| Co-inhibition of BET and NAE enhances BIM-dependent apoptosis with augmented cancer therapeutic efficacy. | Co-inhibition of BET and NAE enhances BIM-dependent apoptosis with augmented cancer therapeutic efficacy.
Zhang Q, Wu Q, Huan XJ, Song SS, Bao XB, Miao ZH, Wang YQ. | 04/25/2024 |
| BET protein-dependent E2F pathway activity confers bell-shaped type resistance to tankyrase inhibitors in APC-mutated colorectal cancer. | BET protein-dependent E2F pathway activity confers bell-shaped type resistance to tankyrase inhibitors in APC-mutated colorectal cancer.
Morino S, Mashima T, Shirai F, Nagayama S, Katayama R, Seimiya H. | 02/28/2024 |
| Delta/Notch-like Epidermal Growth Factor-Related Receptor (DNER), a Potential Prognostic Marker of Gastric Cancer Regulates Cell Survival and Cell Cycle Progression. | Delta/Notch-like Epidermal Growth Factor-Related Receptor (DNER), a Potential Prognostic Marker of Gastric Cancer Regulates Cell Survival and Cell Cycle Progression.
To HTN, Park JH, Kim JW, Kang D., Free PMC Article | 06/30/2023 |
| Role of Delta/Notch-like EGF-related receptor in blood glucose homeostasis. | Role of Delta/Notch-like EGF-related receptor in blood glucose homeostasis.
Ruiz-Otero N, Kuruvilla R., Free PMC Article | 06/12/2023 |
| mTOR inhibition overcomes RSK3-mediated resistance to BET inhibitors in small cell lung cancer. | mTOR inhibition overcomes RSK3-mediated resistance to BET inhibitors in small cell lung cancer.
Kumari A, Gesumaria L, Liu YJ, Hughitt VK, Zhang X, Ceribelli M, Wilson KM, Klumpp-Thomas C, Chen L, McKnight C, Itkin Z, Thomas CJ, Mock BA, Schrump DS, Chen H., Free PMC Article | 03/10/2023 |
| Development of an intracellular quantitative assay to measure compound binding kinetics. | Development of an intracellular quantitative assay to measure compound binding kinetics.
Lay CS, Thomas DA, Evans JP, Campbell M, McCombe K, Phillipou AN, Gordon LJ, Jones EJ, Riching K, Mahmood M, Messenger C, Carver CE, Gatfield KM, Craggs PD. | 03/12/2022 |
| Epigenetic targeting of Waldenstrom macroglobulinemia cells with BET inhibitors synergizes with BCL2 or histone deacetylase inhibition. | Epigenetic targeting of Waldenström macroglobulinemia cells with BET inhibitors synergizes with BCL2 or histone deacetylase inhibition.
Matissek SJ, Han W, Karbalivand M, Sayed M, Reilly BM, Mallat S, Ghazal SM, Munshi M, Yang G, Treon SP, Walker SR, Elsawa SF., Free PMC Article | 03/5/2022 |
| Repressing MYC by targeting BET synergizes with selective inhibition of PI3Kalpha against B cell lymphoma. | Repressing MYC by targeting BET synergizes with selective inhibition of PI3Kα against B cell lymphoma.
Chen ZQ, Cao ZR, Wang Y, Zhang X, Xu L, Wang YX, Chen Y, Yang CH, Ding J, Meng LH. | 01/8/2022 |
| PROTAC induced-BET protein degradation exhibits potent anti-osteosarcoma activity by triggering apoptosis. | PROTAC induced-BET protein degradation exhibits potent anti-osteosarcoma activity by triggering apoptosis.
Shi C, Zhang H, Wang P, Wang K, Xu D, Wang H, Yin L, Zhang S, Zhang Y., Free PMC Article | 08/29/2020 |
| Synergistic inhibition of BDs encoded in BAZ2A/B, BRD9, and BET proteins induces apoptosis of triple-negative breast cancer (TNBC) by a combinatorial suppression of ribosomal DNA transcription and ETS-regulated genes. | GSK2801, a BAZ2/BRD9 Bromodomain Inhibitor, Synergizes with BET Inhibitors to Induce Apoptosis in Triple-Negative Breast Cancer.
Bevill SM, Olivares-Quintero JF, Sciaky N, Golitz BT, Singh D, Beltran AS, Rashid NU, Stuhlmiller TJ, Hale A, Moorman NJ, Santos CM, Angus SP, Zawistowski JS, Johnson GL., Free PMC Article | 05/2/2020 |
| These findings are important for all SIRT1 and BET inhibitor-related research, and they show that different BET inhibitors might have important individual effects | Impact of structurally diverse BET inhibitors on SIRT1.
Tenhunen J, Kokkola T, Huovinen M, Rahnasto-Rilla M, Lahtela-Kakkonen M. | 04/25/2020 |
| DNER is a novel protein induced in COPD patients and 6months CS-exposed mice that regulates IFNgamma secretion via non-canonical Notch in pro-inflammatory recruited macrophages. | The Notch ligand DNER regulates macrophage IFNγ release in chronic obstructive pulmonary disease.
