| Identification and verification of the prognostic value of CUL7 in colon adenocarcinoma. | Identification and verification of the prognostic value of CUL7 in colon adenocarcinoma.
Wang C, Zhao Z, Zhang Y, Liang W, Zhou C, Lin W, He Y, Wu M, Meng Z, Liao Y, Li M, El Akkawi M, Zhao J, He Y., Free PMC Article | 11/5/2022 |
| Natural history of facial and skeletal features from neonatal period to adulthood in a 3M syndrome cohort with biallelic CUL7 or OBSL1 variants. | Natural history of facial and skeletal features from neonatal period to adulthood in a 3M syndrome cohort with biallelic CUL7 or OBSL1 variants.
Tüysüz B, Alp Ünkar Z, Turan H, Gezdirici A, Uludağ Alkaya D, Kasap B, Yeşil G, Vural M, Ercan O. | 03/5/2022 |
| Identification of two CUL7 variants in two Chinese families with 3-M syndrome by whole-exome sequencing. | Identification of two CUL7 variants in two Chinese families with 3-M syndrome by whole-exome sequencing.
Hu L, Wang X, Jin T, Han Y, Liu J, Jiang M, Yan S, Fu X, An B, Huang S., Free PMC Article | 08/7/2021 |
| A rare cause of syndromic short stature: 3M syndrome in three families. | A rare cause of syndromic short stature: 3M syndrome in three families.
Isik E, Arican D, Atik T, Ooi JE, Darcan S, Ozen S, Simsek Kiper PO, Utine E, Cogulu O, Ozkinay F. | 07/10/2021 |
| A novel mutation within intron 17 of the CUL7 gene results in appearance of premature termination codon. | A novel mutation within intron 17 of the CUL7 gene results in appearance of premature termination codon.
Guo L, Feng Z, Jin X, Yin S, Zhang M, Gao Y, Zhang B, Wang H, Liu L. | 01/16/2021 |
| Cullin-7 (CUL7) is overexpressed in glioma cells and promotes tumorigenesis via NF-kappaB activation. | Cullin-7 (CUL7) is overexpressed in glioma cells and promotes tumorigenesis via NF-κB activation.
Xu J, Zhang Z, Qian M, Wang S, Qiu W, Chen Z, Sun Z, Xiong Y, Wang C, Sun X, Zhao R, Xue H, Li G., Free PMC Article | 12/12/2020 |
| The mutational spectrum of CUL7, OBSL1, and investigation of genotype-phenotype correlation in 3M syndrome has been reported. | Further expanding the mutational spectrum and investigation of genotype-phenotype correlation in 3M syndrome.
Simsek-Kiper PO, Taskiran E, Kosukcu C, Arslan UE, Cormier-Daire V, Gonc N, Ozon A, Alikasifoglu A, Kandemir N, Utine GE, Alanay Y, Alikasifoglu M, Boduroglu K. | 06/13/2020 |
| REVIEW: Cullin-RING E3 Ubiquitin Ligase 7 in Growth Control and Cancer | Cullin-RING E3 Ubiquitin Ligase 7 in Growth Control and Cancer.
Pan ZQ., Free PMC Article | 02/29/2020 |
| CUL7 prevents Caspase-8 activation by promoting Caspase-8 modification with non-degradative polyubiquitin chains at K215. CUL7 knockdown sensitized cancer cells to TRAIL-induced apoptosis in vitro and in nude mice. | CUL7 promotes cancer cell survival through promoting Caspase-8 ubiquitination.
Kong Y, Wang Z, Huang M, Zhou Z, Li Y, Miao H, Wan X, Huang J, Mao X, Chen C. | 01/18/2020 |
| Mutation in Cul7 gene is associated with 3M syndrome. | Novel mutation in Cul7 gene in a family diagnosed with 3M syndrome.
Shaikh S, Shettigar SKG, Kumar S, Kantharia S, Kurva J, Cherian S. | 07/13/2019 |
| Study shows that cullin 7 is highly expressed in breast cancer cells and suggests that positive expression is associated with the malignant phenotype and a predictor of poor prognosis. Cullin 7 is involved in cell proliferation and invasion by regulating the cell cycle and microtubule stability. | Cullin 7 is a predictor of poor prognosis in breast cancer patients and is involved in the proliferation and invasion of breast cancer cells by regulating the cell cycle and microtubule stability.
Qiu N, He Y, Zhang S, Hu X, Chen M, Li H. | 09/8/2018 |
| CUL7 expression was associated with EC progression and poor prognosis. CUL7 may promote EMT via the ERKSNAI2 pathway in EC. | Cullin7 promotes epithelial‑mesenchymal transition of esophageal carcinoma via the ERK‑SNAI2 signaling pathway.
Tian P, Liu D, Sun L, Sun H. | 09/1/2018 |
| overexpression of Cullin7 plays an important role in the pathogenesis and progression of hepatocellular carcinoma and may be a valuable marker for hepatocellular carcinoma management. | Overexpression of Cullin7 is associated with hepatocellular carcinoma progression and pathogenesis.
