| Identification of Alzheimer's disease-associated rare coding variants in the ECE2 gene. | Identification of Alzheimer's disease-associated rare coding variants in the ECE2 gene.
Liao X, Cai F, Sun Z, Zhang Y, Wang J, Jiao B, Guo J, Li J, Liu X, Guo L, Zhou Y, Wang J, Yan X, Jiang H, Xia K, Li J, Tang B, Shen L, Song W., Free PMC Article | 06/26/2021 |
| this is the first report of ECE-2 being an autoantigen in humans. We have identified ECE-2 as a specific autoantigen in APS1 with a restricted neuroendocrine distribution. | Identification of endothelin-converting enzyme-2 as an autoantigen in autoimmune polyendocrine syndrome type 1.
Smith-Anttila CJA, Bensing S, Alimohammadi M, Dalin F, Oscarson M, Zhang MD, Perheentupa J, Husebye ES, Gustafsson J, Björklund P, Fransson A, Nordmark G, Rönnblom L, Meloni A, Scott RJ, Hökfelt T, Crock PA, Kämpe O. | 05/12/2018 |
| ECE-2 and ECE-1 levels are significantly reduced in post-mortem brain from dementia with Lewy body patients. | Endothelin-converting enzymes degrade α-synuclein and are reduced in dementia with Lewy bodies.
Miners JS, Love S. | 07/15/2017 |
| Te results of this study suggested taht genetic variations in MMEL1, ECE1, ECE2, AGER, PLG, PLAT, NR1H3, MMP3, LRP1, TTR, NR1H2, and MMP9 genes do not play major role among the Finnish AD patient cohort. | Genetic analysis of genes involved in amyloid-β degradation and clearance in Alzheimer's disease.
Natunen T, Helisalmi S, Vepsäläinen S, Sarajärvi T, Antikainen L, Mäkinen P, Herukka SK, Koivisto AM, Haapasalo A, Soininen H, Hiltunen M. | 06/16/2012 |
| The PL405 assay is thus the first tool to study ECE-2 inhibition using high throughput screening or for ex vivo ECE-2 quantification. | Identification of an endothelin-converting enzyme-2-specific fluorigenic substrate and development of an in vitro and ex vivo enzymatic assay.
Ouimet T, Orng SV, Poras H, Gagnidze K, Devi LA, Fournié-Zaluski MC, Roques BP., Free PMC Article | 12/4/2010 |
| Data show that CD133 and ECE expressions are associated with lymphoid metastasis and prognosis of NSCLC, and their overexpression often suggests unfavorable prognosis of NSCLC. | [Association of CD133 and endothelin-converting enzyme expressions with prognosis of non-small cell lung carcinoma].
Zhang HZ, Wei YP, Wang M, Wu C, Yang YQ, Chen J, Cao YK. | 08/23/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | Follow-up examination of linkage and association to chromosome 1q43 in multiple sclerosis.
McCauley JL, Zuvich RL, Bradford Y, Kenealy SJ, Schnetz-Boutaud N, Gregory SG, Hauser SL, Oksenberg JR, Mortlock DP, Pericak-Vance MA, Haines JL., Free PMC Article | 09/20/2009 |
| Abeta accumulation in Alzheimer's disease is unlikely to be caused by ECE-2 deficiency. However, ECE-2 expression is up-regulated | Endothelin-converting enzyme-2 is increased in Alzheimer's disease and up-regulated by Abeta.
Palmer JC, Baig S, Kehoe PG, Love S., Free PMC Article | 01/21/2010 |
| An intact SAM-dependent methyltransferase fold is encoded by the human endothelin-converting enzyme-2 gene | An intact SAM-dependent methyltransferase fold is encoded by the human endothelin-converting enzyme-2 gene.
Tempel W, Wu H, Dombrovsky L, Zeng H, Loppnau P, Zhu H, Plotnikov AN, Bochkarev A. | 01/21/2010 |
| Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) | Polymorphism in endothelin-related genes limits exercise-induced decreases in arterial stiffness in older subjects.
Iemitsu M, Maeda S, Otsuki T, Sugawara J, Tanabe T, Jesmin S, Kuno S, Ajisaka R, Miyauchi T, Matsuda M. | 03/13/2008 |
| The most significantly downregulated gene in this data set was the endothelin converting enzyme 2 (ECE2), implicated in amyloid beta clearance. | Alterations in immunological and neurological gene expression patterns in Alzheimer's disease tissues.
Weeraratna AT, Kalehua A, Deleon I, Bertak D, Maher G, Wade MS, Lustig A, Becker KG, Wood W 3rd, Walker DG, Beach TG, Taub DD., Free PMC Article | 01/21/2010 |