| Kallikrein-Related Peptidase 4 Promotes Proliferation, Migration, Invasion, and Pro-Angiogenesis of Endometrial Stromal Cells via Regulation of Brain-Derived Neurotrophic Factor Production in Endometriosis. | Kallikrein-Related Peptidase 4 Promotes Proliferation, Migration, Invasion, and Pro-Angiogenesis of Endometrial Stromal Cells via Regulation of Brain-Derived Neurotrophic Factor Production in Endometriosis.
Shi J, Qi Y, Sun Y, Huang Y. | 01/6/2024 |
| Loss of KLK4::KLKP1 pseudogene expression by RNA chromogenic in-situ hybridization is associated with PTEN loss and increased risk of biochemical recurrence in a cohort of middle eastern men with prostate cancer. | Loss of KLK4::KLKP1 pseudogene expression by RNA chromogenic in-situ hybridization is associated with PTEN loss and increased risk of biochemical recurrence in a cohort of middle eastern men with prostate cancer.
Bakker A, Slack JC, Palanisamy N, Carskadon S, Ghosh S, Khalifeh I, Bismar TA. | 07/7/2023 |
| KLK4 Silencing Inhibits the Growth of Chromophobe Renal Cell Carcinoma through ERK/AKT Signaling Pathway. | KLK4 Silencing Inhibits the Growth of Chromophobe Renal Cell Carcinoma through ERK/AKT Signaling Pathway.
Fan B, Niu Y, Zhang A, Wei S, Ma Y, Su J, Ren Z. | 01/11/2023 |
| lncRNA IGF2-AS promotes the osteogenic differentiation of bone marrow mesenchymal stem cells by sponging miR-3,126-5p to upregulate KLK4. | lncRNA IGF2-AS promotes the osteogenic differentiation of bone marrow mesenchymal stem cells by sponging miR-3,126-5p to upregulate KLK4.
Tang JZ, Zhao GY, Zhao JZ, Di DH, Wang B. | 03/5/2022 |
| MicroRNA-378-3p/5p represses proliferation and induces apoptosis of oral squamous carcinoma cells via targeting KLK4. | MicroRNA-378-3p/5p represses proliferation and induces apoptosis of oral squamous carcinoma cells via targeting KLK4.
Cui Z, Bao X, Liu Q, Li Q, Huang L, Wang H, Jiao K. | 07/17/2021 |
| MicroRNA-378-3p/5p suppresses the migration and invasiveness of oral squamous carcinoma cells by inhibiting KLK4 expression. | MicroRNA-378-3p/5p suppresses the migration and invasiveness of oral squamous carcinoma cells by inhibiting KLK4 expression.
Cui Z, Sun S, Liu Q, Zhou X, Gao S, Peng P, Li Q. | 02/27/2021 |
| miR-378a-5p suppressed angiogenesis of oral squamous cell carcinoma at least partly by the regulation of KLK4. | MiR-378a-5p inhibits angiogenesis of oral squamous cell carcinoma by targeting KLK4.
Cui Z, Liu QL, Sun SQ, Jiao K, Liu DR, Zhou XC, Huang L. | 03/14/2020 |
| crystals of KLK4 obtained belonged to space group P1, contained four molecules in the asymmetric unit and diffracted to 1.64 A resolution | Crystal structure of the inhibitor-free form of the serine protease kallikrein-4.
Riley BT, Hoke DE, McGowan S, Buckle AM., Free PMC Article | 01/4/2020 |
| Study found a significant association of elevated KLK4 mRNA expression levels with shortened overall survival (OS) analyzing a homogenous cohort of advanced high-grade serous ovarian cancer patients (FIGO stage III/IV). Multivariable model showed that KLK4 remains an independent unfavorable predictive biomarker for OS in ovarian cancer. | Characterization of kallikrein-related peptidase 4 (KLK4) mRNA expression in tumor tissue of advanced high-grade serous ovarian cancer patients.
Gong W, Liu Y, Seidl C, Dreyer T, Drecoll E, Kotzsch M, Bronger H, Dorn J, Magdolen V., Free PMC Article | 11/30/2019 |
| Circular RNA (hsa_circ_0051240) promotes cell proliferation, migration and invasion in ovarian cancer through miR-637/KLK4 axis | Circular RNA (hsa_circ_0051240) promotes cell proliferation, migration and invasion in ovarian cancer through miR-637/KLK4 axis.
Zhang M, Xia B, Xu Y, Zhang Y, Xu J, Lou G. | 07/27/2019 |
| Mucin 16 and kallikrein 13 represent independent prognostic markers for colon cancer. | Mucin 16 and kallikrein 13 as potential prognostic factors in colon cancer: Results of an oncological 92-multiplex immunoassay.
Björkman K, Mustonen H, Kaprio T, Haglund C, Böckelman C. | 07/13/2019 |
| Structures of BbKI complexed with the catalytic domain of human plasma kallikrein were modeled, as well as those with KLK4 and KLK7, and the structures were analyzed in order to identify the interactions that are responsible for inhibitory potency. | Crystal structures of the complex of a kallikrein inhibitor from Bauhinia bauhinioides with trypsin and modeling of kallikrein complexes.
Li M, Srp J, Gustchina A, Dauter Z, Mares M, Wlodawer A., Free PMC Article | 05/25/2019 |
| The functional role of glycosylation in prostate-specific KLK4 could pave the way to a deeper understanding of their biology and to medical applications. | Activation and activity of glycosylated KLKs 3, 4 and 11.
