| A MAP1B-cortactin-Tks5 axis regulates TNBC invasion and tumorigenesis. | A MAP1B-cortactin-Tks5 axis regulates TNBC invasion and tumorigenesis.
Inoue H, Kanda T, Hayashi G, Munenaga R, Yoshida M, Hasegawa K, Miyagawa T, Kurumada Y, Hasegawa J, Wada T, Horiuchi M, Yoshimatsu Y, Itoh F, Maemoto Y, Arasaki K, Wakana Y, Watabe T, Matsushita H, Harada H, Tagaya M., Free PMC Article | 02/15/2024 |
| Spontaneous malignant transformation of trigeminal schwannoma: consideration of responsible gene alterations for tumorigenesis-a case report. | Spontaneous malignant transformation of trigeminal schwannoma: consideration of responsible gene alterations for tumorigenesis-a case report.
Ogasawara N, Yamashita S, Yamasaki K, Kawano T, Kawano T, Muta J, Matsumoto F, Watanabe T, Ohta H, Yokogami K, Fukushima T, Sato Y, Takeshima H. | 11/16/2023 |
| STAT3/SH3PXD2A-AS1/miR-125b/STAT3 positive feedback loop affects psoriasis pathogenesis via regulating human keratinocyte proliferation. | STAT3/SH3PXD2A-AS1/miR-125b/STAT3 positive feedback loop affects psoriasis pathogenesis via regulating human keratinocyte proliferation.
Yang Z, Chen Z, Wang C, Huang P, Luo M, Zhou R. | 02/5/2022 |
| Tks5 Regulates Synaptic Podosome Formation and Stabilization of the Postsynaptic Machinery at the Neuromuscular Junction. | Tks5 Regulates Synaptic Podosome Formation and Stabilization of the Postsynaptic Machinery at the Neuromuscular Junction.
Pęziński M, Maliszewska-Olejniczak K, Daszczuk P, Mazurek P, Niewiadomski P, Rędowicz MJ., Free PMC Article | 01/22/2022 |
| Functional Role of the L396R Mutation of Tks5 Identified by an Exome-Wide Association Study in Atrial Fibrillation. | Functional Role of the L396R Mutation of Tks5 Identified by an Exome-Wide Association Study in Atrial Fibrillation.
Yang X, Sasano T, Ebana Y, Takeuchi JK, Ihara K, Yamazoe M, Furukawa T. | 12/11/2021 |
| The clinicopathologic significance of Tks5 expression of peritoneal mesothelial cells in gastric cancer patients. | The clinicopathologic significance of Tks5 expression of peritoneal mesothelial cells in gastric cancer patients.
Sugimoto A, Okuno T, Tsujio G, Sera T, Yamamoto Y, Maruo K, Kushiyama S, Nishimura S, Kuroda K, Togano S, Miki Y, Yoshii M, Tamura T, Toyokawa T, Tanaka H, Muguruma K, Ohira M, Yashiro M., Free PMC Article | 11/22/2021 |
| Serine-Threonine Kinase TAO3-Mediated Trafficking of Endosomes Containing the Invadopodia Scaffold TKS5alpha Promotes Cancer Invasion and Tumor Growth. | Serine-Threonine Kinase TAO3-Mediated Trafficking of Endosomes Containing the Invadopodia Scaffold TKS5α Promotes Cancer Invasion and Tumor Growth.
Iizuka S, Quintavalle M, Navarro JC, Gribbin KP, Ardecky RJ, Abelman MM, Ma CT, Sergienko E, Zeng FY, Pass I, Thomas GV, McWeeney SK, Hassig CA, Pinkerton AB, Courtneidge SA., Free PMC Article | 06/26/2021 |
| Intersection of TKS5 and FGD1/CDC42 signaling cascades directs the formation of invadopodia. | Intersection of TKS5 and FGD1/CDC42 signaling cascades directs the formation of invadopodia.
