| FEZ1 Plays Dual Roles in Early HIV-1 Infection by Independently Regulating Capsid Transport and Host Interferon-Stimulated Gene Expression. | FEZ1 Plays Dual Roles in Early HIV-1 Infection by Independently Regulating Capsid Transport and Host Interferon-Stimulated Gene Expression.
Malikov V, Naghavi MH., Free PMC Article | 07/19/2023 |
| FEZ1 phosphorylation regulates HSPA8 localization and interferon-stimulated gene expression. | FEZ1 phosphorylation regulates HSPA8 localization and interferon-stimulated gene expression.
Malikov V, Meade N, Simons LM, Hultquist JF, Naghavi MH., Free PMC Article | 03/5/2022 |
| Loss of FEZ1, a gene deleted in Jacobsen syndrome, causes locomotion defects and early mortality by impairing motor neuron development. | Loss of FEZ1, a gene deleted in Jacobsen syndrome, causes locomotion defects and early mortality by impairing motor neuron development.
Gunaseelan S, Wang Z, Tong VKJ, Ming SWS, Razar RBBA, Srimasorn S, Ong WY, Lim KL, Chua JJE. | 10/9/2021 |
| FEZ1 Is Recruited to a Conserved Cofactor Site on Capsid to Promote HIV-1 Trafficking. | FEZ1 Is Recruited to a Conserved Cofactor Site on Capsid to Promote HIV-1 Trafficking.
Huang PT, Summers BJ, Xu C, Perilla JR, Malikov V, Naghavi MH, Xiong Y., Free PMC Article | 08/29/2020 |
| Diagnosis of numerous cancers has been closely linked to the expression of certain long non-coding RNAs. This study aimed to evaluate levels of plasma FEZ family zinc finger 1 antisense RNA 1 (FEZF1-AS1) relative to non-small-cell lung carcinoma (NSCLC) diagnosis. | Plasma lncRNA FEZF1-AS1 as a potential biomarker for diagnosis of non-small-cell lung carcinoma.
Huang Y, Liu G, Ma H, Tian Y, Huang C, Liu F, Jia Y, Jiang D., Free PMC Article | 07/11/2020 |
| FEZ1 promotes HIV-1 infection in non-neuronal cells via direct binding to the capsid and kinesin-1 to move the virus into the cell nucleus. | HIV-1 capsids bind and exploit the kinesin-1 adaptor FEZ1 for inward movement to the nucleus.
Malikov V, da Silva ES, Jovasevic V, Bennett G, de Souza Aranha Vieira DA, Schulte B, Diaz-Griffero F, Walsh D, Naghavi MH., Free PMC Article | 03/26/2016 |
| SCOC forms a stable homogeneous complex with the coiled coil domain of FEZ1. SCOC dimerization and the SCOC surface residue R117 are important for this interaction. | Crystal structure of the human short coiled coil protein and insights into SCOC-FEZ1 complex formation.
Behrens C, Binotti B, Schmidt C, Robinson CV, Chua JJ, Kühnel K., Free PMC Article | 08/9/2014 |
| Studies indicate that FEZ1 (fasciculation and elongation protein zeta 1), SCOCO (short coiled-coil protein) and kinesins (kinesin heavy chain) are involved in biological transport process. | Structural analysis of intermolecular interactions in the kinesin adaptor complex fasciculation and elongation protein zeta 1/ short coiled-coil protein (FEZ1/SCOCO).
Alborghetti MR, Furlan Ada S, da Silva JC, Sforça ML, Honorato RV, Granato DC, dos Santos Migueleti DL, Neves JL, de Oliveira PS, Paes-Leme AF, Zeri AC, de Torriani IC, Kobarg J., Free PMC Article | 08/9/2014 |
| Short Disrupted-in-Schizophrenia (DISC)1 splice variants show reduced or no binding to NDEL1 and phosphodiesterase (PDE)4B proteins but fully interact with FEZ1 and GSK3beta. | Interactions of human truncated DISC1 proteins: implications for schizophrenia.
