| Targeting postsynaptic glutamate receptor scaffolding proteins PSD-95 and PICK1 for obesity treatment. | Targeting postsynaptic glutamate receptor scaffolding proteins PSD-95 and PICK1 for obesity treatment.
Fadahunsi N, Petersen J, Metz S, Jakobsen A, Vad Mathiesen C, Silke Buch-Rasmussen A, Kurgan N, Kjærgaard Larsen J, Andersen RC, Topilko T, Svendsen C, Apuschkin M, Skovbjerg G, Hendrik Schmidt J, Houser G, Elgaard Jager S, Bach A, Deshmukh AS, Kilpeläinen TO, Strømgaard K, Madsen KL, Clemmensen C., Free PMC Article | 03/7/2024 |
| Multi-omics study identifies that PICK1 deficiency causes male infertility by inhibiting vesicle trafficking in Sertoli cells. | Multi-omics study identifies that PICK1 deficiency causes male infertility by inhibiting vesicle trafficking in Sertoli cells.
Jin J, Li K, Du Y, Gao F, Wang Z, Li W., Free PMC Article | 12/1/2023 |
| The Scaffold Protein PICK1 as a Target in Chronic Pain. | The Scaffold Protein PICK1 as a Target in Chronic Pain.
Sørensen AT, Rombach J, Gether U, Madsen KL., Free PMC Article | 05/7/2022 |
| Coding variants identified in patients with diabetes alter PICK1 BAR domain function in insulin granule biogenesis. | Coding variants identified in patients with diabetes alter PICK1 BAR domain function in insulin granule biogenesis.
Andersen RC, Schmidt JH, Rombach J, Lycas MD, Christensen NR, Lund VK, Stapleton DS, Pedersen SS, Olsen MA, Stoklund M, Noes-Holt G, Nielsen TT, Keller MP, Jansen AM, Herlo R, Pietropaolo M, Simonsen JB, Kjærulff O, Holst B, Attie AD, Gether U, Madsen KL., Free PMC Article | 04/30/2022 |
| Association of PICK1 and BDNF variations with increased risk of methamphetamine dependence among Iranian population: a case-control study. | Association of PICK1 and BDNF variations with increased risk of methamphetamine dependence among Iranian population: a case-control study.
Tajbakhsh A, Alimardani M, Asghari M, Abedini S, Saghafi Khadem S, Nesaei Bajestani A, Alipoor F, Alidoust M, Savardashtaki A, Hashemian P, Pasdar A., Free PMC Article | 01/15/2022 |
| PICK1 Controls Activity-Dependent Synaptic Vesicle Cargo Retrieval. | PICK1 Controls Activity-Dependent Synaptic Vesicle Cargo Retrieval.
Yong XLH, Cousin MA, Anggono V. | 11/22/2021 |
| Protein interacting with C-kinase 1 is involved in epithelial-mesenchymal transformation and suppresses progress of gastric cancer. | Protein interacting with C-kinase 1 is involved in epithelial-mesenchymal transformation and suppresses progress of gastric cancer.
Zhou Y, Li K, Du Y, Wu Z, Wang H, Zhang X, Yang Y, Chen L, Hao K, Wang Z, Lyu J. | 10/30/2021 |
| PICK1 Deficiency Exacerbates Sepsis-Associated Acute Kidney Injury. | PICK1 Deficiency Exacerbates Sepsis-Associated Acute Kidney Injury.
Dou Q, Tong H, Yang Y, Zhang H, Gan H., Free PMC Article | 09/25/2021 |
| A high-affinity, bivalent PDZ domain inhibitor complexes PICK1 to alleviate neuropathic pain. | A high-affinity, bivalent PDZ domain inhibitor complexes PICK1 to alleviate neuropathic pain.
