| PDZ domain-containing protein NHERF-2 is a novel target of HPV-16 and HPV-18 E proteins. | PDZ Domain-Containing Protein NHERF-2 Is a Novel Target of Human Papillomavirus 16 (HPV-16) and HPV-18.
Saidu NEB, Filić V, Thomas M, Sarabia-Vega V, Đukić A, Miljković F, Banks L, Tomaić V., Free PMC Article | 06/13/2020 |
| Studies support a role for NHERF-1 and NHERF-2 (Na+/H+ exchanger regulatory factors 1 and 2) in regulating the distribution of Group II metabotropic glutamate receptor (mGluRs) in the murine brain, while conversely the effects of the mGluR2/3 PDZ-binding motifs on receptor signaling are likely mediated by interactions with other PDZ scaffold proteins beyond the NHERF proteins. | Group II metabotropic glutamate receptor interactions with NHERF scaffold proteins: Implications for receptor localization in brain.
Ritter-Makinson SL, Paquet M, Bogenpohl JW, Rodin RE, Chris Yun C, Weinman EJ, Smith Y, Hall RA., Free PMC Article | 03/17/2018 |
| Moreover, the S303D mutation enhances the in vivo dynamics of the E3KARP tail alone, whereas in vitro the interaction of E3KARP with active ezrin is unaffected by S303D | The function and dynamics of the apical scaffolding protein E3KARP are regulated by cell-cycle phosphorylation.
Sauvanet C, Garbett D, Bretscher A., Free PMC Article | 08/13/2016 |
| Lysophosphatidic acid stimulation of NHE3 exocytosis in polarized epithelial cells occurs with release from NHERF2 via ERK-PLC-PKCdelta signaling. | Lysophosphatidic acid stimulation of NHE3 exocytosis in polarized epithelial cells occurs with release from NHERF2 via ERK-PLC-PKCδ signaling.
Cha B, Chen T, Sarker R, Yang J, Raben D, Tse CM, Kovbasnjuk O, Donowitz M., Free PMC Article | 08/30/2014 |
| Data indicate that the tails promote different microvillar localizations for EBP50 and E3KARP, which localized along the full length and to the base of microvilli, respectively. | The tails of apical scaffolding proteins EBP50 and E3KARP regulate their localization and dynamics.
Garbett D, Sauvanet C, Viswanatha R, Bretscher A., Free PMC Article | 07/5/2014 |
| Crystal structure of NHERF2 PDZ1 domain complex with C-terminal LPA2 sequence. The PDZ1-LPA2 binding specificity is achieved by hydrogen bonds and hydrophobic contacts with the last four LPA2 residues contributing to specific interactions. | Structural insights into PDZ-mediated interaction of NHERF2 and LPA(2), a cellular event implicated in CFTR channel regulation.
Holcomb J, Jiang Y, Lu G, Trescott L, Brunzelle J, Sirinupong N, Li C, Naren AP, Yang Z., Free PMC Article | 06/14/2014 |
| NHERF2 domain was functionally significant in NHE3 regulation, being necessary for stimulation by lysophosphatidic acid of activity and increased mobility of NHE3 | NHERF2 protein mobility rate is determined by a unique C-terminal domain that is also necessary for its regulation of NHE3 protein in OK cells.
Yang J, Singh V, Cha B, Chen TE, Sarker R, Murtazina R, Jin S, Zachos NC, Patterson GH, Tse CM, Kovbasnjuk O, Li X, Donowitz M., Free PMC Article | 08/31/2013 |
| functional regulation of C3aR by NHERFs in human mast cells | Roles for NHERF1 and NHERF2 on the regulation of C3a receptor signaling in human mast cells.
Subramanian H, Gupta K, Ali H., Free PMC Article | 06/22/2013 |
| AnxA2 and NHERF2 form a scaffold complex that links adjacent Tir molecules at the plasma membrane forming a lattice that could be involved in retention and dissemination of other effectors at the bacterial attachment site. | Recruitment and membrane interactions of host cell proteins during attachment of enteropathogenic and enterohaemorrhagic Escherichia coli.
Munera D, Martinez E, Varyukhina S, Mahajan A, Ayala-Sanmartin J, Frankel G., Free PMC Article | 09/29/2012 |
| NHERF-2 is a negative regulator of endothelial proliferation and may have important roles in endothelial homeostasis and vascular modeling. | NHERF-2 maintains endothelial homeostasis.
Bhattacharya R, Wang E, Dutta SK, Vohra PK, E G, Prakash YS, Mukhopadhyay D., Free PMC Article | 07/21/2012 |
| CaMKII inhibition of NHE3 reguires NHEF2. | Calmodulin kinase II constitutively binds, phosphorylates, and inhibits brush border Na+/H+ exchanger 3 (NHE3) by a NHERF2 protein-dependent process.
Zizak M, Chen T, Bartonicek D, Sarker R, Zachos NC, Cha B, Kovbasnjuk O, Korac J, Mohan S, Cole R, Chen Y, Tse CM, Donowitz M., Free PMC Article | 06/23/2012 |
| Data show that both NHERF2 and NHERF1 are involved in setting NHE3 activity. | NHERF1 and NHERF2 are necessary for multiple but usually separate aspects of basal and acute regulation of NHE3 activity.
Sarker R, Valkhoff VE, Zachos NC, Lin R, Cha B, Chen TE, Guggino S, Zizak M, de Jonge H, Hogema B, Donowitz M., Free PMC Article | 05/21/2011 |
| MAGI-3 competes with NHERF-2 to negatively regulate LPA2 receptor signaling in colon cancer cells. | MAGI-3 competes with NHERF-2 to negatively regulate LPA2 receptor signaling in colon cancer cells.
