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    ATP5IF1 ATP synthase inhibitory factor subunit 1 [ Homo sapiens (human) ]

    Gene ID: 93974, updated on 17-Jun-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    The inhibitor protein IF1 from mammalian mitochondria inhibits ATP hydrolysis but not ATP synthesis by the ATP synthase complex.

    The inhibitor protein IF(1) from mammalian mitochondria inhibits ATP hydrolysis but not ATP synthesis by the ATP synthase complex.
    Carroll J, Watt IN, Wright CJ, Ding S, Fearnley IM, Walker JE., Free PMC Article

    04/5/2024
    Longitudinal Associations Between ATPase Inhibitory Factor 1, Growth Differentiation Factor-15, and Nutritional Status in Older Adults From the MAPT Study.

    Longitudinal Associations Between ATPase Inhibitory Factor 1, Growth Differentiation Factor-15, and Nutritional Status in Older Adults From the MAPT Study.
    Lengelé L, Rolland Y, Martinez LO, Guyonnet S, Parini A, Lucas A, Vellas B, Barreto PS, MAPT/DSA Group.

    01/6/2024
    The pro-oncogenic protein IF1 does not contribute to the Warburg effect and is not regulated by PKA in cancer cells.

    The pro-oncogenic protein IF(1) does not contribute to the Warburg effect and is not regulated by PKA in cancer cells.
    Sgarbi G, Righetti R, Del Dotto V, Grillini S, Giorgio V, Baracca A, Solaini G.

    11/16/2023
    IF1 ablation prevents ATP synthase oligomerization, enhances mitochondrial ATP turnover and promotes an adenosine-mediated pro-inflammatory phenotype.

    IF1 ablation prevents ATP synthase oligomerization, enhances mitochondrial ATP turnover and promotes an adenosine-mediated pro-inflammatory phenotype.
    Domínguez-Zorita S, Romero-Carramiñana I, Santacatterina F, Esparza-Moltó PB, Simó C, Del-Arco A, Núñez de Arenas C, Saiz J, Barbas C, Cuezva JM., Free PMC Article

    07/13/2023
    ATPase Inhibitory Factor 1-A Novel Marker of Cellular Fitness and Exercise Capacity?

    ATPase Inhibitory Factor 1-A Novel Marker of Cellular Fitness and Exercise Capacity?
    Domin R, Pytka M, Niziński J, Żołyński M, Zybek-Kocik A, Wrotkowska E, Zieliński J, Guzik P, Ruchała M., Free PMC Article

    01/7/2023
    Circulating Inhibitory Factor 1 levels in adult patients with Prader-Willi syndrome.

    Circulating Inhibitory Factor 1 levels in adult patients with Prader-Willi syndrome.
    Delvecchio M, Grugni G, Mai S, Favoino E, Ingletto A, Gnoni A.

    02/5/2022
    The F1Fo-ATPase inhibitor, IF1, is a critical regulator of energy metabolism in cancer cells.

    The F1Fo-ATPase inhibitor, IF1, is a critical regulator of energy metabolism in cancer cells.
    Solaini G, Sgarbi G, Baracca A.

    01/29/2022
    ATPase Inhibitory Factor-1 Disrupts Mitochondrial Ca(2+) Handling and Promotes Pathological Cardiac Hypertrophy through CaMKIIdelta.

    ATPase Inhibitory Factor-1 Disrupts Mitochondrial Ca(2+) Handling and Promotes Pathological Cardiac Hypertrophy through CaMKIIδ.
    Pavez-Giani MG, Sánchez-Aguilera PI, Bomer N, Miyamoto S, Booij HG, Giraldo P, Oberdorf-Maass SU, Nijholt KT, Yurista SR, Milting H, van der Meer P, Boer RA, Heller Brown J, Sillje HWH, Westenbrink BD., Free PMC Article

    05/29/2021
    Inhibition of the mitochondrial ATPase function by IF1 changes the spatiotemporal organization of ATP synthase.

    Inhibition of the mitochondrial ATPase function by IF1 changes the spatiotemporal organization of ATP synthase.
    Weissert V, Rieger B, Morris S, Arroum T, Psathaki OE, Zobel T, Perkins G, Busch KB., Free PMC Article

    04/17/2021
    Atpif1 gene is involved in the regulation of hemoglobin synthesis

    [Effects of Atpif1 gene on hemoglobin synthesis in K562 cells].
    Luo Q, Li N, Liu WL, Zhang Y, Chen ZL.

    01/18/2020
    findings enlighten the cellular biology of IF1 and pave the way to development of additional models that address its role in pathophysiology

    Tissue-specific expression and post-transcriptional regulation of the ATPase inhibitory factor 1 (IF1) in human and mouse tissues.
    Esparza-Moltó PB, Nuevo-Tapioles C, Chamorro M, Nájera L, Torresano L, Santacatterina F, Cuezva JM.

    10/5/2019
    Common p2y13 polymorphisms are associated with plasma inhibitory factor 1 and lipoprotein(a) concentrations, heart rate and body fat mass and may modulate cardiovascular risk.

    Common p2y(13) polymorphisms are associated with plasma inhibitory factor 1 and lipoprotein(a) concentrations, heart rate and body fat mass: The GENES study.
    Verdier C, Ruidavets JB, Genoux A, Combes G, Bongard V, Taraszkiewicz D, Galinier M, Elbaz M, Ferrières J, Martinez LO, Perret B.

    04/27/2019
    Results presently demonstrate, both in vitro and in vivo, that polycyclic aromatic hydrocarbons, especially B[a]P, strongly increase IF1 expression. Such an increase, which might rely on beta2-adrenergic receptor activation, notably participates to the B[a]P-induced glycolytic shift and cell survival in liver cells.