Christensen NR, De Luca M, Lever MB, Richner M, Hansen AB, Noes-Holt G, Jensen KL, Rathje M, Jensen DB, Erlendsson S, Bartling CR, Ammendrup-Johnsen I, Pedersen SE, Schönauer M, Nissen KB, Midtgaard SR, Teilum K, Arleth L, Sørensen AT, Bach A, Strømgaard K, Meehan CF, Vaegter CB, Gether U, Madsen KL., Free PMC Article | 09/18/2021 |
| Arf1, AP1, and PICK1 are key coordinators of actin polymerization. | The Host GTPase Arf1 and Its Effectors AP1 and PICK1 Stimulate Actin Polymerization and Exocytosis To Promote Entry of Listeria monocytogenes.
Saila S, Gyanwali GC, Hussain M, Gianfelice A, Ireton K., Free PMC Article | 02/22/2020 |
| PICK1 plays a pivotal role in sepsis-induced acute lung injury by regulating glutathione synthesis via affecting the substrate-specific subunit of lung cystine/glutamate transporter, xCT | PICK1 deficiency exacerbates sepsis-associated acute lung injury and impairs glutathione synthesis via reduction of xCT.
Qian M, Lou Y, Wang Y, Zhang M, Jiang Q, Mo Y, Han K, Jin S, Dai Q, Yu Y, Wang Z, Wang J. | 05/18/2019 |
| Study has demonstrated that ARX is a novel substrate of PRKCA, with phosphorylation at serine 174, and that the c-terminal region of ARX required to bind PICK1. Binding causes a shift in PICK1 subcellular localization to the nucleus to co-locate with the ARX protein, and truncation of this C-terminal region leads to the same loss of transcriptional activation as S174A mutant. | Regulating transcriptional activity by phosphorylation: A new mechanism for the ARX homeodomain transcription factor.
Mattiske T, Tan MH, Dearsley O, Cloosterman D, Hii CS, Gécz J, Shoubridge C., Free PMC Article | 04/13/2019 |
| this is the first study to indicate that PICK1 polymorphisms may associate with cognitive functions in schizophrenic patients. | PICK1 Genetic Variation and Cognitive Function in Patients with Schizophrenia.
Chen YT, Lin CH, Huang CH, Liang WM, Lane HY., Free PMC Article | 12/22/2018 |
| Coincident with the loss of PICK1 by GBF1-activated ARF1, CDC42 recruitment leads to the activation of IRSp53 and the ARP2/3 complex, resulting in a burst of F-actin polymerisation potentially powering scission. | Small GTPases and BAR domain proteins regulate branched actin polymerisation for clathrin and dynamin-independent endocytosis.
Sathe M, Muthukrishnan G, Rae J, Disanza A, Thattai M, Scita G, Parton RG, Mayor S., Free PMC Article | 12/22/2018 |
| PICK1 is a cargo-specific endocytic accessory protein required for efficient, activity-dependent AMPAR endocytosis. | PICK1 regulates AMPA receptor endocytosis via direct interactions with AP2 α-appendage and dynamin.
Fiuza M, Rostosky CM, Parkinson GT, Bygrave AM, Halemani N, Baptista M, Milosevic I, Hanley JG., Free PMC Article | 10/7/2017 |
| Our results demonstrate that downregulation of PICK1 elicited by miR-210-3p overexpression activates the TGF-b pathway, which further promotes bone metastasis in PCa, indicating that the miR- 210-3p/PICK1/TGF-b signalling axis plays an important role in PCa bone metastasis. | The TGF-β signalling negative regulator PICK1 represses prostate cancer metastasis to bone.
Dai Y, Ren D, Yang Q, Cui Y, Guo W, Lai Y, Du H, Lin C, Li J, Song L, Peng X., Free PMC Article | 09/23/2017 |
| This study defines a novel mechanism whereby elevated [Ca(2+)] induced by NMDA receptor activation modulates Ago2 and miRNA activity via PICK1. Our work suggests a Ca(2+)-dependent process to regulate miRNA activity in neurons in response to the induction of long-term depression. | The PICK1 Ca(2+) sensor modulates N-methyl-d-aspartate (NMDA) receptor-dependent microRNA-mediated translational repression in neurons.
