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    BAG3 BAG cochaperone 3 [ Homo sapiens (human) ]

    Gene ID: 9531, updated on 7-Apr-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    BAG3 regulates the specificity of the recognition of specific MAPT species by NBR1 and SQSTM1.

    BAG3 regulates the specificity of the recognition of specific MAPT species by NBR1 and SQSTM1.
    Lin H, Sandkuhler S, Dunlea C, Rodwell-Bullock J, King DH, Johnson GVW.,

    03/11/2024
    Distal hereditary motor neuronopathy as a new phenotype associated with variants in BAG3.

    Distal hereditary motor neuronopathy as a new phenotype associated with variants in BAG3.
    de Fuenmayor-Fernández de la Hoz CP, Lupo V, Bermejo-Guerrero L, Martín-Jiménez P, Hernández-Laín A, Olivé M, Gallardo E, Esteban-Pérez J, Espinós C, Domínguez-González C.

    02/8/2024
    Dysregulated Autophagy and Sarcomere Dysfunction in Patients With Heart Failure With Co-Occurrence of P63A and P380S BAG3 Variants.

    Dysregulated Autophagy and Sarcomere Dysfunction in Patients With Heart Failure With Co-Occurrence of P63A and P380S BAG3 Variants.
    Martin TG, Pak H, Gerhard GS, Merali S, Merali C, Lemster B, Dubey P, McTiernan CF, Bristow MR, Feldman AM, Kirk JA., Free PMC Article

    01/3/2024
    BAG3: Nature's Quintessential Multi-Functional Protein Functions as a Ubiquitous Intra-Cellular Glue.

    BAG3: Nature's Quintessential Multi-Functional Protein Functions as a Ubiquitous Intra-Cellular Glue.
    Brenner CM, Choudhary M, McCormick MG, Cheung D, Landesberg GP, Wang JF, Song J, Martin TG, Cheung JY, Qu HQ, Hakonarson H, Feldman AM., Free PMC Article

    04/12/2023
    MiR-135a-5p suppresses breast cancer cell proliferation, migration, and invasion by regulating BAG3.

    MiR-135a-5p suppresses breast cancer cell proliferation, migration, and invasion by regulating BAG3.
    Zhang H, Wang M, Lang Z, Liu H, Liu J, Ma L., Free PMC Article

    10/22/2022
    Unraveling the mystery: How bad is BAG3 in hematological malignancies?

    Unraveling the mystery: How bad is BAG3 in hematological malignancies?
    Liu Q, Liu J, Huang X.

    10/15/2022
    Therapeutic induction of Bcl2-associated athanogene 3-mediated autophagy in idiopathic pulmonary fibrosis.

    Therapeutic induction of Bcl2-associated athanogene 3-mediated autophagy in idiopathic pulmonary fibrosis.
    Chillappagari S, Schwarz J, Kesireddy V, Knoell J, Korfei M, Hoetzenecker K, Schmitz ML, Behl C, Bellusci S, Guenther A, Mahavadi P., Free PMC Article

    07/30/2022
    BAG3 protects chondrocytes against lumbar facet joint osteoarthritis by regulating autophagy and apoptosis.

    BAG3 protects chondrocytes against lumbar facet joint osteoarthritis by regulating autophagy and apoptosis.
    Lu X, Zhang J, Xue P, Wang Q, Wang X, Sun Y, Cui Z.

    07/9/2022
    BAG3 Regulation of RAB35 Mediates the Endosomal Sorting Complexes Required for Transport/Endolysosome Pathway and Tau Clearance.

    BAG3 Regulation of RAB35 Mediates the Endosomal Sorting Complexes Required for Transport/Endolysosome Pathway and Tau Clearance.
    Lin H, Tang M, Ji C, Girardi P, Cvetojevic G, Chen D, Koren SA, Johnson GVW., Free PMC Article

    06/25/2022
    Metformin rescues muscle function in BAG3 myofibrillar myopathy models.

    Metformin rescues muscle function in BAG3 myofibrillar myopathy models.
    Ruparelia AA, McKaige EA, Williams C, Schulze KE, Fuchs M, Oorschot V, Lacene E, Meregalli M, Lee C, Serrano RJ, Baxter EC, Monro K, Torrente Y, Ramm G, Stojkovic T, Lavoie JN, Bryson-Richardson RJ., Free PMC Article

    04/16/2022
    Lutein induces an inhibitory effect on the malignant progression of pancreatic adenocarcinoma by targeting BAG3/cholesterol homeostasis.

    Lutein induces an inhibitory effect on the malignant progression of pancreatic adenocarcinoma by targeting BAG3/cholesterol homeostasis.
    Han L, Song X.

    04/2/2022
    BAG3 induces alpha-SMA expression in human fibroblasts and its over-expression correlates with poorer survival in fibrotic cancer patients.

    BAG3 induces α-SMA expression in human fibroblasts and its over-expression correlates with poorer survival in fibrotic cancer patients.
    De Marco M, Del Papa N, Reppucci F, Iorio V, Basile A, Falco A, Iaccarino R, Brongo S, De Caro F, Capunzo M, Turco MC, Rosati A, Marzullo L., Free PMC Article

    03/19/2022
    BAG3 is a negative regulator of ciliogenesis in glioblastoma and triple-negative breast cancer cells.

    BAG3 is a negative regulator of ciliogenesis in glioblastoma and triple-negative breast cancer cells.
    Linder B, Klein C, Hoffmann ME, Bonn F, Dikic I, Kögel D.

