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    NFE2L3 NFE2 like bZIP transcription factor 3 [ Homo sapiens (human) ]

    Gene ID: 9603, updated on 31-Mar-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Identification roles of NFE2L3 in digestive system cancers.

    Identification roles of NFE2L3 in digestive system cancers.
    Li F, Wen Z., Free PMC Article

    03/27/2024
    Hypomethylation-Mediated Upregulation of NFE2L3 Promotes Malignant Phenotypes of Clear Cell Renal Cell Carcinoma Cells.

    Hypomethylation-Mediated Upregulation of NFE2L3 Promotes Malignant Phenotypes of Clear Cell Renal Cell Carcinoma Cells.
    Hou X, Liao Q, Wu Y, Wang L, Zhao J, Liao X.

    02/2/2024
    NRF3 suppresses squamous carcinogenesis, involving the unfolded protein response regulator HSPA5.

    NRF3 suppresses squamous carcinogenesis, involving the unfolded protein response regulator HSPA5.
    Gurri S, Siegenthaler B, Cangkrama M, Restivo G, Huber M, Saliba J, Dummer R, Blank V, Hohl D, Werner S., Free PMC Article

    11/14/2023
    Transcription factor NFE2L3 promotes the proliferation of esophageal squamous cell carcinoma cells and causes radiotherapy resistance by regulating IL-6.

    Transcription factor NFE2L3 promotes the proliferation of esophageal squamous cell carcinoma cells and causes radiotherapy resistance by regulating IL-6.
    Chen T, Xu B, Chen H, Sun Y, Song J, Sun X, Zhang X, Hua W.

    01/28/2023
    NFE2L3 as a Potential Functional Gene Regulating Immune Microenvironment in Human Kidney Cancer.

    NFE2L3 as a Potential Functional Gene Regulating Immune Microenvironment in Human Kidney Cancer.
    Zhang Q, Tang D, Zha A, He J, Li D, Chen Y, Cai W, Dai J, Luan S, Yin L, Zhang W, Dai Y., Free PMC Article

    11/19/2022
    NFE2L3 promotes tumor progression and predicts a poor prognosis of bladder cancer.

    NFE2L3 promotes tumor progression and predicts a poor prognosis of bladder cancer.
    Qian J, Huang C, Zhu Z, He Y, Wang Y, Feng N, He S, Li X, Zhou L, Zhang C, Gong Y.

    06/18/2022
    Elevated expression of NFE2L3 promotes the development of gastric cancer through epithelial-mesenchymal transformation.

    Elevated expression of NFE2L3 promotes the development of gastric cancer through epithelial-mesenchymal transformation.
    Wang X, Li Y, Fang Z, Li Y., Free PMC Article

    02/19/2022
    NFE2L3 Controls Colon Cancer Cell Growth through Regulation of DUX4, a CDK1 Inhibitor.

    NFE2L3 Controls Colon Cancer Cell Growth through Regulation of DUX4, a CDK1 Inhibitor.
    Bury M, Le Calvé B, Lessard F, Dal Maso T, Saliba J, Michiels C, Ferbeyre G, Blank V.

    09/26/2020
    NFE2L1 and NFE2L3 Complementarily Maintain Basal Proteasome Activity in Cancer Cells through CPEB3-Mediated Translational Repression.

    NFE2L1 and NFE2L3 Complementarily Maintain Basal Proteasome Activity in Cancer Cells through CPEB3-Mediated Translational Repression.
    Waku T, Katayama H, Hiraoka M, Hatanaka A, Nakamura N, Tanaka Y, Tamura N, Watanabe A, Kobayashi A., Free PMC Article

    08/22/2020
    NRF3-POMP-20S Proteasome Assembly Axis Promotes Cancer Development via Ubiquitin-Independent Proteolysis of p53 and Retinoblastoma Protein.

    NRF3-POMP-20S Proteasome Assembly Axis Promotes Cancer Development via Ubiquitin-Independent Proteolysis of p53 and Retinoblastoma Protein.
    Waku T, Nakamura N, Koji M, Watanabe H, Katoh H, Tatsumi C, Tamura N, Hatanaka A, Hirose S, Katayama H, Tani M, Kubo Y, Hamazaki J, Hamakubo T, Watanabe A, Murata S, Kobayashi A., Free PMC Article

    08/15/2020
    analysis provides a comprehensive description of differential and overlapping gene regulation by the transcriptional regulators NFE2L1(NRF1), NFE2L2 (NRF2), and NFE2L3 (NRF3).

    Differential and overlapping targets of the transcriptional regulators NRF1, NRF2, and NRF3 in human cells.
    Liu P, Kerins MJ, Tian W, Neupane D, Zhang DD, Ooi A., Free PMC Article

    06/20/2020
    we observed that the beta-catenin/TCF4 complex mediates NRF3 expression by binding directly to the WRE site.

