| Identification and validation of KIF23 as a hypoxia-regulated lactate metabolism-related oncogene in uterine corpus endometrial carcinoma. | Identification and validation of KIF23 as a hypoxia-regulated lactate metabolism-related oncogene in uterine corpus endometrial carcinoma.
Wang T, Peng X, Liu W, Ji M, Sun J. | 02/29/2024 |
| SIRT7 promotes the proliferation and migration of anaplastic thyroid cancer cells by regulating the desuccinylation of KIF23. | SIRT7 promotes the proliferation and migration of anaplastic thyroid cancer cells by regulating the desuccinylation of KIF23.
Wu Y, Chen W, Miao H, Xu T., Free PMC Article | 02/23/2024 |
| A Therapeutically Targetable TAZ-TEAD2 Pathway Drives the Growth of Hepatocellular Carcinoma via ANLN and KIF23. | A Therapeutically Targetable TAZ-TEAD2 Pathway Drives the Growth of Hepatocellular Carcinoma via ANLN and KIF23.
Saito Y, Yin D, Kubota N, Wang X, Filliol A, Remotti H, Nair A, Fazlollahi L, Hoshida Y, Tabas I, Wangensteen KJ, Schwabe RF., | 10/26/2023 |
| KCNQ1OT1 promotes retinoblastoma progression by targeting miR-339-3p that suppresses KIF23. | KCNQ1OT1 promotes retinoblastoma progression by targeting miR-339-3p that suppresses KIF23.
Tang W, Zhang L, Li J, Guan Y. | 07/3/2023 |
| Kinesin family member 23 knockdown inhibits cell proliferation and epithelial-mesenchymal transition in esophageal carcinoma by inactivating the Wnt/beta-catenin pathway. | Kinesin family member 23 knockdown inhibits cell proliferation and epithelial-mesenchymal transition in esophageal carcinoma by inactivating the Wnt/β-catenin pathway.
Xu Q, Li X, Li Y, Yu J, Yang A. | 05/17/2023 |
| KIF23, under regulation by androgen receptor, contributes to nasopharyngeal carcinoma deterioration by activating the Wnt/beta-catenin signaling pathway. | KIF23, under regulation by androgen receptor, contributes to nasopharyngeal carcinoma deterioration by activating the Wnt/β-catenin signaling pathway.
Xu H, Liu J, Zhang Y, Zhou Y, Zhang L, Kang J, Ning C, He Z, Song S. | 04/10/2023 |
| [MicroRNA 424-5p promotes the sensitivity of hepatocellular carcinoma cells to sorafenib by targeting Kinesin family member 23]. | [MicroRNA 424-5p promotes the sensitivity of hepatocellular carcinoma cells to sorafenib by targeting Kinesin family member 23].
Liu XL, Sun CF, Yuan Y, Sheng YJ, Deng CL. | 02/11/2023 |
| Kinesin family member 23, regulated by FOXM1, promotes triple negative breast cancer progression via activating Wnt/beta-catenin pathway. | Kinesin family member 23, regulated by FOXM1, promotes triple negative breast cancer progression via activating Wnt/β-catenin pathway.
Li Z, Yang HY, Zhang XL, Zhang X, Huang YZ, Dai XY, Shi L, Zhou GR, Wei JF, Ding Q., Free PMC Article | 05/14/2022 |
| Inhibition of KIF23 Alleviates IPAH by Targeting Pyroptosis and Proliferation of PASMCs. | Inhibition of KIF23 Alleviates IPAH by Targeting Pyroptosis and Proliferation of PASMCs.
Wu Z, Zhou G, Wang H, Yao P., Free PMC Article | 04/30/2022 |
| DEP domain containing 1B (DEPDC1B) exerts the tumor promoter in hepatocellular carcinoma through activating p53 signaling pathway via kinesin family member 23 (KIF23). | DEP domain containing 1B (DEPDC1B) exerts the tumor promoter in hepatocellular carcinoma through activating p53 signaling pathway via kinesin family member 23 (KIF23).
Shen E, Zhang J, Lu Y., Free PMC Article | 02/26/2022 |
| Kinesin family member 23 (KIF23) contributes to the progression of bladder cancer cells in vitro and in vivo. | Kinesin family member 23 (KIF23) contributes to the progression of bladder cancer cells in vitro and in vivo.
Yao DW, Song Q, He XZ. | 08/21/2021 |
| MiR-17-5p downregulation alleviates apoptosis and fibrosis in high glucose-induced human mesangial cells through inactivation of Wnt/beta-catenin signaling by targeting KIF23. | MiR-17-5p downregulation alleviates apoptosis and fibrosis in high glucose-induced human mesangial cells through inactivation of Wnt/β-catenin signaling by targeting KIF23.
Chen X, Gu L, Cheng X, Xing J, Zhang M. | 07/10/2021 |
| Differential tissue specific expression of Kif23 alternative transcripts in mice with the human mutation causing congenital dyserythropoietic anemia type III. | Differential tissue specific expression of Kif23 alternative transcripts in mice with the human mutation causing congenital dyserythropoietic anemia type III.
Vikberg AL, Malla S, Golovleva I. | 05/29/2021 |
| KIF23 activated Wnt/beta-catenin signaling pathway through direct interaction with Amer1 in gastric cancer. | KIF23 activated Wnt/β-catenin signaling pathway through direct interaction with Amer1 in gastric cancer.
