| PPP1R14A is Associated with Immunotherapy Resistance in Head and Neck Squamous Cell Carcinoma Identified by Single-Cell and Bulk RNA-Sequencing. | PPP1R14A is Associated with Immunotherapy Resistance in Head and Neck Squamous Cell Carcinoma Identified by Single-Cell and Bulk RNA-Sequencing.
Ma JJ, Zhang L, Lu J, Zhang HX. | 08/4/2024 |
| Phosphorylated CPI-17 and MLC2 as Biomarkers of Coronary Artery Spasm-Induced Sudden Cardiac Death. | Phosphorylated CPI-17 and MLC2 as Biomarkers of Coronary Artery Spasm-Induced Sudden Cardiac Death.
Dong Y, Wang J, Yang C, Bao J, Liu X, Chen H, Zhang X, Shi W, Zhang L, Qi Q, Li Y, Wang S, Ma R, Cong B, Zhang G., Free PMC Article | 03/20/2024 |
| Novel role of prostate cancer risk variant rs7247241 on PPP1R14A isoform transition through allelic TF binding and CpG methylation. | Novel role of prostate cancer risk variant rs7247241 on PPP1R14A isoform transition through allelic TF binding and CpG methylation.
Tian Y, Soupir A, Liu Q, Wu L, Huang CC, Park JY, Wang L., Free PMC Article | 06/11/2022 |
| CPI-17 Overexpression and Its Correlation With the NF2 Mutation Spectrum in Sporadic Vestibular Schwannomas. | CPI-17 Overexpression and Its Correlation With the NF2 Mutation Spectrum in Sporadic Vestibular Schwannomas.
Xu J, Zhang Y, Shi Y, Yin D, Dai P, Zhao W, Zhang T. | 08/29/2020 |
| The down-regulated expression of CPI-17 phosphorylated proteins might be one of the important factors of uterine atony-induced postpartum hemorrhage. | Relationship between uterine smooth muscular CPI-17-signal pathway-mediated Ca(2+) sensitivity changes and uterine atony-induced postpartum haemorrhage.
Liao Q, Yan J, Zhou Z, Luo J, Han Q, Zhang Q, Chen R. | 07/20/2019 |
| CPI-17 drives Ras activity and tumorigenesis in melanomas in a two-fold way; inactivation of the tumor suppressor merlin and activation of the growth promoting ERM family. | CPI-17 drives oncogenic Ras signaling in human melanomas via Ezrin-Radixin-Moesin family proteins.
Riecken LB, Zoch A, Wiehl U, Reichert S, Scholl I, Cui Y, Ziemer M, Anderegg U, Hagel C, Morrison H., Free PMC Article | 02/24/2018 |
| The authors call the mutual sequestration mechanism through which pCPI-17 and myosin light-chain phosphatase interact inhibition by unfair competition: myosin light-chain phosphatase protects pCPI-17 from other phosphatases, while pCPI-17 blocks other substrates from the active site of myosin light-chain phosphatase. | Unfair competition governs the interaction of pCPI-17 with myosin phosphatase (PP1-MYPT1).
Filter JJ, Williams BC, Eto M, Shalloway D, Goldberg ML., Free PMC Article | 02/17/2018 |
| Study finds that CPI-17 (PPP1R14A protein phosphatase 1 regulatory inhibitor subunit 14A, 17 kDa) is not expressed in the healthy peripheral nervous system or in nontumour pathologies of the peripheral nervous system. CPI-17 up-regulation, however, is observed in over 90% of schwannomas, but not in neurofibroma and only rarely in malignant peripheral nerve sheath tumour. | The putative oncogene CPI-17 is up-regulated in schwannoma.
Hagel C, Dornblut C, Schulz A, Wiehl U, Friedrich RE, Huckhagel T, Mautner VF, Morrison H. | 02/17/2018 |
| CPI-17 has a role in restoring skin homoeostasis in cutaneous field of cancerization lesions | Role of CPI-17 in restoring skin homoeostasis in cutaneous field of cancerization: effects of topical application of a film-forming medical device containing photolyase and UV filters.
Puig-Butillé JA, Malvehy J, Potrony M, Trullas C, Garcia-García F, Dopazo J, Puig S., Free PMC Article | 02/15/2014 |
| analysis of the interaction between plakoglobin and CPI-17, which is affected by the phosphorylation status of CPI-17 in human lung microvascular endothelial cells | Putative protein partners for the human CPI-17 protein revealed by bacterial two-hybrid screening.
Kim KM, Adyshev DM, Kása A, Zemskov EA, Kolosova IA, Csortos C, Verin AD., Free PMC Article | 02/1/2014 |
| The N-terminal 21-residue tail domain of CPI-17 is necessary for nuclear localization. Phospho-mimetic Asp-substitution of CPI-17 at Ser12 attenuates the nuclear import. | Nuclear localization of CPI-17, a protein phosphatase-1 inhibitor protein, affects histone H3 phosphorylation and corresponds to proliferation of cancer and smooth muscle cells.
