cytohesin 2 and modifies its activity.
Venkateswarlu K. | 01/21/2010 |