Zagryazhskaya-Masson A, Monteiro P, Macé AS, Castagnino A, Ferrari R, Infante E, Duperray-Susini A, Dingli F, Lanyi A, Loew D, Génot E, Chavrier P., Free PMC Article | 03/27/2021 |
| The present GWAS was the first to implicate SH3PXD2A in non-syndromic cleft formation in humans. In summary, although performed in a relatively small sample, the present GWAS generated novel insights into nsCL/P etiology. | Non-Syndromic Cleft Lip with or without Cleft Palate: Genome-Wide Association Study in Europeans Identifies a Suggestive Risk Locus at 16p12.1 and Supports SH3PXD2A as a Clefting Susceptibility Gene.
van Rooij IA, Ludwig KU, Welzenbach J, Ishorst N, Thonissen M, Galesloot TE, Ongkosuwito E, Bergé SJ, Aldhorae K, Rojas-Martinez A, Kiemeney LA, Vermeesch JR, Brunner H, Roeleveld N, Devriendt K, Dormaar T, Hens G, Knapp M, Carels C, Mangold E., Free PMC Article | 05/2/2020 |
| in the invadopodia-competent Src-3T3 model system, mutations in any one of the first three SH3 domains had a dominant negative effect that largely eliminated the presence of invadopodia, inhibited gelatin degradation activity, and redistributed both Src, cortactin, and Tks5 to what are likely endosomal compartments | Tks5 SH3 domains exhibit differential effects on invadopodia development.
Daly C, Logan B, Breeyear J, Whitaker K, Ahmed M, Seals DF., Free PMC Article | 04/18/2020 |
| TKS5 is expressed in human pancreatic adenocarcinoma lines. TKS5 localizes at mature and immature invadopodia in pancreatic cancer cells. Pancreatic cancer cells depend on TKS5 for invadopodia formation and function. | TKS5-positive invadopodia-like structures in human tumor surgical specimens.
Chen YC, Baik M, Byers JT, Chen KT, French SW, Díaz B., Free PMC Article | 02/23/2019 |
| Our results suggest that dissociation between XB130 and Tks5 may facilitate lateral cell migration via XB130/Rac1, and vertical cell migration via Tks5/Cdc42. These molecular mechanisms will help our understanding of airway epithelial repair and regeneration. | Stimulus-dependent dissociation between XB130 and Tks5 scaffold proteins promotes airway epithelial cell migration.
Moodley S, Derouet M, Bai XH, Xu F, Kapus A, Yang BB, Liu M., Free PMC Article | 03/3/2018 |
| Suggest the importance of Tks adaptor proteins in melanoma growth and metastasis in vivo is likely via functional invadopodia formation. | The role of Tks adaptor proteins in invadopodia formation, growth and metastasis of melanoma.
Iizuka S, Abdullah C, Buschman MD, Diaz B, Courtneidge SA., Free PMC Article | 02/24/2018 |
| This is the first study that identifies a new Rab40b-Tks5- and miR-204-dependent invadopodia transport pathway that regulates MMP2 and MMP9 secretion, and extracellular matrix remodeling during cancer progression. | Rab40b and Tks5 interact at invadopodia during metastasis.
| 01/27/2018 |
| Rheumatoid arthritis T cells abundantly express the podosome scaffolding protein TKS5, which enables them to form tissue-invasive membrane structures. TKS5 overexpression was regulated by the intracellular metabolic environment of RA T cells-specifically, by reduced glycolytic flux that led to deficiencies in ATP and pyruvate. | Metabolic control of the scaffold protein TKS5 in tissue-invasive, proinflammatory T cells.
Shen Y, Wen Z, Li Y, Matteson EL, Hong J, Goronzy JJ, Weyand CM., Free PMC Article | 09/16/2017 |
| Results show that the interaction between Girdin and Tks5 might be important for Tks5 phosphorylation in HCC cells. | Discs large homolog 5 decreases formation and function of invadopodia in human hepatocellular carcinoma via Girdin and Tks5.