    β-Catenin/TCF4 Complex-Mediated Induction of the NRF3 (NFE2L3) Gene in Cancer Cells.
    Aono S, Hatanaka A, Hatanaka A, Gao Y, Hippo Y, Taketo MM, Waku T, Kobayashi A., Free PMC Article

    12/21/2019
    confirmed the regulatory role of NFE2L3 on VEGFA, an important player involved in tumor angiogenesis

    Elevated expression of NFE2L3 predicts the poor prognosis of pancreatic cancer patients.
    Wang H, Zhan M, Yang R, Shi Y, Liu Q, Wang J., Free PMC Article

    12/14/2019
    Downregulation of NFE2L3 induces G0/G1 phase arrest in colorectal cancer cells through downregulation of CCND1 and pRb1-ser807/811.

    NFE2L3 Inhibition Induces Cell Cycle Arrest at the G0/G1 Phase in Colorectal Cancer Cells through Downregulating CCND1 and pRb1-ser807/811.
    Zhang L, Hu DL, Tang B, Cheng Y, Jiao C, Cheng L, Tan ZR, Zhou HH., Free PMC Article

    11/30/2019
    Multiple regulatory mechanisms of the biological function of NFE2L3 control proliferation of cancer cells.

    Multiple regulatory mechanisms of the biological function of NRF3 (NFE2L3) control cancer cell proliferation.
    Chowdhury AMMA, Katoh H, Hatanaka A, Iwanari H, Nakamura N, Hamakubo T, Natsume T, Waku T, Kobayashi A., Free PMC Article

    07/20/2019
    Study identified that NFE2L3 was closely associated with the grade and stage of hepatocellular carcinoma (HCC) patients based on the TCGA database. Furthermore, study showed that shRNA-mediated knockdown of NFE2L3 exhibited tumor-suppressing effects in HCC cells.

    Short hairpin RNA-mediated knockdown of nuclear factor erythroid 2-like 3 exhibits tumor-suppressing effects in hepatocellular carcinoma cells.
    Yu MM, Feng YH, Zheng L, Zhang J, Luo GH., Free PMC Article

    04/20/2019
    SNPs associated with type 2 diabetes and obesity may also increase the risk of developing gestational diabetes mellitus (GDM) in the Chinese population. Among these SNPs, we report for the first time that rs945508 in ARHGEF11, rs10804591 in PLXND1 and rs10245353 in NFE2L3 were associated with GDM.

    Genetic variants and clinical relevance associated with gestational diabetes mellitus in Chinese women: a case-control study.
    Yan J, Su R, Ao D, Wang Y, Wang H, Yang H.

    10/27/2018
    findings reveal FBW7 and GSK3 as novel regulators of the NFE2L3 transcription factor and a potential mechanism by which FBW7 might regulate detoxification and the cellular response to stress

    Stringent Control of NFE2L3 (Nuclear Factor, Erythroid 2-Like 3; NRF3) Protein Degradation by FBW7 (F-box/WD Repeat-containing Protein 7) and Glycogen Synthase Kinase 3 (GSK3).
    Kannan MB, Dodard-Friedman I, Blank V., Free PMC Article

    02/20/2016
    17beta-Estradiol treatment significantly increased but VC or Res decreased Nrf3 mRNA and protein expression levels.

    Natural antioxidants exhibit chemopreventive characteristics through the regulation of CNC b-Zip transcription factors in estrogen-induced breast carcinogenesis.
    Chatterjee A, Ronghe A, Singh B, Bhat NK, Chen J, Bhat HK., Free PMC Article

    07/25/2015
    Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)

    Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution.
    Heid IM, Jackson AU, Randall JC, Winkler TW, Qi L, Steinthorsdottir V, Thorleifsson G, Zillikens MC, Speliotes EK, Mägi R, Workalemahu T, White CC, Bouatia-Naji N, Harris TB, Berndt SI, Ingelsson E, Willer CJ, Weedon MN, Luan J, Vedantam S, Esko T, Kilpeläinen TO, Kutalik Z, Li S, Monda KL, Dixon AL, Holmes CC, Kaplan LM, Liang L, Min JL, Moffatt MF, Molony C, Nicholson G, Schadt EE, Zondervan KT, Feitosa MF, Ferreira T, Lango Allen H, Weyant RJ, Wheeler E, Wood AR, MAGIC, Estrada K, Goddard ME, Lettre G, Mangino M, Nyholt DR, Purcell S, Smith AV, Visscher PM, Yang J, McCarroll SA, Nemesh J, Voight BF, Absher D, Amin N, Aspelund T, Coin L, Glazer NL, Hayward C, Heard-Costa NL, Hottenga JJ, Johansson A, Johnson T, Kaakinen M, Kapur K, Ketkar S, Knowles JW, Kraft P, Kraja AT, Lamina C, Leitzmann MF, McKnight B, Morris AP, Ong KK, Perry JR, Peters MJ, Polasek O, Prokopenko I, Rayner NW, Ripatti S, Rivadeneira F, Robertson NR, Sanna S, Sovio U, Surakka I, Teumer A, van Wingerden S, Vitart V, Zhao JH, Cavalcanti-Proença C, Chines PS, Fisher E, Kulzer JR, Lecoeur C, Narisu N, Sandholt C, Scott LJ, Silander K, Stark K, Tammesoo ML, Teslovich TM, Timpson NJ, Watanabe RM, Welch R, Chasman DI, Cooper MN, Jansson JO, Kettunen J, Lawrence RW, Pellikka N, Perola M, Vandenput L, Alavere H, Almgren P, Atwood LD, Bennett AJ, Biffar R, Bonnycastle LL, Bornstein SR, Buchanan TA, Campbell H, Day IN, Dei M, Dörr M, Elliott P, Erdos MR, Eriksson JG, Freimer NB, Fu M, Gaget S, Geus EJ, Gjesing AP, Grallert H, Grässler J, Groves CJ, Guiducci C, Hartikainen AL, Hassanali N, Havulinna AS, Herzig KH, Hicks AA, Hui J, Igl W, Jousilahti P, Jula A, Kajantie E, Kinnunen L, Kolcic I, Koskinen S, Kovacs P, Kroemer HK, Krzelj V, Kuusisto J, Kvaloy K, Laitinen J, Lantieri O, Lathrop GM, Lokki ML, Luben RN, Ludwig B, McArdle WL, McCarthy A, Morken MA, Nelis M, Neville MJ, Paré G, Parker AN, Peden JF, Pichler I, Pietiläinen KH, Platou CG, Pouta A, Ridderstråle M, Samani NJ, Saramies J, Sinisalo J, Smit JH, Strawbridge RJ, Stringham HM, Swift AJ, Teder-Laving M, Thomson B, Usala G, van Meurs JB, van Ommen GJ, Vatin V, Volpato CB, Wallaschofski H, Walters GB, Widen E, Wild SH, Willemsen G, Witte DR, Zgaga L, Zitting P, Beilby JP, James AL, Kähönen M, Lehtimäki T, Nieminen MS, Ohlsson C, Palmer LJ, Raitakari O, Ridker PM, Stumvoll M, Tönjes A, Viikari J, Balkau B, Ben-Shlomo Y, Bergman RN, Boeing H, Smith GD, Ebrahim S, Froguel P, Hansen T, Hengstenberg C, Hveem K, Isomaa B, Jørgensen T, Karpe F, Khaw KT, Laakso M, Lawlor DA, Marre M, Meitinger T, Metspalu A, Midthjell K, Pedersen O, Salomaa V, Schwarz PE, Tuomi T, Tuomilehto J, Valle TT, Wareham NJ, Arnold AM, Beckmann JS, Bergmann S, Boerwinkle E, Boomsma DI, Caulfield MJ, Collins FS, Eiriksdottir G, Gudnason V, Gyllensten U, Hamsten A, Hattersley AT, Hofman A, Hu FB, Illig T, Iribarren C, Jarvelin MR, Kao WH, Kaprio J, Launer LJ, Munroe PB, Oostra B, Penninx BW, Pramstaller PP, Psaty BM, Quertermous T, Rissanen A, Rudan I, Shuldiner AR, Soranzo N, Spector TD, Syvanen AC, Uda M, Uitterlinden A, Völzke H, Vollenweider P, Wilson JF, Witteman JC, Wright AF, Abecasis GR, Boehnke M, Borecki IB, Deloukas P, Frayling TM, Groop LC, Haritunians T, Hunter DJ, Kaplan RC, North KE, O'Connell JR, Peltonen L, Schlessinger D, Strachan DP, Hirschhorn JN, Assimes TL, Wichmann HE, Thorsteinsdottir U, van Duijn CM, Stefansson K, Cupples LA, Loos RJ, Barroso I, McCarthy MI, Fox CS, Mohlke KL, Lindgren CM., Free PMC Article

    12/5/2010
    Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)

    Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
    Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators., Free PMC Article

    09/15/2010
    Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)

    Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article

    06/30/2010
    Observational study of gene-disease association. (HuGE Navigator)See all PubMed (2) articles

    New genetic associations detected in a host response study to hepatitis B vaccine.
    Davila S, Froeling FE, Tan A, Bonnard C, Boland GJ, Snippe H, Hibberd ML, Seielstad M.

    Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
    Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium.

    04/7/2010
    Nrf3 is an N-glycosylated protein associated with the endoplasmic reticulum

    Endoplasmic reticulum association and N-linked glycosylation of the human Nrf3 transcription factor.
    Nouhi Z, Chevillard G, Derjuga A, Blank V.

    01/21/2010
    Nrf3 is a negative regulator of ARE-mediated gene expression of NQO1

    Nrf3 negatively regulates antioxidant-response element-mediated expression and antioxidant induction of NAD(P)H:quinone oxidoreductase1 gene.
    Sankaranarayanan K, Jaiswal AK.

    01/21/2010
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