| BTG1 inactivation drives lymphomagenesis and promotes lymphoma dissemination through activation of BCAR1. | BTG1 inactivation drives lymphomagenesis and promotes lymphoma dissemination through activation of BCAR1.
Delage L, Lambert M, Bardel É, Kundlacz C, Chartoire D, Conchon A, Peugnet AL, Gorka L, Auberger P, Jacquel A, Soussain C, Destaing O, Delecluse HJ, Delecluse S, Merabet S, Traverse-Glehen A, Salles G, Bachy E, Billaud M, Ghesquières H, Genestier L, Rouault JP, Sujobert P. | 03/13/2023 |
| The interaction of CFLAR with p130Cas promotes cell migration. | The interaction of CFLAR with p130Cas promotes cell migration.
Li H, Li L, Qiu X, Zhang J, Hua Z. | 01/7/2023 |
| Docking Protein p130Cas Regulates Acinar to Ductal Metaplasia During Pancreatic Adenocarcinoma Development and Pancreatitis. | Docking Protein p130Cas Regulates Acinar to Ductal Metaplasia During Pancreatic Adenocarcinoma Development and Pancreatitis.
Costamagna A, Natalini D, Camacho Leal MDP, Simoni M, Gozzelino L, Cappello P, Novelli F, Ambrogio C, Defilippi P, Turco E, Giovannetti E, Hirsch E, Cabodi S, Martini M. | 05/14/2022 |
| BCAR1 plays critical roles in the formation and immunoevasion of invasive circulating tumor cells in lung adenocarcinoma. | BCAR1 plays critical roles in the formation and immunoevasion of invasive circulating tumor cells in lung adenocarcinoma.
Mao CG, Jiang SS, Wang XY, Tao SL, Jiang B, Mao CY, Yang YL, Hu ZY, Long T, Jin H, Tan QY, Huang Y, Deng B., Free PMC Article | 03/19/2022 |
| Comprehensive immunohistochemical analysis of RET, BCAR1, and BCAR3 expression in patients with Luminal A and B breast cancer subtypes. | Comprehensive immunohistochemical analysis of RET, BCAR1, and BCAR3 expression in patients with Luminal A and B breast cancer subtypes.
Pavanelli AC, Mangone FR, Yoganathan P, Bessa SA, Nonogaki S, de Toledo Osório CAB, de Andrade VP, Soares IC, de Mello ES, Mulligan LM, Nagai MA. | 02/19/2022 |
| Targeting p130Cas- and microtubule-dependent MYC regulation sensitizes pancreatic cancer to ERK MAPK inhibition. | Targeting p130Cas- and microtubule-dependent MYC regulation sensitizes pancreatic cancer to ERK MAPK inhibition.
Waters AM, Khatib TO, Papke B, Goodwin CM, Hobbs GA, Diehl JN, Yang R, Edwards AC, Walsh KH, Sulahian R, McFarland JM, Kapner KS, Gilbert TSK, Stalnecker CA, Javaid S, Barkovskaya A, Grover KR, Hibshman PS, Blake DR, Schaefer A, Nowak KM, Klomp JE, Hayes TK, Kassner M, Tang N, Tanaseichuk O, Chen K, Zhou Y, Kalkat M, Herring LE, Graves LM, Penn LZ, Yin HH, Aguirre AJ, Hahn WC, Cox AD, Der CJ., Free PMC Article | 02/12/2022 |
| p130Cas Is Correlated with EREG Expression and a Prognostic Factor Depending on Colorectal Cancer Stage and Localization Reducing FOLFIRI Efficacy. | p130Cas Is Correlated with EREG Expression and a Prognostic Factor Depending on Colorectal Cancer Stage and Localization Reducing FOLFIRI Efficacy.