Guo S, Briza P, Magdolen V, Brandstetter H, Goettig P. | 05/18/2019 |
| In pregnant women with KLK-4 gene polymorphisms A/A and G/A genotypes the rate of tooth decay growth increases in spite of applying the ternary calcium-phosphate-fluoride-containing gel. | [Age related molecular-genetic preconditions for dental caries in pregnant women].
Gorbunova IL, Kravchenko EN, Krivchik GV, Shestovskikh OL, Lukashevich IK, Strometskaya NN, Abramyan IR. | 03/30/2019 |
| Authors demonstrated that KLF4 was induced by ER stress in melanoma cells, and increased KLF4 inhibited cell apoptosis and promoted cell metastasis. Further mechanistic studies revealed that KLF4 directly bound to the promoter of NUCB2, facilitating its transcription. | Regulation of the adaptation to ER stress by KLF4 facilitates melanoma cell metastasis via upregulating NUCB2 expression.
Zhang D, Lin J, Chao Y, Zhang L, Jin L, Li N, He R, Ma B, Zhao W, Han C., Free PMC Article | 03/30/2019 |
| During the descriptive analysis, the variables ethnicity, biofilm, and gingivitis and the markers rs2242670 and rs2978642 were statistically significant. In the multivariate analysis, the marker rs2242670 and the variable biofilm maintained statistical significance. Genetic variations in the KLK4 gene may contribute to dental decay. | KLK4 Gene and Dental Decay: Replication in a South Brazilian Population.
Cavallari T, Tetu Moyses S, Moyses SJ, Iani Werneck R. | 06/30/2018 |
| Epithelial-derived KLK4 promotes tumour progression by actively promoting cancer-associated fibroblasts differentiation in the prostate stromal microenvironment. | Kallikrein-related peptidase 4 induces cancer-associated fibroblast features in prostate-derived stromal cells.
Kryza T, Silva LM, Bock N, Fuhrman-Luck RA, Stephens CR, Gao J, Samaratunga H, Australian Prostate Cancer BioResource, Lawrence MG, Hooper JD, Dong Y, Risbridger GP, Clements JA., Free PMC Article | 06/2/2018 |
| structural analysis of mechanism of KLK4 inhibition | Direct and indirect mechanisms of KLK4 inhibition revealed by structure and dynamics.
Riley BT, Ilyichova O, Costa MG, Porebski BT, de Veer SJ, Swedberg JE, Kass I, Harris JM, Hoke DE, Buckle AM., Free PMC Article | 05/5/2018 |
| These findings prompt a new mechanistic model and line of enquiry into the role of KLK4 in enamel hardening and malformation. | Direct evidence that KLK4 is a hydroxyapatite-binding protein.
Perez VA, Mangum JE, Hubbard MJ. | 02/17/2018 |
| Results show that AMTN and KLK4 are not essential for biological processes outside of the dentition or during the secretory stage of amelogenesis. Both KLK4 and AMTN proved to be essential for the maturation of dental enamel, a process that requires the removal of extracellularmatrix proteins and the deposition of ions on the sides of enamel crystallites. | Maturation stage enamel malformations in Amtn and Klk4 null mice.
Núñez SM, Chun YP, Ganss B, Hu Y, Richardson AS, Schmitz JE, Fajardo R, Yang J, Hu JC, Simmer JP., Free PMC Article | 12/23/2017 |
| The KLK4 protein is localized in the cytoplasm of tumor and stroma cells. | Tissue kallikrein-related peptidase 4 (KLK4), a novel biomarker in triple-negative breast cancer.
Yang F, Aubele M, Walch A, Gross E, Napieralski R, Zhao S, Ahmed N, Kiechle M, Reuning U, Dorn J, Sweep F, Magdolen V, Schmitt M. | 09/30/2017 |
| KLK4 as a potential multifunctional regulator of prostate cancer progression. | Prostate Cancer-Associated Kallikrein-Related Peptidase 4 Activates Matrix Metalloproteinase-1 and Thrombospondin-1.
Fuhrman-Luck RA, Stansfield SH, Stephens CR, Loessner D, Clements JA. | 09/30/2017 |
| Low KLK4 expression is associated with lupus nephritis. | Micro-RNA analysis of renal biopsies in human lupus nephritis demonstrates up-regulated miR-422a driving reduction of kallikrein-related peptidase 4.
Krasoudaki E, Banos A, Stagakis E, Loupasakis K, Drakos E, Sinatkas V, Zampoulaki A, Papagianni A, Iliopoulos D, Boumpas DT, Bertsias GK. | 09/16/2017 |
| KLK4 may contribute to the metastasis of OSCC through the PI3 K/AKT signaling pathway | Kallikrein-related peptidase 4 contributes to the tumor metastasis of oral squamous cell carcinoma.
Cui Z, Cui Y, Luo G, Yang S, Ling X, Lou Y, Sun X. | 09/9/2017 |
| KLK4 acts as an oncogene in OSCC cells, and targeting KLK4 may be a promising method for OSCC therapy. | KLK4 silencing inhibits the growth of oral squamous cell carcinoma through Wnt/β-catenin signaling pathway.
Cui Z, Cui Y, Yang S, Luo G, Wang Y, Lou Y, Sun X. | 04/1/2017 |