    03/19/2022
    Neurodegeneration and Astrogliosis in the Human CA1 Hippocampal Subfield Are Related to hsp90ab1 and bag3 in Alzheimer's Disease.

    Neurodegeneration and Astrogliosis in the Human CA1 Hippocampal Subfield Are Related to hsp90ab1 and bag3 in Alzheimer's Disease.
    Gonzalez-Rodriguez M, Villar-Conde S, Astillero-Lopez V, Villanueva-Anguita P, Ubeda-Banon I, Flores-Cuadrado A, Martinez-Marcos A, Saiz-Sanchez D., Free PMC Article

    02/5/2022
    PKM2 compensates for proteasome dysfunction by mediating the formation of the CHIP-HSP70-BAG3 complex and the aggregation of ubiquitinated proteins.

    PKM2 compensates for proteasome dysfunction by mediating the formation of the CHIP-HSP70-BAG3 complex and the aggregation of ubiquitinated proteins.
    Zhang C, Tang Q, Xia H, Xu H, Bi F.

    01/15/2022
    An emerging role for BAG3 in gynaecological malignancies.

    An emerging role for BAG3 in gynaecological malignancies.
    De Marco M, Falco A, Iaccarino R, Raffone A, Mollo A, Guida M, Rosati A, Chetta M, Genovese G, De Caro F, Capunzo M, Turco MC, Uversky VN, Marzullo L., Free PMC Article

    12/18/2021
    CDK1-Mediated Phosphorylation of BAG3 Promotes Mitotic Cell Shape Remodeling and the Molecular Assembly of Mitotic p62 Bodies.

    CDK1-Mediated Phosphorylation of BAG3 Promotes Mitotic Cell Shape Remodeling and the Molecular Assembly of Mitotic p62 Bodies.
    Luthold C, Lambert H, Guilbert SM, Rodrigue MA, Fuchs M, Varlet AA, Fradet-Turcotte A, Lavoie JN., Free PMC Article

    12/11/2021
    BAG3 epigenetically regulates GALNT10 expression via WDR5 and facilitates the stem cell-like properties of platin-resistant ovarian cancer cells.

    BAG3 epigenetically regulates GALNT10 expression via WDR5 and facilitates the stem cell-like properties of platin-resistant ovarian cancer cells.
    Zhao FY, Zhang Q, Wang JM, Jiang JY, Huyan LY, Liu BQ, Yan J, Li C, Wang HQ.

    12/4/2021
    Advances in the role and mechanism of BAG3 in dilated cardiomyopathy.

    Advances in the role and mechanism of BAG3 in dilated cardiomyopathy.
    Liu L, Sun K, Zhang X, Tang Y, Xu D.

    10/30/2021
    Novel BAG3 Variants in African American Patients With Cardiomyopathy: Reduced beta-Adrenergic Responsiveness in Excitation-Contraction.

    Novel BAG3 Variants in African American Patients With Cardiomyopathy: Reduced β-Adrenergic Responsiveness in Excitation-Contraction.
    Feldman AM, Gordon J, Wang J, Song J, Zhang XQ, Myers VD, Tomar D, Gerhard GS, Khalili K, Cheung JY., Free PMC Article

    09/25/2021
    BAG3 and BAG6 differentially affect the dynamics of stress granules by targeting distinct subsets of defective polypeptides released from ribosomes.

    BAG3 and BAG6 differentially affect the dynamics of stress granules by targeting distinct subsets of defective polypeptides released from ribosomes.
    Mediani L, Galli V, Carrà AD, Bigi I, Vinet J, Ganassi M, Antoniani F, Tiago T, Cimino M, Mateju D, Cereda C, Pansarasa O, Alberti S, Mandrioli J, Carra S., Free PMC Article

    09/25/2021
    BAG3 interacts with p53 in endometrial carcinoma.

    BAG3 interacts with p53 in endometrial carcinoma.
    De Marco M, Troisi J, Giugliano L, Rosati A, D'Antonio A, Iaccarino R, Capunzo M, Salzano F, Martinelli R, Cavallo P, Guida M, Marzullo L.

    08/14/2021
    BAG3 expression and sarcomere localization in the human heart are linked to HSF-1 and are differentially affected by sex and disease.

    BAG3 expression and sarcomere localization in the human heart are linked to HSF-1 and are differentially affected by sex and disease.
    Martin TG, Tawfik S, Moravec CS, Pak TR, Kirk JA., Free PMC Article

    07/24/2021
    Overexpression of human BAG3(P209L) in mice causes restrictive cardiomyopathy.

    Overexpression of human BAG3(P209L) in mice causes restrictive cardiomyopathy.
    Kimura K, Ooms A, Graf-Riesen K, Kuppusamy M, Unger A, Schuld J, Daerr J, Lother A, Geisen C, Hein L, Takahashi S, Li G, Röll W, Bloch W, van der Ven PFM, Linke WA, Wu SM, Huesgen PF, Höhfeld J, Fürst DO, Fleischmann BK, Hesse M., Free PMC Article

    07/3/2021
    BAG3 Proteomic Signature under Proteostasis Stress.

    BAG3 Proteomic Signature under Proteostasis Stress.
    Hiebel C, Stürner E, Hoffmeister M, Tascher G, Schwarz M, Nagel H, Behrends C, Münch C, Behl C., Free PMC Article

    06/19/2021
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