| Targeting PERK and GRP78 in colorectal cancer: Genetic insights and novel therapeutic approaches. | Targeting PERK and GRP78 in colorectal cancer: Genetic insights and novel therapeutic approaches.
Mafi S, Dehghani M, Khalvati B, Abidi H, Ghorbani M, Jalali P, Whichelo R, Salehi Z, Markowska A, Reyes A, Pecic S, Łos MJ, Ghavami S, Nikseresht M. | 09/23/2024 |
| PERK-ATAD3A interaction provides a subcellular safe haven for protein synthesis during ER stress. | PERK-ATAD3A interaction provides a subcellular safe haven for protein synthesis during ER stress.
Brar KK, Hughes DT, Morris JL, Subramanian K, Krishna S, Gao F, Rieder LS, Uhrig S, Freeman J, Smith HL, Jukes-Jones R, Avezov E, Nunnari J, Prudent J, Butcher AJ, Mallucci GR. | 08/30/2024 |
| Genetic Variations in EIF2AK3 are Associated with Neurocognitive Impairment in People Living with HIV. | Genetic Variations in EIF2AK3 are Associated with Neurocognitive Impairment in People Living with HIV.
Akay-Espinoza C, Newton SEB, Dombroski BA, Kallianpur A, Bharti A, Franklin DR, Schellenberg GD, Heaton RK, Grant I, Ellis RJ, Letendre SL, Jordan-Sciutto KL., Free PMC Article | 06/12/2024 |
| DNAJC10 maintains survival and self-renewal of leukemia stem cells through PERK branch of the unfolded protein response. | DNAJC10 maintains survival and self-renewal of leukemia stem cells through PERK branch of the unfolded protein response.
Li M, Wu X, Chen M, Hao S, Yu Y, Li X, Zhao E, Xu M, Yu Z, Wang Z, Xu N, Jin C, Yin Y., Free PMC Article | 03/12/2024 |
| The PERK Branch of the Unfolded Protein Response Safeguards Protein Homeostasis and Mesendoderm Specification of Human Pluripotent Stem Cells. | The PERK Branch of the Unfolded Protein Response Safeguards Protein Homeostasis and Mesendoderm Specification of Human Pluripotent Stem Cells.
Liu F, Liu Z, Cheng W, Zhao Q, Zhang X, Zhang H, Yu M, Xu H, Gao Y, Jiang Q, Shi G, Wang L, Gu S, Wang J, Cao N, Chen Z., Free PMC Article | 12/22/2023 |
| Pericentrin deficiency in smooth muscle cells augments atherosclerosis through HSF1-driven cholesterol biosynthesis and PERK activation. | Pericentrin deficiency in smooth muscle cells augments atherosclerosis through HSF1-driven cholesterol biosynthesis and PERK activation.
Majumder S, Chattopadhyay A, Wright JM, Guan P, Buja LM, Kwartler CS, Milewicz DM., Free PMC Article | 11/14/2023 |
| Loss of PERK function promotes ferroptosis by downregulating SLC7A11 (System Xc[-]) in colorectal cancer. | Loss of PERK function promotes ferroptosis by downregulating SLC7A11 (System Xc⁻) in colorectal cancer.
Saini KK, Chaturvedi P, Sinha A, Singh MP, Khan MA, Verma A, Nengroo MA, Satrusal SR, Meena S, Singh A, Srivastava S, Sarkar J, Datta D., Free PMC Article | 08/22/2023 |
| PERK-Mediated Cholesterol Excretion from IDH Mutant Glioma Determines Anti-Tumoral Polarization of Microglia. | PERK-Mediated Cholesterol Excretion from IDH Mutant Glioma Determines Anti-Tumoral Polarization of Microglia.
