| Association between iron metabolism and SARS-COV-2 infection, determined by ferritin, hephaestin and hypoxia-induced factor-1 alpha levels in COVID-19 patients. | Association between iron metabolism and SARS-COV-2 infection, determined by ferritin, hephaestin and hypoxia-induced factor-1 alpha levels in COVID-19 patients.
Aslan ES, Aydın H, Tekin YK, Keleş S, White KN, Hekim N., Free PMC Article | 03/17/2023 |
| Zinc induces iron egress from intestinal Caco-2 cells via induction of Hephaestin: A role for PI3K in intestinal iron absorption. | Zinc induces iron egress from intestinal Caco-2 cells via induction of Hephaestin: A role for PI3K in intestinal iron absorption.
Kondaiah P, Sharp PA, Pullakhandam R. | 09/26/2020 |
| Iron supplementation increased surface expression of the iron-efflux complex, and copper depletion knocked down hephaestin (Heph) activity and decreased ferroportin (Fpn) membrane localization. | Fluorescence resonance energy transfer links membrane ferroportin, hephaestin but not ferroportin, amyloid precursor protein complex with iron efflux.
Dlouhy AC, Bailey DK, Steimle BL, Parker HV, Kosman DJ., Free PMC Article | 06/1/2019 |
| This review describes function of hephaestin as ferroxidase is essential for iron binding to apotransferrin in the lamina propria of the intestinal mucosa, a process that is important for further transport of iron to the liver by the portal vein. | [Ceruloplasmin, hephaestin and zyklopen: the three multicopper oxidases important for human iron metabolism].
Wierzbicka D, Gromadzka G. | 03/28/2015 |
| Iron efflux from human brain microvasculature endothelial cells ferroportin requires the action of an exocytoplasmic ferroxidase which can be either endogenous hephaestin or extracellular ceruloplasmin. | Ferroportin and exocytoplasmic ferroxidase activity are required for brain microvascular endothelial cell iron efflux.
McCarthy RC, Kosman DJ., Free PMC Article | 08/31/2013 |
| Heph is active in placenta but may not play a key role in placental iron transport. | Ferroportin 1 and hephaestin expression in BeWo cell line with different iron treatment.
Li YQ, Bai B, Cao XX, Yan H, Zhuang GH. | 08/4/2012 |
| These results support the hypothesis that hephaestin is involved in iron mobilization of iron from the intestine to circulation. | Iron repletion relocalizes hephaestin to a proximal basolateral compartment in polarized MDCK and Caco2 cells.
Lee SM, Attieh ZK, Son HS, Chen H, Bacouri-Haidar M, Vulpe CD., Free PMC Article | 08/4/2012 |
| In contrast to ceruloplasmin, hephaestin was incapable of direct oxidation of adrenaline and dopamine implying a difference in biological substrate specificities between these two homologous ferroxidases. | Oxidation of organic and biogenic amines by recombinant human hephaestin expressed in Pichia pastoris.
Vashchenko G, Bleackley MR, Griffiths TA, MacGillivray RT. | 11/5/2011 |
| Observational study of gene-disease association. (HuGE Navigator) | Examination of genetic polymorphisms in newborns for signatures of sex-specific prenatal selection.
Ucisik-Akkaya E, Davis CF, Do TN, Morrison BA, Stemmer SM, Amadio WJ, Dorak MT. | 09/15/2010 |
| Hephaestin is expressed in enterocytes, in the antral portion of the stomach, in the myenteric and submucous plexi, and in pancreatic beta-cells. | Human hephaestin expression is not limited to enterocytes of the gastrointestinal tract but is also found in the antrum, the enteric nervous system, and pancreatic {beta}-cells.
Hudson DM, Curtis SB, Smith VC, Griffiths TA, Wong AY, Scudamore CH, Buchan AM, MacGillivray RT. | 03/22/2010 |
| Repletion of copper in Caco2 cells leads to reconstitution of hephaestin protein expression, activity, and transepithelial iron transport. | Decreased hephaestin expression and activity leads to decreased iron efflux from differentiated Caco2 cells.
Chen H, Attieh ZK, Dang T, Huang G, van der Hee RM, Vulpe C. | 01/21/2010 |
| stable complex between these Cp and Hp and Tf does not occur under the experimental conditions used | Neither human hephaestin nor ceruloplasmin forms a stable complex with transferrin.
Hudson DM, Krisinger MJ, Griffiths TA, Macgillivray RT. | 01/21/2010 |
| Results suggest the possibility that FPN-1 might associate and interact with Heph in the process of iron exit across the basolateral membrane of intestinal absorptive cell. | Colocalization of ferroportin-1 with hephaestin on the basolateral membrane of human intestinal absorptive cells.
Han O, Kim EY. | 01/21/2010 |
| The gene structure, spanning approximately 100 kb, was assembled from the cDNA clones and the chromosome X genomic sequence data. Modelling supports its role as a membrane-tethered ferroxidase. | Analysis of the human hephaestin gene and protein: comparative modelling of the N-terminus ecto-domain based upon ceruloplasmin.
Syed BA, Beaumont NJ, Patel A, Naylor CE, Bayele HK, Joannou CL, Rowe PS, Evans RW, Srai SK. | 01/21/2010 |
| location was observed on or near the cell surface suggesting it might participate in surface membrane transport of iron | Cellular location of proteins related to iron absorption and transport.
Simovich MJ, Conrad ME, Umbreit JN, Moore EG, Hainsworth LN, Smith HK. | 01/21/2010 |
| Reombinant hephaestin was shown to have both multicopper oxidase and ferroxidase activity. | Recombinant expression and functional characterization of human hephaestin: a multicopper oxidase with ferroxidase activity.
Griffiths TA, Mauk AG, MacGillivray RT. | 01/21/2010 |
| The hephaestin protein mRNA expression is not significantly altered by variations in iron homeostasis. The effect of phlebotomy-induced erythropoiesis did not alter either gene transcript mRNA expression. | Duodenal Dcytb and hephaestin mRNA expression are not significantly modulated by variations in body iron homeostasis.
Gleeson F, Ryan E, Barrett S, Russell J, Kelleher B, Crowe J. | 01/21/2010 |