| Transport of CLCA2 to the nucleus by extracellular vesicles controls keratinocyte survival and migration. | Transport of CLCA2 to the nucleus by extracellular vesicles controls keratinocyte survival and migration.
Seltmann K, Hettich B, Abele S, Gurri S, Mantella V, Leroux JC, Werner S., Free PMC Article | 04/22/2024 |
| TP63 truncating mutation causes increased cell apoptosis and premature ovarian insufficiency by enhanced transcriptional activation of CLCA2. | TP63 truncating mutation causes increased cell apoptosis and premature ovarian insufficiency by enhanced transcriptional activation of CLCA2.
Fan Y, Chen S, Chu C, Yin X, Jin J, Zhang L, Yan H, Cao Z, Liu R, Xin M, Li L, Yin C., Free PMC Article | 04/5/2024 |
| CLCA2 overexpression suppresses epithelial-to-mesenchymal transition in cervical cancer cells through inactivation of ERK/JNK/p38-MAPK signaling pathways. | CLCA2 overexpression suppresses epithelial-to-mesenchymal transition in cervical cancer cells through inactivation of ERK/JNK/p38-MAPK signaling pathways.
Xin W, Zhang J, Zhang H, Ma X, Zhang Y, Li Y, Wang F., Free PMC Article | 10/29/2022 |
| Decreased expression of CLCA2 and the correlating with immune infiltrates in patients with cervical squamous cell carcinoma: A bioinformatics analysis. | Decreased expression of CLCA2 and the correlating with immune infiltrates in patients with cervical squamous cell carcinoma: A bioinformatics analysis.
Yang X, Cao JL, Yang FN, Li XF, Tao LM, Wang F. | 10/23/2021 |
| Genome-wide meta-analysis identified novel variant associated with hallux valgus in Caucasians. | Genome-wide meta-analysis identified novel variant associated with hallux valgus in Caucasians.
Arbeeva L, Yau M, Mitchell BD, Jackson RD, Ryan K, Golightly YM, Hannan MT, Nelson A, Jordan JM, Hochberg MC., Free PMC Article | 03/13/2021 |
| CLCA2 was identified as a potential prognostic marker for triple negative breast cancer in African American women. | CLCA2 expression is associated with survival among African American women with triple negative breast cancer.
Purrington KS, Knight J 3rd, Dyson G, Ali-Fehmi R, Schwartz AG, Boerner JL, Bandyopadhyay S., Free PMC Article | 08/12/2020 |
| CLCA2 knockdown promoted keratinocyte apoptosis induced by hyperosmotic stress through impairment of cell-cell adhesion. | Humidity-regulated CLCA2 protects the epidermis from hyperosmotic stress.
Seltmann K, Meyer M, Sulcova J, Kockmann T, Wehkamp U, Weidinger S, Auf dem Keller U, Werner S. | 09/21/2019 |
| A novel heterozygous missense mutation c.G1725T of the CLCA2 gene may be associated with heart block disease. | A newly identified missense mutation in CLCA2 is associated with autosomal dominant cardiac conduction block.
Mao Z, Wang Y, Peng H, He F, Zhu L, Huang H, Huang X, Lu X, Tan X. | 08/24/2019 |
| CLCA2 suppress NPC proliferation, migration, invasion and epithelial-mesenchymal transition through inhibiting FAK/ERK signaling. | Along with its favorable prognostic role, CLCA2 inhibits growth and metastasis of nasopharyngeal carcinoma cells via inhibition of FAK/ERK signaling.
Qiang YY, Li CZ, Sun R, Zheng LS, Peng LX, Yang JP, Meng DF, Lang YH, Mei Y, Xie P, Xu L, Cao Y, Wei WW, Cao L, Hu H, Yang Q, Luo DH, Liang YY, Huang BJ, Qian CN., Free PMC Article | 05/11/2019 |
| identified a new molecular mechanism to explain PCa and MeS link based on CLCA2 repression by CTBP1 and miR-196b-5p molecules that might act as key factors in the progression onset of this disease | CLCA2 epigenetic regulation by CTBP1, HDACs, ZEB1, EP300 and miR-196b-5p impacts prostate cancer cell adhesion and EMT in metabolic syndrome disease.
Porretti J, Dalton GN, Massillo C, Scalise GD, Farré PL, Elble R, Gerez EN, Accialini P, Cabanillas AM, Gardner K, De Luca P, De Siervi A. | 01/26/2019 |
| we found by calcium imaging that CLCA2 moderately enhanced intracellular-store release but dramatically increased store-operated entry of calcium upon cytosolic depletion | CLCA2 is a positive regulator of store-operated calcium entry and TMEM16A.
Sharma A, Ramena G, Yin Y, Premkumar L, Elble RC., Free PMC Article | 08/11/2018 |
| CLCA2 links junctional adhesion molecule EVA1, to cytosolic signaling proteins that modulate proliferation and differentiation. | CLCA2 Interactor EVA1 Is Required for Mammary Epithelial Cell Differentiation.
Ramena G, Yin Y, Yu Y, Walia V, Elble RC., Free PMC Article | 07/30/2016 |
| CLCA2 expression is higher in squamous cell carcinoma of the lung compared with adenocarcinoma. | CLCA2 as a novel immunohistochemical marker for differential diagnosis of squamous cell carcinoma from adenocarcinoma of the lung.
