| Role of Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 Signaling in Liver and Metabolic Diseases. | Role of Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 Signaling in Liver and Metabolic Diseases.
Ampadu F, Awasthi V, Joshi AD., | 08/19/2024 |
| Syndromic craniosynostosis caused by a novel missense variant in MAP4K4: Expanding the genotype-phenotype relationship in RASopathies. | Syndromic craniosynostosis caused by a novel missense variant in MAP4K4: Expanding the genotype-phenotype relationship in RASopathies.
Yoon JG, Yu JW, Shim KW, Kim YO, Lee MG. | 07/11/2024 |
| MAP4K4 exacerbates cardiac microvascular injury in diabetes by facilitating S-nitrosylation modification of Drp1. | MAP4K4 exacerbates cardiac microvascular injury in diabetes by facilitating S-nitrosylation modification of Drp1.
Chen Y, Li S, Guan B, Yan X, Huang C, Du Y, Yang F, Zhang N, Li Y, Lu J, Wang J, Zhang J, Chen Z, Chen C, Kong X., Free PMC Article | 06/5/2024 |
| FTO promotes gastric cancer progression by modulating MAP4K4 expression via demethylation in an m6A-dependent manner. | FTO promotes gastric cancer progression by modulating MAP4K4 expression via demethylation in an m6A-dependent manner.
Yin Z, Guo X, Liang X, Wang Z. | 05/22/2024 |
| MAP4K4 and WT1 mediate SOX6-induced cellular senescence by synergistically activating the ATF2-TGFbeta2-Smad2/3 signaling pathway in cervical cancer. | MAP4K4 and WT1 mediate SOX6-induced cellular senescence by synergistically activating the ATF2-TGFβ2-Smad2/3 signaling pathway in cervical cancer.
Zheng H, Liu M, Shi S, Huang H, Yang X, Luo Z, Song Y, Xu Q, Li T, Xue L, Lu F, Wang J., Free PMC Article | 05/9/2024 |
| CircCPSF6 promotes hepatocellular carcinoma cancer progression by regulating MAP4K4 through sponging miR-145-5p. | CircCPSF6 promotes hepatocellular carcinoma cancer progression by regulating MAP4K4 through sponging miR-145-5p.
Lu F, Gao J, Luo Y, Jin WL, Wang H, Li CX, Li X. | 09/20/2023 |
| Evaluation of the Role of MAP4K4 in Focal Adhesion Dynamics and Regulation of Cell Migration of Breast Cancer Cell Line MDA-MB-231. | Evaluation of the Role of MAP4K4 in Focal Adhesion Dynamics and Regulation of Cell Migration of Breast Cancer Cell Line MDA-MB-231.
Al-Fahad D, Al-Bedhawi M, Ateya H., Free PMC Article | 06/21/2023 |
| MAP4K4 promotes ovarian cancer metastasis through diminishing ADAM10-dependent N-cadherin cleavage. | MAP4K4 promotes ovarian cancer metastasis through diminishing ADAM10-dependent N-cadherin cleavage.
Chen K, Yuan X, Wang S, Zheng F, Fu Z, Shen Z, Cheng X, Wang Y, Tang S, Ni H, Wang F, Lu G, Wu Y, Xia D, Lu W., Free PMC Article | 05/5/2023 |
| Abrogation of MAP4K4 protein function causes congenital anomalies in humans and zebrafish. | Abrogation of MAP4K4 protein function causes congenital anomalies in humans and zebrafish.
Patterson V, Ullah F, Bryant L, Griffin JN, Sidhu A, Saliganan S, Blaile M, Saenz MS, Smith R, Ellingwood S, Grange DK, Hu X, Mireguli M, Luo Y, Shen Y, Mulhern M, Zackai E, Ritter A, Izumi K, Hoefele J, Wagner M, Riedhammer KM, Seitz B, Robin NH, Goodloe D, Mignot C, Keren B, Cox H, Jarvis J, Hempel M, Gibson CF, Tran Mau-Them F, Vitobello A, Bruel AL, Sorlin A, Mehta S, Raymond FL, Gilmore K, Powell BC, Weck K, Li C, Vulto-van Silfhout AT, Giacomini T, Mancardi MM, Accogli A, Salpietro V, Zara F, Vora NL, Davis EE, Burdine R, Bhoj E., Free PMC Article | 05/4/2023 |
| Integrated exome and transcriptome analysis prioritizes MAP4K4 de novo frameshift variants in autism spectrum disorder as a novel disease-gene association. | Integrated exome and transcriptome analysis prioritizes MAP4K4 de novo frameshift variants in autism spectrum disorder as a novel disease-gene association.
Cesana M, Vaccaro L, Larsen MJ, Kibæk M, Micale L, Riccardo S, Annunziata P, Colantuono C, Di Filippo L, De Brasi D, Castori M, Fagerberg C, Acquaviva F, Cacchiarelli D., Free PMC Article | 03/1/2023 |
| MAP4K4/JNK Signaling Pathway Stimulates Proliferation and Suppresses Apoptosis of Human Spermatogonial Stem Cells and Lower Level of MAP4K4 Is Associated with Male Infertility. | MAP4K4/JNK Signaling Pathway Stimulates Proliferation and Suppresses Apoptosis of Human Spermatogonial Stem Cells and Lower Level of MAP4K4 Is Associated with Male Infertility.
Wan C, Chen W, Cui Y, He Z., Free PMC Article | 12/31/2022 |
| Bioinformatics and Experimental Analyses Reveal MAP4K4 as a Potential Marker for Gastric Cancer. | Bioinformatics and Experimental Analyses Reveal MAP4K4 as a Potential Marker for Gastric Cancer.
