| SCARB2 associates with tumor-infiltrating neutrophils and predicts poor prognosis in breast cancer. | SCARB2 associates with tumor-infiltrating neutrophils and predicts poor prognosis in breast cancer.
Zhang D, Fang J, Shan J, Xu L, Wu Y, Lu B, Zhang X, Wang C, Sun P, Wang Q. | 08/1/2024 |
| Enterovirus A71 does not meet the uncoating receptor SCARB2 at the cell surface. | Enterovirus A71 does not meet the uncoating receptor SCARB2 at the cell surface.
Nishimura Y, Sato K, Koyanagi Y, Wakita T, Muramatsu M, Shimizu H, Bergelson JM, Arita M., Free PMC Article | 02/29/2024 |
| Lysosomal membrane proteins LAMP1 and LIMP2 are segregated in the Golgi apparatus independently of their clathrin adaptor binding motif. | Lysosomal membrane proteins LAMP1 and LIMP2 are segregated in the Golgi apparatus independently of their clathrin adaptor binding motif.
Ecard J, Lian YL, Divoux S, Gouveia Z, Vigne E, Perez F, Boncompain G., Free PMC Article | 02/6/2024 |
| SCARB2 drives hepatocellular carcinoma tumor initiating cells via enhanced MYC transcriptional activity. | SCARB2 drives hepatocellular carcinoma tumor initiating cells via enhanced MYC transcriptional activity.
Wang F, Gao Y, Xue S, Zhao L, Jiang H, Zhang T, Li Y, Zhao C, Wu F, Siqin T, Liu Y, Wu J, Yan Y, Yuan J, Jiang JD, Li K., Free PMC Article | 09/28/2023 |
| Knockdown LIMP2 inhibits colorectal cancer cells migration, invasion, and metastasis. | Knockdown LIMP2 inhibits colorectal cancer cells migration, invasion, and metastasis.
Tian Y, Liang L, Chen J, Liu J, Su Y, Shi M, Li W, Zhang J, Feng Y, He L, Liu H, Yang X. | 09/11/2023 |
| The effects of SCARB2 and SELPLG gene polymorphisms on EV71 infection in hand, foot and mouth disease. | The effects of SCARB2 and SELPLG gene polymorphisms on EV71 infection in hand, foot and mouth disease.
Duan FY, Du ZQ, Wang Y, Luo L, Du LJ, Jiang H, Ma Y, Yang YL., Free PMC Article | 09/8/2023 |
| Human SCARB2 Acts as a Cellular Associator for Helping Coxsackieviruses A10 Infection. | Human SCARB2 Acts as a Cellular Associator for Helping Coxsackieviruses A10 Infection.
Yu SL, Chung NH, Lin YC, Liao YA, Chen YC, Chow YH., Free PMC Article | 08/25/2023 |
| LIMP-2 enhances cancer stem-like cell properties by promoting autophagy-induced GSK3beta degradation in head and neck squamous cell carcinoma. | LIMP-2 enhances cancer stem-like cell properties by promoting autophagy-induced GSK3β degradation in head and neck squamous cell carcinoma.
Liu Y, Li S, Wang S, Yang Q, Wu Z, Zhang M, Chen L, Sun Z., Free PMC Article | 06/21/2023 |
| LIMP2 gene, evolutionarily conserved regulation by TFE3, relieves lysosomal stress induced by cholesterol. | LIMP2 gene, evolutionarily conserved regulation by TFE3, relieves lysosomal stress induced by cholesterol.
Guo H, Zhu Y, Li J, Zhang Q, Chi Y. | 10/15/2022 |
| Relationship between polymorphism of receptor SCARB2 gene and clinical severity of enterovirus-71 associated hand-foot-mouth disease. | Relationship between polymorphism of receptor SCARB2 gene and clinical severity of enterovirus-71 associated hand-foot-mouth disease.
Wang X, Liu H, Li Y, Su R, Liu Y, Qiao K., Free PMC Article | 02/26/2022 |
| Enterovirus A71 Induces Neurological Diseases and Dynamic Variants in Oral Infection of Human SCARB2-Transgenic Weaned Mice. | Enterovirus A71 Induces Neurological Diseases and Dynamic Variants in Oral Infection of Human SCARB2-Transgenic Weaned Mice.
Lin JY, Weng KF, Chang CK, Gong YN, Huang GJ, Lee HL, Chen YC, Huang CC, Lu JY, Huang PN, Chiang HJ, Chen CM, Shih SR., Free PMC Article | 12/25/2021 |
| A novel homozygous splice-site mutation in SCARB2 is associated with progressive myoclonic epilepsy with renal failure. | A novel homozygous splice-site mutation in SCARB2 is associated with progressive myoclonic epilepsy with renal failure.
Yari A, Ali-Nejad RM, Saleh-Gohari N. | 12/11/2021 |
| Class B Scavenger Receptors BI and BII Protect against LPS-Induced Acute Lung Injury in Mice by Mediating LPS. | Class B Scavenger Receptors BI and BII Protect against LPS-Induced Acute Lung Injury in Mice by Mediating LPS.
Baranova IN, Bocharov AV, Vishnyakova TG, Chen Z, Birukova AA, Ke Y, Hu X, Yuen PST, Star RA, Birukov KG, Patterson AP, Eggerman TL., Free PMC Article | 11/13/2021 |
| Fibroblasts from idiopathic Parkinson's disease exhibit deficiency of lysosomal glucocerebrosidase activity associated with reduced levels of the trafficking receptor LIMP2. | Fibroblasts from idiopathic Parkinson's disease exhibit deficiency of lysosomal glucocerebrosidase activity associated with reduced levels of the trafficking receptor LIMP2.
