| Hippocampal Excitatory Synaptic Transmission and Plasticity Are Differentially Altered during Postnatal Development by Loss of the X-Linked Intellectual Disability Protein Oligophrenin-1. | Hippocampal Excitatory Synaptic Transmission and Plasticity Are Differentially Altered during Postnatal Development by Loss of the X-Linked Intellectual Disability Protein Oligophrenin-1.
Cresto N, Lebrun N, Dumont F, Letourneur F, Billuart P, Rouach N., Free PMC Article | 05/28/2022 |
| Androgen deprivationinduced OPHN1 amplification promotes castrationresistant prostate cancer. | Androgen deprivation‑induced OPHN1 amplification promotes castration‑resistant prostate cancer.
Liu J, Zhang Y, Li S, Sun F, Wang G, Wei D, Yang T, Gu S., Free PMC Article | 01/15/2022 |
| Oligophrenin-1 moderates behavioral responses to stress by regulating parvalbumin interneuron activity in the medial prefrontal cortex. | Oligophrenin-1 moderates behavioral responses to stress by regulating parvalbumin interneuron activity in the medial prefrontal cortex.
Wang M, Gallo NB, Tai Y, Li B, Van Aelst L., Free PMC Article | 06/26/2021 |
| Altered Cl(-) homeostasis hinders forebrain GABAergic interneuron migration in a mouse model of intellectual disability. | Altered Cl(-) homeostasis hinders forebrain GABAergic interneuron migration in a mouse model of intellectual disability.
Maset A, Galla L, Francia S, Cozzolino O, Capasso P, Goisis RC, Losi G, Lombardo A, Ratto GM, Lodovichi C., Free PMC Article | 05/22/2021 |
| Ophn1 deficiency generates severe impairments in performance at spatial working memory tests. | Protein Kinase A Deregulation in the Medial Prefrontal Cortex Impairs Working Memory in Murine Oligophrenin-1 Deficiency.
Zhang CL, Aime M, Laheranne E, Houbaert X, El Oussini H, Martin C, Lepleux M, Normand E, Chelly J, Herzog E, Billuart P, Humeau Y., Free PMC Article | 12/2/2017 |
| Here, we report that chronic treatment in adult mouse with Fasudil, is able to counteract vertical and horizontal hyperactivities, restores recognition memory and limits the brain ventricular dilatation observed in Ophn1(-)(/y) However, deficits in working and spatial memories are partially or not rescued by the treatment | Fasudil treatment in adult reverses behavioural changes and brain ventricular enlargement in Oligophrenin-1 mouse model of intellectual disability.
Meziane H, Khelfaoui M, Morello N, Hiba B, Calcagno E, Reibel-Foisset S, Selloum M, Chelly J, Humeau Y, Riet F, Zanni G, Herault Y, Bienvenu T, Giustetto M, Billuart P. | 09/30/2017 |
| Furthermore, we found that olfactory behaviour was perturbed in OPHN1 ko mice. Chronic treatment with a Rho kinase inhibitor rescued most of the defects of the newly generated neurons. Altogether, our data indicated that OPHN1 plays a key role in regulating the number, morphology and function of adult-born inhibitory interneurons and contributed to identify potential therapeutic targets. | Oligophrenin-1 regulates number, morphology and synaptic properties of adult-born inhibitory interneurons in the olfactory bulb.
Redolfi N, Galla L, Maset A, Murru L, Savoia E, Zamparo I, Gritti A, Billuart P, Passafaro M, Lodovichi C. | 07/29/2017 |
| OPHN1 mediated regulation of RhoA, Rac1 and Cdc42 is crucial for the preservation of cardiac function after myocardial injury. | Oligophrenin1 protects mice against myocardial ischemia and reperfusion injury by modulating inflammation and myocardial apoptosis.
Niermann C, Gorressen S, Klier M, Gowert NS, Billuart P, Kelm M, Merx MW, Elvers M. | 02/25/2017 |
| Identify OPHN1 as an important regulator of platelet cytoskeletal reorganization and thrombus formation. | Loss of oligophrenin1 leads to uncontrolled Rho activation and increased thrombus formation in mice.
