| Cottontail rabbit papillomavirus E6 proteins: Interaction with MAML1 and modulation of the Notch signaling pathway. | Cottontail rabbit papillomavirus E6 proteins: Interaction with MAML1 and modulation of the Notch signaling pathway.
Lim J, Frecot DI, Stubenrauch F, Iftner T, Simon C. | 10/29/2022 |
| Elucidated tumorigenic role of MAML1 and TWIST1 in gastric cancer is associated with Helicobacter pylori infection. | Elucidated tumorigenic role of MAML1 and TWIST1 in gastric cancer is associated with Helicobacter pylori infection.
Hamidi AA, Forghanifard MM, Gholamin M, Moghbeli M, Memar B, Jangjoo A, Motie MR, Molaei F, Abbaszadegan MR. | 01/22/2022 |
| MAML1 promotes ESCC aggressiveness through upregulation of EMT marker TWIST1. | MAML1 promotes ESCC aggressiveness through upregulation of EMT marker TWIST1.
Forghanifard MM, Azaraz S, Ardalan Khales S, Morshedi Rad D, Abbaszadegan MR. | 02/6/2021 |
| MAML1/2 promote YAP/TAZ nuclear localization and tumorigenesis. | MAML1/2 promote YAP/TAZ nuclear localization and tumorigenesis.
Kim J, Kwon H, Shin YK, Song G, Lee T, Kim Y, Jeong W, Lee U, Zhang X, Nam G, Jeung HC, Kim W, Jho EH., Free PMC Article | 09/19/2020 |
| MAML1-Dependent Notch-Responsive Genes Exhibit Differing Cofactor Requirements for Transcriptional Activation. | MAML1-Dependent Notch-Responsive Genes Exhibit Differing Cofactor Requirements for Transcriptional Activation.
Rogers JM, Guo B, Egan ED, Aster JC, Adelman K, Blacklow SC., Free PMC Article | 08/15/2020 |
| ZBP-89 negatively regulates self-renewal of liver cancer stem cells via suppression of Notch1 signaling pathway. | ZBP-89 negatively regulates self-renewal of liver cancer stem cells via suppression of Notch1 signaling pathway.
Wang N, Li MY, Liu Y, Yu J, Ren J, Zheng Z, Wang S, Yang S, Yang SL, Liu LP, Hu BG, Chong CC, Merchant JL, Lai PB, Chen GG., Free PMC Article | 08/15/2020 |
| MAML1 may be utilized for targeted therapy with a low side effect. | Role of MAML1 in targeted therapy against the esophageal cancer stem cells.
Moghbeli M, Mosannen Mozaffari H, Memar B, Forghanifard MM, Gholamin M, Abbaszadegan MR., Free PMC Article | 04/11/2020 |
| Knockdown of MAML1 inhibits proliferation and induces apoptosis of T-ALL cells through SP1-dependent inactivation of TRIM59. | Knockdown of MAML1 inhibits proliferation and induces apoptosis of T-cell acute lymphoblastic leukemia cells through SP1-dependent inactivation of TRIM59.
Cheng H, Chen L, Hu X, Qiu H, Xu X, Gao L, Tang G, Zhang W, Wang J, Yang J, Huang C. | 03/21/2020 |
| Neuron production in human cerebral cortex is coordinated by the MAML1. | Coordination of Neuron Production in Mouse and Human Cerebral Cortex by the Homolog of Drosophila Mastermind Protein.
Ayoub AE, Dominguez MH, Benoit J, Ortega JA, Radonjic N, Zecevic N, Rakic P., Free PMC Article | 02/8/2020 |
| Data indicated that MAML1 negatively regulates epithelial-mesenchymal transition markers expression in breast cancer cells. | MAML1 regulates EMT markers expression through NOTCH-independent pathway in breast cancer cell line MCF7.
Shariat Razavi SM, Forghanifard MM, Kordi-Tamandani DM, Abbaszadegan MR. | 11/9/2019 |
| These new findings suggest an oncogenic role for concomitant expression of MAML1 and TWIST1 genes in head and neck squamous cell carcinoma invasion and metastasis | MAML1 and TWIST1 co-overexpression promote invasion of head and neck squamous cell carcinoma.
Ardalan Khales S, Ebrahimi E, Jahanzad E, Ardalan Khales S, Forghanifard MM. | 05/11/2019 |
| Our results showed that MEIS1 may have a negative role in regulation of MAML1expression during the esophageal squamous cell carcinoma progression. | Role of MAML1 and MEIS1 in Esophageal Squamous Cell Carcinoma Depth of Invasion.
Abbaszadegan MR, Moghbeli M. | 09/1/2018 |
| The divergence of E6 proteins from either MAML1 or E6AP binding preference is a major event in papillomavirus evolution. | Association of papillomavirus E6 proteins with either MAML1 or E6AP clusters E6 proteins by structure, function, and evolutionary relatedness.
