| Recruitment of BAG2 to DNAJ-PKAc scaffolds promotes cell survival and resistance to drug-induced apoptosis in fibrolamellar carcinoma. | Recruitment of BAG2 to DNAJ-PKAc scaffolds promotes cell survival and resistance to drug-induced apoptosis in fibrolamellar carcinoma.
Lauer SM, Omar MH, Golkowski MG, Kenerson HL, Lee KS, Pascual BC, Lim HC, Forbush K, Smith FD, Gordan JD, Ong SE, Yeung RS, Scott JD., Free PMC Article | 03/4/2024 |
| BAG2 drives chemoresistance of breast cancer by exacerbating mutant p53 aggregate. | BAG2 drives chemoresistance of breast cancer by exacerbating mutant p53 aggregate.
Huang X, Shi D, Zou X, Wu X, Huang S, Kong L, Yang M, Xiao Y, Chen B, Chen X, Ouyang Y, Song L, Jian Y, Lin C., Free PMC Article | 01/14/2023 |
| BAG2 prevents Tau hyperphosphorylation and increases p62/SQSTM1 in cell models of neurodegeneration. | BAG2 prevents Tau hyperphosphorylation and increases p62/SQSTM1 in cell models of neurodegeneration.
Lima RS, Carrettiero DC, Ferrari MFR. | 07/30/2022 |
| c-MYC-USP49-BAG2 axis promotes proliferation and chemoresistance of colorectal cancer cells in vitro. | c-MYC-USP49-BAG2 axis promotes proliferation and chemoresistance of colorectal cancer cells in vitro.
Tu R, Kang W, Kang Y, Chen Z, Zhang P, Xiong X, Ma J, Du RL, Zhang C. | 05/7/2022 |
| Helicobacter pylori Targets in AGS Human Gastric Adenocarcinoma: In Situ Proteomic Profiling and Systematic Analysis. | Helicobacter pylori Targets in AGS Human Gastric Adenocarcinoma: In Situ Proteomic Profiling and Systematic Analysis.
Yang JS, Kang CY, Su CH, Chen CJ, Chiu YJ, Hsu YM. | 01/15/2022 |
| Bcl-2 Associated Athanogene 2 (BAG2) is Associated With Progression and Prognosis of Hepatocellular Carcinoma: A Bioinformatics-Based Analysis. | Bcl-2 Associated Athanogene 2 (BAG2) is Associated With Progression and Prognosis of Hepatocellular Carcinoma: A Bioinformatics-Based Analysis.
Zhang X, Zhang J, Liu Y, Li J, Tan J, Song Z., Free PMC Article | 12/25/2021 |
| Identification of BAG2 and Cathepsin D as Plasma Biomarkers for Parkinson's Disease. | Identification of BAG2 and Cathepsin D as Plasma Biomarkers for Parkinson's Disease.
Kang J, Kim JW, Heo H, Lee J, Park KY, Yoon JH, Chang J., Free PMC Article | 12/11/2021 |
| LOXL1 confers antiapoptosis and promotes gliomagenesis through stabilizing BAG2. | LOXL1 confers antiapoptosis and promotes gliomagenesis through stabilizing BAG2.
Yu H, Ding J, Zhu H, Jing Y, Zhou H, Tian H, Tang K, Wang G, Wang X., Free PMC Article | 11/22/2021 |
| High-regulated BAG2 is related to poor prognosis and could promote proliferation, invasion and migration of oral squamous cell carcinomas | Over-expression of Bcl2-associated athanogene 2 in oral cancer promotes cellular proliferation and is associated with poor prognosis.
Liu YS, Wei B. | 12/21/2019 |
| the nucleotide exchange factor (NEF) Bag2 stimulates SV40 release from Hsc70, thereby enabling successful virus arrival at the cytosol, which leads to infection. Hsp105, another NEF of Hsc70, displays a function overlapping that of Bag2, underscoring the importance of this release reaction. | Bag2 Is a Component of a Cytosolic Extraction Machinery That Promotes Membrane Penetration of a Nonenveloped Virus.
Dupzyk A, Tsai B., Free PMC Article | 07/28/2018 |
| A comprehensive review of the structure, functions, and protein interactions of BAG2 | BAG2 structure, function and involvement in disease.
