| Cytosolic DNA sensor AIM2 promotes KRAS-driven lung cancer independent of inflammasomes. | Cytosolic DNA sensor AIM2 promotes KRAS-driven lung cancer independent of inflammasomes.
Alanazi M, Weng T, McLeod L, Gearing LJ, Smith JA, Kumar B, Saad MI, Jenkins BJ., Free PMC Article | 07/8/2024 |
| Inflammatory corpuscle AIM2 facilitates macrophage foam cell formation by inhibiting cholesterol efflux protein ABCA1. | Inflammatory corpuscle AIM2 facilitates macrophage foam cell formation by inhibiting cholesterol efflux protein ABCA1.
Zhuo S, Song S, Wang C, Wang Z, Zhang M, Lin D, Chen K., Free PMC Article | 07/3/2024 |
| Herpes Simplex Virus ICP27 Protein Inhibits AIM 2-Dependent Inflammasome Influencing Pro-Inflammatory Cytokines Release in Human Pigment Epithelial Cells (hTert-RPE 1). | Herpes Simplex Virus ICP27 Protein Inhibits AIM 2-Dependent Inflammasome Influencing Pro-Inflammatory Cytokines Release in Human Pigment Epithelial Cells (hTert-RPE 1).
Caproni A, Nordi C, Fontana R, Facchini M, Melija S, Pappadà M, Buratto M, Marconi P., Free PMC Article | 07/1/2024 |
| AIM2 inflammasome regulated by the IFN-gamma/JAK2/STAT1 pathway promotes activation and pyroptosis of monocytes in Coronary Artery Disease. | AIM2 inflammasome regulated by the IFN-γ/JAK2/STAT1 pathway promotes activation and pyroptosis of monocytes in Coronary Artery Disease.
Zhao Y, Liang B, Sheng S, Wang C, Jin B, Zhang X, Cheng Y, Shen C, Zheng F., Free PMC Article | 06/27/2024 |
| AIM2 participates in house dust mite (HDM)-induced epithelial dysfunctions and ovalbumin (OVA)-induced allergic asthma in infant mice. | AIM2 participates in house dust mite (HDM)-induced epithelial dysfunctions and ovalbumin (OVA)-induced allergic asthma in infant mice.
Yang S, Guo R, Meng X, Zhang Y. | 05/28/2024 |
| Association of salivary levels of DNA sensing inflammasomes AIM2, IFI16, and cytokine IL18 with periodontitis and diabetes. | Association of salivary levels of DNA sensing inflammasomes AIM2, IFI16, and cytokine IL18 with periodontitis and diabetes.
Arunachalam LT, Suresh S, Lavu V, Vedamanickam S, Viswanathan S, Thirumalai Nathan RD. | 03/7/2024 |
| Cutting Edge: Cytosolic Receptor AIM2 Is Induced by Peroxisome Proliferator-activated Receptor gamma following Mycobacterium tuberculosis Infection of Human Macrophages but Does Not Contribute to IL-1beta Release. | Cutting Edge: Cytosolic Receptor AIM2 Is Induced by Peroxisome Proliferator-activated Receptor γ following Mycobacterium tuberculosis Infection of Human Macrophages but Does Not Contribute to IL-1β Release.
Arnett E, Wolff J, Leopold Wager CM, Simper J, Badrak JL, Ontiveros CO, Ni B, Schlesinger LS., | 02/23/2024 |
| Activation of AIM2 by hepatitis B virus results in antiviral immunity that suppresses hepatitis C virus during coinfection. | Activation of AIM2 by hepatitis B virus results in antiviral immunity that suppresses hepatitis C virus during coinfection.
Li Y, Yang Y, Li T, Wang Z, Gao C, Deng R, Ma F, Li X, Ma L, Tian R, Li H, Zhu H, Zeng L, Gao Y, Lv G, Niu J, Crispe IN, Tu Z., Free PMC Article | 02/2/2024 |
| AIM2 inflammasome: A potential therapeutic target in ischemic stroke. | AIM2 inflammasome: A potential therapeutic target in ischemic stroke.
Fu R, Zhao L, Guo Y, Qin X, Xu W, Cheng X, Zhang Y, Xu S. | 02/1/2024 |
| AIM2 promotes irradiation resistance, migration ability and PD-L1 expression through STAT1/NF-kappaB activation in oral squamous cell carcinoma. | AIM2 promotes irradiation resistance, migration ability and PD-L1 expression through STAT1/NF-κB activation in oral squamous cell carcinoma.
Chiu HW, Lee HL, Lee HH, Lu HW, Lin KY, Lin YF, Lin CH., Free PMC Article | 01/17/2024 |
| Absent in melanoma 2 attenuates proliferation and migration and promotes apoptosis of human colorectal cancer cells by activating P38MAPK signaling pathway. | Absent in melanoma 2 attenuates proliferation and migration and promotes apoptosis of human colorectal cancer cells by activating P38MAPK signaling pathway.
Zhang Z, Li X, Zhang Y, Zhu H, Qiao Z, Lu Y, Mi X, Cao H, Shen G, He S., Free PMC Article | 01/12/2024 |
| TRIM11 attenuates Treg cell differentiation by p62-selective autophagic degradation of AIM2. | TRIM11 attenuates Treg cell differentiation by p62-selective autophagic degradation of AIM2.