Ballester-López C, Conlon TM, Ertüz Z, Greiffo FR, Irmler M, Verleden SE, Beckers J, Fernandez IE, Eickelberg O, Yildirim AÖ., Free PMC Article | 11/30/2019 |
| Taken together, DNER could promote proliferation, migration, and invasion of HCC cells by regulating the activation of PI3K/AKT pathway. | Oncogene Delta/Notch-Like EGF-Related Receptor Promotes Cell Proliferation, Invasion, and Migration in Hepatocellular Carcinoma and Predicts a Poor Prognosis.
Liang Y, Luo H, Zhang H, Dong Y, Bao Y., Free PMC Article | 03/23/2019 |
| quantum dot-based immunofluorescent imaging and quantitative analytical system (QD-IIQAS) is an easy and accurate method for assessing DNER and the DNER expression was an independent prognostic factor in prostate cancer. | Quantum dot-based immunofluorescent imaging and quantitative detection of DNER and prognostic value in prostate cancer.
Wang L, Wu Q, Zhu S, Li Z, Yuan J, Liu L, Yu D, Xu Z, Li J, Sun S, Wang C. | 11/10/2018 |
| Collectively, our study identified an unexpected transcriptional repression function of the BET bromodomain and a novel mechanism for TAZ upregulation. | BET bromodomain is a novel regulator of TAZ and its activity.
Duan Q, Xiao Y, Zhu L, Liu Z, Mao X, Zhou Z, Liao C, Cai J, Huang F, Liu Z, Zeng J, Xia K, Chang C, Qi J, Chen Z, Huang H, Yang T. | 11/4/2017 |
| our findings show that targeting BET proteins for degradation represents an effective therapeutic strategy for Triple-negative breast cancers (TNBC)treatment | Targeted Degradation of BET Proteins in Triple-Negative Breast Cancer.
Bai L, Zhou B, Yang CY, Ji J, McEachern D, Przybranowski S, Jiang H, Hu J, Xu F, Zhao Y, Liu L, Fernandez-Salas E, Xu J, Dou Y, Wen B, Sun D, Meagher J, Stuckey J, Hayes DF, Li S, Ellis MJ, Wang S., Free PMC Article | 09/16/2017 |
| is not a Notch ligand | Delta/Notch-Like EGF-Related Receptor (DNER) Is Not a Notch Ligand.
Greene M, Lai Y, Pajcini K, Bailis W, Pear WS, Lancaster E., Free PMC Article | 08/5/2017 |
| we review and discuss the structural biology of BET family BDs and their applications in major diseases. | Bromodomain and extra-terminal (BET) family proteins: New therapeutic targets in major diseases.
Padmanabhan B, Mathur S, Manjula R, Tripathi S. | 03/25/2017 |
| DNER rs1861612 C to T change and variant T genotype may contribute to T2DM in a Chinese Han population | Association between single nucleotide polymorphisms of delta/notch-like epidermal growth factor (EGF)-related receptor (DNER) and Delta-like 1 Ligand (DLL 1) with the risk of type 2 diabetes mellitus in a Chinese Han population.
Deng Z, Shen J, Ye J, Shu Q, Zhao J, Fang M, Zhang T. | 04/30/2016 |
| These studies implicate DNER as a susceptibility gene for T2DM in American Indians. | A genome-wide association study in American Indians implicates DNER as a susceptibility locus for type 2 diabetes.
Hanson RL, Muller YL, Kobes S, Guo T, Bian L, Ossowski V, Wiedrich K, Sutherland J, Wiedrich C, Mahkee D, Huang K, Abdussamad M, Traurig M, Weil EJ, Nelson RG, Bennett PH, Knowler WC, Bogardus C, Baier LJ., Free PMC Article | 03/1/2014 |
| Our data suggest that clathrin-independent endocytosis is critical for the polarized targeting of somatodendritic proteins(DNER). | Polarized targeting of DNER into dendritic plasma membrane in hippocampal neurons depends on endocytosis.
Kurisu J, Fukuda T, Yokoyama S, Hirano T, Kengaku M. | 08/9/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | New genetic associations detected in a host response study to hepatitis B vaccine.
Davila S, Froeling FE, Tan A, Bonnard C, Boland GJ, Snippe H, Hibberd ML, Seielstad M. | 04/7/2010 |
| The inhibition of DNER protein resulted in an increase in adipocyte maturation, partly via a reduction of cell proliferation through elevation of CCAAT-Enhancer-Binding Protein-delta expression. | DNER modulates adipogenesis of human adipose tissue-derived mesenchymal stem cells via regulation of cell proliferation.
Park JR, Jung JW, Seo MS, Kang SK, Lee YS, Kang KS., Free PMC Article | 02/15/2010 |
| expression in developing and mature central nervous system | Delta/notch-like epidermal growth factor (EGF)-related receptor, a novel EGF-like repeat-containing protein targeted to dendrites of developing and adult central nervous system neurons.
Eiraku M, Hirata Y, Takeshima H, Hirano T, Kengaku M. | 01/21/2010 |