Wang T, Zhou Y, Fan Y, Duan H, Guo X, Chang J, Jiang Y, Li C, Fu Z, Gao Y, Guo X, Sidlauskas K, He Z, Da Costa C, Sheng X, Wu D, Yuan J, Li H, He Y, Mou Y, Li N., Free PMC Article | 07/28/2023 |
| Connexin 37 sequestering of activated-ERK in the cytoplasm promotes p27-mediated endothelial cell cycle arrest. | Connexin 37 sequestering of activated-ERK in the cytoplasm promotes p27-mediated endothelial cell cycle arrest.
Acharya BR, Fang JS, Jeffery ED, Chavkin NW, Genet G, Vasavada H, Nelson EA, Sheynkman GM, Humphries MJ, Hirschi KK., Free PMC Article | 06/7/2023 |
| Neurodegeneration risk factor, EIF2AK3 (PERK), influences tau protein aggregation. | Neurodegeneration risk factor, EIF2AK3 (PERK), influences tau protein aggregation.
Park G, Xu K, Chea L, Kim K, Safarta L, Song KH, Wu J, Park S, Min H, Hiramatsu N, Han J, Lin JH., Free PMC Article | 03/2/2023 |
| PERK recruits E-Syt1 at ER-mitochondria contacts for mitochondrial lipid transport and respiration. | PERK recruits E-Syt1 at ER-mitochondria contacts for mitochondrial lipid transport and respiration.
Sassano ML, van Vliet AR, Vervoort E, Van Eygen S, Van den Haute C, Pavie B, Roels J, Swinnen JV, Spinazzi M, Moens L, Casteels K, Meyts I, Pinton P, Marchi S, Rochin L, Giordano F, Felipe-Abrio B, Agostinis P., Free PMC Article | 02/27/2023 |
| Mycobacterium tuberculosis PE_PGRS1 promotes mycobacteria intracellular survival via reducing the concentration of intracellular free Ca[2+] and suppressing endoplasmic reticulum stress. | Mycobacterium tuberculosis PE_PGRS1 promotes mycobacteria intracellular survival via reducing the concentration of intracellular free Ca(2+) and suppressing endoplasmic reticulum stress.
Yu X, Huang Y, Li Y, Li T, Yan S, Ai X, Lv X, Fan L, Xie J. | 02/26/2023 |
| Loss of ATF6alpha in a human carcinoma cell line is compensated not by its paralogue ATF6beta but by sustained activation of the IRE1 and PERK arms for tumor growth in nude mice. | Loss of ATF6α in a human carcinoma cell line is compensated not by its paralogue ATF6β but by sustained activation of the IRE1 and PERK arms for tumor growth in nude mice.
Jin S, Jin B, Ishikawa T, Ninagawa S, Okada T, Koyasu S, Harada H, Mori K., Free PMC Article | 02/24/2023 |
| Fatty acid palmitate suppresses FoxO1 expression via PERK and IRE1 unfolded protein response in C2C12 myotubes. | Fatty acid palmitate suppresses FoxO1 expression via PERK and IRE1 unfolded protein response in C2C12 myotubes.
Zhang B, Zhu R, Sun X, Guo Q, Zhang Y, Zhang N, Oh Y, Fan L, Wang C, Gu N. | 10/29/2022 |
| PERK/EIF2AK3 integrates endoplasmic reticulum stress-induced apoptosis, oxidative stress and autophagy responses in immortalised retinal pigment epithelial cells. | PERK/EIF2AK3 integrates endoplasmic reticulum stress-induced apoptosis, oxidative stress and autophagy responses in immortalised retinal pigment epithelial cells.
Saptarshi N, Porter LF, Paraoan L., Free PMC Article | 08/13/2022 |
| A non-canonical cGAS-STING-PERK pathway facilitates the translational program critical for senescence and organ fibrosis. | A non-canonical cGAS-STING-PERK pathway facilitates the translational program critical for senescence and organ fibrosis.
