| Emerging insights into CP110 removal during early steps of ciliogenesis. | Emerging insights into CP110 removal during early steps of ciliogenesis.
Xie S, Naslavsky N, Caplan S., | 02/29/2024 |
| CCP5 and CCP6 retain CP110 and negatively regulate ciliogenesis. | CCP5 and CCP6 retain CP110 and negatively regulate ciliogenesis.
Wang Y, Zhang Y, Guo X, Zheng Y, Zhang X, Feng S, Wu HY., Free PMC Article | 07/19/2023 |
| EHD1 promotes CP110 ubiquitination by centriolar satellite delivery of HERC2 to the mother centriole. | EHD1 promotes CP110 ubiquitination by centriolar satellite delivery of HERC2 to the mother centriole.
Xie S, Naslavsky N, Caplan S., Free PMC Article | 06/14/2023 |
| Primary cilia biogenesis and associated retinal ciliopathies. | Primary cilia biogenesis and associated retinal ciliopathies.
Chen HY, Kelley RA, Li T, Swaroop A., Free PMC Article | 01/22/2022 |
| LUBAC regulates ciliogenesis by promoting CP110 removal from the mother centriole. | LUBAC regulates ciliogenesis by promoting CP110 removal from the mother centriole.
Shen XL, Yuan JF, Qin XH, Song GP, Hu HB, Tu HQ, Song ZQ, Li PY, Xu YL, Li S, Jian XX, Li JN, He CY, Yu XP, Liang LY, Wu M, Han QY, Wang K, Li AL, Zhou T, Zhang YC, Wang N, Li HY., Free PMC Article | 12/25/2021 |
| CEP78 functions downstream of CEP350 to control biogenesis of primary cilia by negatively regulating CP110 levels. | CEP78 functions downstream of CEP350 to control biogenesis of primary cilia by negatively regulating CP110 levels.
Gonçalves AB, Hasselbalch SK, Joensen BB, Patzke S, Martens P, Ohlsen SK, Quinodoz M, Nikopoulos K, Suleiman R, Damsø Jeppesen MP, Weiss C, Christensen ST, Rivolta C, Andersen JS, Farinelli P, Pedersen LB., Free PMC Article | 11/6/2021 |
| Myeloid/lymphoid neoplasm with CEP110-FGFR1 fusion: An analysis of 16 cases show common features and poor prognosis. | Myeloid/lymphoid neoplasm with CEP110-FGFR1 fusion: An analysis of 16 cases show common features and poor prognosis.
Chen M, Wang K, Cai X, Zhang X, Chao H, Chen S, Shen H, Wang Q, Zhang R. | 05/15/2021 |
| PLK4 specifically phosphorylates CP110 at the S98 position and is an essential step for centriole assembly. | PLK4 phosphorylation of CP110 is required for efficient centriole assembly.
Lee M, Seo MY, Chang J, Hwang DS, Rhee K., Free PMC Article | 04/14/2018 |
| This brief communication reports on a patient with an exceedingly rare "8p11 (eight-p-eleven) myeloproliferative syndrome" (EMS) with CEP110-FGFR1 rearrangement who responded to treatment with the multi-tyrosine kinase inhibitor (TKI) dasatinib | Response to Tyrosine Kinase Inhibitors in Myeloproliferative Neoplasia with 8p11 Translocation and CEP110-FGFR1 Rearrangement.
Wehrli M, Oppliger Leibundgut E, Gattiker HH, Manz MG, Müller AM, Goede JS., Free PMC Article | 02/17/2018 |
| In tissues of prostate cancer patients, low CP110 and high miR-129-3p expression levels correlated with metastasi | miR-129-3p controls centrosome number in metastatic prostate cancer cells by repressing CP110.
Bijnsdorp IV, Hodzic J, Lagerweij T, Westerman B, Krijgsman O, Broeke J, Verweij F, Nilsson RJ, Rozendaal L, van Beusechem VW, van Moorselaar JA, Wurdinger T, Geldof AA., Free PMC Article | 12/9/2017 |
| We demonstrated that restoration of CP110 expression in MDA-MB-231 and MCF-7 cells by miR-129 overexpression rendered the cells sensitive to docetaxel. | MiR-129-3p promotes docetaxel resistance of breast cancer cells via CP110 inhibition.
Zhang Y, Wang Y, Wei Y, Li M, Yu S, Ye M, Zhang H, Chen S, Liu W, Zhang J., Free PMC Article | 09/17/2016 |
| Data show thata combining cyclin-dependent kinase 2 (CDK2) antagonism and ubiquitin thioesterase 33 (USP33) depletion augments anaphase catastrophe via changes in centrosomal protein of 110 kDa (CP110) protein expression. | Specific CP110 Phosphorylation Sites Mediate Anaphase Catastrophe after CDK2 Inhibition: Evidence for Cooperation with USP33 Knockdown.
