| Activin A and Acvr2b mRNA from Umbilical Cord Blood Are Not Reliable Markers of Mild or Moderate Neonatal Hypoxic-Ischemic Encephalopathy. | Activin A and Acvr2b mRNA from Umbilical Cord Blood Are Not Reliable Markers of Mild or Moderate Neonatal Hypoxic-Ischemic Encephalopathy.
O'Sullivan MP, Denihan N, Sikora K, Finder M, Ahearne C, Clarke G, Hallberg B, Boylan GB, Murray DM. | 04/16/2022 |
| The association between sarcopenia susceptibility and polymorphisms of FTO, ACVR2B, and IRS1 in Tibetans. | The association between sarcopenia susceptibility and polymorphisms of FTO, ACVR2B, and IRS1 in Tibetans.
Zhang X, Ye L, Li X, Chen Y, Jiang Y, Li W, Wen Y., Free PMC Article | 03/5/2022 |
| Effects of Roux-en-Y gastric bypass on circulating follistatin, activin A, and peripheral ActRIIB signaling in humans with obesity and type 2 diabetes. | Effects of Roux-en-Y gastric bypass on circulating follistatin, activin A, and peripheral ActRIIB signaling in humans with obesity and type 2 diabetes.
Pham TCP, Bojsen-Møller KN, Madsbad S, Wojtaszewski JFP, Richter EA, Sylow L. | 01/8/2022 |
| Deficiency of myostatin protects skeletal muscle cells from ischemia reperfusion injury. | Deficiency of myostatin protects skeletal muscle cells from ischemia reperfusion injury.
Wallner C, Drysch M, Becerikli M, Schmidt SV, Hahn S, Wagner JM, Reinkemeier F, Dadras M, Sogorski A, von Glinski M, Lehnhardt M, Behr B., Free PMC Article | 10/30/2021 |
| Activation of activin receptor-2B by myostatin modulates the fibrogenic phenotype of human stellate cells, indicating that a myokine may be implicated in the pathogenesis of hepatic fibrosis. | Myostatin regulates the fibrogenic phenotype of hepatic stellate cells via c-jun N-terminal kinase activation.
Delogu W, Caligiuri A, Provenzano A, Rosso C, Bugianesi E, Coratti A, Macias-Barragan J, Galastri S, Di Maira G, Marra F. | 05/2/2020 |
| MicroRNA-194 protects against chronic hepatitis B-related liver damage by promoting hepatocyte growth via ACVR2B. | MicroRNA-194 protects against chronic hepatitis B-related liver damage by promoting hepatocyte growth via ACVR2B.
Gao X, Zhao P, Hu J, Zhu H, Zhang J, Zhou Z, Zhao J, Tang F., Free PMC Article | 11/2/2019 |
| Study supported ACVR2B as the facilitator for clear cell kidney carcinoma (KIRC) development. Its up-regulation controls the growth, viability, and EMT-specific protein expressions of KIRC cells. | LncRNA MALAT1 modified progression of clear cell kidney carcinoma (KIRC) by regulation of miR-194-5p/ACVR2B signaling.
Ye Y, Zhang F, Chen Q, Huang Z, Li M. | 06/22/2019 |
| the A allele of genetic variant rs2276541 in ACVR2B is associated with lean muscle mass | Genetic Variant in ACVR2B Is Associated with Lean Mass.
Klimentidis YC, Bea JW, Thompson P, Klimecki WT, Hu C, Wu G, Nicholas JS, Ryckman KK, Chen Z., Free PMC Article | 09/30/2017 |
| TGF-beta receptor mediated telomerase inhibition, telomere shortening and breast cancer cell senescence.( | TGF-beta receptor mediated telomerase inhibition, telomere shortening and breast cancer cell senescence.
Cassar L, Nicholls C, Pinto AR, Chen R, Wang L, Li H, Liu JP., Free PMC Article | 06/10/2017 |
| ActR-IIB is expressed in male germ cells and Sertoli cells. | NODAL secreted by male germ cells regulates the proliferation and function of human Sertoli cells from obstructive azoospermia and nonobstructive azoospermia patients.
Tian RH, Yang S, Zhu ZJ, Wang JL, Liu Y, Yao C, Ma M, Guo Y, Yuan Q, Hai Y, Huang YR, He Z, Li Z., Free PMC Article | 08/13/2016 |
| Activin A inhibited signaling by BMP-6 and BMP-9 by competing for type 2 receptors ACVR2A and ACVR2B. | Activin A inhibits BMP-signaling by binding ACVR2A and ACVR2B.
Olsen OE, Wader KF, Hella H, Mylin AK, Turesson I, Nesthus I, Waage A, Sundan A, Holien T., Free PMC Article | 03/12/2016 |
| We found that the AAAAA, AGGAG, and AGGGA haplotypes in ACVR2B were associated with susceptibility to Premature Ovarian Failure when they also had at least one CATAG haplotype in ADAMTS19. | Epistasis between polymorphisms in ACVR2B and ADAMTS19 is associated with premature ovarian failure.
