| The mechanisms behind the dual role of long non-coding RNA (lncRNA) metastasis suppressor-1 in human tumors: Shedding light on the molecular mechanisms. | The mechanisms behind the dual role of long non-coding RNA (lncRNA) metastasis suppressor-1 in human tumors: Shedding light on the molecular mechanisms.
Abdullaev B, Alsaab HO, Hjazi A, Alkhafaji AT, Alawadi AH, Hamzah HF. | 04/18/2024 |
| Prognostic value of MTSS1 gene expression on acute leukemia patients outcome. | Prognostic value of MTSS1 gene expression on acute leukemia patients outcome.
Aref S, Sabry M, Menshawy NE, Aref A, Tantawy AE, Ayed M, El-Sebaie A. | 01/30/2024 |
| Metastasis suppressor 1 interacts with protein tyrosine phosphatase receptor-delta to regulate adipogenesis. | Metastasis suppressor 1 interacts with protein tyrosine phosphatase receptor-δ to regulate adipogenesis.
Chen M, Dong Y, Tian L, Zhou J, Zhu E, Yuan H, Li X, Wang B. | 03/16/2023 |
| MTSS1 suppresses mammary tumor-initiating cells by enhancing RBCK1-mediated p65 ubiquitination. | MTSS1 suppresses mammary tumor-initiating cells by enhancing RBCK1-mediated p65 ubiquitination.
Cong M, Wang Y, Yang Y, Lian C, Zhuang X, Li X, Zhang P, Liu Y, Tang J, Yang Q, Zhang X, Xiong H, Hu R, Hu G. | 04/23/2022 |
| Downregulation of MTSS1 in acute myeloid leukemia is associated with a poor prognosis, chemotherapy resistance, and disease aggressiveness. | Downregulation of MTSS1 in acute myeloid leukemia is associated with a poor prognosis, chemotherapy resistance, and disease aggressiveness.
Grandits AM, Nguyen CH, Schlerka A, Hackl H, Sill H, Etzler J, Heyes E, Stoiber D, Grebien F, Heller G, Wieser R., Free PMC Article | 01/1/2022 |
| Circular RNA SFMBT2 Inhibits the Proliferation and Metastasis of Glioma Cells Through Mir-182-5p/Mtss1 Pathway. | Circular RNA SFMBT2 Inhibits the Proliferation and Metastasis of Glioma Cells Through Mir-182-5p/Mtss1 Pathway.
Zhang S, Qin W, Yang S, Guan N, Sui X, Guo W., Free PMC Article | 12/4/2021 |
| Circ_002059 suppresses cell proliferation and migration of gastric cancer via miR-182/MTSS1 axis. | Circ_002059 suppresses cell proliferation and migration of gastric cancer via miR-182/MTSS1 axis.
Li T, Zuo X, Meng X. | 07/17/2021 |
| A reciprocal feedback of Myc and lncRNA MTSS1-AS contributes to extracellular acidity-promoted metastasis of pancreatic cancer. | A reciprocal feedback of Myc and lncRNA MTSS1-AS contributes to extracellular acidity-promoted metastasis of pancreatic cancer.
Hu Y, Wang F, Xu F, Fang K, Fang Z, Shuai X, Cai K, Chen J, Hu P, Chen D, Xu P, Hu C, Zeng Z, Zhong J, Li W, Tang J, Huang M, Zhao Y, Wang C, Zhao G., Free PMC Article | 05/29/2021 |
| MicroRNA-182-5p Modulates Oral Squamous Cell Carcinoma Migration and Invasion Via Targeting MTSS1 Gene. | MicroRNA-182-5p Modulates Oral Squamous Cell Carcinoma Migration and Invasion Via Targeting MTSS1 Gene.
Guo Y, Qiao X, Zhu L, Song R. | 04/3/2021 |
| miR-28-5p targets MTSS1 to regulate cell proliferation and apoptosis in esophageal cancer. | miR-28-5p targets MTSS1 to regulate cell proliferation and apoptosis in esophageal cancer.
Zhang L, Wang X, Liu X, Lv M, Shen E, Zhu G, Sun Z. | 01/9/2021 |
| MTSS1 hypermethylation is associated with prostate cancer progression. | MTSS1 hypermethylation is associated with prostate cancer progression.
Chen J, Huang L, Zhu Q, Wang Z, Tang Z. | 12/19/2020 |
| Metastasis suppressor 1 acts as a tumor suppressor by inhibiting epithelial-to-mesenchymal transition in triple-negative breast cancer. | Metastasis suppressor 1 acts as a tumor suppressor by inhibiting epithelial-to-mesenchymal transition in triple-negative breast cancer.
Yu J, Shen W, Gao B, Xu J, Gong B. | 12/5/2020 |
| Low MTSS1 expression is associated with Epithelial-mesenchymal transition in gastric carcinoma. | Metastasis suppressor protein 1 regulated by PTEN suppresses invasion, migration, and EMT of gastric carcinoma by inactivating PI3K/AKT signaling.
Wang H, Zhao Y, Cao L, Zhang J, Wang Y, Xu M. | 07/18/2020 |
| MEG3 was a promising tumor suppressor that may upregulate MTSS1 through the miR-96-5p pathway, subsequently suppressing the growth and metastasis of glioma. | Long non‑coding RNA MEG3 suppresses the growth of glioma cells by regulating the miR‑96‑5p/MTSS1 signaling pathway.