Qin L, Guo J, Zheng Q, Zhang H., Free PMC Article | 07/15/2017 |
| Data show that BAG2 Inhibits CHIP-Mediated HSP72 ubiquitination in aged cells. | BAG2 Interferes with CHIP-Mediated Ubiquitination of HSP72.
Schönbühler B, Schmitt V, Huesmann H, Kern A, Gamerdinger M, Behl C., Free PMC Article | 04/22/2017 |
| repression of BAG2 expression or BAG2 activity by cold-sensitive pathways, as modeled in undifferentiated and differentiated cells, respectively, may be a causal factor in the accumulation of cytotoxic hyperphosphorylated tau protein. | The Co-chaperone BAG2 Mediates Cold-Induced Accumulation of Phosphorylated Tau in SH-SY5Y Cells.
de Paula CA, Santiago FE, de Oliveira AS, Oliveira FA, Almeida MC, Carrettiero DC. | 02/18/2017 |
| NF-kappaB-mediated modulation of BAG2 expression regulates the shift between the neurotrophic and neurotoxic effects of Abeta1-42. | BAG2 Is Repressed by NF-κB Signaling, and Its Overexpression Is Sufficient to Shift Aβ1-42 from Neurotrophic to Neurotoxic in Undifferentiated SH-SY5Y Neuroblastoma.
Santiago FE, Almeida MC, Carrettiero DC. | 06/28/2016 |
| Thus, BAG2 promotes mutant p53 accumulation and gain-of-function in tumor growth, metastasis and chemoresistance. | BAG2 promotes tumorigenesis through enhancing mutant p53 protein levels and function.
Yue X, Zhao Y, Liu J, Zhang C, Yu H, Wang J, Zheng T, Liu L, Li J, Feng Z, Hu W., Free PMC Article | 05/21/2016 |
| This study showed that BAG2 (Bcl-2 associated athanogene family protein 2) and BAG5 (Bcl-2-associated athanogene family protein 5) stabilise pathogenic ataxin3-80Q by inhibiting its ubiquitination | The BAG2 and BAG5 proteins inhibit the ubiquitination of pathogenic ataxin3-80Q.
Che XQ, Tang BS, Wang HF, Yan XX, Jiang H, Shen L, Xu Q, Wang GH, Zhang HN, Wang CY, Guo JF. | 03/12/2016 |
| we measured the binding of human Hsp72 (HSPA1A) to BAG1, BAG2, BAG3, and the unrelated NEF Hsp105. These studies revealed a clear hierarchy of affinities: BAG3 > BAG1 > Hsp105 >> BAG2. | Binding of human nucleotide exchange factors to heat shock protein 70 (Hsp70) generates functionally distinct complexes in vitro.
Rauch JN, Gestwicki JE., Free PMC Article | 03/22/2014 |
| this data correlate BAG2 to PINK1 for the first time, strengthening the important role of BAG2 in Parkinson disease -related neurodegeneration. | The BAG2 protein stabilises PINK1 by decreasing its ubiquitination.
Che X, Tang B, Wang X, Chen D, Yan X, Jiang H, Shen L, Xu Q, Wang G, Guo J. | 01/18/2014 |
| The activity of BAG-2 resembles that of the previously characterized Hsc70 cochaperone and CHIP inhibitor HspBP1. | BAG-2 acts as an inhibitor of the chaperone-associated ubiquitin ligase CHIP.
Arndt V, Daniel C, Nastainczyk W, Alberti S, Höhfeld J., Free PMC Article | 01/21/2010 |
| BAG2 binds to the carboxyl terminus of Hsp70-interacting protein (CHIP) and provides a cochaperone-dependent regulatory mechanism for preventing unregulated ubiquitylation of misfolded proteins by CHIP | Regulation of the cytoplasmic quality control protein degradation pathway by BAG2.
Dai Q, Qian SB, Li HH, McDonough H, Borchers C, Huang D, Takayama S, Younger JM, Ren HY, Cyr DM, Patterson C. | 01/21/2010 |
| BAG2 was directly phosphorylated at serine 20 in vitro by MAPKAPK2 and MAPKAP2 is also required for phosphorylation of BAG2 in vivo. | Proteomic identification of Bcl2-associated athanogene 2 as a novel MAPK-activated protein kinase 2 substrate.
Ueda K, Kosako H, Fukui Y, Hattori S. | 01/21/2010 |