Pyun JA, Kim S, Kwack K. | 02/27/2016 |
| miR-21 interacts directly with the 3'-untranslated region of ACVR2B mRNA. Mechanical stretch suppressed ACVR2B protein levels in periodontal ligament stem cells. Gain- and loss of function of ACVR2B mediated the osteogenic differentiation of PDLSCs. | microRNA-21 mediates stretch-induced osteogenic differentiation in human periodontal ligament stem cells.
Wei F, Liu D, Feng C, Zhang F, Yang S, Hu Y, Ding G, Wang S., Free PMC Article | 01/23/2016 |
| Adenomyotic tissues express high levels of myostatin, follistatin, and activin type II receptors. | Myostatin, follistatin and activin type II receptors are highly expressed in adenomyosis.
Carrarelli P, Yen CF, Arcuri F, Funghi L, Tosti C, Wang TH, Huang JS, Petraglia F. | 11/28/2015 |
| Activin type IIB receptors are clearly demonstrable throughout the adult human hypothalamus and basal forebrain. | Expression of inhibin/activin proteins and receptors in the human hypothalamus and basal forebrain.
Miller MC, Lambert-Messerlian GM, Eklund EE, Heath NL, Donahue JE, Stopa EG. | 09/29/2012 |
| After eccentric exercise, postmenopausal women not using hormone therapy (HT) expressed lower levels of ActRIIb while postmenopausal women using HT showed a heightened response. | Hormone therapy and maximal eccentric exercise alters myostatin-related gene expression in postmenopausal women.
Dieli-Conwright CM, Spektor TM, Rice JC, Sattler FR, Schroeder ET. | 09/15/2012 |
| The interaction between all five miRNAs and ACVR2B was verified by an in vitro assay. | miR-192, miR-194, miR-215, miR-200c and miR-141 are downregulated and their common target ACVR2B is strongly expressed in renal childhood neoplasms.
Senanayake U, Das S, Vesely P, Alzoughbi W, Fröhlich LF, Chowdhury P, Leuschner I, Hoefler G, Guertl B. | 08/11/2012 |
| Mutations in Activin A Receptor Type IIB were identified in 4 of the 47 patients (8.5%) with heterotaxy syndrome. Our results expand the mutation spectrum of monogenic heterotaxy syndrome with associated cardiac anomalies. | Mutations in ZIC3 and ACVR2B are a common cause of heterotaxy and associated cardiovascular anomalies.
Ma L, Selamet Tierney ES, Lee T, Lanzano P, Chung WK., Free PMC Article | 06/30/2012 |
| discussion of crystal structure of kinase domain of ActRIIB; structural analysis may be of help in developing selective inhibitors [REVIEW] | Crystal structure of activin receptor type IIB kinase domain.
Han S. | 06/18/2011 |
| Inhibition of negative regulators of skeletal muscle by a soluble form of activin type IIB receptor (ACE-031) increases muscle mass independent of fiber-type expression. | Administration of a soluble activin type IIB receptor promotes skeletal muscle growth independent of fiber type.
Cadena SM, Tomkinson KN, Monnell TE, Spaits MS, Kumar R, Underwood KW, Pearsall RS, Lachey JL., Free PMC Article | 01/15/2011 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (3) articlesA large-scale candidate gene association study of age at menarche and age at natural menopause.
He C, Kraft P, Chasman DI, Buring JE, Chen C, Hankinson SE, Paré G, Chanock S, Ridker PM, Hunter DJ. L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms.
Yokoyama K, Urashima M, Ohkido I, Kono T, Yoshida T, Muramatsu M, Niu T, Hosoya T. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men.
Yerges LM, Klei L, Cauley JA, Roeder K, Kammerer CM, Moffett SP, Ensrud KE, Nestlerode CS, Marshall LM, Hoffman AR, Lewis C, Lang TF, Barrett-Connor E, Ferrell RE, Orwoll ES, Zmuda JM, MrOS Research Group. | 06/24/2009 |
| The high-resolution structure of human ActRIIB kinase domain in complex with adenine establishes the conserved bilobal architecture consistent with all other catalytic kinase domains. | Crystal structure of activin receptor type IIB kinase domain from human at 2.0 Angstrom resolution.
Han S, Loulakis P, Griffor M, Xie Z., Free PMC Article | 01/21/2010 |
| These results indicate that haplotype structure at the ACVR2B and follistatin loci may contribute to interindividual variation in skeletal muscle mass and strength, although these data indicate sex-specific relationships. | Activin-type II receptor B (ACVR2B) and follistatin haplotype associations with muscle mass and strength in humans.
Walsh S, Metter EJ, Ferrucci L, Roth SM., Free PMC Article | 01/21/2010 |
| Data indicate that activin A and activin receptors IIA and IIB may be involved in the regulation of germ cell proliferation in the human ovary during the period leading up to primordial follicle formation. | Expression of activin subunits and receptors in the developing human ovary: activin A promotes germ cell survival and proliferation before primordial follicle formation.
Martins da Silva SJ, Bayne RA, Cambray N, Hartley PS, McNeilly AS, Anderson RA. | 01/21/2010 |
| activin signaling via type II receptors requires a specific sequence for ALK4 binding | An activin mutant with disrupted ALK4 binding blocks signaling via type II receptors.
Harrison CA, Gray PC, Fischer WH, Donaldson C, Choe S, Vale W. | 01/21/2010 |