Zhang S, Guo W., Free PMC Article | 02/29/2020 |
| SCAMP1 enhances Mtss1 anti-invasive function in HER2+/ER-/PR- breast cancer, by promoting its protein trafficking leading to elevated levels of RAC1-GTP and increased cell-cell adhesions. | MTSS1 and SCAMP1 cooperate to prevent invasion in breast cancer.
Vadakekolathu J, Al-Juboori SIK, Johnson C, Schneider A, Buczek ME, Di Biase A, Pockley AG, Ball GR, Powe DG, Regad T., Free PMC Article | 11/2/2019 |
| deletion of the SH3 domain in IRTKS abolished the IRTKS-RAB11 interaction and promoted CXCR4 degradation. Furthermore, the SH3 domain was required for selective targeting of MIM-IRTKS fusion proteins by both RAB7 and RAB11. | Differential interactions of missing in metastasis and insulin receptor tyrosine kinase substrate with RAB proteins in the endocytosis of CXCR4.
Li L, Baxter SS, Zhao P, Gu N, Zhan X., Free PMC Article | 10/19/2019 |
| In vitro data suggests MTSS1 regulates lung adenocarcinoma through augmentation of cell invasion and migration. | Metastasis suppressor 1 (MTSS1) expression is associated with reduced in-vivo metastasis and enhanced patient survival in lung adenocarcinoma.
Taylor MD, Bollt O, Iyer SC, Robertson GP. | 02/16/2019 |
| MTSS1 is stabilized by the protein phosphatase activity of the tumor suppressor PTEN. Our data show that PTEN loss in PDAC cells results in both increased metastatic potential and decreased MTSS1 expression. Furthermore, we show that ectopic MTSS1 expression rescues this effect. | PTEN-Dependent Stabilization of MTSS1 Inhibits Metastatic Phenotype in Pancreatic Ductal Adenocarcinoma.
Zeleniak AE, Huang W, Fishel ML, Hill R., Free PMC Article | 12/1/2018 |
| Missing in metastasis B, regulated by DNMT1, functions as a putative cancer suppressor in human lung giant-cell carcinoma. | Missing in metastasis B, regulated by DNMT1, functions as a putative cancer suppressor in human lung giant-cell carcinoma.
Wang H, Yu X, Wang X, Li X, Yang S. | 05/12/2018 |
| Data identify MTSS1 as a new Akt2-regulated gene, and point to suppression of MTSS1 as a key step in the metastasis-promoting effects of Akt2 in CRC cells. | Role of Akt2 in regulation of metastasis suppressor 1 expression and colorectal cancer metastasis.
Agarwal E, Robb CM, Smith LM, Brattain MG, Wang J, Black JD, Chowdhury S., Free PMC Article | 09/30/2017 |
| Data suggest that overexpression of MAEL, caused by gene amplification and/or decreased miR-186, has a critical oncogenic role in UCB pathogenesis by downregulation of MTSS1. | Overexpression of maelstrom promotes bladder urothelial carcinoma cell aggressiveness by epigenetically downregulating MTSS1 through DNMT3B.
Li XD, Zhang JX, Jiang LJ, Wang FW, Liu LL, Liao YJ, Jin XH, Chen WH, Chen X, Guo SJ, Zhou FJ, Zeng YX, Guan XY, Liu ZW, Xie D. | 09/16/2017 |
| Overexpression of MTSS1 in PDAC cell lines leads to a loss of migratory potential in vitro and an increase in overall survival in vivo. Data provide insight into an important role for MTSS1 in suppressing tumor cell invasion and migration driven by the tumor microenvironment. | Loss of MTSS1 results in increased metastatic potential in pancreatic cancer.
Zeleniak AE, Huang W, Brinkman MK, Fishel ML, Hill R., Free PMC Article | 08/26/2017 |
| Overexpression of MTSS1 reduced BUCC cell proliferation, cell-cycle progression and colony formation, but had no influence on BUCC cell apoptosis. | Reduced Expression of Metastasis Suppressor-1 (MTSS1) Accelerates Progression of Human Bladder Uroepithelium Cell Carcinoma.
Du P, Wang S, Tang X, An C, Yang Y, Jiang WG. | 08/5/2017 |
| in contrast to MIM, which is a prototype of I-BAR proteins and does not contain an SH3 domain, IRTKS promoted serum-induced cell migration along with enhanced phosphorylation of mitogen activated kinases Erk1/2 and p38 | The SH3 domain distinguishes the role of I-BAR proteins IRTKS and MIM in chemotactic response to serum.
Li L, Liu H, Baxter SS, Gu N, Ji M, Zhan X., Free PMC Article | 06/3/2017 |
| this study shows a previously unknown property of MIM that establishes the linkage of protein ubiquitylation with Rab-guided trafficking of CXCR4 in endocytic vesicles | Missing-in-metastasis protein downregulates CXCR4 by promoting ubiquitylation and interaction with small Rab GTPases.
Li L, Baxter SS, Gu N, Ji M, Zhan X., Free PMC Article | 05/6/2017 |