Kumbrink J, Li P, Pók-Udvari A, Klauschen F, Kirchner T, Jung A., Free PMC Article | 12/18/2021 |
| High Expression of BCAR1 by Circulating Tumor Cells and Tumor Tissues Is Predictive of a Poor Prognosis of Early-Stage Lung Adenocarcinoma Potentially Due to Regulation of Epithelial-Mesenchymal Transition. | High Expression of BCAR1 by Circulating Tumor Cells and Tumor Tissues Is Predictive of a Poor Prognosis of Early-Stage Lung Adenocarcinoma Potentially Due to Regulation of Epithelial-Mesenchymal Transition.
Jiang S, Mao C, Jiang B, Tan Q, Deng B., Free PMC Article | 11/6/2021 |
| A Cas-BCAR3 co-regulatory circuit controls lamellipodia dynamics. | A Cas-BCAR3 co-regulatory circuit controls lamellipodia dynamics.
Steenkiste EM, Berndt JD, Pilling C, Simpkins C, Cooper JA., Free PMC Article | 10/9/2021 |
| BCAR1 promotes proliferation and cell growth in lung adenocarcinoma via upregulation of POLR2A. | BCAR1 promotes proliferation and cell growth in lung adenocarcinoma via upregulation of POLR2A.
Mao CG, Jiang SS, Shen C, Long T, Jin H, Tan QY, Deng B., Free PMC Article | 08/7/2021 |
| CSRP2 suppresses colorectal cancer progression via p130Cas/Rac1 axis-meditated ERK, PAK, and HIPPO signaling pathways. | CSRP2 suppresses colorectal cancer progression via p130Cas/Rac1 axis-meditated ERK, PAK, and HIPPO signaling pathways.
Chen L, Long X, Duan S, Liu X, Chen J, Lan J, Liu X, Huang W, Geng J, Zhou J., Free PMC Article | 06/5/2021 |
| Mutant TP53 interacts with BCAR1 to contribute to cancer cell invasion. | Mutant TP53 interacts with BCAR1 to contribute to cancer cell invasion.
Guo AK, Itahana Y, Seshachalam VP, Chow HY, Ghosh S, Itahana K., Free PMC Article | 04/24/2021 |
| p130Cas (BCAR1) is recruited to filopodia tips via its C-terminal Cas family homology domain (CCHD) and acts as a mechanosensitive regulator of filopodia stability. | Filopodome Mapping Identifies p130Cas as a Mechanosensitive Regulator of Filopodia Stability.
Jacquemet G, Stubb A, Saup R, Miihkinen M, Kremneva E, Hamidi H, Ivaska J., Free PMC Article | 02/8/2020 |
| a novel interaction of p130Cas with Ser/Thr kinase PKN3, is reported. | The interaction of p130Cas with PKN3 promotes malignant growth.
Gemperle J, Dibus M, Koudelková L, Rosel D, Brábek J., Free PMC Article | 12/21/2019 |
| a feedforward autocrine loop to promote invasion through a FAK>p130Cas>c-Jun>MMP-9 signaling axis. | Resistance to Src inhibition alters the BRAF-mutant tumor secretome to promote an invasive phenotype and therapeutic escape through a FAK>p130Cas>c-Jun signaling axis.
Kessler BE, Mishall KM, Kellett MD, Clark EG, Pugazhenthi U, Pozdeyev N, Kim J, Tan AC, Schweppe RE., Free PMC Article | 05/4/2019 |
| study showed that RBMS1 gene rs7593730 and BCAR1 gene rs7202877 were significantly associated with type 2 diabetes in the Chinese population | Association between RBMS1 gene rs7593730 and BCAR1 gene rs7202877 and Type 2 diabetes mellitus in the Chinese Han population.
Kazakova EV, Chen M, Jamaspishvili E, Lin Z, Yu J, Sun L, Qiao H. | 12/22/2018 |
| These results suggest that miR-24-3p functions as a tumor suppressor and the miR-24-3p/p130Cas axis is a novel factor of cancer progression by regulating cell migration and invasion. | The miR-24-3p/p130Cas: a novel axis regulating the migration and invasion of cancer cells.