Zhang D, Liu Y, Zhu Y, Zhang Q, Guan H, Liu S, Chen S, Mei C, Chen C, Liao Z, Xi Y, Ouyang S, Feng XH, Liang T, Shen L, Xu P. | 06/11/2022 |
| PERK reprograms hematopoietic progenitor cells to direct tumor-promoting myelopoiesis in the spleen. | PERK reprograms hematopoietic progenitor cells to direct tumor-promoting myelopoiesis in the spleen.
Liu M, Wu C, Luo S, Hua Q, Chen HT, Weng Y, Xu J, Lin H, Wang L, Li J, Zhu L, Guo Z, Zhuang SM, Kang T, Zheng L., Free PMC Article | 05/7/2022 |
| Endoplasmic Reticulum Stress in Colonic Mucosa of Ulcerative Colitis Patients Is Mediated by PERK and IRE1 Pathway Activation. | Endoplasmic Reticulum Stress in Colonic Mucosa of Ulcerative Colitis Patients Is Mediated by PERK and IRE1 Pathway Activation.
Rodrigues BL, Dotti I, Pascoal LB, Morari J, Esteller M, Coope A, Ayrizono MLS, Salas A, Leal RF., Free PMC Article | 04/9/2022 |
| The alternative initiation factor eIF2A plays key role in RAN translation of myotonic dystrophy type 2 CCUG*CAGG repeats. | The alternative initiation factor eIF2A plays key role in RAN translation of myotonic dystrophy type 2 CCUG•CAGG repeats.
Tusi SK, Nguyen L, Thangaraju K, Li J, Cleary JD, Zu T, Ranum LPW., Free PMC Article | 03/5/2022 |
| pERK-mediated IL8 secretion can enhance the migration, invasion, and cisplatin resistance of CD10-positive oral cancer cells. | pERK-mediated IL8 secretion can enhance the migration, invasion, and cisplatin resistance of CD10-positive oral cancer cells.
Pu Y, Li Q, Wang Y, Xu L, Qiao Q, Guo Y, Guo C., Free PMC Article | 02/26/2022 |
| Targeting UPR branches, a potential strategy for enhancing efficacy of cancer chemotherapy. | Targeting UPR branches, a potential strategy for enhancing efficacy of cancer chemotherapy.
Yu M, Lun J, Zhang H, Wang L, Zhang G, Zhang H, Fang J. | 02/19/2022 |
| PERK signaling through C/EBPdelta contributes to ER stress-induced expression of immunomodulatory and tumor promoting chemokines by cancer cells. | PERK signaling through C/EBPδ contributes to ER stress-induced expression of immunomodulatory and tumor promoting chemokines by cancer cells.
Sheshadri N, Poria DK, Sharan S, Hu Y, Yan C, Koparde VN, Balamurugan K, Sterneck E., Free PMC Article | 02/5/2022 |
| PERK mediates oxidative stress and adipogenesis in Graves' orbitopathy pathogenesis. | PERK mediates oxidative stress and adipogenesis in Graves' orbitopathy pathogenesis.
Ko J, Kim JY, Kyoung Chae M, Jig Lee E, Sook Yoon J. | 01/8/2022 |
| PERK-eIF2alpha-ERK1/2 axis drives mesenchymal-endothelial transition of cancer-associated fibroblasts in pancreatic cancer. | PERK-eIF2α-ERK1/2 axis drives mesenchymal-endothelial transition of cancer-associated fibroblasts in pancreatic cancer.
Cai W, Sun X, Jin F, Xiao D, Li H, Sun H, Wang Y, Lu Y, Liu J, Huang C, Wang X, Gao S, Wang H, Gao C, Zhao T, Hao J. | 12/25/2021 |
| PERK Is Critical for Alphavirus Nonstructural Protein Translation. | PERK Is Critical for Alphavirus Nonstructural Protein Translation.
Dahal B, Lehman CW, Akhrymuk I, Bracci NR, Panny L, Barrera MD, Bhalla N, Jacobs JL, Dinman JD, Kehn-Hall K., Free PMC Article | 12/18/2021 |