| FtMt reduces oxidative stress-induced trophoblast cell dysfunction via the HIF-1alpha/VEGF signaling pathway. | FtMt reduces oxidative stress-induced trophoblast cell dysfunction via the HIF-1α/VEGF signaling pathway.
Xu X, Ye X, Zhu M, Zhang Q, Li X, Yan J., Free PMC Article | 03/7/2023 |
| LC3/FtMt Colocalization Patterns Reveal the Progression of FtMt Accumulation in Nigral Neurons of Patients with Progressive Supranuclear Palsy. | LC3/FtMt Colocalization Patterns Reveal the Progression of FtMt Accumulation in Nigral Neurons of Patients with Progressive Supranuclear Palsy.
Abu Bakar ZH, Bellier JP, Yanagisawa D, Kato T, Mukaisho KI, Tooyama I., Free PMC Article | 02/12/2022 |
| Mitochondrial Ferritin Deficiency Promotes Osteoblastic Ferroptosis Via Mitophagy in Type 2 Diabetic Osteoporosis. | Mitochondrial Ferritin Deficiency Promotes Osteoblastic Ferroptosis Via Mitophagy in Type 2 Diabetic Osteoporosis.
Wang X, Ma H, Sun J, Zheng T, Zhao P, Li H, Yang M. | 11/27/2021 |
| FtMt promotes glioma tumorigenesis and angiogenesis via lncRNA SNHG1/miR-9-5p axis. | FtMt promotes glioma tumorigenesis and angiogenesis via lncRNA SNHG1/miR-9-5p axis.
Mi S, Du J, Liu J, Hou K, Ji H, Ma S, Ba Y, Chen L, Xie R, Hu S. | 10/23/2021 |
| Effects of FTMT Expression by Retinal Pigment Epithelial Cells on Features of Angiogenesis. | Effects of FTMT Expression by Retinal Pigment Epithelial Cells on Features of Angiogenesis.
Buyandelger U, Walker DG, Yanagisawa D, Morimura T, Tooyama I., Free PMC Article | 02/20/2021 |
| These results suggest that the elevation of expression levels of FTMT in the reticulocytes of patients with alpha-thalassaemia may be associated with iron loading and oxidative stress. | Mitochondrial ferritin expression in erythroid cells from patients with alpha-thalassaemia.
Putburee R, Jetsrisuparb A, Fucharoen S, Tripatara A. | 11/3/2018 |
| Via activation of cAMP/PKA/CREB pathway and upregulation of the downstream FtMt expression. | Roflumilast enhances cisplatin-sensitivity and reverses cisplatin-resistance of ovarian cancer cells via cAMP/PKA/CREB-FtMt signalling axis.
Gong S, Chen Y, Meng F, Zhang Y, Li C, Zhang G, Huan W, Wu F., Free PMC Article | 10/6/2018 |
| The expression of FTMT appears regulated by a complex mechanism involving epigenetic events and interplay between transcription factors. | Characterization of human mitochondrial ferritin promoter: identification of transcription factors and evidences of epigenetic control.
Guaraldo M, Santambrogio P, Rovelli E, Di Savino A, Saglio G, Cittaro D, Roetto A, Levi S., Free PMC Article | 06/9/2018 |
| Age-related increase is found in FtMt and hypoxia-inducible factor-1a (HIF-1a) in murine retinal pigment epithelium (RPE).HIF-1alpha stabilization reduced the protein level of the mature, functional form of mitochondrial ferritin. | Mitochondrial ferritin affects mitochondria by stabilizing HIF-1α in retinal pigment epithelium: implications for the pathophysiology of age-related macular degeneration.
Wang X, Yang H, Yanagisawa D, Bellier JP, Morino K, Zhao S, Liu P, Vigers P, Tooyama I. | 10/21/2017 |
| Study characterized a new human FtMt antibody, and with it created the first map of FtMt immunoreactivity in a monkey brainstem. This showed the widespread distribution of FtMt in various brainstem regions and co-localization with catecholaminergic neurons. | Mapping of mitochondrial ferritin in the brainstem of Macaca fascicularis.
Yang M, Yang H, Guan H, Bellier JP, Zhao S, Tooyama I. | 07/22/2017 |
| experimental overexpression of FTMT may modify mitochondrial iron availability and lead to ineffective erythropoiesis | Effects of mitochondrial ferritin overexpression in normal and sideroblastic erythroid progenitors.
Invernizzi R, Travaglino E, Della Porta MG, Gallì A, Malcovati L, Rosti V, Bergamaschi G, Erba BG, Bellistri F, Bastia R, Santambrogio P, Levi S, Cazzola M. | 07/13/2013 |
| FtMt mutation may determine a condition similar to haploinsufficiency resulting in a reduced protection from iron-dependent oxidative stress in mitochondria | Study of FTMT and ABCA4 genes in a patient affected by age-related macular degeneration: identification and analysis of new mutations.
Stenirri S, Santambrogio P, Setaccioli M, Erba BG, Pia Manitto M, Rovida E, Ferrari M, Levi S, Cremonesi L. | 10/20/2012 |
| Stat5-dependent transcriptional regulation is displaced by strong cytosolic iron starvation status induced by mitochondrial ferritin. | Over-expression of mitochondrial ferritin affects the JAK2/STAT5 pathway in K562 cells and causes mitochondrial iron accumulation.
