| CDC6 may serve as an indicator of lung adenocarcinoma prognosis and progression based on TCGA and GEO data mining and experimental analyses. | CDC6 may serve as an indicator of lung adenocarcinoma prognosis and progression based on TCGA and GEO data mining and experimental analyses.
Lou H, Wu Z, Wei G., Free PMC Article | 01/12/2024 |
| Role of TOP2A and CDC6 in liver cancer. | Role of TOP2A and CDC6 in liver cancer.
Jia W, Liu X, Zhang Z., Free PMC Article | 10/30/2023 |
| CDC6 is a prognostic biomarker and correlated with immune infiltrates in glioma. | CDC6 is a prognostic biomarker and correlated with immune infiltrates in glioma.
Wang F, Zhao F, Zhang L, Xiong L, Mao Q, Liu Y, Qiu X, Wang X, Shui L, Chen X, Ren K, Shui P, Zhang Q, Deng Y, Li W, Xie X, Wu D, Li T, Lang J, Liu L, Chen H, Xu J, Bai S, Li Z, Yue Q, Chen N, Zhou B, Yi C, Wei Y, Fu Y, Luo Y, Gou Q, Liu L, Liu Y, Kang J, Wang J, Jing D, Zhang F, Yang X, Li X, Jiang T, Zhang Z, Zhou Y, Yi J., Free PMC Article | 07/30/2022 |
| FOXM1 Promotes Malignant Proliferation of Esophageal Squamous Cell Carcinoma Through Transcriptional Activating CDC6. | FOXM1 Promotes Malignant Proliferation of Esophageal Squamous Cell Carcinoma Through Transcriptional Activating CDC6.
Chen X, Chen J, Yu X, Lin G, Chen T., Free PMC Article | 07/16/2022 |
| The Effect of High CDC6 Levels on Predicting Poor Prognosis in Colorectal Cancer. | The Effect of High CDC6 Levels on Predicting Poor Prognosis in Colorectal Cancer.
Yang C, Xie N, Luo Z, Ruan X, Zhang Y, Wang W, Huang Y. | 03/5/2022 |
| MiR-128-3p suppresses tumor proliferation and metastasis via targeting CDC6 in hepatocellular carcinoma cells. | MiR-128-3p suppresses tumor proliferation and metastasis via targeting CDC6 in hepatocellular carcinoma cells.
Shi Y, Yan F, Wang F, Pan L. | 01/22/2022 |
| UHRF1 promotes androgen receptor-regulated CDC6 transcription and anti-androgen receptor drug resistance in prostate cancer through KDM4C-Mediated chromatin modifications. | UHRF1 promotes androgen receptor-regulated CDC6 transcription and anti-androgen receptor drug resistance in prostate cancer through KDM4C-Mediated chromatin modifications.
Gao Y, Liu Y, Liu Y, Peng Y, Yuan B, Fu Y, Qi X, Zhu Q, Cao T, Zhang S, Yin L, Li X. | 01/8/2022 |
| CDC6 is up-regulated and a poor prognostic signature in glioblastoma multiforme. | CDC6 is up-regulated and a poor prognostic signature in glioblastoma multiforme.
Zhao H, Zhou X, Yuan G, Hou Z, Sun H, Zhai N, Huang B, Li X. | 09/18/2021 |
| Interactome analysis of gene expression profiles identifies CDC6 as a potential therapeutic target modified by miR-215-5p in hepatocellular carcinoma. | Interactome analysis of gene expression profiles identifies CDC6 as a potential therapeutic target modified by miR-215-5p in hepatocellular carcinoma.
Xu H, Huang J, Hua S, Liang L, He X, Zhan M, Lu L, Chu J., Free PMC Article | 08/7/2021 |
| Multiple, short protein binding motifs in ORC1 and CDC6 control the initiation of DNA replication. | Multiple, short protein binding motifs in ORC1 and CDC6 control the initiation of DNA replication.
Hossain M, Bhalla K, Stillman B., Free PMC Article | 06/19/2021 |
| A pilot study of cdc6 as a biomarker for circulating tumor cells in patients with lung cancer. | A pilot study of cdc6 as a biomarker for circulating tumor cells in patients with lung cancer.
An C, Liu G, Cheng S, Pang B, Sun S, Zhang Y, Pan Z, Kang X., Free PMC Article | 06/5/2021 |
| Cdc6 as a novel target in cancer: Oncogenic potential, senescence and subcellular localisation. | Cdc6 as a novel target in cancer: Oncogenic potential, senescence and subcellular localisation.
Lim N, Townsend PA., Free PMC Article | 04/17/2021 |
| miR-215-5p decreases migration and invasion of trophoblast cells through regulating CDC6 in preeclampsia. | miR-215-5p decreases migration and invasion of trophoblast cells through regulating CDC6 in preeclampsia.
Yang X, Meng T. | 01/9/2021 |
| ZNF143-Mediated H3K9 Trimethylation Upregulates CDC6 by Activating MDIG in Hepatocellular Carcinoma. | ZNF143-Mediated H3K9 Trimethylation Upregulates CDC6 by Activating MDIG in Hepatocellular Carcinoma.
Zhang L, Huo Q, Ge C, Zhao F, Zhou Q, Chen X, Tian H, Chen T, Xie H, Cui Y, Yao M, Li H, Li J. | 11/21/2020 |
| mTOR Signaling Upregulates CDC6 via Suppressing miR-3178 and Promotes the Loading of DNA Replication Helicase. | mTOR Signaling Upregulates CDC6 via Suppressing miR-3178 and Promotes the Loading of DNA Replication Helicase.
