| Dual Role of Mitogen-Activated Protein Kinase 8 Interacting Protein-1 in Inflammasome and Pancreatic beta-Cell Function. | Dual Role of Mitogen-Activated Protein Kinase 8 Interacting Protein-1 in Inflammasome and Pancreatic β-Cell Function.
Saeed R, Mohammed AK, Saleh SE, Aboulwafa MM, Aboshanab KM, Taneera J., Free PMC Article | 03/15/2023 |
| Identification of Key Biomarkers and Immune Infiltration in Sporadic Vestibular Schwannoma Basing Transcriptome-Wide Profiling. | Identification of Key Biomarkers and Immune Infiltration in Sporadic Vestibular Schwannoma Basing Transcriptome-Wide Profiling.
Shi J, Lu D, Gu R, Xu Y, Pan R, Bo F, Zhang Y. | 04/9/2022 |
| Retrospective analysis of the incidence and predictive factors of parametrial involvement in FIGO IB1 cervical cancer. | Retrospective analysis of the incidence and predictive factors of parametrial involvement in FIGO IB1 cervical cancer.
Yang Q, Zhou Q, He X, Cai J, Sun S, Huang B, Wang Z. | 01/1/2022 |
| Sequential dynein effectors regulate axonal autophagosome motility in a maturation-dependent pathway. | Sequential dynein effectors regulate axonal autophagosome motility in a maturation-dependent pathway.
Cason SE, Carman PJ, Van Duyne C, Goldsmith J, Dominguez R, Holzbaur ELF., Free PMC Article | 10/9/2021 |
| extensive biochemical characterization of the KLC:JIP1 interaction, as well as identification of potential KLC1-binding partners, improves the understanding of how this growing family of cargos is recruited to kinesin1 by KLC1. | Characterization of the binding mode of JNK-interacting protein 1 (JIP1) to kinesin-light chain 1 (KLC1).
Nguyen TQ, Aumont-Nicaise M, Andreani J, Velours C, Chenon M, Vilela F, Geneste C, Varela PF, Llinas P, Ménétrey J., Free PMC Article | 03/2/2019 |
| All binary complexes (KLC1:APP, KLC1:JIP1, and APP:JIP1) contain conformations with favorable binding free energies indicating that KLC1 and JIP1 may take part in APP transport in Alzheimer's disease patients. | A molecular dynamics study of the binary complexes of APP, JIP1, and the cargo binding domain of KLC.
Taylor CA, Miller BR 3rd, Shah SS, Parish CA. | 06/24/2017 |
| analysis of the role of JIP1 in APP transport; knockdown of JIP1 did not affect either amyloid precursor protein transport or amyloid-beta peptide production | Loss of c-Jun N-terminal kinase-interacting protein-1 does not affect axonal transport of the amyloid precursor protein or Aβ production.
Vagnoni A, Glennon EB, Perkinton MS, Gray EH, Noble W, Miller CC., Free PMC Article | 06/7/2014 |
| Data show that small GTPase RALA regulates formation of a JIP1 (C-Jun-amino-terminal-interacting protein 1) scaffold complex to propagate JNK signaling toward FOXO4 (forkhead box O transcription factor) in response to reactive oxygen species (ROS). | The small GTPase RALA controls c-Jun N-terminal kinase-mediated FOXO activation by regulation of a JIP1 scaffold complex.
van den Berg MC, van Gogh IJ, Smits AM, van Triest M, Dansen TB, Visscher M, Polderman PE, Vliem MJ, Rehmann H, Burgering BM., Free PMC Article | 11/16/2013 |
| In resected pancreatic cancer, carriers of a minor allele for rs3824872 (MAPK8IP1) were associated with a survival advantage compared with noncarriers with an additional 2-year survival if both minor alleles were present. | Survival is associated with genetic variation in inflammatory pathway genes among patients with resected and unresected pancreatic cancer.
Reid-Lombardo KM, Fridley BL, Bamlet WR, Cunningham JM, Sarr MG, Petersen GM., Free PMC Article | 08/3/2013 |
| Lysine 63-linked ubiquitination modulates mixed lineage kinase-3 interaction with JIP1 scaffold protein in cytokine-induced pancreatic beta cell death | Lysine 63-linked ubiquitination modulates mixed lineage kinase-3 interaction with JIP1 scaffold protein in cytokine-induced pancreatic β cell death.
Humphrey RK, Yu SM, Bellary A, Gonuguntla S, Yebra M, Jhala US., Free PMC Article | 04/6/2013 |
| Data suggest that caspase 3-mediated cleavage of JIP1 scaffold proteins may represent an important mechanism for modulation of JNK signalling during apoptotic cell death. | Disassembly of the JIP1/JNK molecular scaffold by caspase-3-mediated cleavage of JIP1 during apoptosis.
Vaishnav M, MacFarlane M, Dickens M., Free PMC Article | 05/21/2011 |
| This review discusses the role of the JIP1 and the c-Jun NH(2)-terminal kinase pathway in the molecular pathogenesis of Alzheimer's and type 2 diabetes. JIP1 is a key regulator of the JNK pathway in neuronal and beta-cells. | Role of the JNK-interacting protein 1/islet brain 1 in cell degeneration in Alzheimer disease and diabetes.
