| CKAP5 stabilizes CENP-E at kinetochores by regulating microtubule-chromosome attachments. | CKAP5 stabilizes CENP-E at kinetochores by regulating microtubule-chromosome attachments.
Lakshmi RB, Nayak P, Raz L, Sarkar A, Saroha A, Kumari P, Nair VM, Kombarakkaran DP, Sajana S, M G S, Agasti SS, Paul R, Ben-David U, Manna TK., Free PMC Article | 05/20/2024 |
| Competing endogenous RNA analysis reveals the regulatory potency of CKAP5 in HPV+ HNSCC. | Competing endogenous RNA analysis reveals the regulatory potency of CKAP5 in HPV+ HNSCC.
Wang Y, Ma X, Wang S, Li Z, Wang F, Tian X, Fu H, Xing G, Sun L, Wang W. | 12/15/2023 |
| TACC3-ch-TOG interaction regulates spindle microtubule assembly by controlling centrosomal recruitment of gamma-TuRC. | TACC3-ch-TOG interaction regulates spindle microtubule assembly by controlling centrosomal recruitment of γ-TuRC.
Rajeev R, Mukhopadhyay S, Bhagyanath S, Devu Priya MRS, Manna TK., Free PMC Article | 03/22/2023 |
| Circular RNA ZNF609/CKAP5 mRNA interaction regulates microtubule dynamics and tumorigenicity. | Circular RNA ZNF609/CKAP5 mRNA interaction regulates microtubule dynamics and tumorigenicity.
Rossi F, Beltran M, Damizia M, Grelloni C, Colantoni A, Setti A, Di Timoteo G, Dattilo D, Centrón-Broco A, Nicoletti C, Fanciulli M, Lavia P, Bozzoni I., Free PMC Article | 02/19/2022 |
| Tyrosine phosphorylation regulates hnRNPA2 granule protein partitioning and reduces neurodegeneration. | Tyrosine phosphorylation regulates hnRNPA2 granule protein partitioning and reduces neurodegeneration.
Ryan VH, Perdikari TM, Naik MT, Saueressig CF, Lins J, Dignon GL, Mittal J, Hart AC, Fawzi NL., Free PMC Article | 10/9/2021 |
| chTOG is a conserved mitotic error correction factor. | chTOG is a conserved mitotic error correction factor.
Herman JA, Miller MP, Biggins S., Free PMC Article | 03/20/2021 |
| Eribulin binding to the tip of microtubules and subsequent loss of ch-TOG is a priming event leading to alterations in microtubule dynamics and breast cancer cell migration. | Eribulin targets a ch-TOG-dependent directed migration of cancer cells.
Chanez B, Gonçalves A, Badache A, Verdier-Pinard P., Free PMC Article | 10/1/2016 |
| Data show that cytoskeleton associated protein 5 (chTOG) only weakly promotes importin-regulated microtubule nucleation, but acts synergistically with microtubule- associated protein TPX2. | Complementary activities of TPX2 and chTOG constitute an efficient importin-regulated microtubule nucleation module.
Roostalu J, Cade NI, Surrey T., Free PMC Article | 03/19/2016 |
| Aurora-A kinase does not regulate TACC3-chTOG complex formation, indicating that Aurora-A solely functions as a recruitment factor for the TACC3-chTOG complex to centrosomes and proximal mitotic spindles. | The centrosomal adaptor TACC3 and the microtubule polymerase chTOG interact via defined C-terminal subdomains in an Aurora-A kinase-independent manner.
Thakur HC, Singh M, Nagel-Steger L, Kremer J, Prumbaum D, Fansa EK, Ezzahoini H, Nouri K, Gremer L, Abts A, Schmitt L, Raunser S, Ahmadian MR, Piekorz RP., Free PMC Article | 03/22/2014 |
| Data show that five genes CKAP5, KPNB1, RAN, TPX2 and KIF11 were shown to be essential for tumor cell survival in both head and neck squamous cell carcinoma (HNSCC)and non-small cell lung cancer (NSCLC), but most particularly in HNSCC. | Functional genetic screens identify genes essential for tumor cell survival in head and neck and lung cancer.
Martens-de Kemp SR, Nagel R, Stigter-van Walsum M, van der Meulen IH, van Beusechem VW, Braakhuis BJ, Brakenhoff RH. | 11/16/2013 |
| These observations indicate that EB1 and ch-TOG regulate microtubule organisation differently via distinct regions in the plus ends of microtubules. | Dissecting the nanoscale distributions and functions of microtubule-end-binding proteins EB1 and ch-TOG in interphase HeLa cells.
