| The Collagen Receptor uPARAP in Malignant Mesothelioma: A Potential Diagnostic Marker and Therapeutic Target. | The Collagen Receptor uPARAP in Malignant Mesothelioma: A Potential Diagnostic Marker and Therapeutic Target.
Çakılkaya P, Sørensen RR, Jürgensen HJ, Krigslund O, Gårdsvoll H, Nielsen CF, Santoni-Rugiu E, Behrendt N, Engelholm LH., Free PMC Article | 01/15/2022 |
| MRC2 Promotes Proliferation and Inhibits Apoptosis of Diabetic Nephropathy. | MRC2 Promotes Proliferation and Inhibits Apoptosis of Diabetic Nephropathy.
Li L, Chen X, Zhang H, Wang M, Lu W., Free PMC Article | 12/18/2021 |
| Mathematical modelling of the role of Endo180 network in the development of metastatic bone disease in prostate cancer. | Mathematical modelling of the role of Endo180 network in the development of metastatic bone disease in prostate cancer.
Ji B, Chen J, Zhen C, Yang Q, Yu N. | 07/17/2021 |
| These results indicate that a substance secreted from UVB-exposed keratinocytes regulates Endo180 expression and that IL-1alpha may play an important role in the maintenance of Endo180. | Interleukin-1 alpha derived from ultraviolet B-exposed keratinocytes is associated with a decrease of endocytic collagen receptor Endo180.
Iwahashi H, Kawashima Y, Masaki H. | 06/6/2020 |
| In lung tissue from idiopathic pulmonary fibrosis patients, a strong up-regulation of uPARAP was observed in fibroblasts adjacent to regions with SP-D secretion. | Immune regulation by fibroblasts in tissue injury depends on uPARAP-mediated uptake of collectins.
Jürgensen HJ, Nørregaard KS, Sibree MM, Santoni-Rugiu E, Madsen DH, Wassilew K, Krustrup D, Garred P, Bugge TH, Engelholm LH, Behrendt N., Free PMC Article | 10/26/2019 |
| Endo180 knockdown in pancreatic stellate cells (PSCs) attenuated the invasive abilities of PSCs and co-cultured pancreatic cancer cells, and decreased the expression level of phosphorylated myosin light chain 2 (MLC2). | Pancreatic stellate cells reorganize matrix components and lead pancreatic cancer invasion via the function of Endo180.
Koikawa K, Ohuchida K, Takesue S, Ando Y, Kibe S, Nakayama H, Endo S, Abe T, Okumura T, Horioka K, Sada M, Iwamoto C, Moriyama T, Nakata K, Miyasaka Y, Ohuchida R, Manabe T, Ohtsuka T, Nagai E, Mizumoto K, Hashizume M, Nakamura M. | 12/9/2017 |
| results provide a molecular mechanism to support the structural flexibility of uPARAP, and shed light on the structural flexibility of other members of the MR family | Crystal structures of the ligand-binding region of uPARAP: effect of calcium ion binding.
Yuan C, Jürgensen HJ, Engelholm LH, Li R, Liu M, Jiang L, Luo Z, Behrendt N, Huang M. | 06/10/2017 |
| A model of the ligand-binding region of uPARAP was obtained by molecular replacement. | Expression and crystallographic studies of the ligand-binding region of the human endocytic collagen receptor uPARAP.
Yuan C, Huang JH, Liu M, Huang M., Free PMC Article | 09/17/2016 |
| The positive correlation between suPLAUR expression and body mass index, suggests that leukocyte recruitment in obese tissue may be regulated, at least in part, through the splicing of the PLAUR transcript. | The mRNA expression of soluble urokinase plasminogen activator surface receptor in human adipose tissue is positively correlated with body mass index.
Ng HF, Chin KF, Chan KG, Ngeow YF. | 06/11/2016 |
| Our findings identify sarcoma cell-resident uPARAP/Endo180 as a central player in the bone degeneration of advanced osteosarcoma | Targeting a novel bone degradation pathway in primary bone cancer by inactivation of the collagen receptor uPARAP/Endo180.
Engelholm LH, Melander MC, Hald A, Persson M, Madsen DH, Jürgensen HJ, Johansson K, Nielsen C, Nørregaard KS, Ingvarsen SZ, Kjaer A, Trovik CS, Laerum OD, Bugge TH, Eide J, Behrendt N. | 05/28/2016 |
| Study identifies the interaction between lectin domain in Endo180 and CD147 as an Epithelial-to-mesenchymal transition suppressor and indicates that stabilization of this molecular complex improves prostate cancer survival rates. | Survival Outcome and EMT Suppression Mediated by a Lectin Domain Interaction of Endo180 and CD147.
Rodriguez-Teja M, Gronau JH, Minamidate A, Darby S, Gaughan L, Robson C, Mauri F, Waxman J, Sturge J. | 02/6/2016 |
| AGE-dependent modification of the basal lamina induces invasive behaviour in non-transformed prostate epithelial cells via Endo180 pathway linked to cancer progression. | AGE-modified basement membrane cooperates with Endo180 to promote epithelial cell invasiveness and decrease prostate cancer survival.
