HDAC4 influences the DNA damage response and counteracts senescence by assembling with HDAC1/HDAC2 to control H2BK120 acetylation and homology-directed repair. | HDAC4 influences the DNA damage response and counteracts senescence by assembling with HDAC1/HDAC2 to control H2BK120 acetylation and homology-directed repair. Di Giorgio E, Dalla E, Tolotto V, D'Este F, Paluvai H, Ranzino L, Brancolini C., Free PMC Article | 08/22/2024 |
Targeting SIK3 to modulate hippocampal synaptic plasticity and cognitive function by regulating the transcription of HDAC4 in a mouse model of Alzheimer's disease. | Targeting SIK3 to modulate hippocampal synaptic plasticity and cognitive function by regulating the transcription of HDAC4 in a mouse model of Alzheimer's disease. Dai X, Lin A, Zhuang L, Zeng Q, Cai L, Wei Y, Liang H, Gao W, Zhang J, Chen X., | 05/3/2024 |
Structural insights into the HDAC4-MEF2A-DNA complex and its implication in long-range transcriptional regulation. | Structural insights into the HDAC4-MEF2A-DNA complex and its implication in long-range transcriptional regulation. Dai S, Guo L, Dey R, Guo M, Zhang X, Bates D, Cayford J, Jiang L, Wei H, Chen Z, Zhang Y, Chen L, Chen Y., Free PMC Article | 03/26/2024 |
ZIP4 upregulation aggravates nucleus pulposus cell degradation by promoting inflammation and oxidative stress by mediating the HDAC4-FoxO3a axis. | ZIP4 upregulation aggravates nucleus pulposus cell degradation by promoting inflammation and oxidative stress by mediating the HDAC4-FoxO3a axis. Shen M, Li K, Wang L, Feng L, Zhang X, Zhang H, Zhou H, Pei G., Free PMC Article | 01/29/2024 |
HDAC4 regulates the proliferation, migration, and invasion of trophoblasts in pre-eclampsia through the miR-134-5p/FOXM1 axis. | HDAC4 regulates the proliferation, migration, and invasion of trophoblasts in pre-eclampsia through the miR-134-5p/FOXM1 axis. Xu Y, Kang X, Jiang H, Liu H, Wang W. | 12/28/2023 |
Association between circHIPK3/miR-378a-3p/HDAC4 axis and osteoporotic fractures: A comprehensive investigation. | Association between circHIPK3/miR-378a-3p/HDAC4 axis and osteoporotic fractures: A comprehensive investigation. Wang L, Sheng Z, Yao T. | 12/6/2023 |
Candidate Oligo Therapeutic Target, miR-330-3p, Induces Tamoxifen Resistance in Estrogen Receptor-Positive Breast Cancer Cells via HDAC4. | Candidate Oligo Therapeutic Target, miR-330-3p, Induces Tamoxifen Resistance in Estrogen Receptor-Positive Breast Cancer Cells via HDAC4. Zhang M, Wang M, Jiang Z, Fu Z, Ma J, Gao S., Free PMC Article | 09/20/2023 |
LncRNA CASC11 upregulation promotes HDAC4 to alleviate oxidized low-density lipoprotein-induced injury of cardiac microvascular endothelial cells. | LncRNA CASC11 upregulation promotes HDAC4 to alleviate oxidized low-density lipoprotein-induced injury of cardiac microvascular endothelial cells. Hu K, Huang MJ, Ling S, Li YX, Cao XY, Chen YF, Lei JM, Fu WZ, Tan BF. | 08/16/2023 |
Silencing circular RNA hsa_circABCC1 inhibits osteosarcoma progression through down-regulating HDAC4 via sponging miR-591. | Silencing circular RNA hsa_circABCC1 inhibits osteosarcoma progression through down-regulating HDAC4 via sponging miR-591. Wang K, Wang N, Liu J, Zhou J, Lei S, Yue H, Feng H, Feng K, Kang X. | 06/23/2023 |
WTAP-Mediated m6A RNA Methylation Regulates the Differentiation of Bone Marrow Mesenchymal Stem Cells via the miR-29b-3p/HDAC4 Axis. | WTAP-Mediated m6A RNA Methylation Regulates the Differentiation of Bone Marrow Mesenchymal Stem Cells via the miR-29b-3p/HDAC4 Axis. Liu J, You Y, Sun Z, Zhang L, Li X, Dai Z, Ma J, Chen Y, Jiao G., Free PMC Article | 05/17/2023 |
Circulating HDAC4 reflects lipid profile, coronary stenosis and inflammation in coronary heart disease patients. | Circulating HDAC4 reflects lipid profile, coronary stenosis and inflammation in coronary heart disease patients. Guo Z, Wu Y, Feng Q, Wang C, Wang Z, Zhu Y, Lu X, Chen W, Yang Q, Huo Y. | 04/14/2023 |
HDAC4 depletion ameliorates IL-13-triggered inflammatory response and mucus production in nasal epithelial cells via activation of SIRT1/NF-kappaB signaling. | HDAC4 depletion ameliorates IL-13-triggered inflammatory response and mucus production in nasal epithelial cells via activation of SIRT1/NF-κB signaling. Xu H, Wang L, Chen H, Cai H., Free PMC Article | 11/5/2022 |
