| Paxillin family proteins Hic-5 and LPXN promote lipid storage by regulating the ubiquitination degradation of CIDEC. | Paxillin family proteins Hic-5 and LPXN promote lipid storage by regulating the ubiquitination degradation of CIDEC.
Fang M, Liu X, Xu W, Wang X, Xu L, Zhao TJ, Li P, Yang H., Free PMC Article | 02/27/2024 |
| LPXN may facilitate bladder cancer progression by upregulating the expression of S100P via PI3K/AKT pathway. These results provide a novel insight into the role of LPXN in tumorigenesis and progression of bladder cancer and potential therapeutic target of bladder cancer. | Leupaxin Promotes Bladder Cancer Proliferation, Metastasis, and Angiogenesis Through the PI3K/AKT Pathway.
Hou T, Zhou L, Wang L, Kazobinka G, Chen Y, Zhang X, Chen Z. | 08/18/2018 |
| this is the first demonstration of a role for the leupaxin in the regulation of hepatocellular carcinoma progression, at least in part, by enhancing beta-catenin transcription activity. | Regulation of β-catenin transcription activity by leupaxin in hepatocellular carcinoma.
Shi J, Wu WJ, Hu G, Yu X, Yu GS, Lu H, Yang ML, Liu B, Wu ZX. | 02/4/2017 |
| The full-length leupaxin binds to the Pyk2-focal adhesion targeting domain. | Structural Basis for the Interaction between Pyk2-FAT Domain and Leupaxin LD Repeats.
Vanarotti MS, Finkelstein DB, Guibao CD, Nourse A, Miller DJ, Zheng JJ., Free PMC Article | 07/30/2016 |
| Authors demonstrate that LPXN directly influences cytoskeletal dynamics via interaction with the actin-binding protein CaD and regulates CaD phosphorylation by recruiting ERK to highly dynamic structures within PCa cells. | Leupaxin stimulates adhesion and migration of prostate cancer cells through modulation of the phosphorylation status of the actin-binding protein caldesmon.
Dierks S, von Hardenberg S, Schmidt T, Bremmer F, Burfeind P, Kaulfuß S., Free PMC Article | 04/23/2016 |
| Results show that leupaxin has particular influence on the progression and invasion of breast cancer cells and may therefore represent an interesting candidate protein for diagnosis and therapeutic interventions. | Leupaxin is expressed in mammary carcinoma and acts as a transcriptional activator of the estrogen receptor α.
Kaulfuss S, Herr AM, Büchner A, Hemmerlein B, Günthert AR, Burfeind P., Free PMC Article | 03/26/2016 |
| first evidence of dynamic regulation of leupaxin localization and tyrosine phosphorylation by G-Protein Coupled Receptors | Leupaxin is similar to paxillin in focal adhesion targeting and tyrosine phosphorylation but has distinct roles in cell adhesion and spreading.
Chen PW, Kroog GS., Free PMC Article | 06/25/2011 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators., Free PMC Article | 09/15/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium., Free PMC Article | 09/15/2010 |
| leupaxin functions as a paxillin counterpart that potently suppresses the tyrosine phosphorylation of paxillin during integrin signaling. | LIM domain-containing adaptor, leupaxin, localizes in focal adhesion and suppresses the integrin-induced tyrosine phosphorylation of paxillin.
Tanaka T, Moriwaki K, Murata S, Miyasaka M., Free PMC Article | 03/22/2010 |
| LPXN, a member of the paxillin superfamily, is fused to RUNX1 in an acute myeloid leukemia patient with a t(11;21)(q12;q22) translocation. | LPXN, a member of the paxillin superfamily, is fused to RUNX1 in an acute myeloid leukemia patient with a t(11;21)(q12;q22) translocation.
Dai HP, Xue YQ, Zhou JW, Li AP, Wu YF, Pan JL, Wang Y, Zhang J. | 01/21/2010 |
| leupaxin could serve as a potential progression marker for a subset of PCa and may represent a novel coactivator of the androgen receptor | Leupaxin, a novel coactivator of the androgen receptor, is expressed in prostate cancer and plays a role in adhesion and invasion of prostate carcinoma cells.
Kaulfuss S, Grzmil M, Hemmerlein B, Thelen P, Schweyer S, Neesen J, Bubendorf L, Glass AG, Jarry H, Auber B, Burfeind P., Free PMC Article | 01/21/2010 |
| Leupaxin is enriched in vascular smooth nuscle. It undergoes cytoplasmic/nuclear shuttling & functions as an serum response factor cofactor. It associates with CArG-containing regions. Its ectopic expression induces smooth muscle marker gene expression. | The LIM protein leupaxin is enriched in smooth muscle and functions as an serum response factor cofactor to induce smooth muscle cell gene transcription.
Sundberg-Smith LJ, DiMichele LA, Sayers RL, Mack CP, Taylor JM., Free PMC Article | 01/21/2010 |
| Leupaxin plays an inhibitory role in BCR signaling and B cell function. | Leupaxin negatively regulates B cell receptor signaling.
Chew V, Lam KP. | 01/21/2010 |
| leupaxin may be a critical nucleating component of the osteoclast podosomal signaling complex | Leupaxin is a critical adaptor protein in the adhesion zone of the osteoclast.
Gupta A, Lee BS, Khadeer MA, Tang Z, Chellaiah M, Abu-Amer Y, Goldknopf J, Hruska KA. | 01/21/2010 |
| These data demonstrate that LPXN forms a signaling complex with Pyk2, c-Src, and PTP-PEST to regulate migration of prostate cancer cells. | Interaction of Pyk2 and PTP-PEST with leupaxin in prostate cancer cells.
Sahu SN, Nunez S, Bai G, Gupta A. | 01/21/2010 |
| Leupaxin binding to tyrosine phosphatase PEP suggests that leupaxin may function as a signal-transducing complex with PEP. | Leupaxin binds to PEST domain tyrosine phosphatase PEP.
Watanabe N, Amano N, Ishizuka H, Mashima K. | 01/21/2010 |