Wu X, Li S, Hu X, Xiang X, Halloran M, Yang L, Williams TM, Houghton PJ, Shen C, He Z., Free PMC Article | 10/24/2020 |
| MicroRNA-1297 inhibits proliferation and promotes apoptosis in gastric cancer cells by downregulating CDC6 expression. | MicroRNA-1297 inhibits proliferation and promotes apoptosis in gastric cancer cells by downregulating CDC6 expression.
Zhang X, Zhang M, Guo Q, Hu X, Zhao Z, Ni L, Liu L, Wang X, Wang Z, Tong D, Chang S, Cao Y, Huang C. | 09/26/2020 |
| RYBP suppresses esophageal squamous cell carcinoma proliferation by downregulating CDC6 and CDC45, thus inhibiting the G1-S transition | RYBP inhibits esophageal squamous cell carcinoma proliferation through downregulating CDC6 and CDC45 in G1-S phase transition process.
Ke Y, Guo W, Huang S, Li Y, Guo Y, Liu X, Jin Y, Ma H. | 05/9/2020 |
| Acute IR exposure raised CDC6 protein levels due to the attenuation of ubiquitination. CDC6 overexpression was seen in the radioresistant cells because lack of CDC6 phosphorylation blocked protein translocation from nucleus to cytoplasm, causing subcellular protein accumulation when the cells were arrested in G0/G1 phase. CDC6 ectopic overexpression in CNE2 cells caused apoptosis resistance, G0/G1 arrest, EMT and aging. | Radiation-promoted CDC6 protein stability contributes to radioresistance by regulating senescence and epithelial to mesenchymal transition.
Yu X, Liu Y, Yin L, Peng Y, Peng Y, Gao Y, Yuan B, Zhu Q, Cao T, Xie B, Sun L, Chen Y, Gong Z, Qiu Y, Fan X, Li X., Free PMC Article | 05/11/2019 |
| DNA replication licensing factor Cdc6 is recruited to the proximal side of the centrioles via cyclin A to negatively regulate centrosome duplication by binding and inhibiting the cartwheel protein Sas-6 from forming a stable complex with another centriole duplication core protein, STIL. | DNA replication licensing factor Cdc6 and Plk4 kinase antagonistically regulate centrosome duplication via Sas-6.
Xu X, Huang S, Zhang B, Huang F, Chi W, Fu J, Wang G, Li S, Jiang Q, Zhang C., Free PMC Article | 11/24/2018 |
| Results show that both Cdc6 and Cdt1, when expressed in a high level, alone or in combination, were significantly associated with poorer survival in the breast cancer patient cohort. In line with this finding, the expression of Cdc6 and Cdt1 was upregulated in breast cancer cells compared to normal breast epithelial cells. Expression of Cdc6 and Cdt1 was significantly higher in ER negative breast cancer. | The prognostic significance of Cdc6 and Cdt1 in breast cancer.
Mahadevappa R, Neves H, Yuen SM, Bai Y, McCrudden CM, Yuen HF, Wen Q, Zhang SD, Kwok HF., Free PMC Article | 09/8/2018 |
| Results suggested that Cdc6 controls centrosome duplication in a manner independent of its recruitment of PCM proteins to the centrosome. | The Replication Protein Cdc6 Suppresses Centrosome Over-Duplication in a Manner Independent of Its ATPase Activity.
Kim GS, Lee I, Kim JH, Hwang DS., Free PMC Article | 08/18/2018 |
| WHSC1L1 and H3K36me2 are enriched in the gene bodies of the cell cycle-related genes CDC6 and CDK2, implying that WHSC1L1 directly regulates the transcription of these gene | WHSC1L1 drives cell cycle progression through transcriptional regulation of CDC6 and CDK2 in squamous cell carcinoma of the head and neck.
Saloura V, Vougiouklakis T, Zewde M, Kiyotani K, Park JH, Gao G, Karrison T, Lingen M, Nakamura Y, Hamamoto R., Free PMC Article | 01/20/2018 |
| Cdc6 expression is up-regulated in bladder cancer tissues and is positively correlated to high tumor grade. | Cdc6 contributes to cisplatin-resistance by activation of ATR-Chk1 pathway in bladder cancer cells.
Chen S, Chen X, Xie G, He Y, Yan D, Zheng D, Li S, Fu X, Li Y, Pang X, Hu Z, Li H, Tan W, Li J., Free PMC Article | 01/20/2018 |
| PPP2R3B codes for the PR70 protein, a regulatory substrate-recognizing subunit of protein phosphatase 2A. PR70 decreased melanoma growth by negatively interfering with DNA replication and cell cycle progression through its role in stabilizing CDC6-chromatin licensing and CDT1 interaction | The protein phosphatase 2A regulatory subunit PR70 is a gonosomal melanoma tumor suppressor gene.
van Kempen LC, Redpath M, Elchebly M, Klein KO, Papadakis AI, Wilmott JS, Scolyer RA, Edqvist PH, Pontén F, Schadendorf D, van Rijk AF, Michiels S, Dumay A, Helbling-Leclerc A, Dessen P, Wouters J, Stass M, Greenwood CM, Ghanem GE, van den Oord J, Feunteun J, Spatz A. | 12/30/2017 |
| AZD7762 demonstrates synergy with regard to inhibition of AR-CDC6-ATR-Chk1 signaling. | Targeting DNA Damage Response in Prostate Cancer by Inhibiting Androgen Receptor-CDC6-ATR-Chk1 Signaling.
Karanika S, Karantanos T, Li L, Wang J, Park S, Yang G, Zuo X, Song JH, Maity SN, Manyam GC, Broom B, Aparicio AM, Gallick GE, Troncoso P, Corn PG, Navone N, Zhang W, Li S, Thompson TC., Free PMC Article | 12/2/2017 |