Deacetylation of Glutaminase by HDAC4 contributes to Lung Cancer Tumorigenesis. | Deacetylation of Glutaminase by HDAC4 contributes to Lung Cancer Tumorigenesis. Wang T, Lu Z, Han T, Wang Y, Gan M, Wang JB., Free PMC Article | 07/30/2022 |
LncRNA MALAT1 promotes decidualization of endometrial stromal cells via sponging miR-498-3p and targeting histone deacetylase 4. | LncRNA MALAT1 promotes decidualization of endometrial stromal cells via sponging miR-498-3p and targeting histone deacetylase 4. Shi L, Zhu L, Gu Q, Kong C, Liu X, Zhu Z. | 07/30/2022 |
Clinical role of serum histone deacetylase 4 measurement in acute ischemic stroke: Relation to disease risk, severity, and prognosis. | Clinical role of serum histone deacetylase 4 measurement in acute ischemic stroke: Relation to disease risk, severity, and prognosis. Wang M, Pang X, Lu H, Wang X., Free PMC Article | 05/21/2022 |
Circular RNA circPSAP functions as an efficient miR-331-3p sponge to regulate proliferation, apoptosis and bortezomib sensitivity of human multiple myeloma cells by upregulating HDAC4. | Circular RNA circPSAP functions as an efficient miR-331-3p sponge to regulate proliferation, apoptosis and bortezomib sensitivity of human multiple myeloma cells by upregulating HDAC4. Ma H, Shen L, Yang H, Gong H, Du X. | 04/9/2022 |
Cytoplasmic HDAC4 regulates the membrane repair mechanism in Duchenne muscular dystrophy. | Cytoplasmic HDAC4 regulates the membrane repair mechanism in Duchenne muscular dystrophy. Renzini A, Marroncelli N, Cavioli G, Di Francescantonio S, Forcina L, Lambridis A, Di Giorgio E, Valente S, Mai A, Brancolini C, Giampietri C, Magenta A, De Santa F, Adamo S, Coletti D, Moresi V., Free PMC Article | 04/9/2022 |
Circular RNA circ_0008360 Inhibits the Proliferation, Migration, and Inflammation and Promotes Apoptosis of Fibroblast-Like Synoviocytes by Regulating miR-135b-5p/HDAC4 Axis in Rheumatoid Arthritis. | Circular RNA circ_0008360 Inhibits the Proliferation, Migration, and Inflammation and Promotes Apoptosis of Fibroblast-Like Synoviocytes by Regulating miR-135b-5p/HDAC4 Axis in Rheumatoid Arthritis. Hao J, Chen Y, Yu Y. | 03/26/2022 |
GAS5 regulates viability and apoptosis in TGF-beta1-stimulated bronchial epithelial cells by regulating miR-217/HDAC4 axis. | GAS5 regulates viability and apoptosis in TGF-β1-stimulated bronchial epithelial cells by regulating miR-217/HDAC4 axis. Zhao S, Ning Y, Qin N, Ping N, Yu Y, Yin G. | 02/26/2022 |
Histone deacetylase 4 inhibits NF-kappaB activation by facilitating IkappaBalpha sumoylation. | Histone deacetylase 4 inhibits NF-κB activation by facilitating IκBα sumoylation. Yang Q, Tang J, Xu C, Zhao H, Zhou Y, Wang Y, Yang M, Chen X, Chen J., Free PMC Article | 02/12/2022 |
miRNA-483-5p Targets HDCA4 to Regulate Renal Tubular Damage in Diabetic Nephropathy. | miRNA-483-5p Targets HDCA4 to Regulate Renal Tubular Damage in Diabetic Nephropathy. Liu L, Chen H, Yun J, Song L, Ma X, Luo S, Song Y. | 01/15/2022 |
HDAC4 degradation during senescence unleashes an epigenetic program driven by AP-1/p300 at selected enhancers and super-enhancers. | HDAC4 degradation during senescence unleashes an epigenetic program driven by AP-1/p300 at selected enhancers and super-enhancers. Di Giorgio E, Paluvai H, Dalla E, Ranzino L, Renzini A, Moresi V, Minisini M, Picco R, Brancolini C., Free PMC Article | 01/15/2022 |
Coupling HDAC4 with transcriptional factor MEF2D abrogates SPRY4-mediated suppression of ERK activation and elicits hepatocellular carcinoma drug resistance. | Coupling HDAC4 with transcriptional factor MEF2D abrogates SPRY4-mediated suppression of ERK activation and elicits hepatocellular carcinoma drug resistance. Ma Q, Xu Q, Zhao J, Zhang W, Wang Q, Fang J, Lu Z, Liu J, Ma L. | 01/8/2022 |
HDAC4 Knockdown Induces Preeclampsia Cell Autophagy and Apoptosis by miR-29b. | HDAC4 Knockdown Induces Preeclampsia Cell Autophagy and Apoptosis by miR-29b. Du J, Ji Q, Dong L, Meng Y, Xin G. | 11/27/2021 |
Neddylation Regulates Class IIa and III Histone Deacetylases to Mediate Myoblast Differentiation. | Neddylation Regulates Class IIa and III Histone Deacetylases to Mediate Myoblast Differentiation. Zhou H, Su H, Chen W., Free PMC Article | 10/23/2021 |