    Role for the ATPase inhibitory factor 1 in the environmental carcinogen-induced Warburg phenotype.
    Hardonnière K, Fernier M, Gallais I, Mograbi B, Podechard N, Le Ferrec E, Grova N, Appenzeller B, Burel A, Chevanne M, Sergent O, Huc L, Bortoli S, Lagadic-Gossmann D., Free PMC Article

    09/8/2018
    results suggest that IF1 overexpression promotes cancer cells survival under temporary anoxic conditions by preserving cellular ATP despite mitochondria dysfunction.

    The role of the ATPase inhibitor factor 1 (IF(1)) in cancer cells adaptation to hypoxia and anoxia.
    Sgarbi G, Barbato S, Costanzini A, Solaini G, Baracca A.

    06/16/2018
    IF1 suppresses programmed cell death.

    Control of Mitochondrial Remodeling by the ATPase Inhibitory Factor 1 Unveils a Pro-survival Relay via OPA1.
    Faccenda D, Nakamura J, Gorini G, Dhoot GK, Piacentini M, Yoshida M, Campanella M.

    12/2/2017
    reverse phase protein microarrays identified the glycolysis promoting PKM2 and IF1 proteins as specific biomarkers of dermatomyositis.

    Pyruvate kinase M2 and the mitochondrial ATPase Inhibitory Factor 1 provide novel biomarkers of dermatomyositis: a metabolic link to oncogenesis.
    Santacatterina F, Sánchez-Aragó M, Catalán-García M, Garrabou G, de Arenas CN, Grau JM, Cardellach F, Cuezva JM., Free PMC Article

    11/4/2017
    CF6-induced increase in apoptotic cells was blocked by immature or mature IF1, being accompanied by protein kinase B (PKB) phosphorylation. IF1 antagonizes the pro-apoptotic action of CF6 by relief of intracellular acidification and resultant phosphorylation of PKB.

    Mitochondrial Inhibitory Factor Protein 1 Functions as an Endogenous Inhibitor for Coupling Factor 6.
    Kawai M, Osanai T, Tanaka M, Magota K, Tomita H, Okumura K.

    09/16/2017
    The potential role of mitochondrial ATPIF1 in coronary heart disease was reviewed.

    The potential role of mitochondrial ATP synthase inhibitory factor 1 (IF1) in coronary heart disease: a literature review.
    Maierean S, Serban MC, Rizzo M, Lippi G, Sahebkar A, Banach M., Free PMC Article

    06/10/2017
    this study shows that abnormal expression of ATPase inhibitor, mitochondrial isoform 1 precursor(IF1) may relate to the hyperfunction of immune responses and excessive apoptosis of severe aplastic anemia CD34(+) cells

    Comparative proteomic analysis of CD34(+) cells in bone marrow between severe aplastic anemia and normal control.
    Qi W, Fu R, Wang H, Liu C, Ren Y, Shao Y, Shao Z.

    02/18/2017
    These data suggest that in mammalian neurons mitochondria adapt to respiratory stress by upregulating IF1, which exerts a protective role by coordinating pro-survival cell mitophagy and bioenergetics resilience

    Neuroprotective coordination of cell mitophagy by the ATPase Inhibitory Factor 1.
    Matic I, Cocco S, Ferraina C, Martin-Jimenez R, Florenzano F, Crosby J, Lupi R, Amadoro G, Russell C, Pignataro G, Annunziato L, Abramov AY, Campanella M.

    12/17/2016
    Data indicate that oxidative phosphorylation (OXPHOS) is inhibited in the liver of mice expressing human ATPase inhibitory factor 1 (hIF1).

    Down-regulation of oxidative phosphorylation in the liver by expression of the ATPase inhibitory factor 1 induces a tumor-promoter metabolic state.
    Santacatterina F, Sánchez-Cenizo L, Formentini L, Mobasher MA, Casas E, Rueda CB, Martínez-Reyes I, Núñez de Arenas C, García-Bermúdez J, Zapata JM, Sánchez-Aragó M, Satrústegui J, Valverde ÁM, Cuezva JM., Free PMC Article

    11/5/2016
    Upon IF1 interaction with the ATP synthase both the synthetic and hydrolytic activities of the engine of oxidative phosphorylation are inhibited. (Review)

    The ATPase Inhibitory Factor 1 (IF1): A master regulator of energy metabolism and of cell survival.
    García-Bermúdez J, Cuezva JM.

    08/20/2016
    PKA phosphorylates the ATPase inhibitory factor 1 and inactivates its capacity to bind and inhibit the mitochondrial H(+)-ATP synthase.

    PKA Phosphorylates the ATPase Inhibitory Factor 1 and Inactivates Its Capacity to Bind and Inhibit the Mitochondrial H(+)-ATP Synthase.
    García-Bermúdez J, Sánchez-Aragó M, Soldevilla B, Del Arco A, Nuevo-Tapioles C, Cuezva JM.

    07/16/2016
    IF1 was overexpressed in bladder cancer; concluded that IF1 may be a novel therapeutic target for bladder cancer

    Silencing of ATPase Inhibitory Factor 1 Inhibits Cell Growth via Cell Cycle Arrest in Bladder Cancer.
    Wei S, Fukuhara H, Kawada C, Kurabayashi A, Furihata M, Ogura S, Inoue K, Shuin T.

    07/16/2016
    interaction of IF1 with the complex either directly, by increasing the catalytic activity of the enzyme, or indirectly, by improving the structure of mitochondrial cristae, can increase the oxidative phosphorylation rate in osteosarcoma cells

    The inhibitor protein (IF1) of the F1F0-ATPase modulates human osteosarcoma cell bioenergetics.
    Barbato S, Sgarbi G, Gorini G, Baracca A, Solaini G., Free PMC Article

    05/23/2015
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