Beeler N, Riederer BM, Waeber G, Abderrahmani A. | 01/21/2010 |
| The pathological Tau/JIP1 interaction requires phosphorylation of Tau, and Tau competes with the physiological binding of JIP1 to kinesin light chain. | Phosphorylated Tau interacts with c-Jun N-terminal kinase-interacting protein 1 (JIP1) in Alzheimer disease.
Ittner LM, Ke YD, Götz J., Free PMC Article | 01/21/2010 |
| Thyroid cancers are characterized by APP upregulation, increased membrane targeting of the APP ectodomain and significantly increased mRNA levels of the APP scaffold proteins JIP1, ShcA and Fe65. | Evidence for a role of the amyloid precursor protein in thyroid carcinogenesis.
Krause K, Karger S, Sheu SY, Aigner T, Kursawe R, Gimm O, Schmid KW, Dralle H, Fuhrer D. | 01/21/2010 |
| the activity of JIP1-JNK complexes is downregulated by VRK2 in response to interleukin-1beta | Modulation of interleukin-1 transcriptional response by the interaction between VRK2 and the JIP1 scaffold protein.
Blanco S, Sanz-García M, Santos CR, Lazo PA., Free PMC Article | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | Islet-brain1/C-Jun N-terminal kinase interacting protein-1 (IB1/JIP-1) promoter variant is associated with Alzheimer's disease.
Helbecque N, Abderrahamani A, Meylan L, Riederer B, Mooser V, Miklossy J, Delplanque J, Boutin P, Nicod P, Haefliger JA, Cottel D, Amouyel P, Froguel P, Waeber G, Helbecque N, Abderrahamani A, Meylan L, Riederer B, Mooser V, Miklossy J, Delplanque J, Boutin P, Nicod P, Haefliger JA, Cottel D, Amouyel P, Froguel P, Waeber G. | 03/13/2008 |
| the phosphorylation of APP regulates the formation of a pAPP-JIP-1 complex that accumulates in neurites independent of nonphosphorylated APP | Coordinated transport of phosphorylated amyloid-beta precursor protein and c-Jun NH2-terminal kinase-interacting protein-1.
Muresan Z, Muresan V., Free PMC Article | 01/21/2010 |
| Binding of JIP1 and FEZ1 to Kinesin-1 is sufficient to activate the motor for microtubule binding and motility. | Two binding partners cooperate to activate the molecular motor Kinesin-1.
Blasius TL, Cai D, Jih GT, Toret CP, Verhey KJ., Free PMC Article | 01/21/2010 |
| Growth control of prostate cancer cells can be mediated through JNK/c-Jun pathway, but androgen responsiveness can be independent of this pathway; androgen independence in progressive prostate cancer may not occur through activation of this pathway. | JNK interacting protein 1 (JIP-1) protects LNCaP prostate cancer cells from growth arrest and apoptosis mediated by 12-0-tetradecanoylphorbol-13-acetate (TPA).
Ikezoe T, Yang Y, Taguchi H, Koeffler HP., Free PMC Article | 01/21/2010 |
| High IGF II expression was followed by high expression of JIP-1 in testicular neoplasms. | The JNK interacting protein JIP-1 and insulin like growth factor II genes are co-expressed in human embryonic tumours.
Engström W, Rising A, Grip S. | 01/21/2010 |
| JIP-1 protein may regulate kinesin-I-dependent neuronal AbetaPP transport, which controls AbetaPP processing | Amyloid beta protein precursor (AbetaPP), but not AbetaPP-like protein 2, is bridged to the kinesin light chain by the scaffold protein JNK-interacting protein 1.
Matsuda S, Matsuda Y, D'Adamio L. | 01/21/2010 |
| JIP1 and JIP3, have a cross-talk that leads to the regulation of the ASK1-SEK1-JNK signal during glucose deprivation; cross-talk between JIP3 and JIP1 is mediated through SEK1-JNK2 and Akt1. | Cross-talk between JIP3 and JIP1 during glucose deprivation: SEK1-JNK2 and Akt1 act as mediators.
Song JJ, Lee YJ. | 01/21/2010 |
| Promoter variant is associated with Alzheimer's disease. | Islet-brain1/C-Jun N-terminal kinase interacting protein-1 (IB1/JIP-1) promoter variant is associated with Alzheimer's disease.
Helbecque N, Abderrahamani A, Meylan L, Riederer B, Mooser V, Miklossy J, Delplanque J, Boutin P, Nicod P, Haefliger JA, Cottel D, Amouyel P, Froguel P, Waeber G, Helbecque N, Abderrahamani A, Meylan L, Riederer B, Mooser V, Miklossy J, Delplanque J, Boutin P, Nicod P, Haefliger JA, Cottel D, Amouyel P, Froguel P, Waeber G. | 01/21/2010 |
| stability is modulated by intracellular calcium | Calcium- and proteasome-dependent degradation of the JNK scaffold protein islet-brain 1.
Allaman-Pillet N, Størling J, Oberson A, Roduit R, Negri S, Sauser C, Nicod P, Beckmann JS, Schorderet DF, Mandrup-Poulsen T, Bonny C. | 01/21/2010 |
| JIP-1 only facilitated (but is not required for) phosphorylation of Amyloid beta protein precursor but not of the two other family members APLP1 (amyloid precursor-like protein 1) and APLP2 | Amyloid beta protein precursor is phosphorylated by JNK-1 independent of, yet facilitated by, JNK-interacting protein (JIP)-1.
Scheinfeld MH, Ghersi E, Davies P, D'Adamio L. | 01/21/2010 |