Hu S, Lu Y, Orr B, Godek K, Mustachio LM, Kawakami M, Sekula D, Compton DA, Freemantle S, Dmitrovsky E., Free PMC Article | 09/10/2016 |
| CP110 plays a mechanistic role in response of lung cancer cells to CDK2 inhibition, especially in the presence of activated KRAS mutations. | CDK2 Inhibition Causes Anaphase Catastrophe in Lung Cancer through the Centrosomal Protein CP110.
Hu S, Danilov AV, Godek K, Orr B, Tafe LJ, Rodriguez-Canales J, Behrens C, Mino B, Moran CA, Memoli VA, Mustachio LM, Galimberti F, Ravi S, DeCastro A, Lu Y, Sekula D, Andrew AS, Wistuba II, Freemantle S, Compton DA, Dmitrovsky E., Free PMC Article | 08/1/2015 |
| Centrin2 regulates primary ciliogenesis through controlling CP110 levels. | Centrin2 regulates CP110 removal in primary cilium formation.
Prosser SL, Morrison CG., Free PMC Article | 05/30/2015 |
| Both protein and mRNA levels of ciliogenesis-associated markers CP110, Foxj1, TAp73 were significantly increased in patients with nasal polyps versus those seen in control subjects and were positively correlated with cilia length | Impairment of cilia architecture and ciliogenesis in hyperplastic nasal epithelium from nasal polyps.
Li YY, Li CW, Chao SS, Yu FG, Yu XM, Liu J, Yan Y, Shen L, Gordon W, Shi L, Wang Y. | 02/7/2015 |
| using human cells, identification of a new mechanism for the regulation of centrosome duplication that requires USP33, a deubiquitinating enzyme that is able to regulate CP110 levels | USP33 regulates centrosome biogenesis via deubiquitination of the centriolar protein CP110.
Li J, D'Angiolella V, Seeley ES, Kim S, Kobayashi T, Fu W, Campos EI, Pagano M, Dynlacht BD., Free PMC Article | 04/20/2013 |
| Neurl4 counteracts accumulation of CP110, thereby maintaining normal centriolar homeostasis and preventing formation of ectopic microtubular organizing centres | Neurl4, a novel daughter centriole protein, prevents formation of ectopic microtubule organizing centres.
Li J, Kim S, Kobayashi T, Liang FX, Korzeniewski N, Duensing S, Dynlacht BD., Free PMC Article | 09/29/2012 |
| miR-129-3p controls cilia assembly by regulating CP110 and actin dynamics. | miR-129-3p controls cilia assembly by regulating CP110 and actin dynamics.
Cao J, Shen Y, Zhu L, Xu Y, Zhou Y, Wu Z, Li Y, Yan X, Zhu X. | 09/8/2012 |
| Cp110 expression in mucosa from patients with chronic rhinosinusitis might contribute to the poor ciliation observed in these patients | Inflammation-mediated upregulation of centrosomal protein 110, a negative modulator of ciliogenesis, in patients with chronic rhinosinusitis.
Lai Y, Chen B, Shi J, Palmer JN, Kennedy DW, Cohen NA. | 01/21/2012 |
| Study found that loss of Kif24 leads to the disappearance of CP110 from mother centrioles in cycling cells able to form cilia; thus, identifying a centriolar kinesin that specifically remodels a subset of microtubules, thereby regulating cilia assembly. | Centriolar kinesin Kif24 interacts with CP110 to remodel microtubules and regulate ciliogenesis.
Kobayashi T, Tsang WY, Li J, Lane W, Dynlacht BD. | 08/20/2011 |
| SCF(Cyclin F)-mediated degradation of CP110 is required for the fidelity of mitosis and genome integrity | SCF(Cyclin F) controls centrosome homeostasis and mitotic fidelity through CP110 degradation.
D'Angiolella V, Donato V, Vijayakumar S, Saraf A, Florens L, Washburn MP, Dynlacht B, Pagano M., Free PMC Article | 08/9/2010 |
| Results suggest that CPAP and CP110 play antagonistic roles in determining the extent of tubulin addition during centriole elongation, thereby controlling the length of newly formed centrioles. | Control of centriole length by CPAP and CP110.
Schmidt TI, Kleylein-Sohn J, Westendorf J, Le Clech M, Lavoie SB, Stierhof YD, Nigg EA. | 01/21/2010 |
| These results suggest that CEP290 cooperates with Rab8a to promote ciliogenesis and that this function is antagonized by CP110. | CP110 suppresses primary cilia formation through its interaction with CEP290, a protein deficient in human ciliary disease.
Tsang WY, Bossard C, Khanna H, Peränen J, Swaroop A, Malhotra V, Dynlacht BD., Free PMC Article | 01/21/2010 |
| The transition from centrioles to basal bodies is negatively regulated by CP11 protein. | Centrioles want to move out and make cilia.
Pearson CG, Culver BP, Winey M. | 01/21/2010 |
| CP110 suppresses a cilia assembly program. | Cep97 and CP110 suppress a cilia assembly program.
Spektor A, Tsang WY, Khoo D, Dynlacht BD. | 01/21/2010 |