Eto M, Kirkbride JA, Chugh R, Karikari NK, Kim JI., Free PMC Article | 07/6/2013 |
| The study characterized the CPI-17 promoter and identified binding sites for GATA-6 and nuclear factor kappa B (NF-kappaB). | GATA-6 and NF-κB activate CPI-17 gene transcription and regulate Ca2+ sensitization of smooth muscle contraction.
Boopathi E, Hypolite JA, Zderic SA, Gomes CM, Malkowicz B, Liou HC, Wein AJ, Chacko S., Free PMC Article | 04/13/2013 |
| a novel signaling cascade that links RhoA-mediated calcium sensitivity to MEF2-dependent myocardin expression in VSMCs through a mechanism involving p38 MAPK, PP1alpha, and CPI-17. | A novel RhoA/ROCK-CPI-17-MEF2C signaling pathway regulates vascular smooth muscle cell gene expression.
Pagiatakis C, Gordon JW, Ehyai S, McDermott JC., Free PMC Article | 05/5/2012 |
| RACK1 may play a role in PKC/CPI-17 signaling pathway. | A functional interaction between CPI-17 and RACK1 proteins in bronchial smooth muscle cells.
Chiba Y, Tanabe M, Sakai H, Kimura S, Misawa M., Free PMC Article | 12/4/2010 |
| cAMP/PKA regulates the endothelial barrier via inhibition of the contractile machinery, mainly by the activation of MLCP via inhibition of CPI-17 and RhoA/Rock. | cAMP/PKA antagonizes thrombin-induced inactivation of endothelial myosin light chain phosphatase: role of CPI-17.
Aslam M, Härtel FV, Arshad M, Gündüz D, Abdallah Y, Sauer H, Piper HM, Noll T. | 10/23/2010 |
| NF2 is rendered inactive by phosphorylation of Ser 518 and this can be explained at least in part by an increased expression of CPI-17. | Functional inactivation of NF2/merlin in human mesothelioma.
Thurneysen C, Opitz I, Kurtz S, Weder W, Stahel RA, Felley-Bosco E. | 01/21/2010 |
| These results are consistent with a key molecular role for CPI-17 in airway hyperresponsiveness, in the absence of bronchial wall remodeling. | CPI-17 silencing-reduced responsiveness in control and TNF-alpha-treated human bronchi.
Morin C, Sirois M, Echave V, Rousseau E. | 01/21/2010 |
| Human pregnancy is characterized by increases in PKN1 expression and PPP1R14A phosphorylation in the myometrium. | Up-regulation of myometrial RHO effector proteins (PKN1 and DIAPH1) and CPI-17 (PPP1R14A) phosphorylation in human pregnancy is associated with increased GTP-RHOA in spontaneous preterm labor.
Lartey J, Smith M, Pawade J, Strachan B, Mellor H, López Bernal A. | 01/21/2010 |
| mapped to chromosome 19q13.13-q13.2 | Identification of human, mouse and rat PPP1R14A, protein phosphatase-1 inhibitor subunit 14A, & mapping human PPP1R14A to chromosome 19q13.13-q13.2.
Li Z, Yu L, Zhang Y, Gao J, Zhang P, Wan B, Chen C, Zhao S. | 01/21/2010 |
| CPI-17 binds directly to protein kinase C and casein kinase I. | Association of CPI-17 with protein kinase C and casein kinase I.
Zemlickova E, Johannes FJ, Aitken A, Dubois T. | 01/21/2010 |
| CPI-17 siRNA decreased the level of merlin phosphorylation and consequently Ras and ERK activity in human tumor cell lines | Tumorigenic transformation by CPI-17 through inhibition of a merlin phosphatase.
Jin H, Sperka T, Herrlich P, Morrison H. | 01/21/2010 |
| importance of PKC/CPI-17-mediated pathway in histamine-triggered cytoskeletal rearrangements leading to lung microvascular barrier compromise. | Role of CPI-17 in the regulation of endothelial cytoskeleton.
Kolosova IA, Ma SF, Adyshev DM, Wang P, Ohba M, Natarajan V, Garcia JG, Verin AD. | 01/21/2010 |
| These data indicate that 14,15-epoxyeicosatrienoic acid hyperpolarizes airway smooth muscle cells and relaxes precontracted human bronchi and intracellular effects are related to a PKC-dependent process involving a lower phosphorylation level of CPI-17. | Epoxyeicosatrienoic acid relaxing effects involve Ca2+-activated K+ channel activation and CPI-17 dephosphorylation in human bronchi.
Morin C, Sirois M, Echave V, Gomes MM, Rousseau E. | 01/21/2010 |