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    CLINT1 clathrin interactor 1 [ Homo sapiens (human) ]

    Gene ID: 9685, updated on 28-Oct-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    The cargo adapter protein CLINT1 is phosphorylated by the Numb-associated kinase BIKE and mediates dengue virus infection.

    The cargo adapter protein CLINT1 is phosphorylated by the Numb-associated kinase BIKE and mediates dengue virus infection.
    Schor S, Pu S, Nicolaescu V, Azari S, Kõivomägi M, Karim M, Cassonnet P, Saul S, Neveu G, Yueh A, Demeret C, Skotheim JM, Jacob Y, Randall G, Einav S., Free PMC Article

    07/2/2022
    Although epsinR has been shown to be a cargo adaptor, the present study indicates that it is an order of magnitude more abundant in CCVs than its known cargo protein, vti1b, suggesting that it may have other functions as well.

    Contributions of epsinR and gadkin to clathrin-mediated intracellular trafficking.
    Hirst J, Edgar JR, Borner GH, Li S, Sahlender DA, Antrobus R, Robinson MS., Free PMC Article

    06/11/2016
    These results do not support a significant role of GRIA1 or CLINT1 in the development of schizophrenia in the German population.

    Association study of the GRIA1 and CLINT1 (Epsin 4) genes in a German schizophrenia sample.
    Leon CA, Schumacher J, Kluck N, Herold C, Schulze TG, Propping P, Rietschel M, Cichon S, Nöthen MM, Jamra RA.

    01/21/2012
    Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)

    Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article

    06/30/2010
    Variation in the Epsin 4 gene is significantly associated with psychotic disorder in this Latino population

    The epsin 4 gene is associated with psychotic disorders in families of Latin American origin.
    Escamilla M, Lee BD, Ontiveros A, Raventos H, Nicolini H, Mendoza R, Jerez A, Munoz R, Medina R, Figueroa A, Walss-Bass C, Armas R, Contreras S, Ramirez ME, Dassori A, Escamilla M, Lee BD, Ontiveros A, Raventos H, Nicolini H, Mendoza R, Jerez A, Munoz R, Medina R, Figueroa A, Walss-Bass C, Armas R, Contreras S, Ramirez ME, Dassori A.

    01/21/2010
    Our results suggest that the examined region of Epsin 4 does not have a major influence on susceptibility to schizophrenia in Japanese.

    Failure to confirm an association between Epsin 4 and schizophrenia in a Japanese population.
    Richards M, Iijima Y, Shizuno T, Kamegaya Y, Hori H, Omori M, Arima K, Saitoh O, Kunugi H, Richards M, Iijima Y, Shizuno T, Kamegaya Y, Hori H, Omori M, Arima K, Saitoh O, Kunugi H.

    01/21/2010
    Observational study of gene-disease association. (HuGE Navigator)See all PubMed (3) articles

    Comprehensive copy number variant (CNV) analysis of neuronal pathways genes in psychiatric disorders identifies rare variants within patients.
    Saus E, Brunet A, Armengol L, Alonso P, Crespo JM, Fernández-Aranda F, Guitart M, Martín-Santos R, Menchón JM, Navinés R, Soria V, Torrens M, Urretavizcaya M, Vallès V, Gratacòs M, Estivill X.

    The epsin 4 gene is associated with psychotic disorders in families of Latin American origin.
    Escamilla M, Lee BD, Ontiveros A, Raventos H, Nicolini H, Mendoza R, Jerez A, Munoz R, Medina R, Figueroa A, Walss-Bass C, Armas R, Contreras S, Ramirez ME, Dassori A, Escamilla M, Lee BD, Ontiveros A, Raventos H, Nicolini H, Mendoza R, Jerez A, Munoz R, Medina R, Figueroa A, Walss-Bass C, Armas R, Contreras S, Ramirez ME, Dassori A.

    Failure to confirm an association between Epsin 4 and schizophrenia in a Japanese population.
    Richards M, Iijima Y, Shizuno T, Kamegaya Y, Hori H, Omori M, Arima K, Saitoh O, Kunugi H, Richards M, Iijima Y, Shizuno T, Kamegaya Y, Hori H, Omori M, Arima K, Saitoh O, Kunugi H.

    08/20/2008
    characterization of the molecular details governing the sorting of a SNARE into clathrin-coated vesicles, namely the direct recognition of the three-helical bundle H(abc) domain of the mouse SNARE Vti1b by the human clathrin adaptor epsinR

    A SNARE-adaptor interaction is a new mode of cargo recognition in clathrin-coated vesicles.
    Miller SE, Collins BM, McCoy AJ, Robinson MS, Owen DJ.

    01/21/2010
    might participate in the formation of clathrin-coated vesicles at the level of the trans-Golgi network and remains associated with the vesicles longer than clathrin and adaptors

    Clint: a novel clathrin-binding ENTH-domain protein at the Golgi.
    Kalthoff C, Groos S, Kohl R, Mahrhold S, Ungewickell EJ., Free PMC Article

    01/21/2010
    epsinR is an adaptor for vesicle-associated soluble NSF attachment protein receptor

    EpsinR is an adaptor for the SNARE protein Vti1b.
    Hirst J, Miller SE, Taylor MJ, von Mollard GF, Robinson MS., Free PMC Article

    01/21/2010
    Four adjacent markers at the 5' end of the Epsin 4 gene showed significant evidence of linkage disequilibrium with schizophrenia.

    The Epsin 4 gene on chromosome 5q, which encodes the clathrin-associated protein enthoprotin, is involved in the genetic susceptibility to schizophrenia.
    Pimm J, McQuillin A, Thirumalai S, Lawrence J, Quested D, Bass N, Lamb G, Moorey H, Datta SR, Kalsi G, Badacsonyi A, Kelly K, Morgan J, Punukollu B, Curtis D, Gurling H., Free PMC Article

    01/21/2010
    a novel clathrin-associated protein identified through subcellular proteomics; data suggest a role in clathrin-mediated budding on internal membranes

    Enthoprotin: a novel clathrin-associated protein identified through subcellular proteomics.
    Wasiak S, Legendre-Guillemin V, Puertollano R, Blondeau F, Girard M, de Heuvel E, Boismenu D, Bell AW, Bonifacino JS, McPherson PS., Free PMC Article

    01/21/2010
    Our work reveals the existence of clathrin-independent and -dependent transport steps in the retrograde route, and establishes a function for clathrin and epsinR at the endosome-TGN interface.

    Clathrin adaptor epsinR is required for retrograde sorting on early endosomal membranes.
    Saint-Pol A, Yélamos B, Amessou M, Mills IG, Dugast M, Tenza D, Schu P, Antony C, McMahon HT, Lamaze C, Johannes L.

    01/21/2010
    Results indicate the presence of a locus near the 5' end of Epsin 4 conferring susceptibility to the disease and provide further support for Epsin 4 as an important potential contributor to genetic risk in schizophrenia.

    Family-based association study of Epsin 4 and Schizophrenia.
    Tang RQ, Zhao XZ, Shi YY, Tang W, Gu NF, Feng GY, Xing YL, Zhu SM, Sang H, Liang PJ, He L.

    01/21/2010
    EpsinR is an ENTH domain-containing protein that interacts with AP-1

    EpsinR: an ENTH domain-containing protein that interacts with AP-1.
    Hirst J, Motley A, Harasaki K, Peak Chew SY, Robinson MS., Free PMC Article

    01/21/2010
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