Nakamura S, Grigoriev I, Nogi T, Hamaji T, Cassimeris L, Mimori-Kiyosue Y., Free PMC Article | 06/8/2013 |
| Clathrin promotes centrosome maturation by stabilizing the microtubule-binding protein ch-TOG, defining a novel role for the clathrin-ch-TOG complex. | Clathrin promotes centrosome integrity in early mitosis through stabilization of centrosomal ch-TOG.
Foraker AB, Camus SM, Evans TM, Majeed SR, Chen CY, Taner SB, Corrêa IR Jr, Doxsey SJ, Brodsky FM., Free PMC Article | 11/17/2012 |
| Data show that ILK performs its centrosome clustering activity in a centrosome-dependent, manner through the microtubule regulating proteins TACC3 and ch-TOG. | A critical role of integrin-linked kinase, ch-TOG and TACC3 in centrosome clustering in cancer cells.
Fielding AB, Lim S, Montgomery K, Dobreva I, Dedhar S. | 04/23/2011 |
| the association between aurora A phosphorylation and spindle apparatus; regulation from aurora A is mediated by CHC in recruiting phospho-TACC3 and subsequently ch-TOG to mitotic spindles. | Clathrin heavy chain mediates TACC3 targeting to mitotic spindles to ensure spindle stability.
Lin CH, Hu CK, Shih HM., Free PMC Article | 08/16/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (2) articlesCentrosome-related genes, genetic variation, and risk of breast cancer.
Olson JE, Wang X, Pankratz VS, Fredericksen ZS, Vachon CM, Vierkant RA, Cerhan JR, Couch FJ. Replication of previous genome-wide association studies of bone mineral density in premenopausal American women.
Ichikawa S, Koller DL, Padgett LR, Lai D, Hui SL, Peacock M, Foroud T, Econs MJ. | 04/7/2010 |
| Data show that 4-oxo-4-HPR inhibited tubulin polymerization and modulated gene expression of spindle aberration associated genes Kif 1C, Kif 2A, Eg5, Tara, tankyrase-1, centractin, and TOGp. | Antimitotic effect of the retinoid 4-oxo-fenretinide through inhibition of tubulin polymerization: a novel mechanism of retinoid growth-inhibitory activity.
Appierto V, Tiberio P, Cavadini E, Casalini P, Cappelletti G, Formelli F. | 03/29/2010 |
| Data hypothesize that TOGp is required for chromosome motility as a downstream consequence of reduced microtubule dynamics and/or density. | TOGp regulates microtubule assembly and density during mitosis and contributes to chromosome directional instability.
Cassimeris L, Becker B, Carney B. | 01/21/2010 |
| ch-Tog has at least two distinct roles in spindle formation: it protects kinetochore microtubules from depolymerization by MCAK, and ch-Tog plays an essential role in centrosomal microtubule assembly, a function independent of MCAK activity. | MCAK-independent functions of ch-Tog/XMAP215 in microtubule plus-end dynamics.
Barr AR, Gergely F., Free PMC Article | 01/21/2010 |
| A novel function of Aurora-A, the regulation of ch-TOG and MCAK localization, in a common pathway in control of spindle pole integrity. | Aurora-A and ch-TOG act in a common pathway in control of spindle pole integrity.
De Luca M, Brunetto L, Asteriti IA, Giubettini M, Lavia P, Guarguaglini G. | 01/21/2010 |
| Interaction of the transforming acidic coiled-coil 1 (TACC1) protein with ch-TOG and GAS41/NuBI1 suggests multiple TACC1-containing protein complexes in human cells | Interaction of the transforming acidic coiled-coil 1 (TACC1) protein with ch-TOG and GAS41/NuBI1 suggests multiple TACC1-containing protein complexes in human cells.
Lauffart B, Howell SJ, Tasch JE, Cowell JK, Still IH., Free PMC Article | 01/21/2010 |
| TOG has roles during mitosis in focusing MT minus ends at spindle poles, maintaining centrosome integrity, and contributing to spindle bipolarity | TOGp, the human homolog of XMAP215/Dis1, is required for centrosome integrity, spindle pole organization, and bipolar spindle assembly.
Cassimeris L, Morabito J., Free PMC Article | 01/21/2010 |
| TOG mediates the association of hnRNP A2-positive granules with microtubules during transport and/or localization | The microtubule-associated protein tumor overexpressed gene binds to the RNA trafficking protein heterogeneous nuclear ribonucleoprotein A2.
Kosturko LD, Maggipinto MJ, D'Sa C, Carson JH, Barbarese E., Free PMC Article | 01/21/2010 |
| Hsp90 is required to localize ch-TOG to the mitotic spindle. | Hsp90 is required to localise cyclin B and Msps/ch-TOG to the mitotic spindle in Drosophila and humans.
Basto R, Gergely F, Draviam VM, Ohkura H, Liley K, Raff JW. | 01/21/2010 |