Rajgor D, Fiuza M, Parkinson GT, Hanley JG., Free PMC Article | 06/24/2017 |
| We propose that PICK1 negatively regulates neoplastic infiltration of astrocytic tumors and that manipulation of PICK1 is an attractive possibility for therapeutic intervention | Protein interacting with C kinase 1 suppresses invasion and anchorage-independent growth of astrocytic tumor cells.
Cockbill LM, Murk K, Love S, Hanley JG., Free PMC Article | 10/1/2016 |
| PICK1 domain ACT links PICK1-associated vesicles to a motility factor, likely myosin, but, contrary to previous reports, PICK1 neither binds nor inhibits Arp2/3 complex. | PICK1 is implicated in organelle motility in an Arp2/3 complex-independent manner.
Madasu Y, Yang C, Boczkowska M, Bethoney KA, Zwolak A, Rebowski G, Svitkina T, Dominguez R., Free PMC Article | 04/23/2016 |
| Unlike accessory domains in other BAR domain proteins, the positioning of the PDZ domains is flexible, enabling PICK1 to perform long-range, dynamic scaffolding of membrane-associated proteins. | Structure of Dimeric and Tetrameric Complexes of the BAR Domain Protein PICK1 Determined by Small-Angle X-Ray Scattering.
Karlsen ML, Thorsen TS, Johner N, Ammendrup-Johnsen I, Erlendsson S, Tian X, Simonsen JB, Høiberg-Nielsen R, Christensen NM, Khelashvili G, Streicher W, Teilum K, Vestergaard B, Weinstein H, Gether U, Arleth L, Madsen KL., Free PMC Article | 04/16/2016 |
| Data indicate three principal binding modes can account for protein interacting with C-kinase 1 (PICK1) PDZ domains binding specificity. | Protein interacting with C-kinase 1 (PICK1) binding promiscuity relies on unconventional PSD-95/discs-large/ZO-1 homology (PDZ) binding modes for nonclass II PDZ ligands.
Erlendsson S, Rathje M, Heidarsson PO, Poulsen FM, Madsen KL, Teilum K, Gether U., Free PMC Article | 01/31/2015 |
| PICK1 promotes Ago2 localization at endosomal compartments in neuronal dendrites and inhibits Ago2 function in translational repression following neuronal stimulation. | PICK1 links Argonaute 2 to endosomes in neuronal dendrites and regulates miRNA activity.
Antoniou A, Baptista M, Carney N, Hanley JG., Free PMC Article | 01/17/2015 |
| These data indicate that Pick1 is involved in regulating the cell-cell junction in epithelial cells. | Pick1 modulates ephrinB1-induced junctional disassembly through an association with ephrinB1.
Son J, Park MS, Park I, Lee HK, Lee SH, Kang B, Min BH, Ryoo J, Lee S, Bae JS, Kim SH, Park MJ, Lee HS. | 09/27/2014 |
| C-terminal domain of ICA69 interacts with PICK1 and acts on trafficking of PICK1-PKCalpha complex and cerebellar plasticity. | C-terminal domain of ICA69 interacts with PICK1 and acts on trafficking of PICK1-PKCα complex and cerebellar plasticity.
Wang Z, Wang YN, Sun CL, Yang D, Su LD, Xie YJ, Zhou L, Wang Y, Shen Y., Free PMC Article | 09/20/2014 |
| Family-based association study failed to observe a statistically significant association for any of the genotyped SNPs in the PICK1 gene and attention-deficit hyperactivity disorder. | Family-based association study of cocaine- and amphetamine-regulated transcript (CARTPT) and protein interaction with C-kinase-1 (PICK1) genes in attention-deficit hyperactivity disorder.
Hsu CD, Tzang RF, Loh el-W, Liou YJ, Hong CJ, Tsai SJ. | 06/8/2013 |