| eIF5B and eIF1A reorient initiator tRNA to allow ribosomal subunit joining. | eIF5B and eIF1A reorient initiator tRNA to allow ribosomal subunit joining.
Lapointe CP, Grosely R, Sokabe M, Alvarado C, Wang J, Montabana E, Villa N, Shin BS, Dever TE, Fraser CS, Fernández IS, Puglisi JD., Free PMC Article | 07/16/2022 |
| eIF5B drives integrated stress response-dependent translation of PD-L1 in lung cancer. | eIF5B drives integrated stress response-dependent translation of PD-L1 in lung cancer.
Suresh S, Chen B, Zhu J, Golden RJ, Lu C, Evers BM, Novaresi N, Smith B, Zhan X, Schmid V, Jun S, Karacz CM, Peyton M, Zhong L, Wen Z, Sathe AA, Xing C, Behrens C, Wistuba II, Xiao G, Xie Y, Fu YX, Minna JD, Mendell JT, O'Donnell KA., Free PMC Article | 04/30/2022 |
| Dynamic interaction network involving the conserved intrinsically disordered regions in human eIF5. | Dynamic interaction network involving the conserved intrinsically disordered regions in human eIF5.
Paul EE, Lin KY, Gamble N, Tsai AW, Swan SHK, Yang Y, Doran M, Marintchev A., Free PMC Article | 04/23/2022 |
| Depletion of eukaryotic initiation factor 5B (eIF5B) reprograms the cellular transcriptome and leads to activation of endoplasmic reticulum (ER) stress and c-Jun N-terminal kinase (JNK). | Depletion of eukaryotic initiation factor 5B (eIF5B) reprograms the cellular transcriptome and leads to activation of endoplasmic reticulum (ER) stress and c-Jun N-terminal kinase (JNK).
Bressler KR, Ross JA, Ilnytskyy S, Vanden Dungen K, Taylor K, Patel K, Zovoilis A, Kovalchuk I, Thakor N., Free PMC Article | 12/25/2021 |
| eIF5B regulates the expression of PD-L1 in prostate cancer cells by interacting with Wig1. | eIF5B regulates the expression of PD-L1 in prostate cancer cells by interacting with Wig1.
Li Q, Xiao M, Shi Y, Hu J, Bi T, Wang C, Yan L, Li X., Free PMC Article | 10/16/2021 |
| Eukaryotic initiation factor 5B (eIF5B) regulates temozolomide-mediated apoptosis in brain tumour stem cells (BTSCs). | Eukaryotic initiation factor 5B (eIF5B) regulates temozolomide-mediated apoptosis in brain tumour stem cells (BTSCs).
Ross JA, Ahn BY, King J, Bressler KR, Senger DL, Thakor N. | 06/12/2021 |
| Data suggest that eIF5B represents a regulatory node, allowing cancer cells to evade apoptosis by promoting the translation of pro-survival proteins from IRES-containing mRNAs. | Eukaryotic initiation factor 5B (eIF5B) provides a critical cell survival switch to glioblastoma cells via regulation of apoptosis.
Ross JA, Dungen KV, Bressler KR, Fredriksen M, Khandige Sharma D, Balasingam N, Thakor N., Free PMC Article | 06/6/2020 |
| results indicate that in humans, eIF5B displacing eIF2 from Met-tRNAi upon subunit joining may be coupled to eIF1A displacing eIF5 from eIF5B, allowing the eIF5:eIF2-GDP complex to leave the ribosome. | Human eIF5 and eIF1A Compete for Binding to eIF5B.
Lin KY, Nag N, Pestova TV, Marintchev A., Free PMC Article | 07/20/2019 |
| aerobic eukarya retained eIF5B/IF2 to remodel anaerobic pathways during episodes of oxygen deficiency. | Oxygen-Sensitive Remodeling of Central Carbon Metabolism by Archaic eIF5B.
Ho JJD, Balukoff NC, Cervantes G, Malcolm PD, Krieger JR, Lee S., Free PMC Article | 03/30/2019 |
| eIF5B promoted hepatocellular carcinoma cell proliferation and migration in vitro and in vivo partly through increasing ASAP1 expression. | eIF5B increases ASAP1 expression to promote HCC proliferation and invasion.
Wang ZG, Zheng H, Gao W, Han J, Cao JZ, Yang Y, Li S, Gao R, Liu H, Pan ZY, Fu SY, Gu FM, Xing H, Ni JS, Yan HL, Ren H, Zhou WP., Free PMC Article | 02/10/2018 |
| eIF5B silencing provides a negative feedback to deactivate MAPK signaling | Proteomic Analysis of eIF5B Silencing-Modulated Proteostasis.
Jiang X, Jiang X, Feng Y, Xu R, Wang Q, Deng H., Free PMC Article | 07/15/2017 |
| results indicate that the interactions between eIF1A and eIF5B are being continuously rearranged during translation initiation; presentation of a model how the dynamic eIF1A/eIF5B interaction network can promote remodeling of the translation initiation complexes, and the roles in the process played by intrinsically disordered protein segments | eIF1A/eIF5B interaction network and its functions in translation initiation complex assembly and remodeling.
Nag N, Lin KY, Edmonds KA, Yu J, Nadkarni D, Marintcheva B, Marintchev A., Free PMC Article | 06/24/2017 |
| eIF5B overexpression promotes maturation of G0-like immature oocytes and causes cell death, an alternative to G0, in serum-starved THP1 cells. | Upregulation of eIF5B controls cell-cycle arrest and specific developmental stages.
Lee S, Truesdell SS, Bukhari SI, Lee JH, LeTonqueze O, Vasudevan S., Free PMC Article | 05/2/2015 |
| The authors show that the cleavage of initiation factor eIF5B during enteroviral infection, along with the viral internal ribosome entry site, plays a role in mediating viral translation under conditions that are nonpermissive for host cell translation. | Poliovirus switches to an eIF2-independent mode of translation during infection.
White JP, Reineke LC, Lloyd RE., Free PMC Article | 10/8/2011 |
| 3Cpro-mediated cleavage of eIF5B may thus play an accessory role in the shutoff of translation that occurs in enterovirus-infected cells. | Cleavage of eukaryotic initiation factor eIF5B by enterovirus 3C proteases.
de Breyne S, Bonderoff JM, Chumakov KM, Lloyd RE, Hellen CU., Free PMC Article | 01/21/2010 |
| binding of eIF5B might induce conformational changes in both subunits, with ribosomal segments wrapping around the factor | Position of eukaryotic initiation factor eIF5B on the 80S ribosome mapped by directed hydroxyl radical probing.
Unbehaun A, Marintchev A, Lomakin IB, Didenko T, Wagner G, Hellen CU, Pestova TV., Free PMC Article | 01/21/2010 |
| Transfected nuclear factor 2 trans activates the IF2 promoter in a cell line. | Nuclear respiratory factor 2 activates transcription of human mitochondrial translation initiation factor 2 gene.
Hayashi R, Ueda T, Farwell MA, Takeuchi N. | 01/21/2010 |
| determination of binding site on eukaryotic initiation factor 1A | Mapping the binding interface between human eukaryotic initiation factors 1A and 5B: a new interaction between old partners.
Marintchev A, Kolupaeva VG, Pestova TV, Wagner G., Free PMC Article | 01/21/2010 |