Fotinos A, Klier M, Gowert NS, Münzer P, Klatt C, Beck S, Borst O, Billuart P, Schaller M, Lang F, Gawaz M, Elvers M. | 02/13/2016 |
| OPHN1 is a bifunctional protein that is able, through distinct mechanisms, to regulate and most likely link exocytosis to compensatory endocytosis in chromaffin cells. | Oligophrenin-1 Connects Exocytotic Fusion to Compensatory Endocytosis in Neuroendocrine Cells.
Houy S, Estay-Ahumada C, Croisé P, Calco V, Haeberlé AM, Bailly Y, Billuart P, Vitale N, Bader MF, Ory S, Gasman S., Free PMC Article | 11/7/2015 |
| OPHN1 is a powerful regulator of Rho GTPase activity in platelets that is critical for the reorganization of the cytoskeleton, which is a major process required for stable platelet adhesion and thrombus formation to occur. | The GRAF family member oligophrenin1 is a RhoGAP with BAR domain and regulates Rho GTPases in platelets.
Elvers M, Beck S, Fotinos A, Ziegler M, Gawaz M. | 09/22/2012 |
| Ophn1 is involved in processes of normal retinal vessel function during adulthood. | Oligophrenin-1 (Ophn1) is expressed in mouse retinal vessels.
Sel S, Kaiser M, Nass N, Trau S, Roepke A, Storsberg J, Hampel U, Paulsen F, Kalinski T. | 06/2/2012 |
| our data establish a role for rapid OPHN1 synthesis in mGluR long-term depression. | Rapid synthesis of the X-linked mental retardation protein OPHN1 mediates mGluR-dependent LTD through interaction with the endocytic machinery.
Nadif Kasri N, Nakano-Kobayashi A, Van Aelst L., Free PMC Article | 12/24/2011 |
| The results of this study indicated the presence of a circadian oscillator in the hippocampus, involving the clock gene Bmal1 (also known as Arntl), that is modulated by Rev-erbalpha and requires oligophrenin-1 for normal oscillation. | A circadian clock in hippocampus is regulated by interaction between oligophrenin-1 and Rev-erbα.
Valnegri P, Khelfaoui M, Dorseuil O, Bassani S, Lagneaux C, Gianfelice A, Benfante R, Chelly J, Billuart P, Sala C, Passafaro M. | 11/19/2011 |
| Results sugest that reduced or defective OPHN1 signaling impairs synaptic vesicle cycling at hippocampal synapses. | The Rho-linked mental retardation protein OPHN1 controls synaptic vesicle endocytosis via endophilin A1.
Nakano-Kobayashi A, Kasri NN, Newey SE, Van Aelst L., Free PMC Article | 01/21/2010 |
| Loss of OPHN1 leads to the activation of the RhoA/ROCK signaling pathway. | Inhibition of RhoA pathway rescues the endocytosis defects in Oligophrenin1 mouse model of mental retardation.
Khelfaoui M, Pavlowsky A, Powell AD, Valnegri P, Cheong KW, Blandin Y, Passafaro M, Jefferys JG, Chelly J, Billuart P., Free PMC Article | 01/21/2010 |
| This study indicates that cognitive impairment related to OPHN1 loss of function is associated with both presynaptic and postsynaptic alterations. | Loss of X-linked mental retardation gene oligophrenin1 in mice impairs spatial memory and leads to ventricular enlargement and dendritic spine immaturity.
Khelfaoui M, Denis C, van Galen E, de Bock F, Schmitt A, Houbron C, Morice E, Giros B, Ramakers G, Fagni L, Chelly J, Nosten-Bertrand M, Billuart P., Free PMC Article | 01/21/2010 |
| Oligophrenin-1 is expressed in developing CNS areas that evince synaptic plasticity. OPHN1 is expressed in both glial and neuronal cells, where it colocalizes with actin at the tip of growing neurites. | The RhoGAP activity of OPHN1, a new F-actin-binding protein, is negatively controlled by its amino-terminal domain.
Fauchereau F, Herbrand U, Chafey P, Eberth A, Koulakoff A, Vinet MC, Ahmadian MR, Chelly J, Billuart P. | 01/21/2010 |