Liu Y, Chen H, Dong P, Xie G, Zhou Y, Ma Y, Yuan X, Yang J, Han L, Chen L, Shen L., Free PMC Article | 02/27/2021 |
| miR-424/503 cluster is silenced by DNA hypermethylation, which promotes the expression of KIF23, thereby regulating the proliferation and migration of ovarian cancer cells. | Methylation-mediated repression of MiR-424/503 cluster promotes proliferation and migration of ovarian cancer cells through targeting the hub gene KIF23.
Li T, Li Y, Gan Y, Tian R, Wu Q, Shu G, Yin G., Free PMC Article | 08/22/2020 |
| Study revealed that PP1beta-MYPT1 phosphatase regulates microtubule dynamics in late cytokinesis and de-phosphorylates the kinesin component MKLP1/KIF23 of the centralspindlin complex. This de-phosphorylation antagonizes Aurora B kinase to modify the functions and interactions of centralspindlin in late cytokinesis. | The midbody interactome reveals unexpected roles for PP1 phosphatases in cytokinesis.
Capalbo L, Bassi ZI, Geymonat M, Todesca S, Copoiu L, Enright AJ, Callaini G, Riparbelli MG, Yu L, Choudhary JS, Ferrero E, Wheatley S, Douglas ME, Mishima M, D'Avino PP., Free PMC Article | 02/15/2020 |
| MiR-424 functions as a tumor-suppressor, inhibiting cell metastasis and epithelial mesenchymal transformation by targeting KIF23 in gliomas. | MicroRNA-424 inhibits cell migration, invasion and epithelial-mesenchymal transition in human glioma by targeting KIF23 and functions as a novel prognostic predictor.
Zhao C, Wang XB, Zhang YH, Zhou YM, Yin Q, Yao WC. | 12/7/2019 |
| Data show that p120-catenin interacts with kinesin family member 23 (MKLP1) to regulate focused rhoA GTP-binding protein (RhoA) activity during cytokinesis. | p120-catenin prevents multinucleation through control of MKLP1-dependent RhoA activity during cytokinesis.
van de Ven RA, de Groot JS, Park D, van Domselaar R, de Jong D, Szuhai K, van der Wall E, Rueda OM, Ali HR, Caldas C, van Diest PJ, Hetzer MW, Sahai E, Derksen PW., Free PMC Article | 09/29/2018 |
| KIF23 was found highly expressed in NSCLC | [Expression of KIF23 and Its Prognostic Role in Non-small Cell Lung Cancer:
Analysis Based on the Data-mining of Oncomine].
Ye L, Li H, Zhang F, Lv T, Liu H, Song Y., Free PMC Article | 07/28/2018 |
| Results show the mitotic regulators KIF23 and MIS18BP1 to be co-modified by SUMO and ubiquitin on inhibition of the proteasome and subsequently identified as novel RNF4 targets. | Converging Small Ubiquitin-like Modifier (SUMO) and Ubiquitin Signaling: Improved Methodology Identifies Co-modified Target Proteins.
Cuijpers SAG, Willemstein E, Vertegaal ACO., Free PMC Article | 07/21/2018 |
| Authors found that KIF23 was regulated by TCF-4 at transcriptionally level. Therefore, this evidence indicates KIF23 over-expression is associated with glioma malignancy and conferred a worse survival time in glioma. | KIF23 is an independent prognostic biomarker in glioma, transcriptionally regulated by TCF-4.
Sun L, Zhang C, Yang Z, Wu Y, Wang H, Bao Z, Jiang T., Free PMC Article | 12/30/2017 |
| Data show high level of KIF23 expression in the majority of primary and metastatic lung cancer tissues or cell lines and associates with poor survival. | Overexpression of KIF23 predicts clinical outcome in primary lung cancer patients.
Kato T, Wada H, Patel P, Hu HP, Lee D, Ujiie H, Hirohashi K, Nakajima T, Sato M, Kaji M, Kaga K, Matsui Y, Tsao MS, Yasufuku K. | 11/19/2016 |
| In this study we show for the first time that KIF23 V1 and V2 have different localizations in hepatocellular carcinoma cells | Evaluation of KIF23 variant 1 expression and relevance as a novel prognostic factor in patients with hepatocellular carcinoma.
Sun X, Jin Z, Song X, Wang J, Li Y, Qian X, zhang Y, Yin Y., Free PMC Article | 09/3/2016 |
| Phosphorylation of S716 NDR/LATS, present only in the longest Kif23 isoform, is required for phosphorylation at S814, revealing phosphorylation at these two sites, and differential regulation of Kif23-14-3-3 interaction for the two Kif23 isoforms. | Binding of Kif23-iso1/CHO1 to 14-3-3 is regulated by sequential phosphorylations at two LATS kinase consensus sites.
Fesquet D, De Bettignies G, Bellis M, Espeut J, Devault A., Free PMC Article | 11/28/2015 |
| TRAF6 mediates ubiquitination of the midbody ring localized protein KIF23/MKLP1. | TRAF6 mediates ubiquitination of KIF23/MKLP1 and is required for midbody ring degradation by selective autophagy.
Isakson P, Lystad AH, Breen K, Koster G, Stenmark H, Simonsen A. | 09/6/2014 |