Newburn EN, Hyde TM, Ye T, Morita Y, Weinberger DR, Kleinman JE, Lipska BK., Free PMC Article | 04/6/2013 |
| FEZ1 operates as a kinesin adaptor for the transport of Stx, with cargo loading and unloading being regulated by protein kinases. | Phosphorylation-regulated axonal dependent transport of syntaxin 1 is mediated by a Kinesin-1 adapter.
Chua JJ, Butkevich E, Worseck JM, Kittelmann M, Grønborg M, Behrmann E, Stelzl U, Pavlos NJ, Lalowski MM, Eimer S, Wanker EE, Klopfenstein DR, Jahn R., Free PMC Article | 06/9/2012 |
| The data of this study suggested that FEZ1 may play important roles in human astrocytes, and that mood stabilizers might exert their cytoprotective and mood-stabilizing effects by inducing FEZ1 expression in astrocytes. | Four mood stabilizers commonly induce FEZ1 expression in human astrocytes.
Yu Z, Ono C, Kim HB, Komatsu H, Tanabe Y, Sakae N, Nakayama KI, Matsuoka H, Sora I, Bunney WE, Tomita H. | 02/18/2012 |
| Genetic association analysis of two independent cohorts of schizophrenia patients and healthy controls reveals an epistatic interaction between FEZ1 and disrupted in schizophrenia (DISC)1. | Interaction between FEZ1 and DISC1 in regulation of neuronal development and risk for schizophrenia.
Kang E, Burdick KE, Kim JY, Duan X, Guo JU, Sailor KA, Jung DE, Ganesan S, Choi S, Pradhan D, Lu B, Avramopoulos D, Christian K, Malhotra AK, Song H, Ming GL., Free PMC Article | 01/14/2012 |
| FEZ2 interacted with 59 proteins and that of these only 40 interacted with FEZ1. | FEZ2 has acquired additional protein interaction partners relative to FEZ1: functional and evolutionary implications.
Alborghetti MR, Furlan AS, Kobarg J., Free PMC Article | 07/9/2011 |
| Demonstrated the formation of an intermolecular disulfide bond through FEZ1 Cys-133, which appears to be essential for dimerization. | Human FEZ1 protein forms a disulfide bond mediated dimer: implications for cargo transport.
Alborghetti MR, Furlan AS, Silva JC, Paes Leme AF, Torriani IC, Kobarg J. | 01/8/2011 |
| Studies indicate that suppression of FEZ1 expression in cultured embryonic neurons causes deficiency of neuronal differentiation. | Functions of fasciculation and elongation protein zeta-1 (FEZ1) in the brain.
Maturana AD, Fujita T, Kuroda S., Free PMC Article | 11/27/2010 |
| Data report that NEK1 and CLASP2 colocalize with FEZ1 in a perinuclear region in mammalian cells, and observed that coiled-coil interactions occur between FEZ1/CLASP2 and FEZ1/NEK1 in vitro. | FEZ1 interacts with CLASP2 and NEK1 through coiled-coil regions and their cellular colocalization suggests centrosomal functions and regulation by PKC.
Lanza DC, Meirelles GV, Alborghetti MR, Abrile CH, Lenz G, Kobarg J. | 10/23/2010 |
| There was no strong evidence for association with FEZ1 in schizophrenia. | Genetic association and post-mortem brain mRNA analysis of DISC1 and related genes in schizophrenia.
Rastogi A, Zai C, Likhodi O, Kennedy JL, Wong AH, Rastogi A, Zai C, Likhodi O, Kennedy JL, Wong AH. | 01/21/2010 |
| Meta-analysis of gene-disease association. (HuGE Navigator) | Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database.
Allen NC, Bagade S, McQueen MB, Ioannidis JP, Kavvoura FK, Khoury MJ, Tanzi RE, Bertram L. | 12/2/2009 |
| FEZ1 appears to represent a unique neuron-specific determinant of cellular susceptibility to infection in a cell type that is naturally resistant to HIV-1 | The brain-specific factor FEZ1 is a determinant of neuronal susceptibility to HIV-1 infection.