Shinmura K, Igarashi H, Kato H, Kawanishi Y, Inoue Y, Nakamura S, Ogawa H, Yamashita T, Kawase A, Funai K, Sugimura H., Free PMC Article | 08/1/2015 |
| Variants in CLCA2 were associated with an ileal involvement phenotype of Crohn's disease. | Identification of risk loci for Crohn's disease phenotypes using a genome-wide association study.
Alonso A, Domènech E, Julià A, Panés J, García-Sánchez V, Mateu PN, Gutiérrez A, Gomollón F, Mendoza JL, Garcia-Planella E, Barreiro-de Acosta M, Muñoz F, Vera M, Saro C, Esteve M, Andreu M, Chaparro M, Manyé J, Cabré E, López-Lasanta M, Tortosa R, Gelpí JL, García-Montero AC, Bertranpetit J, Absher D, Myers RM, Marsal S, Gisbert JP. | 05/30/2015 |
| These results strongly suggest that CLCA2 is involved in the p53 tumor suppressor network and has a significant effect on cell migration and invasion. | CLCA2, a target of the p53 family, negatively regulates cancer cell migration and invasion.
Sasaki Y, Koyama R, Maruyama R, Hirano T, Tamura M, Sugisaka J, Suzuki H, Idogawa M, Shinomura Y, Tokino T., Free PMC Article | 06/29/2013 |
| hCLCA2 is required for epithelial differentiation, and its loss during tumor progression contributes to metastasis. | Loss of breast epithelial marker hCLCA2 promotes epithelial-to-mesenchymal transition and indicates higher risk of metastasis.
Walia V, Yu Y, Cao D, Sun M, McLean JR, Hollier BG, Cheng J, Mani SA, Rao K, Premkumar L, Elble RC., Free PMC Article | 06/30/2012 |
| the reduced expression of CLCA2 was frequently observed in various kinds of cancers including prostate cancer | CLCA2 as a p53-inducible senescence mediator.
Tanikawa C, Nakagawa H, Furukawa Y, Nakamura Y, Matsuda K., Free PMC Article | 04/21/2012 |
| Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) | Polymorphisms in innate immunity genes and risk of childhood leukemia.
Han S, Lan Q, Park AK, Lee KM, Park SK, Ahn HS, Shin HY, Kang HJ, Koo HH, Seo JJ, Choi JE, Ahn YO, Chanock SJ, Kim H, Rothman N, Kang D., Free PMC Article | 06/30/2010 |
| hCLCA2 Is a p53-Inducible Inhibitor of Breast Cancer Cell Proliferation. | hCLCA2 Is a p53-Inducible Inhibitor of Breast Cancer Cell Proliferation.
Walia V, Ding M, Kumar S, Nie D, Premkumar LS, Elble RC., Free PMC Article | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (3) articlesRisk of meningioma and common variation in genes related to innate immunity.
Rajaraman P, Brenner AV, Neta G, Pfeiffer R, Wang SS, Yeager M, Thomas G, Fine HA, Linet MS, Rothman N, Chanock SJ, Inskip PD. Common variation in genes related to innate immunity and risk of adult glioma.
Rajaraman P, Brenner AV, Butler MA, Wang SS, Pfeiffer RM, Ruder AM, Linet MS, Yeager M, Wang Z, Orr N, Fine HA, Kwon D, Thomas G, Rothman N, Inskip PD, Chanock SJ. Evaluating new candidate SNPs as low penetrance risk factors in sporadic breast cancer: a two-stage Spanish case-control study.
Vega A, Salas A, Milne RL, Carracedo B, Ribas G, Ruibal A, de León AC, González-Hernández A, Benítez J, Carracedo A. | 11/5/2008 |
| Expression of hSK4 as well as hCACC-2 and hCACC-3 but not hCACC-1 was demonstrated by reverse transcriptase PCR on native nasal tissues. | Modulation of Ca2+-activated Cl- secretion by basolateral K+ channels in human normal and cystic fibrosis airway epithelia.
Mall M, Gonska T, Thomas J, Schreiber R, Seydewitz HH, Kuehr J, Brandis M, Kunzelmann K. | 01/21/2010 |
| immunohistochemistry clearly demonstrated colocalisation between hCLCA2 and integrin beta4 | The quantification of hCLCA2 and colocalisation with integrin beta4 in stratified human epithelia.
Connon CJ, Kawasaki S, Yamasaki K, Quantock AJ, Kinoshita S. | 01/21/2010 |
| human CLCA2 protein and mRNA expression are elevated during epithelial stratification, suggesting that this protein plays a role in the growth of multi-layered corneal epithelia during both natural development and tissue cultivation. | Gene expression and immunolocalisation of a calcium-activated chloride channel during the stratification of cultivated and developing corneal epithelium.
Connon CJ, Kawasaki S, Liles M, Koizumi N, Yamasaki K, Nakamura T, Quantock AJ, Kinoshita S. | 01/21/2010 |
| Mostly extracellular with only a single transmembrane segment, unlikely to form a channel. | The putative chloride channel hCLCA2 has a single C-terminal transmembrane segment.
Elble RC, Walia V, Cheng HC, Connon CJ, Mundhenk L, Gruber AD, Pauli BU. | 01/21/2010 |