Lee SJ, Ritter SL, Zhang H, Shim H, Hall RA, Yun CC., Free PMC Article | 05/14/2011 |
| The results of this study revealed that NHERF-2 can interact with GLAST in astrocytes to enhance GLAST stability and activity. | GLAST stability and activity are enhanced by interaction with the PDZ scaffold NHERF-2.
Ritter SL, Asay MJ, Paquet M, Paavola KJ, Reiff RE, Yun CC, Hall RA., Free PMC Article | 03/12/2011 |
| WNK4 and NHERF2 synergistically regulate TRPV5 by enhancing its forward trafficking and increasing its stability at plasma membrane, respectively. | Concerted actions of NHERF2 and WNK4 in regulating TRPV5.
Jing H, Na T, Zhang W, Wu G, Liu C, Peng JB., Free PMC Article | 03/12/2011 |
| The authors generated a HeLa cell line stably expressing HA-tagged NHERF2 and found that Map, EspI and NleH1 colocalize and interact with intracellular NHERF2 via their C-terminal PDZ-binding motif. | Binding to Na(+) /H(+) exchanger regulatory factor 2 (NHERF2) affects trafficking and function of the enteropathogenic Escherichia coli type III secretion system effectors Map, EspI and NleH.
Martinez E, Schroeder GN, Berger CN, Lee SF, Robinson KS, Badea L, Simpson N, Hall RA, Hartland EL, Crepin VF, Frankel G., Free PMC Article | 02/26/2011 |
| Apical scaffolding protein NHERF2 modulates the localization of alternatively spliced plasma membrane Ca2+ pump 2B variants in polarized epithelial cells. | Apical scaffolding protein NHERF2 modulates the localization of alternatively spliced plasma membrane Ca2+ pump 2B variants in polarized epithelial cells.
Padányi R, Xiong Y, Antalffy G, Lór K, Pászty K, Strehler EE, Enyedi A., Free PMC Article | 11/6/2010 |
| NHERF1 and NHERF2 exhibit isotype-specific effects on G protein activation. | Na/H exchanger regulatory factors control parathyroid hormone receptor signaling by facilitating differential activation of G(alpha) protein subunits.
Wang B, Ardura JA, Romero G, Yang Y, Hall RA, Friedman PA., Free PMC Article | 09/20/2010 |
| While the presence of forskolin results in an increase in OCTN2 protein expression, the increase in uptake capacity may be compensated by the decreased expression of PDZK1, NHERF1 or NHERF2. | Regulation of protein expression and function of octn2 in forskolin-induced syncytialization in BeWo Cells.
Huang FD, Kung FL, Tseng YC, Chen MR, Chan HS, Lin CJ. | 01/21/2010 |
| NHERF2 and SGK1 interact to enhance ROMK1 activity by enhancing abundance of channel protein in cell membrane, allowing integration of genomic regulation and activation of SGK1 and NHERF2 in control of ROMK1 activity and renal K(+) excretion. | The serum and glucocorticoid-inducible kinase SGK1 and the Na+/H+ exchange regulating factor NHERF2 synergize to stimulate the renal outer medullary K+ channel ROMK1.
Yun CC, Palmada M, Embark HM, Fedorenko O, Feng Y, Henke G, Setiawan I, Boehmer C, Weinman EJ, Sandrasagra S, Korbmacher C, Cohen P, Pearce D, Lang F. | 01/21/2010 |
| Na(+)/H(+ ) exchanger regulatory factor 2 directs parathyroid hormone 1 receptor signalling. | Na(+)/H(+ ) exchanger regulatory factor 2 directs parathyroid hormone 1 receptor signalling.
Mahon MJ, Donowitz M, Yun CC, Segre GV. | 01/21/2010 |
| A2BR binds to E3KARP upon agonist stimulation. | The adenosine 2b receptor is recruited to the plasma membrane and associates with E3KARP and Ezrin upon agonist stimulation.
Sitaraman SV, Wang L, Wong M, Bruewer M, Hobert M, Yun CH, Merlin D, Madara JL. | 01/21/2010 |
| analysis of NHERF recognition by ERM proteins | Structural basis for NHERF recognition by ERM proteins.
Terawaki S, Maesaki R, Hakoshima T. | 01/21/2010 |
| When the second PDZ domain of E3KARP is bound to down regulated in adenoma (dra) gene product, a structural link is built between the functionally coupled Na+/H+ and Cl-/HCO3- exchangers in the proximal colon. | The down regulated in adenoma (dra) gene product binds to the second PDZ domain of the NHE3 kinase A regulatory protein (E3KARP), potentially linking intestinal Cl-/HCO3- exchange to Na+/H+ exchange.
Lamprecht G, Heil A, Baisch S, Lin-Wu E, Yun CC, Kalbacher H, Gregor M, Seidler U. | 01/21/2010 |
| demonstration of the significance of SGK1 and NHERF2 as TRPV5 modulators which are likely to participate in the regulation of calcium homeostasis by 1,25(OH)2D3 | Requirement of PDZ domains for the stimulation of the epithelial Ca2+ channel TRPV5 by the NHE regulating factor NHERF2 and the serum and glucocorticoid inducible kinase SGK1.
Palmada M, Poppendieck S, Embark HM, van de Graaf SF, Boehmer C, Bindels RJ, Lang F. | 01/21/2010 |