Rodriguez-Teja M, Gronau JH, Breit C, Zhang YZ, Minamidate A, Caley MP, McCarthy A, Cox TR, Erler JT, Gaughan L, Darby S, Robson C, Mauri F, Waxman J, Sturge J. | 04/18/2015 |
| MRC2 is downregulated by UVA irradiation and reduces collagen internalization; this can be recovered by all-trans retinoic acid | Reduced collagen internalization via down-regulation of MRC2 expression by UVA irradiation and its recovery by all-trans retinoic acid.
Shim JH, Shin DW, Noh MS, Lee TR. | 09/20/2014 |
| Our findings correlate for the first time impaired collagen uptake via Endo180 with the pericellular accumulation of collagen fragments during photoaging. | UV-mediated downregulation of the endocytic collagen receptor, Endo180, contributes to accumulation of extracellular collagen fragments in photoaged skin.
Tang S, Lucius R, Wenck H, Gallinat S, Weise JM. | 10/19/2013 |
| TGFbeta1-Endo180-dependent collagen deposition is dysregulated at the tumour-stromal interface in bone metastasis. | TGFβ1-Endo180-dependent collagen deposition is dysregulated at the tumour-stromal interface in bone metastasis.
Caley MP, Kogianni G, Adamarek A, Gronau JH, Rodriguez-Teja M, Fonseca AV, Mauri F, Sandison A, Rhim JS, Pchejetski D, Palmieri C, Cobb JP, Waxman J, Sturge J. | 04/28/2012 |
| A novel functional role of collagen glycosylation: interaction with the endocytic collagen receptor uparap/ENDO180. | A novel functional role of collagen glycosylation: interaction with the endocytic collagen receptor uparap/ENDO180.
Jürgensen HJ, Madsen DH, Ingvarsen S, Melander MC, Gårdsvoll H, Patthy L, Engelholm LH, Behrendt N., Free PMC Article | 11/26/2011 |
| Our present study suggests that uPARAP may be involved in glioma cell invasiveness through actin cytoskeletal rearrangement | Downregulation of uPARAP mediates cytoskeletal rearrangements and decreases invasion and migration properties in glioma cells.
Takahashi S, Yamada-Okabe H, Hamada K, Ohta S, Kawase T, Yoshida K, Toda M. | 10/1/2011 |
| fibrillar collagen deposition and the collagen internalization receptor endo180 have roles in glioma invasion | A role for fibrillar collagen deposition and the collagen internalization receptor endo180 in glioma invasion.
Huijbers IJ, Iravani M, Popov S, Robertson D, Al-Sarraj S, Jones C, Isacke CM., Free PMC Article | 01/15/2011 |
| Endo180 is a novel regulator of membrane-bound matrix metalloproteinase (MT1-MMP) activity, MT1-MMP-dependent MMP-2 activation and urokinase plasminogen activator (uPA) activity. | Membrane type-1 matrix metalloproteinase activity is regulated by the endocytic collagen receptor Endo180.
Messaritou G, East L, Roghi C, Isacke CM, Yarwood H., Free PMC Article | 07/26/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | Novel susceptibility loci for second primary tumors/recurrence in head and neck cancer patients: large-scale evaluation of genetic variants.
Wu X, Spitz MR, Lee JJ, Lippman SM, Ye Y, Yang H, Khuri FR, Kim E, Gu J, Lotan R, Hong WK., Free PMC Article | 08/12/2009 |
| To investigate the consequence of Endo180 up-regulation, MCF7 cells transfected with Endo180 were inoculated into immunocompromised mice; expression of wild-type Endo180, but not an internalization-defective Endo180 mutant, showed enhanced tumor growth. | The collagen receptor Endo180 (CD280) Is expressed on basal-like breast tumor cells and promotes tumor growth in vivo.
Wienke D, Davies GC, Johnson DA, Sturge J, Lambros MB, Savage K, Elsheikh SE, Green AR, Ellis IO, Robertson D, Reis-Filho JS, Isacke CM. | 01/21/2010 |
| Endo180 plays a physiological role in mediating collagen matrix remodelling during tissue development and homeostasis | Identification and characterization of the endocytic transmembrane glycoprotein Endo180 as a novel collagen receptor.
Wienke D, MacFadyen JR, Isacke CM., Free PMC Article | 01/21/2010 |
| Data suggest that uPARAP/Endo180 participates in the connective tissue destruction during head and neck squamous cell carcinoma progression by mediating cellular uptake and lysosomal degradation of collagen. | Increased expression of the collagen internalization receptor uPARAP/Endo180 in the stroma of head and neck cancer.
Sulek J, Wagenaar-Miller RA, Shireman J, Molinolo A, Madsen DH, Engelholm LH, Behrendt N, Bugge TH. | 01/21/2010 |
| Investigation of the role of Endo180/urokinase-type plasminogen activator receptor-associated protein as a collagenase 3 (matrix metalloproteinase 13) receptor | Investigation of the role of Endo180/urokinase-type plasminogen activator receptor-associated protein as a collagenase 3 (matrix metalloproteinase 13) receptor.
Bailey L, Wienke D, Howard M, Knäuper V, Isacke CM, Murphy G., Free PMC Article | 01/21/2010 |
| Mannose receptor activity is up-regulated by surfactant protein A on monocyte-derived macrophages. | Pulmonary surfactant protein A up-regulates activity of the mannose receptor, a pattern recognition receptor expressed on human macrophages.
Beharka AA, Gaynor CD, Kang BK, Voelker DR, McCormack FX, Schlesinger LS. | 01/21/2010 |