Haedicke J, Brown C, Naghavi MH., Free PMC Article | 01/21/2010 |
| Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) | See all PubMed (3) articlesEvidence of statistical epistasis between DISC1, CIT and NDEL1 impacting risk for schizophrenia: biological validation with functional neuroimaging.
Nicodemus KK, Callicott JH, Higier RG, Luna A, Nixon DC, Lipska BK, Vakkalanka R, Giegling I, Rujescu D, St Clair D, Muglia P, Shugart YY, Weinberger DR. Genetic association and post-mortem brain mRNA analysis of DISC1 and related genes in schizophrenia.
Rastogi A, Zai C, Likhodi O, Kennedy JL, Wong AH, Rastogi A, Zai C, Likhodi O, Kennedy JL, Wong AH. Identification of neuroglycan C and interacting partners as potential susceptibility genes for schizophrenia in a Southern Chinese population.
So HC, Fong PY, Chen RY, Hui TC, Ng MY, Cherny SS, Mak WW, Cheung EF, Chan RC, Chen EY, Li T, Sham PC. | 08/12/2009 |
| Human FEZ1 has characteristics of a natively unfolded protein and dimerizes in solution. | Human FEZ1 has characteristics of a natively unfolded protein and dimerizes in solution.
Lanza DC, Silva JC, Assmann EM, Quaresma AJ, Bressan GC, Torriani IL, Kobarg J. | 01/21/2010 |
| Data show that the expression of FEZ1,GAD1, and RGS4 are high correlated with one another in the prefrontal cortex of postmortem brain samples. | Age-related changes in the expression of schizophrenia susceptibility genes in the human prefrontal cortex.
Colantuoni C, Hyde TM, Mitkus S, Joseph A, Sartorius L, Aguirre C, Creswell J, Johnson E, Deep-Soboslay A, Herman MM, Lipska BK, Weinberger DR, Kleinman JE. | 01/21/2010 |
| Data suggest that FEZ1 has an important centrosomal function and supply new mechanistic insights to the formation of flower-like nuclei, which are a phenotypical hallmark of human leukemia cells. | Over-expression of GFP-FEZ1 causes generation of multi-lobulated nuclei mediated by microtubules in HEK293 cells.
Lanza DC, Trindade DM, Assmann EM, Kobarg J. | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (4) articlesCentrosome-related genes, genetic variation, and risk of breast cancer.
Olson JE, Wang X, Pankratz VS, Fredericksen ZS, Vachon CM, Vierkant RA, Cerhan JR, Couch FJ. Association between genes of Disrupted in schizophrenia 1 (DISC1) interactors and schizophrenia supports the role of the DISC1 pathway in the etiology of major mental illnesses.
Tomppo L, Hennah W, Lahermo P, Loukola A, Tuulio-Henriksson A, Suvisaari J, Partonen T, Ekelund J, Lönnqvist J, Peltonen L. Failure to confirm the association between the FEZ1 gene and schizophrenia in a Japanese population.
Koga M, Ishiguro H, Horiuchi Y, Albalushi T, Inada T, Iwata N, Ozaki N, Ujike H, Muratake T, Someya T, Arinami T. Association analysis of FEZ1 variants with schizophrenia in Japanese cohorts.
Yamada K, Nakamura K, Minabe Y, Iwayama-Shigeno Y, Takao H, Toyota T, Hattori E, Takei N, Sekine Y, Suzuki K, Iwata Y, Miyoshi K, Honda A, Baba K, Katayama T, Tohyama M, Mori N, Yoshikawa T. | 03/13/2008 |
| Binding of JIP1 and FEZ1 to Kinesin-1 is sufficient to activate the motor for microtubule binding and motility. | Two binding partners cooperate to activate the molecular motor Kinesin-1.
Blasius TL, Cai D, Jih GT, Toret CP, Verhey KJ., Free PMC Article | 01/21/2010 |