An J, Zhang Z, Liu Z, Wang R, Hui D, Jin Y., Free PMC Article | 07/28/2018 |
| Hepatocellular carcinoma patients with positive expression for both Rabl3 and Cullin7 had a remarkably shorter survival time compared with patients with negative expression for both proteins. | Overexpression of Rabl3 and Cullin7 is associated with pathogenesis and poor prognosis in hepatocellular carcinoma.
An J, Liu Z, Liang Q, Pan Y, Li H, Wang R, Jin Y. | 10/21/2017 |
| our study provided evidence that Cullin7 functions as a novel oncogene in lung cancer and may be a potential therapeutic target for lung cancer management. | Cullin7 is required for lung cancer cell proliferation and is overexpressed in lung cancer.
Men X, Wang L, Yu W, Ju Y., Free PMC Article | 02/18/2017 |
| Cullin7 promotes epithelial-mesenchymal transformation of cancer cells. | Inhibition of Liver Carcinoma Cell Invasion and Metastasis by Knockdown of Cullin7 In Vitro and In Vivo.
Zhang D, Yang G, Li X, Xu C, Ge H., Free PMC Article | 12/31/2016 |
| We report a family with variable phenotypic features of 3-M syndrome and we describe the prenatal and postnatal growth pattern of two affected sisters with a novel homozygous CUL7 mutation (c.3173-1G>C), showing a pre- and post-natal growth deficiency and a normal cranial circumference. | Pre- and post-natal growth in two sisters with 3-M syndrome.
Lugli L, Bertucci E, Mazza V, Elmakky A, Ferrari F, Neuhaus C, Percesepe A. | 12/17/2016 |
| report an adult female with 3-M syndrome that was caused by novel compound heterozygous mutations (c.4023-1 G>A in splice acceptor site of exon 22 and c.4359_4363dupGGCTG in exon 23) in the CUL7 gene | Changes in facial appearance from neonate to adult in 3-M syndrome patient with novel CUL7 gene mutations.
Hasegawa K, Tanaka H, Higuchi Y, Yamashita M, Tsukahara H. | 10/29/2016 |
| Cullin7 may serve as an indicator of poor prognosis in patients with epithelial ovarian cancer. | High Expression of Cullin7 Correlates with Unfavorable Prognosis in Epithelial Ovarian Cancer Patients.
Xi J, Zeng ST, Guo L, Feng J. | 08/6/2016 |
| study provided evidence that Cullin7 functions as a novel oncogene in breast cancer and may be a potential therapeutic target for breast cancer management | Overexpressed ubiquitin ligase Cullin7 in breast cancer promotes cell proliferation and invasion via down-regulating p53.
Guo H, Wu F, Wang Y, Yan C, Su W. | 08/10/2015 |
| CUL7, OBSL1 and CCDC8 modulate the alternative splicing of the INSR | Identifying biological pathways that underlie primordial short stature using network analysis.
Hanson D, Stevens A, Murray PG, Black GC, Clayton PE., Free PMC Article | 01/17/2015 |
| The CUL7, OBSL1, and CCDC8 proteins form a 3M complex that functions in maintaining microtubule and genome integrity and normal development. | The 3M complex maintains microtubule and genome integrity.
Yan J, Yan F, Li Z, Sinnott B, Cappell KM, Yu Y, Mo J, Duncan JA, Chen X, Cormier-Daire V, Whitehurst AW, Xiong Y., Free PMC Article | 08/9/2014 |
| CUL7/Fbxw8 ubiquitin ligase-mediated HPK1 degradation revealed a direct link and novel role of CUL7/Fbxw8 ubiquitin ligase in the MAPK pathway, which plays a critical role in cell proliferation and differentiation. | The CUL7/F-box and WD repeat domain containing 8 (CUL7/Fbxw8) ubiquitin ligase promotes degradation of hematopoietic progenitor kinase 1.
Wang H, Chen Y, Lin P, Li L, Zhou G, Liu G, Logsdon C, Jin J, Abbruzzese JL, Tan TH, Wang H., Free PMC Article | 05/3/2014 |
| Homozygous deletion in exon 18 of the CUL7 gene, which has not been previously described, could be responsible for the 3-M syndrome. | 3-M syndrome associated with growth hormone deficiency: 18 year follow-up of a patient.
Meazza C, Lausch E, Pagani S, Bozzola E, Calcaterra V, Superti-Furga A, Silengo M, Bozzola M., Free PMC Article | 09/21/2013 |
| This study demonstrates specific genomic alterations in HCC/MS and points to CUL7 as a novel gene potentially involved in liver carcinogenesis associated with metabolic Syndrome, the amplification of which might influence cell proliferation. | Cullin7: a new gene involved in liver carcinogenesis related to metabolic syndrome.
Paradis V, Albuquerque M, Mebarki M, Hernandez L, Zalinski S, Quentin S, Belghiti J, Soulier J, Bedossa P. | 07/6/2013 |