Brimer N, Drews CM, Vande Pol SB., Free PMC Article | 06/30/2018 |
| Authors report that p300 and CBP acetylate Mastermind-like 1 (Maml1) on amino acid residues K188 and K189 to recruit NACK to the Notch1 ternary complex, which results in the recruitment of RNA polymerase II to initiate transcription. | Acetylation of Mastermind-like 1 by p300 Drives the Recruitment of NACK to Initiate Notch-Dependent Transcription.
Jin K, Zhou W, Han X, Wang Z, Li B, Jeffries S, Tao W, Robbins DJ, Capobianco AJ. | 09/30/2017 |
| Overexpression of Mastermind like1 was detected in 59% of tumor samples | Contribution of MAML1 in esophageal squamous cell carcinoma tumorigenesis.
Hashemi Bidokhti M, Abbaszadegan MR, Sharifi N, Abbasi Sani S, Forghanifard MM. | 04/15/2017 |
| MAML1 may play an important role in tumor progression of Hepatocellular Carcinoma. | Mastermind-like Transcriptional Coactivator 1 Overexpression Predicts Poor Prognosis in Human with Hepatocellular Carcinoma.
Wang J, Zhang SM, Wu JM, Lu ZC, Yang JR, Wu HS, Chen H, Lin B, Xu RH, Cao TS. | 01/14/2017 |
| Notch signaling was altered in almost half of the clear-cell renal cell carcinoma patients and copy number variances in MAML1 and KAT2B were predominant changes. | Genetic alteration in notch pathway is associated with better prognosis in renal cell carcinoma.
Feng C, Xiong Z, Jiang H, Ding Q, Fang Z, Hui W. | 11/12/2016 |
| The transcriptional coregulator MAML1 affects DNA methylation and gene expression patterns in human embryonic kidney cells. | The transcriptional coregulator MAML1 affects DNA methylation and gene expression patterns in human embryonic kidney cells.
Putnik M, Brodin D, Wojdacz TK, Fagerström-Billai F, Dahlman-Wright K, Wallberg AE. | 10/29/2016 |
| MMAL1 overexpression is associated with Esophageal Squamous Cell Carcinoma. | Role of Msi1 and MAML1 in Regulation of Notch Signaling Pathway in Patients with Esophageal Squamous Cell Carcinoma.
Moghbeli M, Forghanifard MM, Sadrizadeh A, Mozaffari HM, Golmakani E, Abbaszadegan MR. | 09/17/2016 |
| study identifies that MAML1 is ubiquitinated in the absence of Notch signaling to maintain low levels of MAML1 in the cell | Mastermind-Like 1 Is Ubiquitinated: Functional Consequences for Notch Signaling.
Farshbaf M, Lindberg MJ, Truong A, Bevens Z, Chambers E, Pournara A, Wallberg AE, White JB., Free PMC Article | 05/7/2016 |
| In MCF-7 cells p53 associates with the Notch transcriptional complex (NTC) in a MAML1-dependent fashion, most likely through a p53-MAML1 interaction. | p53 Modulates Notch Signaling in MCF-7 Breast Cancer Cells by Associating With the Notch Transcriptional Complex Via MAML1.
Yun J, Espinoza I, Pannuti A, Romero D, Martinez L, Caskey M, Stanculescu A, Bocchetta M, Rizzo P, Band V, Band H, Kim HM, Park SK, Kang KW, Avantaggiati ML, Gomez CR, Golde T, Osborne B, Miele L., Free PMC Article | 11/21/2015 |
| The impact of MAML1 genetic variants to heart rate was discovered. | Insight into genetic determinants of resting heart rate.
Mezzavilla M, Iorio A, Bobbo M, D'Eustacchio A, Merlo M, Gasparini P, Ulivi S, Sinagra G. | 08/30/2014 |
| Data indicate that EpCAM, CK19, and hMAM triple-marker-positive circulating tumor cells (CTCs) were detected in 86 of 98 (87.8 %) patients. | Circulating tumor cells (CTCs) detected by triple-marker EpCAM, CK19, and hMAM RT-PCR and their relation to clinical outcome in metastatic breast cancer patients.
Zhao S, Yang H, Zhang M, Zhang D, Liu Y, Liu Y, Song Y, Zhang X, Li H, Ma W, Zhang Q. | 08/31/2013 |
| Snail decreased transcription of Notch1 intracellular domain (NICD) target genes via competing with MAML1, co-activator, in NICD complex. | Snail inhibits Notch1 intracellular domain mediated transcriptional activation via competing with MAML1.
Kim HS, Jeong H, Lim SO, Jung G. | 05/25/2013 |
| Authors report that human papillomavirus type 8 E6 subverts NOTCH activation during keratinocyte differentiation by inhibiting RBPJ/MAML1 transcriptional activator complexes at NOTCH target DNA. | The human papillomavirus type 8 E6 protein interferes with NOTCH activation during keratinocyte differentiation.
Meyers JM, Spangle JM, Munger K., Free PMC Article | 05/18/2013 |