Kang H, Rho JG, Kim C, Tak H, Lee H, Ji E, Ahn S, Shin AR, Cho HI, Huh YH, Song WK, Kim W, Lee EK., Free PMC Article | 11/17/2018 |
| The authors herein prove, for the first time, that the transcriptional repressor Blimp1 is a novel mediator of p130Cas/ErbB2-mediated invasiveness. Indeed, high Blimp1 expression levels are detected in invasive p130Cas/ErbB2 cells and correlate with metastatic status in human breast cancer patients. | Dysregulation of Blimp1 transcriptional repressor unleashes p130Cas/ErbB2 breast cancer invasion.
Sciortino M, Camacho-Leal MDP, Orso F, Grassi E, Costamagna A, Provero P, Tam W, Turco E, Defilippi P, Taverna D, Cabodi S., Free PMC Article | 09/22/2018 |
| the results of our study identify BCAR1 as a prognostic biomarker with potential clinical value for risk stratification of ERG-negative prostate cancer. | High BCAR1 expression is associated with early PSA recurrence in ERG negative prostate cancer.
Heumann A, Heinemann N, Hube-Magg C, Lang DS, Grupp K, Kluth M, Minner S, Möller-Koop C, Graefen M, Heinzer H, Tsourlakis MC, Wilczak W, Wittmer C, Jacobsen F, Huland H, Simon R, Schlomm T, Sauter G, Steurer S, Lebok P, Hinsch A., Free PMC Article | 08/18/2018 |
| Silencing of p130Cas and inhibition of FAK activity both strongly reduced imatinib and nilotinib stimulated invasion. | Imatinib and Nilotinib increase glioblastoma cell invasion via Abl-independent stimulation of p130Cas and FAK signalling.
Frolov A, Evans IM, Li N, Sidlauskas K, Paliashvili K, Lockwood N, Barrett A, Brandner S, Zachary IC, Frankel P., Free PMC Article | 04/14/2018 |
| the p130Cas FAT domain uniquely confers a mechanosensing function. | The focal adhesion targeting domain of p130Cas confers a mechanosensing function.
Bradbury PM, Turner K, Mitchell C, Griffin KR, Middlemiss S, Lau L, Dagg R, Taran E, Cooper-White J, Fabry B, O'Neill GM. | 08/5/2017 |
| Tyrosine phosphorylation of focal adhesion kinase (FAK) and p130 Crk-associated substrate (CAS) was found to be correlated with pancreatic cancer cell invasiveness. | Tyrosine Phosphorylation of Focal Adhesion Anchoring Proteins Enhances Human Pancreatic Cancer Cell Invasion.
Okamoto H, Kusama T, Fujii H. | 04/1/2017 |
| Full-length and truncated p130Cas phosphorylated substrate domain molecules were expressed in breast cancer cells. Breast cancer cells expressing the full-length SD and the functional smaller SD fragment (spanning SD motifs 6-10) were injected into the mammary fat pads of mice. Both the complete and truncated SD significantly increased the occurrence of metastases to multiple organs. | A truncated phosphorylated p130Cas substrate domain is sufficient to drive breast cancer growth and metastasis formation in vivo.
Kumbrink J, de la Cueva A, Soni S, Sailer N, Kirsch KH. | 02/25/2017 |
| Elevated levels of p130Cas is associated with trastuzumab resistance in breast cancer. | p130Cas scaffold protein regulates ErbB2 stability by altering breast cancer cell sensitivity to autophagy.
Bisaro B, Sciortino M, Colombo S, Camacho Leal MP, Costamagna A, Castellano I, Montemurro F, Rossi V, Valabrega G, Turco E, Defilippi P, Cabodi S., Free PMC Article | 11/5/2016 |
| blockade of GD3-mediated growth signaling pathways by siRNAs might be a novel and promising therapeutic strategy against malignant melanomas, provided signaling molecules such as p130Cas and paxillin are significantly expressed in individual cases. | A therapeutic trial of human melanomas with combined small interfering RNAs targeting adaptor molecules p130Cas and paxillin activated under expression of ganglioside GD3.
Makino Y, Hamamura K, Takei Y, Bhuiyan RH, Ohkawa Y, Ohmi Y, Nakashima H, Furukawa K, Furukawa K. | 09/10/2016 |