Thomas R, Moloney EB, Macbain ZK, Hallett PJ, Isacson O., Free PMC Article | 09/4/2021 |
| Genetics variants and expression of the SCARB2 gene in the pathogenesis of Parkinson's disease in Russia. | Genetics variants and expression of the SCARB2 gene in the pathogenesis of Parkinson's disease in Russia.
Usenko TS, Bezrukova AI, Bogdanova DA, Kopytova AE, Senkevich KA, Gracheva EV, Timofeeva AA, Miliukhina IV, Zakharova EY, Emelyanov AK, Pchelina SN. | 05/8/2021 |
| GCase and LIMP2 Abnormalities in the Liver of Niemann Pick Type C Mice. | GCase and LIMP2 Abnormalities in the Liver of Niemann Pick Type C Mice.
van der Lienden MJC, Aten J, Marques ARA, Waas ISE, Larsen PWB, Claessen N, van der Wel NN, Ottenhoff R, van Eijk M, Aerts JMFG., Free PMC Article | 04/24/2021 |
| Our findings show disease-specific deregulation of TFEB and SCARB2 expression affecting alternative promoter usage and alternative splicing in Lewy body diseases | Glucocerebrosidase regulators SCARB2 and TFEB are up-regulated in Lewy body disease brain.
Pérez-Roca L, Prada-Dacasa P, Segú-Vergés C, Gámez-Valero A, Serrano-Muñoz MA, Santos C, Beyer K. | 12/28/2019 |
| Study provides multiple lines of evidence that LIMP-2 participates in lipid transport from lysosomes by transporting cholesterol (and possibly also other lipid species) through its luminal cavity to the lysosomal membrane and later to lipid droplets. Data indicate that LIMP-2 operates in parallel with Niemann Pick (NPC)-proteins, mediating a slower mode of lysosomal cholesterol export. | Lysosomal integral membrane protein-2 (LIMP-2/SCARB2) is involved in lysosomal cholesterol export.
Heybrock S, Kanerva K, Meng Y, Ing C, Liang A, Xiong ZJ, Weng X, Ah Kim Y, Collins R, Trimble W, Pomès R, Privé GG, Annaert W, Schwake M, Heeren J, Lüllmann-Rauch R, Grinstein S, Ikonen E, Saftig P, Neculai D., Free PMC Article | 12/14/2019 |
| Results provide evidence that SCARB2 is essential for the virulence of Enterovirus &1. | Amino Acid Variation at VP1-145 of Enterovirus 71 Determines Attachment Receptor Usage and Neurovirulence in Human Scavenger Receptor B2 Transgenic Mice.
Kobayashi K, Sudaka Y, Takashino A, Imura A, Fujii K, Koike S., Free PMC Article | 09/7/2019 |
| Here, we report the EV71-SCARB2 complex structure determined at 3.4 A resolution using cryo-electron microscopy. This reveals that SCARB2 binds EV71 on the southern rim of the canyon, rather than across the canyon, as predicted. | Unexpected mode of engagement between enterovirus 71 and its receptor SCARB2.
Zhou D, Zhao Y, Kotecha A, Fry EE, Kelly JT, Wang X, Rao Z, Rowlands DJ, Ren J, Stuart DI. | 06/8/2019 |
| SCARB2 polymorphisms (rs6824953 and rs11097262) were associated with susceptibility to EV71 infection (OR 1.60, 95% CI 1.07-2.39; and OR 1.64, 95% CI 1.09-2.47, respectively). | Polymorphisms in enterovirus 71 receptors associated with susceptibility and clinical severity.
Yen TY, Shih WL, Huang YC, Lee JT, Huang LM, Chang LY., Free PMC Article | 04/27/2019 |
| Glycosylation, ubiquitination and palmitoylation are involved in regulating CD36 stability, while phosphorylation at extracellular sites affect the rate of fatty acid uptake. In addition, CD36 modification by O-linked N-acetylglucosamine may regulate the translocation of CD36 from endosomes to the cell surface. | Post-translational modifications of CD36 (SR-B2): Implications for regulation of myocellular fatty acid uptake.
Luiken JJ, Chanda D, Nabben M, Neumann D, Glatz JF. | 03/30/2019 |
| Crystal structure of a LIMP-2 luminal domain dimer with bound cholesterol and phosphatidylcholine is described. Binding of these lipids alters LIMP-2 from functioning as a glucocerebrosidase-binding monomer toward a dimeric state that preferentially binds anionic phosphatidylserine over neutral phosphatidylcholine. | Lysosomal integral membrane protein-2 as a phospholipid receptor revealed by biophysical and cellular studies.
Conrad KS, Cheng TW, Ysselstein D, Heybrock S, Hoth LR, Chrunyk BA, Am Ende CW, Krainc D, Schwake M, Saftig P, Liu S, Qiu X, Ehlers MD., Free PMC Article | 10/6/2018 |
| The binding of a monoclonal antibody to the apical region of SCARB2 blocks EV71 infection. | The binding of a monoclonal antibody to the apical region of SCARB2 blocks EV71 infection.
Zhang X, Yang P, Wang N, Zhang J, Li J, Guo H, Yin X, Rao Z, Wang X, Zhang L., Free PMC Article | 08/26/2017 |
| The findings identify SR-BII as a functional SAA receptor that mediates SAA uptake and contributes to its proinflammatory signaling via the MAPK-mediated signaling pathways. | Human SR-BII mediates SAA uptake and contributes to SAA pro-inflammatory signaling in vitro and in vivo.
Baranova IN, Souza ACP, Bocharov AV, Vishnyakova TG, Hu X, Vaisman BL, Amar MJ, Chen Z, Remaley AT, Patterson AP, Yuen PST, Star RA, Eggerman TL., Free PMC Article | 04/29/2017 |