Santambrogio P, Erba BG, Campanella A, Cozzi A, Causarano V, Cremonesi L, Gallì A, Della Porta MG, Invernizzi R, Levi S., Free PMC Article | 02/11/2012 |
| higher protein levels in prostate cancer cells expressing a dominant negative mutant of p66Shc | P66Shc mediated ferritin degradation--a novel mechanism of ROS formation.
Borkowska A, Sielicka-Dudzin A, Herman-Antosiewicz A, Halon M, Wozniak M, Antosiewicz J. | 12/10/2011 |
| MtF is involved in the pathology of Alzheimer's disease and may play a neuroprotective role against oxidative stress | Expression and localization of mitochondrial ferritin mRNA in Alzheimer's disease cerebral cortex.
Wang L, Yang H, Zhao S, Sato H, Konishi Y, Beach TG, Abdelalim EM, Bisem NJ, Tooyama I., Free PMC Article | 12/10/2011 |
| MtF expression is downregulated during ATRA-induced K562 cell differentiation, with concomitant downregulation of TfR1 and upregulation of Fn. | [Expression of mitochondrial ferritin in K562 leukemic cell during ATRA-induced cell differentiation].
Sun L, Liao G, Gao J, Chen TT, Pan LL, Yuan LX. | 05/28/2011 |
| The analysis suggests that sequence variations in the coding region of FtMt are not involved in the development of myelodysplastic syndromes and Parkinson's disease. | Sequence variations in mitochondrial ferritin: distribution in healthy controls and different types of patients.
Castiglioni E, Finazzi D, Goldwurm S, Levi S, Pezzoli G, Garavaglia B, Nardocci N, Malcovati L, Porta MG, Gallì A, Forni GL, Girelli D, Maccarinelli F, Poli M, Ferrari M, Cremonesi L, Arosio P, Castiglioni E, Finazzi D, Goldwurm S, Levi S, Pezzoli G, Garavaglia B, Nardocci N, Malcovati L, Porta MG, Gallì A, Forni GL, Girelli D, Maccarinelli F, Poli M, Ferrari M, Cremonesi L, Arosio P. | 03/19/2011 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (2) articlesSequence variations in mitochondrial ferritin: distribution in healthy controls and different types of patients.
Castiglioni E, Finazzi D, Goldwurm S, Levi S, Pezzoli G, Garavaglia B, Nardocci N, Malcovati L, Porta MG, Gallì A, Forni GL, Girelli D, Maccarinelli F, Poli M, Ferrari M, Cremonesi L, Arosio P, Castiglioni E, Finazzi D, Goldwurm S, Levi S, Pezzoli G, Garavaglia B, Nardocci N, Malcovati L, Porta MG, Gallì A, Forni GL, Girelli D, Maccarinelli F, Poli M, Ferrari M, Cremonesi L, Arosio P. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ. | 12/5/2010 |
| Primary spontaneous pneumothorax in smokers is associated with lung macrophage oxidative stress. The response to this condition involves HIF-1alpha-mediated induction of HO-1, BVR and H-ferritin. | Induction of heme oxygenase-1, biliverdin reductase and H-ferritin in lung macrophage in smokers with primary spontaneous pneumothorax: role of HIF-1alpha.
Goven D, Boutten A, Leçon-Malas V, Marchal-Sommé J, Soler P, Boczkowski J, Bonay M., Free PMC Article | 09/13/2010 |
| Data present density functional theory optimizations of structures of dizinc(II) complexes with a model of the ferroxidase center of human H ferritin, and the results compared with the crystallographically determined structure of the complex. | Computational modeling of the dizinc-ferroxidase complex of human H ferritin: direct comparison of the density functional theory calculated and experimental structures.
Binning RC Jr, Bacelo DE. | 01/21/2010 |
| Increased numbers of mitochondria in neurons in restless legs syndrome (RLS) and increased mitochondrial ferritin might contribute to insufficient cytosolic iron levels in RLS substantia nigra neurons. | Mitochondrial ferritin in the substantia nigra in restless legs syndrome.
Snyder AM, Wang X, Patton SM, Arosio P, Levi S, Earley CJ, Allen RP, Connor JR., Free PMC Article | 01/21/2010 |
| FtMt expression in fibroblasts from Friedreich ataxia patients prevented the formation of reactive oxygen species and partially rescued the impaired activity of mitochondrial Fe-S enzymes. | Mitochondrial ferritin limits oxidative damage regulating mitochondrial iron availability: hypothesis for a protective role in Friedreich ataxia.
Campanella A, Rovelli E, Santambrogio P, Cozzi A, Taroni F, Levi S., Free PMC Article | 01/21/2010 |
| ferritin pore gating influences to the amount of iron (59Fe) in ferritin in vivo | Ferritin contains less iron (59Fe) in cells when the protein pores are unfolded by mutation.
Hasan MR, Tosha T, Theil EC., Free PMC Article | 01/21/2010 |
| p53 overexpression strongly downregulates the transcriptional efficiency driven by an H ferritin promoter construct containing only the NF-Y recognition sequence. | p53-mediated downregulation of H ferritin promoter transcriptional efficiency via NF-Y.
Faniello MC, Di Sanzo M, Quaresima B, Baudi F, Di Caro V, Cuda G, Morrone G, Del Sal G, Spinelli G, Venuta S, Costanzo F. | 01/21/2010 |
| ferritin H transcription is activated by rotenone via an oxidative stress-mediated pathway leading to antioxidant-responsive element activation | Role and regulation of ferritin H in rotenone-mediated mitochondrial oxidative stress.
MacKenzie EL, Ray PD, Tsuji Y., Free PMC Article | 01/21/2010 |