Zhang J, Cai X, Cui W, Wei Z., Free PMC Article | 11/5/2022 |
| MiR-181c suppresses triple-negative breast cancer tumorigenesis by targeting MAP4K4. | MiR-181c suppresses triple-negative breast cancer tumorigenesis by targeting MAP4K4.
Xie D, Li S, Wu T, Wang X, Fang L. | 03/26/2022 |
| MAP4K4 mediates the SOX6-induced autophagy and reduces the chemosensitivity of cervical cancer. | MAP4K4 mediates the SOX6-induced autophagy and reduces the chemosensitivity of cervical cancer.
Huang H, Han Q, Zheng H, Liu M, Shi S, Zhang T, Yang X, Li Z, Xu Q, Guo H, Lu F, Wang J., Free PMC Article | 03/26/2022 |
| MAP4K4 promotes pancreatic tumorigenesis via phosphorylation and activation of mixed lineage kinase 3. | MAP4K4 promotes pancreatic tumorigenesis via phosphorylation and activation of mixed lineage kinase 3.
Singh SK, Kumar S, Viswakarma N, Principe DR, Das S, Sondarva G, Nair RS, Srivastava P, Sinha SC, Grippo PJ, Thatcher GRJ, Rana B, Rana A., Free PMC Article | 01/1/2022 |
| HGK promotes metastatic dissemination in prostate cancer. | HGK promotes metastatic dissemination in prostate cancer.
Garcia-Garcia S, Rodrigo-Faus M, Fonseca N, Manzano S, Győrffy B, Ocaña A, Bragado P, Porras A, Gutierrez-Uzquiza A., Free PMC Article | 10/30/2021 |
| MAP4K4 negatively regulates CD8 T cell-mediated antitumor and antiviral immunity. | MAP4K4 negatively regulates CD8 T cell-mediated antitumor and antiviral immunity.
Esen E, Sergin I, Jesudason R, Himmels P, Webster JD, Zhang H, Xu M, Piskol R, McNamara E, Gould S, Capietto AH, Delamarre L, Walsh K, Ye W. | 01/2/2021 |
| Targeted genomic CRISPR-Cas9 screen identifies MAP4K4 as essential for glioblastoma invasion. | Targeted genomic CRISPR-Cas9 screen identifies MAP4K4 as essential for glioblastoma invasion.
Prolo LM, Li A, Owen SF, Parker JJ, Foshay K, Nitta RT, Morgens DW, Bolin S, Wilson CM, Vega L JCM, Luo EJ, Nwagbo G, Waziri A, Li G, Reimer RJ, Bassik MC, Grant GA., Free PMC Article | 11/21/2020 |
| STRIPAK directs PP2A activity toward MAP4K4 to promote oncogenic transformation of human cells. | STRIPAK directs PP2A activity toward MAP4K4 to promote oncogenic transformation of human cells.
Kim JW, Berrios C, Kim M, Schade AE, Adelmant G, Yeerna H, Damato E, Iniguez AB, Florens L, Washburn MP, Stegmaier K, Gray NS, Tamayo P, Gjoerup O, Marto JA, DeCaprio J, Hahn WC., Free PMC Article | 10/24/2020 |
| These studies highlight a MAP4K4-initiated signaling cascade that induces motor neuron degeneration. | MAP4K4 Activation Mediates Motor Neuron Degeneration in Amyotrophic Lateral Sclerosis.
Wu C, Watts ME, Rubin LL. | 03/14/2020 |
| TIIA triggered HGK/JNK1-dependent Jun activation and led to increased Jun recruitment to AP-1-binding site in the SESN2 promoter region. | HGK-sestrin 2 signaling-mediated autophagy contributes to antitumor efficacy of Tanshinone IIA in human osteosarcoma cells.
Yen JH, Huang ST, Huang HS, Fong YC, Wu YY, Chiang JH, Su YC., Free PMC Article | 11/16/2019 |
| miR-200c could suppress cervical cancer cell proliferation and progression via regulating MAP4K4, which might provide a new target for cervical cancer diagnosis and therapy | MicroRNA-200c suppressed cervical cancer cell metastasis and growth via targeting MAP4K4.
Mei J, Wang DH, Wang LL, Chen Q, Pan LL, Xia L. | 10/26/2019 |
| Our findings showed that 5-FU inhibited malignant behavior of human colorectal cancer (CRC) cells in vitro and in vivo by enhancing the efficiency of miR-141 Our data suggested that targetting the miR-141/MAP4K4 signaling pathway could be a potential molecular target that may enhance chemotherapeutic efficacy in the treatment of CRC | Chemotherapy-induced miR-141/MAP4K4 signaling suppresses progression of colorectal cancer.
Wang F, Zhao L, Zhang J, Meng Z, Zhou C, Wang G, Liu Y, Li M, Xi J, Niu W, Wang G., Free PMC Article | 07/27/2019 |
| Results show that MAP4K4 is a target gene for the novel miR-TG. Its expression is up-regulated in papillary thyroid carcinoma (PTC) which is inversely correlated with that of miR-TG. | Functional analysis of a novel, thyroglobulin-embedded microRNA gene deregulated in papillary thyroid carcinoma.
Kolanowska M, Wójcicka A, Kubiak A, Świerniak M, Kotlarek M, Maciąg M, Gaj P, Koperski Ł, Górnicka B, Jażdżewski K., Free PMC Article | 06/15/2019 |
| These results suggest that downregulation of miR-98-5p promotes tumor development by downregulation of MAP4K4 and inhibition of the downstream MAPK/ERK signaling | Downregulated miR-98-5p promotes PDAC proliferation and metastasis by reversely regulating MAP4K4.
Fu Y, Liu X, Chen Q, Liu T, Lu C, Yu J, Miao Y, Wei J., Free PMC Article | 05/11/2019 |