Ke Y, Bao T, Zhou Q, Wang Y, Ge J, Fu B, Wu X, Tang H, Shi Z, Lei X, Zhang C, Tan Y, Chen H, Guo Z, Wang L. | 09/16/2017 |
| This is the first study that identifies a new Rab40b-Tks5- and miR-204-dependent invadopodia transport pathway that regulates MMP2 and MMP9 secretion, and extracellular matrix remodeling during cancer progression. | The role and regulation of Rab40b-Tks5 complex during invadopodia formation and cancer cell invasion.
Jacob A, Linklater E, Bayless BA, Lyons T, Prekeris R., Free PMC Article | 08/5/2017 |
| Results suggest that Tks5, similar to XB130, plays a role in cell proliferation and cell survival and that the interaction between XB130 and Tks5 appears to be critical for regulation of Src-mediated cellular homeostasis. | XB130/Tks5 scaffold protein interaction regulates Src-mediated cell proliferation and survival.
Moodley S, Hui Bai X, Kapus A, Yang B, Liu M., Free PMC Article | 10/22/2016 |
| TKS5 and MYLK represent two mediators of invasive behavior of cancer cells that are regulated by the ZEB1/miR-200 feedback loop | The ZEB1/miR-200c feedback loop regulates invasion via actin interacting proteins MYLK and TKS5.
Sundararajan V, Gengenbacher N, Stemmler MP, Kleemann JA, Brabletz T, Brabletz S., Free PMC Article | 08/20/2016 |
| establishes an important role for Tks5 in tumor growth in vivo, and suggests that invadopodia may play broad roles in tumor progression | The invadopodia scaffold protein Tks5 is required for the growth of human breast cancer cells in vitro and in vivo.
Blouw B, Patel M, Iizuka S, Abdullah C, You WK, Huang X, Li JL, Diaz B, Stallcup WB, Courtneidge SA., Free PMC Article | 03/26/2016 |
| Results show that TKS5 is highly expressed in many cancer types with strong correlation with increased metastatic events and a poorer prognosis suggesting a clinical importance. | Expression of the adaptor protein Tks5 in human cancer: prognostic potential.
Stylli SS, Luwor RB, Kaye AH, I ST, Hovens CM, Lock P. | 11/7/2015 |
| Inhibiting the function of Tks5 both reduced extracellular matrix degradation in vitro and disrupted motoneuron axons from exiting the spinal cord and extending into the periphery. | Regulation of ECM degradation and axon guidance by growth cone invadosomes.
Santiago-Medina M, Gregus KA, Nichol RH, O'Toole SM, Gomez TM., Free PMC Article | 03/21/2015 |
| Tks5 is needed for breast carcinoma cell invadopodium precursor stabilization, where the phox homology (PX) domain of Tks5 interacts with PI(3,4)P2. SHIP2 arrival at the invadopodium precursor coincides with the onset of PI(3,4)P2 accumulation. | Tks5 and SHIP2 regulate invadopodium maturation, but not initiation, in breast carcinoma cells.
Sharma VP, Eddy R, Entenberg D, Kai M, Gertler FB, Condeelis J., Free PMC Article | 07/12/2014 |
| Src-dependent Tks5 phosphorylation regulates invadopodia-associated invasion in prostate cancer cells. | Src-dependent Tks5 phosphorylation regulates invadopodia-associated invasion in prostate cancer cells.
Burger KL, Learman BS, Boucherle AK, Sirintrapun SJ, Isom S, Díaz B, Courtneidge SA, Seals DF., Free PMC Article | 03/15/2014 |
| high Tks5long and low Tks5short expressions in human lung adenocarcinomas correlated with metastatic disease and predicted worse survival of early stage patients | Differential Tks5 isoform expression contributes to metastatic invasion of lung adenocarcinoma.
Li CM, Chen G, Dayton TL, Kim-Kiselak C, Hoersch S, Whittaker CA, Bronson RT, Beer DG, Winslow MM, Jacks T., Free PMC Article | 09/21/2013 |