Yu T, Yang X, Fu Q, Liang J, Wu X, Sheng J, Chen Y, Xiao L, Wu Y, Nie D, You X, Mai H, Chen K, Hu S. | 12/5/2023 |
| Effects of AIM2 and IFI16 on Infectious Diseases and Inflammation. | Effects of AIM2 and IFI16 on Infectious Diseases and Inflammation.
Fan Z, Chen R, Yin W, Xie X, Wang S, Hao C. | 09/20/2023 |
| The role of AIM2 in human hepatocellular carcinoma and its clinical significance. | The role of AIM2 in human hepatocellular carcinoma and its clinical significance.
Zheng P, Xiao W, Zhang J, Zheng X, Jiang J. | 05/20/2023 |
| The cytosolic DNA sensor AIM2 promotes Helicobacter-induced gastric pathology via the inflammasome. | The cytosolic DNA sensor AIM2 promotes Helicobacter-induced gastric pathology via the inflammasome.
Dawson RE, Deswaerte V, West AC, Sun E, Wray-McCann G, Livis T, Kumar B, Rodriguez E, Gabay C, Ferrero RL, Jenkins BJ., Free PMC Article | 05/12/2023 |
| Filament assembly underpins the double-stranded DNA specificity of AIM2-like receptors. | Filament assembly underpins the double-stranded DNA specificity of AIM2-like receptors.
Garg A, Stallings CM, Sohn J., Free PMC Article | 04/12/2023 |
| AIM2 promotes renal cell carcinoma progression and sunitinib resistance through FOXO3a-ACSL4 axis-regulated ferroptosis. | AIM2 promotes renal cell carcinoma progression and sunitinib resistance through FOXO3a-ACSL4 axis-regulated ferroptosis.
Wang Q, Gao S, Shou Y, Jia Y, Wei Z, Liu Y, Shi J, Miao D, Miao Q, Zhao C, Liu C, Yang H, Xu T, Zhang X., Free PMC Article | 03/21/2023 |
| AIM2 was found to be activated in an inflammasome-dependent way to release IL-1beta and IL-18 to mediate inflammation, and to participate in immune regulation in psoriasis, or in an inflammasome-independent way by regulating the function of regulatory T cells or programming cell death in keratinocytes as well as controlling the proliferative state of different cells. | AIM2 and Psoriasis.
Zhang Y, Xu X, Cheng H, Zhou F., Free PMC Article | 03/21/2023 |
| AIM2 upregulation promotes metastatic progression and PD-L1 expression in lung adenocarcinoma. | AIM2 upregulation promotes metastatic progression and PD-L1 expression in lung adenocarcinoma.
Zheng JQ, Lin CH, Lee HH, Chang WM, Li LJ, Su CY, Lee KY, Chiu HW, Lin YF., Free PMC Article | 01/11/2023 |
| AIM2 sensors mediate immunity to Plasmodium infection in hepatocytes. | AIM2 sensors mediate immunity to Plasmodium infection in hepatocytes.
Marques-da-Silva C, Poudel B, Baptista RP, Peissig K, Hancox LS, Shiau JC, Pewe LL, Shears MJ, Kanneganti TD, Sinnis P, Kyle DE, Gurung P, Harty JT, Kurup SP., Free PMC Article | 01/11/2023 |
| dsDNA-induced AIM2 pyroptosis halts aberrant inflammation during rhabdomyolysis-induced acute kidney injury. | dsDNA-induced AIM2 pyroptosis halts aberrant inflammation during rhabdomyolysis-induced acute kidney injury.
Baatarjav C, Komada T, Karasawa T, Yamada N, Sampilvanjil A, Matsumura T, Takahashi M., Free PMC Article | 12/24/2022 |
| Pan-cancer analysis of AIM2 inflammasomes with potential implications for immunotherapy in human cancer: A bulk omics research and single cell sequencing validation. | Pan-cancer analysis of AIM2 inflammasomes with potential implications for immunotherapy in human cancer: A bulk omics research and single cell sequencing validation.
Qin Y, Pan L, Qin T, Ruan H, Zhang Y, Zhang Y, Li J, Yang J, Li W., Free PMC Article | 10/22/2022 |
| AIM2-inflammasome role in systemic lupus erythematous and rheumatoid arthritis. | AIM2-inflammasome role in systemic lupus erythematous and rheumatoid arthritis.
Uresti-Rivera EE, García-Hernández MH. | 10/15/2022 |
| Expression of NLRP3 and AIM2 inflammasome in Peripheral blood in Chinese patients with acute and chronic brucellosis. | Expression of NLRP3 and AIM2 inflammasome in Peripheral blood in Chinese patients with acute and chronic brucellosis.
Su X, Zhao S, Song Y., Free PMC Article | 09/17/2022 |
| Cross-talk between IL-6 trans-signaling and AIM2 inflammasome/IL-1beta axes bridge innate immunity and epithelial apoptosis to promote emphysema. | Cross-talk between IL-6 trans-signaling and AIM2 inflammasome/IL-1β axes bridge innate immunity and epithelial apoptosis to promote emphysema.
Ruwanpura SM, McLeod L, Dousha LF, Seow HJ, West AC, West AJ, Weng T, Alanazi M, MacDonald M, King PT, Bardin PG, Gabay C, Klinman DM, Bozinovski S, Vlahos R, Anderson GP, Rose-John S, Saad MI, Jenkins BJ., Free PMC Article | 09/3/2022 |